Small Type 1 Fibers: Causes & Reasons

Possible Causes for Small Type 1 Fibers

Samples taken from the same patient at 5 years showed a predominance of type-1/MyHC-β expression with small, scattered type-1 fibers. [jbc.org]

At 15 months, the individual had a higher level of MyHC-peri expression (>20% of all fibers) compared with that of eight “healthy” control samples (0–2% of all fibers) taken [jbc.org]

Congenital Fiber-Type Disproportion Myopathy

[…] and type 1 fiber predominance without smallness. [ncbi.nlm.nih.gov]

A Adult onset subject with red stained central nuclei (arrows) seen in small type 1 fibers (arrow head). [rrnursingschool.biz]

CFTD is characterized by non-progressive childhood neuromuscular disorders with a relatively good prognosis and type 1 fiber predominance and smallness. [ncbi.nlm.nih.gov]

Nemaline Myopathy Type 8

Skeletal muscle histology demonstrated nemaline bodies and small type 1 fibers, but without central cores or minicores. [pubmed.ncbi.nlm.nih.gov]

Congenital Fiber-Type Disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

Other common features are type-1 fiber predominance and reduced or absent type-2B fibers. [emedicine.medscape.com]

Nemaline Myopathy Type 1

A muscle biopsy specimen showed small type 1 fibers but no inclusions. Electromyography showed a myopathic pattern. Figure 1. [jamanetwork.com]

Congenital Fiber-Type Disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

In both patients there was type 1 fiber uniformity and a considerable variability of fiber size. [jamanetwork.com]

Nemaline Myopathy

A Adult onset subject with red stained central nuclei (arrows) seen in small type 1 fibers (arrow head). [rrnursingschool.biz]

Skeletal muscle histology demonstrated nemaline bodies and small type 1 fibers, but without central cores or minicores. [ncbi.nlm.nih.gov]

B NADH tetrazo-lium reductase showing small type 1 fibers (arrows), and central nuclei with mitochondria arranged like spokes in a wheel (arrow heads) Fig. 22. [rrnursingschool.biz]

Fingerprint Body Myopathy

A Adult onset subject with red stained central nuclei (arrows) seen in small type 1 fibers (arrow head). [rrnursingschool.biz]

type disproportion myopathy (CFTD) is a congenital myopathy in which the chief pathologic features are small type 1 fibers and type 1 fiber predominance (T1FP). 5 Type 1 [synapse.koreamed.org]

Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. [uniprot.org]

Centronuclear Myopathy Type 4

[…] disproportion, with a predominance of small type 1 fibers. [n.neurology.org]

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

RECENTLY patients have been described with muscle fibers that resembled the myotubes seen in early fetal life. 1-11 In some of these cases, there were many fibers of small [jamanetwork.com]

Myosin Storage Myopathy

Other pathologic alterations were type-1 fiber predominance and frequent small type-1 fibers. [jamanetwork.com]

Congenital fiber-type disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

The biopsy specimen obtained at age 5 years showed marked type-1 fiber predominance and scattered, small, type-1 fibers. [jamanetwork.com]

Scapuloperoneal Myopathy

The most common myopathic feature is excessive variation in fiber size, with either type 1 or type 2 fibers involved. Fiber type predominance is common. [ncbi.nlm.nih.gov]

In one large family, ten of 14 muscle biopsies showed abnormally small type 1 fibers with type 1 predominance, fulfilling criteria for congenital fiber-type disproportion [ncbi.nlm.nih.gov]

Cardioneuromyopathy with Hyaline Masses and Nemaline Rods

Congenital fiber-type disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

In the deltoid muscle of patient 1 and the anterior tibial muscle of patient 2, myriad type 1 fibers harbored large, irregularly polygonal, and mostly central hyaline masses [ncbi.nlm.nih.gov]

Type-1 muscle fiber hypotrophy is usually present. [emedicine.medscape.com]

Nemaline Myopathy Type 9

Congenital Fiber-Type Disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

Other common features are type-1 fiber predominance and reduced or absent type-2B fibers. [emedicine.medscape.com]

This term was initially coined to describe a group of infants with small type-1 muscle fibers and the clinical syndrome of hypotonia and diffuse weakness that may improve [emedicine.medscape.com]

Multicore Myopathy with External Ophthalmoplegia

[…] sizes: Abnormal variation Internal nuclei NADH stain Minicores ATPase pH 9.4 stain Fiber types Type 1 fibers: Predominance; Smallness Muscle Multi/Minicores: Ultrastructure [neuromuscular.wustl.edu]

Multiple small unstained areas were seen in both Type 1 and 2 fibers on SDH, NADH-TR and COX staining [Figure - 2]. These cores were not evident in ATPase stain. [neurologyindia.com]

[…] almost always type 1 fibers. [scielo.br]

Antenatal-Onset Multicore Myopathy with Arthrogryposis

Muscle biopsy showed cytoplasmic nemaline bodies and very small type 1 fibers, which were the predominant fiber type (71%). Central cores or minicores were not observed. [bio2rdf.org]

Multiple small unstained areas were seen in both Type 1 and 2 fibers on SDH, NADH-TR and COX staining [Figure - 2]. These cores were not evident in ATPase stain. [bioline.org.br]

Type 1 and Type 2 fibers. [bioline.org.br]

Autosomal Dominant Centronuclear Myopathy

Muscle biopsy in autosomal recessive BIN1-related CNM show uniformity of small type 1 fibers with central nuclei and small package of nuclei in muscle fibers. [path.upmc.edu]

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

43:5 ) Type 1 myofiber predominance, myofiber size variation and fatty infiltration Necklace fibers: basophilic ring along the periphery of the cell membrane visible with [pathologyoutlines.com]

Nemaline Myopathy Type 7

A muscle biopsy specimen showed small type 1 fibers but no inclusions. Electromyography showed a myopathic pattern. Figure 1. [jamanetwork.com]

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

Congenital Fiber-Type Disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 1E

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

CFTD Congenital fiber type disproportion. The dark (type 1) fibers are smaller than type 2. ATPase pH 4.6 Congenital fiber type disproportion (CFTD). [neuropathology-web.org]

Some children with the clinical phenotype of CM have only type 1 fiber predominance and smallness without other structural abnormalities. [neuropathology-web.org]

Muscular Dystrophy-Dystroglycanopathy Type B6

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

CFTD Congenital fiber type disproportion. The dark (type 1) fibers are smaller than type 2. ATPase pH 4.6 Congenital fiber type disproportion (CFTD). [neuropathology-web.org]

Some children with the clinical phenotype of CM have only type 1 fiber predominance and smallness without other structural abnormalities. [neuropathology-web.org]

Congenital Myopathy with Excess of Thin Filaments

In cases with Type 1 fiber hypoplasia, the small-diameter fibers showed diffuse intense reaction. [neurologyindia.com]

References Congenital Fiber-Type Disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [misc.medscape.com]

Muscle bx shows small muscle fibers, type 1 muscle fiber predominance with central nuclei. [sites.google.com]

Nemaline Myopathy Type 4

A muscle biopsy specimen showed small type 1 fibers but no inclusions. Electromyography showed a myopathic pattern. Figure 1. [jamanetwork.com]

The majority of the small muscle fibers showed peripherally located caplike structures, sharply demarcated from the rest of the fiber ( Figure 2 A and B). [jamanetwork.com]

Congenital Fiber-Type Disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

Myosinopathy

Many of the type 1 fibers are small (arrows). a Myofibrillar ATPase, pH 4.3 and b NADH-tetrazolium reductase Fig. 15 The assembly of MyHC LMM rod domain into coiled-coil α-helices [pubmed.ncbi.nlm.nih.gov]

Autosomal Recessive Inclusion Body Myopathy Type 2

Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. [genecards.org]

Distal Myopathy Type 3

Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. [genecards.org]

Congenital fiber-type disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

Muscle bx shows small muscle fibers, type 1 muscle fiber predominance with central nuclei. [sites.google.com]

Multicore Myopathy

Multiple small unstained areas were seen in both Type 1 and 2 fibers on SDH, NADH-TR and COX staining [Figure - 2]. These cores were not evident in ATPase stain. [neurologyindia.com]

Diagnosis is also difficult in the small number of patients whose muscle biopsy demonstrates uniformity of type 1 fibers without cores. [ncbi.nlm.nih.gov]

[…] almost always type 1 fibers. [scielo.br]

Nemaline Myopathy Type 2

fibers; Type 1 fibers small KBTBD13 : Rods, Diffusely distributed, All fibers; Type 1 fibers Predominant & Large KLHL40 : Rods, Many small; No normal myofibers LMOD3 : Rods [neuromuscular.wustl.edu]

1 fibers; Type 1 fiber predominance ACTA1 : Rods, Numerous, Most in small fibers, Cytoplasmic & Nuclear; Clusters of glycogen & actin filaments TNNT1 : Rods, Central in muscle [neuromuscular.wustl.edu]

Gomori trichrome stain Gomori trichrome stain ATPase pH 9.4 stain Fiber types Type 1 fibers: Usually small Type 2 fibers: Larger; Abnormal intermediate staining (2C) at ATPase [neuromuscular.wustl.edu]

X-Linked Reducing-Body Myopathy 1A

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

Congenital fiber-type disproportion Congenital fiber-type disproportion (CFTD) has as the main pathologic hallmark small type-1 muscle fibers. [emedicine.medscape.com]

CFTD Congenital fiber type disproportion. The dark (type 1) fibers are smaller than type 2. ATPase pH 4.6 Congenital fiber type disproportion (CFTD). [neuropathology-web.org]

Faciocardiomusculoskeletal Syndrome Type Uruguay

[…] muscular atrophy Large muscle fibers: Type 1 Muscle size: Normal or small Grouped atrophy : Other Small fibers: Type 2 fiber predominance Beckwith-Wiedemann syndrome ● Cyclin-dependent [neuromuscular.wustl.edu]

fibers: Type 1 & 2 Muscle size: Normal or small Hypercontracted muscle fibers Duchenne muscular dystrophy : Biopsies from younger patients Endomysial connective tissue: Increased [neuromuscular.wustl.edu]

2B muscle fibers Muscular dystrophy Fatty replacement of muscle Duchenne & Becker dystrophies Muscle fiber hypertrophy FSH & some chronic limb-girdle syndromes Large muscle [neuromuscular.wustl.edu]

Nemaline Myopathy Type 5

Muscle histology from two affected children showed marked fiber size variation owing to both Type 1 myofiber smallness (hypotrophy) and Type 2 fiber hypertrophy, with evidence [clinicforspecialchildren.org]

King Syndrome

[…] number of small-sized type 1 fibers and muscle atrophy. [symptoma.com]

The available exams include: Muscle biopsy: Microscopic examination of muscle may reveal a range of abnormalities, including a change in the size of muscle fibers, a large [symptoma.com]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

Introduction: Hereditary Sensory Autonomic Neuropathy Type 1 (HSAN1) is a severe, autosomal dominant, axonal neuropathy that manifests with marked, small fiber predominant [deaterfoundation.org]

Sequencing of SPTLC2 should be considered in all patients presenting with mild late-onset sensory-predominant small or large fiber neuropathy. [helda.helsinki.fi]

For example, in small-fiber neuropathy (SFN) ( Table 1 ), small-caliber, unmyelinated, or only thinly myelinated autonomic fibers and somatic sensory fibers that subserve [clevelandclinicmeded.com]

Emery-Dreifuss Muscular Dystrophy Type 1

The CMs described above share in common a predominance and smallness of type 1 fibers. [neuropathology-web.org]

CFTD Congenital fiber type disproportion. The dark (type 1) fibers are smaller than type 2. ATPase pH 4.6 Congenital fiber type disproportion (CFTD). [neuropathology-web.org]

Some children with the clinical phenotype of CM have only type 1 fiber predominance and smallness without other structural abnormalities. [neuropathology-web.org]