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569 Possible Causes for Sore Mouth, T Cell Activation Increased, Weight Loss

  • Celiac Disease

    APC presents the toxic peptide to CD4 T cells. Activated gluten-reactive CD4 T-cells produce high levels of pro-inflammatory cytokines.[doi.org] […] problems such a canker sores or dry mouth seizures tingling numbness in the hands and feet tiredness weak and brittle bones Adults who have digestive symptoms with celiac[web.archive.org] Rarely, patients can present with severe lab abnormalities, dehydration and weight loss caused by celiac disease - a celiac crisis.[ncbi.nlm.nih.gov]

  • Malabsorption Syndrome

    […] of the mouth), and anemia.[iffgd.org] Even if the patient started out dieting or exercising to lose weight, it should never be assumed that excessive weight loss is due to mental illness.[randyschellenberg.tripod.com] […] in the intestinal permeability.  One such peptide is a 33-amino acid sequence, which is a potent activator of specific T-cell lines from patients with CD. 41.  The subsequent[slideshare.net]

  • Systemic Scleroderma

    Levels of IL-4 are elevated in the sera of patients with SSc ( 83 ), and the number of IL-4–producing T cells is increased in their peripheral blood ( 84, 85 ).[jci.org] 0200042 Telangiectasia of the skin 0100585 Xerostomia Dry mouth Dry mouth syndrome Reduced salivation [ more ] 0000217 5%-29% of people have these symptoms Abnormal bowel[rarediseases.info.nih.gov] Lastly, substances used to minimize appetite and contribute to weight loss (derivatives of phenylethylamine ) are also believed to trigger systemic sclerosis.[symptoma.com]

  • Sjögren Syndrome

    Human exposure to an extremely high dose of TCDD in vivo induced a selective increase in the frequency of T cells producing IL-22 but not IL-17, IL-10, or IFN-γ ( 69 ).[doi.org] Other symptoms may include: Contact lens discomfort Dry sinuses and frequent sinus infections or nosebleeds Sore mouth, tongue or throat Difficulty chewing or swallowing Dry[allaboutvision.com] A 65-year-old woman with Sjögren's syndrome presented with recurrent abdominal distension, constipation, weight loss, orthostatic dizziness, loss of sweating and incomplete[ncbi.nlm.nih.gov]

  • HIV Infection

    […] the vaginas of mice increased numbers of the activated CD4 T cells that are the virus’s primary target, establishing a direct link between the high-risk bacteria and a known[ragoninstitute.org] ulcers.[health24.com] loss.[medicinenet.com]

  • Stevens-Johnson Syndrome

    […] normal T-cell expressed and secreted (RANTES), IL-7, IL-12p70 and IL-13, with maximal increase in GM-CSF and maximal downregulation of IP-10, respectively.[ncbi.nlm.nih.gov] The initial signs of SJS are bloody crusts on the lips, a sore mouth that has a foul smell, and purple-red tender spots on the skin.[childrensclinicofraceland.com] loss 90% Abnormality of neutrophils 50% Excessive salivation 50% Feeding difficulties in infancy 50% Abdominal pain 7.5% Abnormality of the eyelid 7.5% Abnormality of the[web.archive.org]

  • Toxic Epidermal Necrolysis

    Cyclosporin (3-5mg/kg daily) • Blocks T-cell activation/proliferation • CD8 activation continuous vs. full complement of activated cells by time of presentation • Inhibits[slideshare.net] mouth and throat Fatigue Cough Burning eyes When to see a doctor Stevens-Johnson syndrome requires immediate medical attention.[mayoclinic.org] Loss Surgery) Cancer (Oncology) Cardiovascular Dentistry Dermatology Diabetes Ear, Nose, and Throat (ENT) Endocrinology, Diabetes and Metabolism Eye Care Fertility Center[uhealthsystem.com]

  • Stomatitis

    […] of natural killer cells in various stages of disease [43] Increased adherence of neutrophils Reduced quantities and functionality of regulatory T cells in lesional tissue[emedicine.medscape.com] Denture Sore Mouth (Denture-Related Stomatitis) Denture sore mouth is also known as sore mouth under plates, chronic denture palatitis, stomatitis prosthetica, denture-related[exodontia.info] Pain and difficulty swallowing may limit food and water intake, leading to dehydration and weight loss.[jamanetwork.com]

  • Idiopathic Neutropenia

    The percentage of activated T-lymphocytes was increased in patients' BM as indicated by the proportions of human leucocyte antigen (HLA)-DR( ), CD25( ), CD38( ), CD69( ) and[ncbi.nlm.nih.gov] […] throat mouth sores that keep returning toothache skin rashes tiredness flu-like symptoms Occasionally, infections can lead to a life-threatening condition called sepsis.[nhs.uk] However, among those most often reported are bone pain, weight loss, fatigue, dyspnea, and anemia.[ncbi.nlm.nih.gov]

  • HIV-2 Infection

    CONCLUSION: Increased frequencies of CD4 T cells with an activated/exhausted phenotype correlate with exacerbated immunodeficiency in aviremic HIV-2-infected individuals.[ncbi.nlm.nih.gov] […] throat Long-lasting or multiple viral skin problems, such as herpes sores or plantar warts Repeated, severe yeast infections in your mouth or vagina despite treatment Chronic[privatemdlabs.com] These are signs and symptoms of HIV infection: Sudden weight loss Night sweats or fever Extreme tiredness Swollen lymph nodes White spots in your mouth or throat Ongoing ([urmc.rochester.edu]

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