Possible Causes for Small Widely Spaced Teeth Tricho-Dento-Osseous Syndrome Teeth Thin and/or pitted enamel (common feature) Small, widely spaced teeth Enlarged pulp chambers and taurodontism. [nfed.org] […] syndrome * Kinky hair * Small teeth * Widely spaced teeth * Pitted teeth * Poor tooth enamel * Increased tooth pulp chamber size * Frontal bossing * Long head * Squarish [checkorphan.org] Early intraoral photographs demonstrate enamel hypoplasia with associated discoloration, and small, widely spaced teeth with localized severe attrition (Figure 4). [dimensionsofdentalhygiene.com] Cornelia De Lange Syndrome Craniofacial features include synophrys, arched eyebrows, long eyelashes, small upturned nose and thin downturned lips, small widely spaced teeth, and microcephaly. [asperbio.com] Congenital Malformation of the Inner Ear They can also have unusually small, widely spaced teeth (microdontia). Is congenital deafness with labyrinthine aplasia, microtia and microdontia common? [lazoi.com] They can also have unusually small, widely spaced teeth (microdontia). LAMM syndrome is a rare condition, although its prevalence is unknown. [ghr.nlm.nih.gov] […] narrow external auditory canal; and microdontia with widely spaced teeth. [orpha.net] Disproportionate Short Stature - Ptosis - Valvular Heart Lesions […] mouth with full lips Small chin Small, widely spaced teeth Missing or crooked teeth Uneven eyes Folds over the corners of the eyes White starburst pattern around the iris [webmd.com] Dental abnormalities Slightly small, widely spaced teeth are common in children with Williams syndrome. [williams-syndrome.org] Individuals with Williams syndrome have a small upturned nose, a small chin, long upper lip with a wide mouth, small widely spaced teeth, and puffiness around the eyes. [encyclopedia.com] Williams-Beuren Syndrome Many affected people have dental problems such as small, widely spaced teeth and teeth that are crooked or missing. [williamssyndrome.org.au] defective tooth enamel, or small, widely spaced teeth Exams and Tests Signs include: Blood vessel narrowing including supravalvular aortic stenosis, pulmonary stenosis, [web.archive.org] Young children with Williams syndrome have distinctive facial features including a broad forehead, a short nose with a broad tip, full cheeks, and a wide mouth with full lips [williamssyndrome.org.au] Kuster-Majewski-Hammerstein Syndrome Main clinical features include syndactyly and other abnormalities of the fingers and toes, sparse head hair from birth, bilateral macular degeneration, and small widely spaced [accesspediatrics.mhmedical.com] teeth. [accesspediatrics.mhmedical.com] 17q21.31 Microdeletion Syndrome The chromosome 17q21.31 deletion syndrome is a genomic disorder characterized by highly distinctive facial features, moderate-to-severe intellectual disability, hypotonia and friendly behavior. Here, we show that de novo loss-of-function mutations in KANSL1 (also called KIAA1267) cause a full del(17q21.31) phenotype in[…] [publires.unicatt.it] Deafness with Labyrinthine Aplasia - Microtia - Microdontia They can also have unusually small, widely spaced teeth (microdontia). Frequency LAMM syndrome is a rare condition, although its prevalence is unknown. [medlineplus.gov] Small teeth have been observed in all reported individuals. Dental anomalies include conical shape and decreased tooth diameter resulting in widely spaced teeth. [ncbi.nlm.nih.gov] In addition, people with LAMM syndrome often have abnormally small outer ears (microtia) with narrow ear canals. [medlineplus.gov] Amelogenesis Imperfecta Type 4 Enamel is thin, teeth are small and widely spaced. [malacards.org] Macrocephaly Type Fryns & widely spaced teeth), microcephaly, growth restriction, hirsutism, upper-limb reduction defects, ID, autistic features, self-destructive behavior WT1 WT1 disorder (incl [ncbi.nlm.nih.gov] NIPBL 4 RAD21 SMC1A SMC3 Cornelia de Lange syndrome (CdLS) AD XL Rare Facial anomalies (high-arched &/or joined eyebrows, long eyelashes, short nose w/anteverted nares, small [ncbi.nlm.nih.gov] Autosomal Dominant Mental Retardation Type 1 […] between the nose and upper lip) a thin tented upper-lip small teeth widely spaced teeth or other dental abnormalities a mouth that stays more in an open position when at [2q23.org] arched eyebrows Large or small nose Widely-spaced teeth Thin upper lip with downturned corners Small chin Short stature Hirsutism (excessive body hair) Feeding difficulties [dovemed.com] […] include: a broad forehead a uni-brow thick and/or arched eyebrows eye abnormalities almond-shaped eyes a short up-turned nose other nasal abnormalities short philtrum (or space [2q23.org] Brachmann-De Lange-Like Facial Changes with Microcephaly, Metatarsus Adductus, and Developmental Delay […] and widely spaced teeth, and a small and upturned nose. [medlineplus.gov] (micrognathia); late-erupting, widely-spaced, unusually small teeth; and low-set ears. [rarediseases.org] […] with Cornelia de Lange syndrome also have distinctive facial features, including arched eyebrows that often meet in the middle (synophrys), long eyelashes, low-set ears, small [medlineplus.gov] Microdontia They can also have unusually small, widely spaced teeth (microdontia). Frequency LAMM syndrome is a rare condition, although its prevalence is unknown. [medlineplus.gov] Persistence of primary teeth Premature loss of primary teeth Small, conical teeth Widely spaced primary teeth Synonyms Exact Synonyms: Decreased width of baby teeth ; Decreased [rgd.mcw.edu] People born with this condition might have very small, underdeveloped outer and inner ear structures, as well as very small, widely spaced teeth. Down Syndrome. [healthline.com] Nance-Horan Syndrome He had microcephaly, dysmorphic facies with a long face, sparse brown hair and large pinna, Hutchinsonian teeth (small, widely spaced teeth with notch on the biting surface [roah.ch] They may be ‘screwdriver shaped’ or small and pointed. Extra teeth are often present but sometimes several are missing. [disorders.eyes.arizona.edu] The front teeth often have wide spaces between them (diastema). About 30% of males have some intellectual impairment but this is not seen in females. [disorders.eyes.arizona.edu] Axenfeld-Rieger Syndrome Type 1 The teeth are frequently small and conical in shape with wide spaces between them (diastema). Some teeth may be missing. [djo.org.in] The condition is also associated with dental abnormalities including unusually small teeth (microdontia) or fewer than normal teeth (oligodontia). [encyclopedia.pub] The teeth were small ,few missing teeth were noted and teeth were conical in shape with wide spaces between them (diastema)(Figure1). [djo.org.in] Oculo-Cerebral Hypopigmentation Syndrome Type Preus […] and widely spaced teeth Skin: generalized hypopigmentation Neuro: psychomotor retardation Heme: hypochromic anemia Growth: growth retardation Clinical features from OMIM: [malacards.org] […] palate 33 HP:0002705 31 iris hypopigmentation 60 Very frequent (99-80%) Symptoms via clinical synopsis from OMIM: 58 H E E N T: dolichocephaly cataracts high arched palate small [malacards.org] Oculotrichodysplasia carious teeth missing teeth small, pointed deciduous teeth widely spaced deciduous teeth Nails: fragile nails onychodysplasia brittle nails H E E N T: retinitis pigmentosa [malacards.org] Other clinical features involve the eyes (retinopathy pigmentosa, sparse eyelashes and [lateral] eyebrows), the teeth (caries, widely spaced, small, pointy deciduous teeth [accessanesthesiology.mhmedical.com] * Dental caries * Dry skin * Scaly skin * Small primary teeth * Pointy primary teeth * Widely spaced primary teeth * Short stature Causes - Cecato De lima Pinheiro syndrome [checkorphan.org] Wiedemann-Steiner Syndrome Craniofacial features include synophrys, arched eyebrows, long eyelashes, small upturned nose, small widely spaced teeth, and microcephaly. [preventiongenetics.com] Filippi Syndrome […] alae nasi, long philtrum, thin lips, small wide-spaced teeth and pointed chin. * This information is courtesy of the L M D. [fdna.health] Dysmorphic features were plagiocephaly, thin hair, high hairline, arched eyebrows, long eyelashes, large ear pinnae, wide nasal bridge, bulbous nasal tip with hypoplastic [fdna.health] Axenfeld-Rieger Syndrome Type 3 The teeth are frequently small and conical in shape with wide spaces between them (diastema). Some teeth may be missing. [djo.org.in] The teeth were small ,few missing teeth were noted and teeth were conical in shape with wide spaces between them (diastema)(Figure1). [djo.org.in] Axenfeld-Rieger Syndrome Type 2 The teeth are frequently small and conical in shape with wide spaces between them (diastema). Some teeth may be missing. [djo.org.in] The condition is also associated with dental abnormalities including unusually small teeth (microdontia) or fewer than normal teeth (oligodontia). [encyclopedia.pub] Symptoms affecting the teeth include cone-shaped teeth (peg-like incisors), missing teeth (oligodontia), small teeth (microdontia), and abnormal spacing of the teeth. [rareguru.com] Hypertelorism - Tetralogy of Fallot Williams7 deletionSmall, upturned nose; wide mouth; full lips; small chin; widely spaced teeth; long philtrum.Developmental delay; supravalvular aortic stenosis; hypercalcaemia [dontforgetthebubbles.com] Cornelia de LangeCohesin complex, CDLS1, CDLS2, CDLS 3Microcephaly; long eyelashes; long philtrum; synophrys (joined eyebrows); small, wide-spaced teeth; curved 5th finger [dontforgetthebubbles.com] TurnerX0 or mosaicismShort stature; wide carrying angle; short, webbed neck; low hairline on neck; wide-spaced nipples; small lower jaw.Lymphoedema; coarctation of the aorta [dontforgetthebubbles.com] Humeroradial Synostosis with Craniofacial Anomalies Craniofacial features include synophrys, highly arched and/or thick eyebrows, long eyelashes, short nasal bridge with anteverted nares, small widely spaced teeth, and microcephaly [203.71.232.25] Witteveen-Kolk Syndrome widely spaced teeth). [medicover-genetics.com] […] puffiness around the eyelids, eyebrows that are thinner in the middle, blue iris with a star-shaped pattern, full lips, especially the lower lip, micrognathia, hoarse voice, and small [medicover-genetics.com] Mucopolysaccharidosis Type 3B […] nose, widely spaced teeth, and widely separated eyes). [checkrare.com] […] about the age of 2 or 3 years, characteristic symptoms will be begin to appear, most notably the course facial features (enlarged head, broad mouth, prominent cheekbones, small [checkrare.com] Blepharophimosis - Intellectual Disability Syndrome Type Verloes widely spaced teeth and flat occiput/microcephaly/brachycephaly, are also chararteristic. [mendelian.co] […] on a crescent moon shape when smiling, broad nasal bridge and tip with anteverted nostrils, mild midfacial hypoplasia, long, smooth philtrum, thin upper lip vermillion, small [mendelian.co] Mucopolysaccharidosis Type 4B Affected children have a characteristic facial appearance that may include an enlarged head, broad mouth, prominent cheekbones, an unusually small nose, widely spaced and [rarediseases.org] […] thinly enameled teeth, and widely separated eyes with subtle corneal clouding. [rarediseases.org] Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations Widely spaced teeth MedGen UID: 337093 •Concept ID: C1844813 • Finding Increased spaces (diastemata) between most of the teeth in the same dental arch. [ncbi.nlm.nih.gov] Small epiphyses MedGen UID: 339612 •Concept ID: C1846803 • Finding Reduction in the size or volume of epiphyses. [ncbi.nlm.nih.gov] Roberts Syndrome Craniofacial features include synophrys, arched eyebrows, long eyelashes, small upturned nose, small widely spaced teeth, and microcephaly. [thefetus.net] Naguib Syndrome small widely spaced teeth, and a small lower jaw. [cags.org.ae] Abnormal facial features typical of CdLS include microcephaly, arched confluent eyebrows, long eyelashes, low-set ears, low hairlines, small, upturned nose, cleft palate, [cags.org.ae]
