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7 Possible Causes for Some Patients Have Asymptomatic Hypocalcemia

  • Autosomal Dominant Hypocalcemia Type 1

    These patients usually have mild hypocalcemia, which is generally asymptomatic, but may, in some patients, be associated with carpopedal spasm and seizures.[ijem.in] Investigation of kindreds with autosomal-dominant forms of hypocalcemia identified such CaSR mutations.[ijem.in] […] associated with familial hypocalciuric hypercalcemia, and it was speculated that CaSR mutations that resulted in a gain-of-function may result in the opposite phenotype of hypocalcemia[ijem.in]

  • Neonatal Severe Primary Hyperparathyroidism

    These patients usually have mild hypocalcemia, which is generally asymptomatic, but may, in some patients, be associated with carpopedal spasm and seizures.[ijem.in] Investigation of kindreds with autosomal-dominant forms of hypocalcemia identified such CaSR mutations.[ijem.in] […] associated with familial hypocalciuric hypercalcemia, and it was speculated that CaSR mutations that resulted in a gain-of-function may result in the opposite phenotype of hypocalcemia[ijem.in]

  • Familial Hypocalciuric Hypercalcemia Type 2

    These patients usually have mild hypocalcemia, which is generally asymptomatic, but may, in some patients, be associated with carpopedal spasm and seizures.[ijem.in] Investigation of kindreds with autosomal-dominant forms of hypocalcemia identified such CaSR mutations.[ijem.in] […] associated with familial hypocalciuric hypercalcemia, and it was speculated that CaSR mutations that resulted in a gain-of-function may result in the opposite phenotype of hypocalcemia[ijem.in]

  • Familial Hypocalciuric Hypercalcemia Type 3

    These patients usually have mild hypocalcemia, which is generally asymptomatic, but may, in some patients, be associated with carpopedal spasm and seizures.[ijem.in] Investigation of kindreds with autosomal-dominant forms of hypocalcemia identified such CaSR mutations.[ijem.in] […] associated with familial hypocalciuric hypercalcemia, and it was speculated that CaSR mutations that resulted in a gain-of-function may result in the opposite phenotype of hypocalcemia[ijem.in]

  • Autosomal Dominant Primary Hypomagnesemia with Hypocalciuria

    These patients usually have mild hypocalcemia, which is generally asymptomatic, but may, in some patients, be associated with carpopedal spasm and seizures.[ijem.in] Investigation of kindreds with autosomal-dominant forms of hypocalcemia identified such CaSR mutations.[ijem.in] […] associated with familial hypocalciuric hypercalcemia, and it was speculated that CaSR mutations that resulted in a gain-of-function may result in the opposite phenotype of hypocalcemia[ijem.in]

  • Congenital Digital Clubbing

    Most patients with hyperparathyroidism are asymptomatic or have vague, nonspecific complaints.[aafp.org] Chronic hypocalcemia leads to a compensatory parathyroid hyperplasia. The enlarged parathyroid glands may become autonomous in some cases.[aafp.org] Hypocalcemia and increased levels of parathyroid hormone are seen early in the course of renal failure and are usually worse in those patients with more severe metabolic acidosis[aafp.org]

  • Familal Benign Hypercalcemia

    These patients usually have mild hypocalcemia, which is generally asymptomatic, but may, in some patients, be associated with carpopedal spasm and seizures.[ijem.in] Investigation of kindreds with autosomal-dominant forms of hypocalcemia identified such CaSR mutations.[ijem.in] […] associated with familial hypocalciuric hypercalcemia, and it was speculated that CaSR mutations that resulted in a gain-of-function may result in the opposite phenotype of hypocalcemia[ijem.in]

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