Small Vessel Disease: Causes & Reasons

Possible Causes for Small Vessel Disease

Background: the diagnosis of cerebral small vessel disease, a leading cause of vascular dementia (VaD), relies solely on neuroimaging studies. [ncbi.nlm.nih.gov]

Small vessel disease affects all the small vessels of the brain and produces 2 major syndromes, Binswanger disease and lacunar state. [emedicine.com]

Our aim was to identify differentially expressed, circulating miRNAs in small vessel VaD which could serve as diagnostic biomarkers for this disease. [ncbi.nlm.nih.gov]

Multi-Infarct Dementia

Small vessel disease affects all the small vessels of the brain and produces 2 major syndromes, Binswanger disease and lacunar state. [emedicine.medscape.com]

Lacunar state is a condition in which numerous lacunae, which indicate widespread severe small vessel disease, are present. [emedicine.medscape.com]

The 3 most common mechanisms of vascular dementia are multiple cortical infarcts, a strategic single infarct, and small vessel disease. [emedicine.medscape.com]

Microangiopathy

Microangiopathy Other names Microvascular disease, small vessel disease Microangiopathy (or microvascular disease, or small vessel disease) is an angiopathy (i.e. disease [en.wikipedia.org]

Microangiopathy (or microvascular disease, or small vessel disease ) is an angiopathy (i.e. disease of blood vessels) affecting small blood vessels in the body. [1] It can [en.m.wikipedia.org]

The first types of small-vessel disease to be described were white matter hyperintensities (WMHs). [ncbi.nlm.nih.gov]

CADASIL Syndrome

What is Small Vessel Disease (SVD)? SVD refers to pathological processes that affect the structure and function of small penetrating vessels within the brain. [uvm.edu]

Mutations in the Notch3 gene are the cause of CADASIL, a hereditary small vessel disease leading to stroke and vascular dementia. [ncbi.nlm.nih.gov]

vessel disease. [journals.sagepub.com]

Binswanger Disease

LS, Lacunar state; LVD, Large vessel disease; SVD, Small vessel disease. [academic.oup.com]

vessel disease (SVD), a silently progressing disease of ageing responsible for nearly half of all cases of dementia along with a large percentage of strokes. [thebiochemistblog.com]

Small vessel disease affects all the small vessels of the brain and produces 2 major syndromes, Binswanger disease and lacunar state. [emedicine.medscape.com]

Coronary Microvascular Disease

Small vessel disease is sometimes called coronary microvascular disease or small vessel heart disease. [mayoclinic.org]

Small vessel disease makes blood flow more difficult. Symptoms of small vessel disease Angina is the most common symptom of small vessel disease. [familydoctor.org]

Microangiopathy Other names Microvascular disease, small vessel disease Microangiopathy (or microvascular disease, or small vessel disease ) is an angiopathy (i.e. disease [en.wikipedia.org]

Cerebral Cortical Atrophy

Signs of cerebral small vessel disease. [betterhealthwhileaging.net]

[…] of events leading to cerebral small vessel disease is not clear. [stroke.ahajournals.org]

What is cerebral small vessel disease? [betterhealthwhileaging.net]

Trochlear Nerve Paralysis

Causes include the following: Closed head injury (common), which may cause unilateral or bilateral palsies Infarction due to small-vessel disease (eg, in diabetes) Rarely, [merckmanuals.com]

Vasculitis

Small-vessel vasculitic diseases There are several types of small-vessel vasculitic diseases. [emedicinehealth.com]

Some small-vessel vasculitis diseases can be related to an underlying rheumatologic disorder (connective tissue disorders), such as systemic lupus erythematosus (SLE) or lupus [emedicinehealth.com]

Vasculitis may affect large vessels (Takayasu arteritis, giant cell arteritis), medium-sized vessels (Kawasaki disease, polyarteritis nodosa), small vessels (immunoglobulin [ncbi.nlm.nih.gov]

Systemic Vasculitis

Small-vessel vasculitic diseases There are several types of small-vessel vasculitic diseases. [emedicinehealth.com]

Wegener's granulomatosis Immune complex small vessel vasculitis Behçet's disease Cryoglobulinemic vasculitis Drug-induced immune complex vasculitis Goodpasture syndrome Henoch-Schönlein [medical-dictionary.thefreedictionary.com]

Leukocytoclastic Vasculitis

Small-vessel vasculitic diseases There are several types of small-vessel vasculitic diseases. [emedicinehealth.com]

The disease demonstrates purple lesions on the skin due to the destruction of small cutaneous blood vessels. [ncbi.nlm.nih.gov]

Diseases Cancer is found in fewer than 5% of patients with cutaneous small vessel vasculitis. [dermnetnz.org]

Brain Stem Infarction

vessels and small vessel disease (see below). [neuropathology-web.org]

Diversity of single small subcortical infarctions according to infarct location and parent artery disease: analysis of indicators for small vessel disease and atherosclerosis [journals.sagepub.com]

Small Vessel Disease: PICA (posterior cerebellar artery syndrome). [dizziness-and-balance.com]

Congenital Cerebral Cyst

We conclude that dominant COL4A2 mutations are a novel major risk factor for familial cerebrovascular disease, including porencephaly and small-vessel disease with reduced [ncbi.nlm.nih.gov]

Abstract Background: COL4A1 mutations cause familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD), and hemorrhagic stroke. [neurology.org]

Role of COLA41 in small-vessel disease and hemorrhagic stroke. N Eng J Med. 2006;354:1489-1496. Gould DB, Phalan FC, Breedveld GJ, et al. [rarediseases.org]

Foville Syndrome

vessel disease. [statpearls.com]

However, the most common etiology is vascular disease, either small vessel or atheromatous branch occlusion. [statpearls.com]

Evaluation In terms of etiology, there are three potential artery disease subtypes: large artery disease of the basilar artery, branch disease of the basilar artery, and small [statpearls.com]

Cerebral Angiitis

Small-vessel vasculitic diseases There are several types of small-vessel vasculitic diseases. [emedicinehealth.com]

It is with medium and small vessels disease that cerebral angiography is concerned. [med.nyu.edu]

Moreover, gradient-echo MR imaging, but not conventional MR imaging, reveals coexisting chronic micro-hemorrhages in patients with hypertensive small vessel disease ( 6 ). [ajnr.org]

Cutaneous Vasculitis

Small-vessel vasculitic diseases There are several types of small-vessel vasculitic diseases. [emedicinehealth.com]

Superficial ulceration is common in small vessel disease while deeper ulcerations are present in medium vessel disease [4]. [faoj.org]

Essential cryoglobulinemia vasculitis is another type of rare small-vessel disease. Cryoglobulins are small protein complexes that can precipitate in cold temperatures. [emedicinehealth.com]

Renal Vasculitis

Vasculitis is best classified based on the size of the involved vessels into large, medium, and small vessel disease. [ncbi.nlm.nih.gov]

Small-vessel vasculitic diseases There are several types of small-vessel vasculitic diseases. [emedicinehealth.com]

Small vessel vasculitis (SVV) that includes glomerulonephritis is by far the most frequent vasculitic lesion in the kidney, and the defining renal lesion is a necrotizing [ncbi.nlm.nih.gov]

COL4A1-Related Disorders

Hereditary cerebral small vessel disease and stroke. [rarediseases.org]

Role of COL4A1 in small-vessel disease and hemorrhagic stroke. [frontiersin.org]

COL4A1 mutations as a monogenic cause of cerebral small vessel disease: a systematic review. Stroke 2010;41:e513–518. [PubMed] [Google Scholar] 7. [ncbi.nlm.nih.gov]

N Engl J Med 27: 2687–2695 CrossRef Google Scholar Gould DB et al. (2006) Role of COL4A1 in small-vessel disease and hemorrhagic stroke. [link.springer.com]

Neuroradiology 49: 471–479 CrossRef PubMed Google Scholar Bousser MG, Biousse V (2004) Small vessel vasculopathies affecting the central nervous system. [link.springer.com]

J Neuroophthalmol 24: 56–61 PubMed Google Scholar Biousse V, Bousser MG (1998) [Angiitis of the central nervous system in systemic diseases]. [link.springer.com]

However, only a minority of patients with familial small vessel disease carry mutations in one of known small vessel disease genes. [pubmed.ncbi.nlm.nih.gov]

[…] with a hereditary small vessel disease of unknown aetiology. [pubmed.ncbi.nlm.nih.gov]

We used whole exome sequencing to identify candidate genes in an autosomal dominant small vessel disease family in which known small vessel disease genes had been excluded [pubmed.ncbi.nlm.nih.gov]

Cerebral Small Vessel Disease

Abstract Small vessel cerebrovascular disease (SVCD) is one of the most frequent vessel disorders in the aged brain. [ncbi.nlm.nih.gov]

Retinal Vasculopathy with Cerebral Leukodystrophy

vessel diseases " (English → French) : TERMINOLOGY see also In-Context Translations below An inherited group of small vessel diseases comprised of cerebroretinal vasculopathy [wordscope.com]

N Engl J Med 27: 2687–2695 CrossRef Google Scholar Gould DB et al. (2006) Role of COL4A1 in small-vessel disease and hemorrhagic stroke. [link.springer.com]

Systemic features of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a monogenic small vessel disease. J Intern Med. 2019;285:317–32. [ncbi.nlm.nih.gov]

CARASIL

Summary of "CADASIL, CARASIL, CARASAL: The linguistic subtleties of cerebral small vessel disease." [bioportfolio.com]

Major two known hereditary small vessel diseases, CADASIL and CARASIL, are reviewed concisely. [sasappa.co.jp]

vessel disease: Lessons from hereditary small vessel disease 2015 Author(s) Onodera, O., Sekine, Y., Kato, T., Koyama, A., Nozaki, H. and Nishizawa, M Journal Title Neurology [nrid.nii.ac.jp]

Lacunar Infarction

COL4A1 mutations as a monogenic cause of cerebral small vessels disease: a systematic review. Stroke 2010;41:e513-e518. PMID: 20558831. 7. Cordonnier C, Leys D. [j-stroke.org]

We investigated the association between the severity of cerebral small vessel disease (CSVD), the pulsatility of cerebral arteries, and the stiffness of large arteries in [ncbi.nlm.nih.gov]

Glutamyl Ribose-5-Phosphate Storage Disease

Malformation GNT123 Genetic Cerebral Malformation GNT121 Genetic Cerebral Small Vessel Disease GNT165 Genetic Chronic Primary Adrenal Insufficiency GNT178 Genetic Complex [malacards.org]

GNT177 Genetic Cardiac Tumor GNT111 Genetic Central Nervous System and Retinal Vascular Disease GNT080 Genetic Central Nervous System Malformation GNT081 Genetic Cerebellar [malacards.org]

Genetic Bone Tumor GNT079 Genetic Branchial Arch or Oral-Acral Syndrome GNT065 Genetic Cardiac Anomaly GNT114 Genetic Cardiac Malformation GNT164 Genetic Cardiac Rhythm Disease [malacards.org]

Subcortical Dementia

vessel disease-related dementia. [dovepress.com]

Lacunar state and Binswanger''s disease are the two types of VAD associated with small vessel disease. [karger.com]

vessel disease is one of the most frequent etiologies of the disorder. [semanticscholar.org]

Familial Porencephaly

Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med. 2006;354:1489–96. [ncbi.nlm.nih.gov]

"COL4A2 mutation associated with familial porencephaly and small-vessel disease", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 20, August 2012 (2012-08-01), pages 844 - 851 [patents.google.com]

COL4A2 mutation associated with familial porencephaly and small-vessel disease. Eur J Hum Genet. 2012;20:844–51. [ncbi.nlm.nih.gov]

Familial Hypertrophic Cardiomyopathy Type 9

Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart. 2000; 84: 476-82. [ Links ] 65. Davies MJ. [scielo.br]

Paraneoplastic Encephalitis

Adult primary angiitis of the central nervous system: isolated small-vessel vasculitis represents distinct disease pattern. [scielo.cl]

Limbic Encephalitis with Neurexin-3 Antibodies

Adult primary angiitis of the central nervous system: isolated small-vessel vasculitis represents distinct disease pattern. [scielo.cl]