Possible Causes for sparse to no axillary hair Hypogonadism Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [msdmanuals.com] As adults, affected patients have poor muscle development, a high-pitched voice, a small scrotum, decreased phallic and testicular growth, sparse pubic and axillary hair, [msdmanuals.com] Hidrotic Ectodermal Dysplasia absent eyebrows short, thin, sparse, pale scalp hair short, sparse eyelashes sparse axillary and pubic hair Clinical features from OMIM: 601375 Human phenotypes related [malacards.org] After puberty, male patterns of hair growth (e.g., moustache and beard) can be normal, while in other cases, facial and pubic hair growth may be sparse. [rarediseases.org] Axillary and pubic hair is sparse or absent. [ncbi.nlm.nih.gov] Adiposis Dolorosa Sparse pubic and axillary hair have also been reported. [orpha.net] Polycystic Ovary Syndrome Clinical description In addition to frontoparietal alopecia, the remaining scalp hair was also sparse, and axillary and pubic hair was absent. [orpha.net] […] scalp hair and absent facial, axillary and pubic hair. [jpma.org.pk] She had fine sparse hair on scalp with absent eye brows but had normal eye lashes. [jpma.org.pk] Klinefelter Syndrome […] facial and axillary hair clinodactyly tall stature narrow shoulders broad hips normal to moderately reduced Leydig cell function increased secretion of follicle-stimulating [radiopaedia.org] […] to puberty and small in post pubertal testes; there is absent spermatogenesis the kidneys may be symmetrically enlarged with small 1-8 mm cysts post pubertal gynecomastia sparse [radiopaedia.org] These include: Feminized body proportions and fat distribution Sparse or absent facial, axillary, pubic, or body hair Decreased muscle mass and strength Gynecomastia Small [symptoma.com] Atrichia with Papular Lesions Examination of the fifteen individuals alive revealed absent hair from the scalp and eyebrows, absent pubic and axillary hair, and sparse eyelashes on the upper eyelid in [cags.org.ae] Eyebrow, eyelash, and body hair may also be sparse or absent; patients may have a few pubic and axillary hairs. [ncbi.nlm.nih.gov] A one-and-a-half-month-old male baby was brought by his maternal grandmother with complaints of frontoparietal scalp hair recession, sparse eyelashes and eyebrows [Figure [idoj.in] Liver Cirrhosis Stigmata of chronic liver disease observed in the patients were Dupuytren's contracture in 21 (37.5%) patients, palmar erythema in 12 (21.4%) patients, and sparse axillary [atmph.org] hair in 12 (21.4%) patients. [atmph.org] Hypogonadotropic Hypogonadism Type 18 Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [merckmanuals.com] On physical examination, there were sparse facial, axillary and pubic hairs, bilateral gynaecomastia, stretch penile length of 5 cm and bilateral testicular volume of 10 mL [casereports.bmj.com] […] and pubic hairs. [casereports.bmj.com] Ruptured Ovarian Cyst Clinical description In addition to frontoparietal alopecia, the remaining scalp hair was also sparse, and axillary and pubic hair was absent. [orpha.net] He had a long face, frontal alopecia, and sparse eyebrows. He had no facial, axillary or pubic hair and his Tanner stage was two. [ncbi.nlm.nih.gov] Tanner stage was 2; she had minimal breast buds and no axillary or pubic hair. [ncbi.nlm.nih.gov] Salti-Salem Syndrome Clinical description In addition to frontoparietal alopecia, the remaining scalp hair was also sparse, and axillary and pubic hair was absent. [orpha.net] Hemochromatosis Skin may be thin and velvety with sparse, delicate hair in facial, pubic, and axillary regions. [clinicaladvisor.com] […] pubic hair, spider angiomas and jaundice. [clinicaladvisor.com] Other cutaneous manifestations include xerosis/ichthyosis, atrophy, koilonychia and any skin symptoms that may suggest damage to the liver, such as palmar erythema, sparse [clinicaladvisor.com] Hypogonadotropic Hypogonadism Type 21 Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [merckmanuals.com] On physical examination, there were sparse facial, axillary and pubic hairs, bilateral gynaecomastia, stretch penile length of 5 cm and bilateral testicular volume of 10 mL [casereports.bmj.com] […] and pubic hairs. [casereports.bmj.com] Sertoli Leydig Cell Tumor […] pubic or axillary hair. [ncbi.nlm.nih.gov] […] testicular feminization) syndrome was described in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or sparse [ncbi.nlm.nih.gov] Ulnar Mammary Syndrome […] or absent axillary hair genital hypoplasia resulting in micropenis, cryptorchidism, and/or shawl scrotum in males defects of the endocrine system, teeth, and palate References [invitae.com] […] digits hypoplasia of the apocrine glands, mammary glands, the areola, or inverted nipples reduced or no ability to lactate and uterine defects in females delayed puberty sparse [invitae.com] Diffuse Palmoplantar Keratoderma The eyelashes are short and sparse, and the eyebrows as well as axillary and pubic hair are also sparse or absent (1), as in our case. [ncbi.nlm.nih.gov] The hair from the beard, eyebrows, eyelashes, moustaches, and pubic and axillary regions was very sparse to nearly absent (Figure 2 a, b, c). [ncbi.nlm.nih.gov] The hair is sparse and pale, and the alopecia can be patchy or total. Hair loss may lead to total alopecia by puberty. [ncbi.nlm.nih.gov] Hypotrichosis 7 Body hair may also be sparse with variable involvement of the eyebrows, eyelashes, and pubic and axillary hair. There are no anomalies of the skin, nails or teeth. [orpha.net] Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. [uniprot.org] Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. {ECO:0000269 PubMed:17095700, ECO:0000269 PubMed:19167195}. [genecards.org] Kallmann Syndrome Type 3 Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [msdmanuals.com] Complete Androgen Insensitivity Syndrome […] pubic or axillary hair. [ncbi.nlm.nih.gov] The physical examination revealed normal female external genitalia, normal breast development, sparse pubic hair and absence of axillary hair. [ncbi.nlm.nih.gov] Karyotypic male individuals with CAIS have unambiguously female external genitalia, sparse or absent axillary and pubic hair, a blindly-ended vagina (which may be shortened [humpath.com] Kallmann Syndrome Type 4 Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [msdmanuals.com] Examination for other secondary sexual characters revealed the absence of axillary hair and presence of breast buds with slightly elevated papillae [Figure 6]. [ijdvl.com] Figure 5: Sparse distribution of pubic hair with vitiliginous patches over the labia majora Click here to view Endocrine evaluation showed low levels of serum follicle stimulating [ijdvl.com] Susac Syndrome Clinical description In addition to frontoparietal alopecia, the remaining scalp hair was also sparse, and axillary and pubic hair was absent. [orpha.net] […] scalp hair and absent facial, axillary and pubic hair. [jpma.org.pk] She had fine sparse hair on scalp with absent eye brows but had normal eye lashes. [jpma.org.pk] Adrenal Insufficiency Sparse axillary hair; increased skin pigmentation, especially of creases, pressure areas, and nipples. Hypotension, small heart. [accessmedicine.mhmedical.com] Hypogonadotropic Hypogonadism Type 22 […] scalp hair and absent facial, axillary and pubic hair. [jpma.org.pk] He displayed child-like facial hair, sparse axillary adult appearing hair, and prepubertal chest hair. [jmg.bmj.com] She had fine sparse hair on scalp with absent eye brows but had normal eye lashes. [jpma.org.pk] Primary Male Hypogonadism Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [merckmanuals.com] As adults, affected patients have poor muscle development, a high-pitched voice, a small scrotum, decreased phallic and testicular growth, sparse pubic and axillary hair, [merckmanuals.com] Addison Disease - Orthostatic hypotension (90%) - Electrolyte abnormalities: hyponatremia (88%), hyperkalemia (64%), hypercalcemia (6%) - Hyperpigmented skin and mucosa - Sparse axillary [clinicaladvisor.com] hair (more common in women), amenorrhea, decreased libido (both men and women) if concomitant androgen deficiency - Associated autoimmune manifestations - autoimmune thyroid [clinicaladvisor.com] Sheehan Syndrome axillary hair Limited armpit hair Little underarm hair [2] Blood loss at delivery can be particularly damaging to the pituitary gland, which enlarges during pregnancy. [rarediseases.info.nih.gov] There was a loss of axillary hairs and only sparse pubic hairs. Examination of other systems was unremarkable. [omicsonline.org] […] hypothyroidism Low thyroid gland function due to abnormal pituitary gland 0008245 Progressive visual field defects 0007987 Reduced circulating prolactin concentration 0008202 Sparse [rarediseases.info.nih.gov] Feminization Gross appearance revealed sparse axillary and pubic hair, poor breast development, clitoromegaly and absence of vagina. [ncbi.nlm.nih.gov] Individuals with this defect usually have undescended or labial testes, a short blind vaginal pouch; no uterus, well-developed breasts, sparse or absent axillary and pubic [medical-dictionary.thefreedictionary.com] hair, normal plasma levels of testosterone and follicle-stimulating hormone, and increased concentrations of estradiol and luteinizing hormone. [medical-dictionary.thefreedictionary.com] Hypogonadotropic Hypogonadism Type 8 He displayed child-like facial hair, sparse axillary adult appearing hair, and prepubertal chest hair. [jmg.bmj.com] Examination for other secondary sexual characters revealed the absence of axillary hair and presence of breast buds with slightly elevated papillae [Figure 6]. [ijdvl.com] He had his growth spurt at age 18–19 years, developed sparse armpit hair at age 20, and penile hair at 16–17, but no penile or testicular enlargement. [jmg.bmj.com] Male Hypogonadism Such patients have poor muscle development, a high-pitched voice, inadequate phallic and testicular growth, a small scrotum, sparse pubic and axillary hair, and absent body [msdmanuals.com] As adults, affected patients have poor muscle development, a high-pitched voice, a small scrotum, decreased phallic and testicular growth, sparse pubic and axillary hair, [merckmanuals.com] Adrenal Infarction axillary hair, hyperpigmentation of the skin (diffuse bronzing of exposed and unexposed body parts) Addison's (hypo cortisol/hypo-adrenal) fever, hypotension, low Na, high [studystack.com] Syndrome) Addison's disease hypo-cortisol/hypo-adrenal pt with weakness, intolerance to stress, personality changes (irritability, restlessness), small heart, hypoTN, wt loss, sparse [studystack.com] Hidradenitis Suppurativa Axillary and/or pubic hair may be sparse or absent, particularly in women. [consultant360.com]
