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19 Possible Causes for Soft Palate Paralysis, Tongue Weakness, Vacuolization

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] It revealed velopharyngeal incompetency with weak elevation of the soft palate and impaired pharyngeal muscles contraction, which may contribute to bulbar paralysis; however[journals.plos.org] […] muscles Bulbar Dysphagia: Oropharyngeal Dysarthria: Hoarse & Nasal voice Tongue weakness Limbs Legs Arms Distal: Anterior tibial; Finger extensors Onset: 5 years after disease[neuromuscular.wustl.edu]

  • Progressive Bulbar Palsy

    IVIg) Myopathies, including inclusion body myositis, which is characterized by wasting and weakness of deep finger flexors and the quadriceps femoris with typical rimmed vacuoles[emedicine.medscape.com] Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles.[icd9data.com] A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem.[ebi.ac.uk]

  • Glomus Jugulare Tumor

    […] histologic) description Classic organoid (zellballen) or nesting pattern of paragangliomas with central round / oval chief cells containing abundant eosinophilic granular or vacuolated[pathologyoutlines.com] Difficulty swallowing Hoarseness Shoulder drooping Tongue weakness In rare cases, these tumors may produce the hormone norepinephrine, which may cause: Headaches Anxiety[upmc.com] A, Glomus tumor, carotid, showing unusually large nuclei (large arrows) in large vacuolated cells.[slideshare.net]

  • Brain Stem Infarction

    Microscopical examination in the first 24 to 48 hours reveals anoxic neurons , pallor of staining and vacuolization of the white matter due to unraveling of myelin, and axonal[neuropathology-web.org] Soft palate paralysis, disturbed sensorium, need of special treatment measures (feeding by gastric tube intravenous infusions, etc.) during the acute phase, abnormalities[ncbi.nlm.nih.gov] Weakness of the tongue ipsilateral to the infarct. Pathology may be in vertebral artery or mesial limb of vertebral artery after PICA. Upbeat nystagmus may occur.[tchain.com]

  • Guillain-Barré Syndrome

    Incorporation of sucrose into lysosomes causes swelling of epithelial cells and cytoplasmic vacuolization of the tubules, especially in the proximal tubules.[web.archive.org] Lofaso , Tongue weakness is associated with respiratory failure in patients with severe Guillain‐Barré syndrome , Acta Neurologica Scandinavica , 119 , 6 , (364-370) , (2008[doi.org] Lofaso, Tongue weakness is associated with respiratory failure in patients with severe Guillain‐Barré syndrome, Acta Neurologica Scandinavica, 119, 6, (364-370), (2008).[dx.doi.org]

  • Poliomyelitis

    Histological appearance of the affected brain cells shows vacuolation and infiltration.[ncbi.nlm.nih.gov] Unilateral or bilateral facial muscles, as well as the tongue and mastication muscles, may become paralyzed. o External oculomotor weakness with pupil sparing may occur in[sites.google.com]

  • Plasmacytoma

    (c) Oil immersion view is showing plasma cells with multiple grape such as cytoplasmic vacuoles or mott cell, marked by arrows (H and E, 1000).[cancerjournal.net] […] of soft palate, ipsilateral Horner's syndrome, ipsilateral hypotonia and ataxia, and dissociated sensory loss [12].[ijri.org] Examination identified left tongue weakness and nonspecific sensory abnormalities of the ear, pharynx, and throat localizing to cranial nerves IX-XII.[ncbi.nlm.nih.gov]

  • Herpes Zoster Oticus

    Moderate depletion of neurons was seen in the ipsilateral geniculate ganglion with some of the remaining neurons showing chromatolysis and coarse vacuolation.[jnnp.bmj.com] The rash also may appear on postauricular skin, lateral nasal wall, soft palate, and anterolateral tongue.• Vertigo and sensorineural hearing loss may be noted, and paralysis[slideshare.net] 2/3 of the tongue[ 6 ].[bmcresnotes.biomedcentral.com]

  • Neurilemmoma

    The Antoni B pattern comprises an irregular arrangement of Schwann cells in a loose stroma with small vacuoles. [6], [8] Neurilemmomas might undergo degenerative changes with[jomfp.in] Coughing, hoarseness, tongue deviation, and paralysis of the soft palate can all point to the nerve of origin. However, neck discomfort is a nonspecific symptom.[jamanetwork.com] He complained of slowly progressive palsy of the tongue on the left side. Weakness of soft palate movement was also noted.[ncbi.nlm.nih.gov]

  • Cerebellar Infarction

    Microscopical examination in the first 24 to 48 hours reveals anoxic neurons, pallor of staining and vacuolization of the white matter due to unraveling of myelin, and axonal[neuropathology-web.org] […] of soft palate and vocal cord and contralateral hemianesthesia Infarct or Tumor Jackson Medulla Tegmentum X,XII Corticospinal Avellis plus ipsilateral tongue Infarct or Tumor[dizziness-and-balance.com] Reduced density of glia and vacuolation were observed in severe WMH suggesting end stage disease. 29 Autopsy MRI studies also found oedema that suggests leakage of fluid from[svn.bmj.com]

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