Sparse to No Eyebrows: Causes & Reasons

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Possible Causes for Sparse to No Eyebrows

Hypotrichosis 7

The locus for LAH2 (characterized by sparse or absent scalp, axillary and body hair, and sparse eyebrows and eyelashes) has been mapped to 3q27.3 and mutations in the lipase-H [orpha.net]

He had sparse hairs on scalp, eyebrows and eyelashes at birth. [ijtrichology.com]

Body hair may also be sparse with variable involvement of the eyebrows, eyelashes, and pubic and axillary hair. There are no anomalies of the skin, nails or teeth. [orpha.net]

Rothmund-Thomson Syndrome

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse eyelashes Scant eyelashes Scanty eyelashes Thin eyelashes [ more ] 0000653 5%-29% of people have these symptoms Abnormal [rarediseases.info.nih.gov]

Children and adults with Rothmund-Thomson syndrome also may have one or more of the following problems: Sparse hair, eyebrows or eyelashes Small stature Bone deformities Dental [texaschildrens.org]

[…] of this syndrome, based on a review of 107 reported cases in the literature, are (in descending order) as follows: early onset of poikiloderma, short stature, absence or sparseness [ncbi.nlm.nih.gov]

Hidrotic Ectodermal Dysplasia

Underdeveloped Thick, discolored Hair Fine, brittle, slow-growing Total balding (alopecia) Missing in spots for males Sparse eyelashes Sparse eyebrow Absent underarm hair [nfed.org]

Sparse or absent eyebrows Sparse or absent eyelashes Diagnosing Fried Syndrome A physician can diagnose Fried syndrome on the basis of physical features. [nfed.org]

Kaufman Oculocerebrofacial Syndrome

[…] and laterally broad eyebrows, preauricular tags, and micrognathia), mental retardation, and generalised hypotonia. [moh-it.pure.elsevier.com]

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Ventricular septal defect Hole in heart wall separating two lower heart chambers 0001629 Ventriculomegaly 0002119 [rarediseases.info.nih.gov]

[…] reduced growth, microcephaly, ocular anomalies (microcornea, strabismus, myopia, and pale optic disk), distinctive facial features (narrow palpebral fissures, telecanthus, sparse [moh-it.pure.elsevier.com]

Dubowitz Syndrome

[…] or absent eyebrows Sparse or thin head hair Malformed ears Low-set ears Wide-set eyes The cause of DS is not known. [forgottendiseases.org]

[…] scalp hair Flexural areas eczema Delayed teeth eruption Dental caries Syndactyly of second toes Brachyclinodactyly of fifth fingers Hair is sparse on lateral eyebrows Syndactyly [syndrome.org]

Affected individuals also tend to have sparse hair and eyebrows. [rarediseases.org]

Hypergonadotropic Hypogonadism - Partial Alopecia

60 Very frequent (99-80%) 42 sparse eyebrow 60 Frequent (79-30%) 43 absent gonadal tissue 60 Very frequent (99-80%) [malacards.org]

eyebrows, absence of breast tissue, absent ovaries, mild-moderate dorsal kyphosis, thin upper lip and unilateral sensorioneural deafness in one of them. [ncbi.nlm.nih.gov]

/absent eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia, multiple joint contractures and an early neonatal lethal [ab-y-ss.com]

Tricho-Rhino-Phalangeal Syndrome

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse eyelashes Scant eyelashes Scanty eyelashes Thin eyelashes [ more ] 0000653 Triangular face Face with broad temples and [rarediseases.info.nih.gov]

Abstract We describe a 5-year-old girl with features resembling Trichorhinophalangeal syndrome, type I (sparse scalp hair, bushy eyebrows, bulbous nose, long philtrum, cone-shaped [ncbi.nlm.nih.gov]

(b) Lateral profile showing sparse hairs in the temporoparietal region, pear-shaped nose with bulbous tip, long philtrum, lateral sparse eyebrows. [jnsbm.org]

Rapp-Hodgkin Syndrome

He also had sparse eyelashes and eyebrows, and obstructed lacrimal puncta and epiphora. Bilateral bony external auditory canal stenosis led to hearing loss. [ncbi.nlm.nih.gov]

His clinical findings included characteristic facies, sparse hair, eyebrows and eyelashes. Obstructed right lacrimal puncta and epiphora. [ashg.org]

[…] by anhidrotic ectodermal dysplasia, cleft lip and palate, and accompanied by a characteristic facies (narrow nose and small mouth); wiry, slow-growing, uncombable hair; sparse [medical-dictionary.thefreedictionary.com]

Wiedemann-Rautenstrauch Syndrome

She had prominent scalp veins, facial dysmorphism sparse eyebrows and hair and significant developmental delay. [ashg.org]

sparse hair, sparse eyebrows, sparse eyelashes, prominent scalp veins, entropion, greatly widened anterior fontanelles, malar hypoplasia, natal teeth, and beaking of the [accesspediatrics.mhmedical.com]

The clinical presentation is characterized by an appearance of premature aging, general absence of subcutaneous fat, prenatal growth deficiency, sparse scalp hair, eyebrows [ashg.org]

Atrichia with Papular Lesions

Eyebrow, eyelash, and body hair may also be sparse or absent; patients may have a few pubic and axillary hairs. [idoj.in]

CASE REPORT A one-and-a-half-month-old male baby was brought by his maternal grandmother with complaints of frontoparietal scalp hair recession, sparse eyelashes and eyebrows [ncbi.nlm.nih.gov]

Sparse hairs over the eyebrows and eyelashes were present [ Figure 1 ]. [ncbi.nlm.nih.gov]

Odonto-Onycho-Dermal Dysplasia

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse body hair 0002231 Sparse scalp hair Scalp hair, thinning Sparse, thin scalp hair sparse-absent scalp hair [ more ] 0002209 [rarediseases.info.nih.gov]

Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies [genecards.org]

Some patients may have dry, thin hair and sparse eyebrows, and may have a smooth tongue with missing taste buds. [sema4genomics.com]

Autosomal Recessive Nail Dysplasia

Sparse or absent eyebrows Sparse or absent eyelashes Diagnosing Fried Syndrome A physician can diagnose Fried syndrome on the basis of physical features. [nfed.org]

At present we can identify dry scaly skin; fine sparse and brittle hair, eyebrows, and eyelashes, hypodontia, nail dystrophy, hypohidrosis, and athelia, with deficient hearing [omicsonline.org]

Hair abnormalities included sparse eyelashes and eyebrows with total absence of scalp hair [Figure - 1]. [ijdvl.com]

Microcephalic Osteodysplastic Primordial Dwarfism Type II

Sparse hair and eyebrows, and dry skin are frequently observed. [orpha.net]

[…] and thin eyebrow ; Sparse eyelashes ; Sparse scalp hair ; Stillbirth ; Tetralogy of Fallot Associated Genes RNU4ATAC (Withdrawn symbols: RNU4ATAC1, U4atac ) Mouse Orthologs [mousephenotype.org]

The patient had intrauterine growth retardation, sparse scalp hair, sparse eyebrows and eyelashes, high arched palate, micrognathia, low set ears, short neck, clenched fists [ajol.info]

Kabuki Syndrome

Facial features include long palpebral fissures with eversion of the lower lateral eyelid, sparse and arched eyebrows, depressed nasal tip, and large prominent earlobes. [dnatesting.uchicago.edu]

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Ventricular septal defect Hole in heart wall separating two lower [rarediseases.info.nih.gov]

[…] lateral eyebrows, prominent ears, and persistent fetal fingertip pads. [ncbi.nlm.nih.gov]

Chromosome 19q13.11 Deletion Syndrome

[…] hair 0008070 Sparse lateral eyebrow Limited hair on end of eyebrow 0005338 Sparse or absent eyelashes 0200102 Supernumerary nipple Accessory nipple 0002558 Thin skin 0000963 [rarediseases.info.nih.gov]

eyebrows in patient 1 and by sparse eyebrows and teeth anomalies in patient 2. [nature.com]

[…] hair, long face, high frontal hair line, sparse eyebrows and eyelashes, hypoplastic alae nasi, and low-set ears; and (d) shawl scrotum. [molecularcytogenetics.biomedcentral.com]

Pallister-Killian Syndrome

Newborns and children also have a specific phenotype, characterized by facial dimorphism: "coarse" facies, high forehead, sparse lashes and eyebrows, shallow supraorbital [symptoma.com]

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse hair 0008070 Thick upper lip vermilion Full upper lip Increased volume of upper lip Plump upper lip Prominent upper [rarediseases.info.nih.gov]

The girl has woolly and sparse hair, absence of lateral eyebrows, dry skin, brittle nails, hypopigmented patches, frontal bossing, hearing loss, hypertrophic dilated cardiomyopathy [ncbi.nlm.nih.gov]

Nestor-Guillermo Progeria Syndrome

[…] and thin eyebrow ; Sparse eyelashes ; Spotty hyperpigmentation ; Wide cranial sutures Associated Genes BANF1 (Withdrawn symbols: BAF ) Mouse Orthologs Banf1 (Withdrawn symbols [mousephenotype.org]

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse eyelashes Scant eyelashes Scanty eyelashes Thin eyelashes [ more ] 0000653 Spotty hyperpigmentation Spotty increased [rarediseases.info.nih.gov]

[…] and thin eyebrow Very Common - Between 80% and 100% cases Insulin resistance Very Common - Between 80% and 100% cases Other less frequent symptoms Patients with BANF1 gene [mendelian.co]

Netherton Syndrome

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse eyelashes Scant eyelashes Scanty eyelashes Thin eyelashes [ more ] 0000653 1%-4% of people have these symptoms Intestinal [rarediseases.info.nih.gov]

[…] location Displaced kidney [ more ] 0000086 Erythroderma 0001019 Hydronephrosis 0000126 Short stature Decreased body height Small stature [ more ] 0004322 Skin rash 0000988 Sparse [rarediseases.info.nih.gov]

Renpenning Syndrome

[…] hair ; Sparse lateral eyebrow ; Spasticity ; Strabismus ; Tetralogy of Fallot ; Thin upper lip vermilion ; Triangular face ; Upslanted palpebral fissure ; Ventricular septal [mousephenotype.org]

eyebrows and hair. [invitae.com]

Pectus excavatum ; Pes cavus ; Phimosis ; Poor suck ; Protruding ear ; Renal hypoplasia ; Scoliosis ; Seizures ; Short philtrum ; Short stature ; Situs inversus totalis ; Sparse [mousephenotype.org]

Ehlers-Danlos Syndrome Spondylodysplastic Type 1

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse eyelashes Scant eyelashes Scanty eyelashes Thin eyelashes [ more ] 0000653 Sparse scalp hair Reduced/lack of hair on [rarediseases.info.nih.gov]

Features that are unique to this type include short stature ; bowing of the legs; weak muscle tone; sparse scalp hair and eyebrows; soft, doughy skin; and thin, translucent [rarediseases.info.nih.gov]

[…] scalp hair, flat face, wide forehead, blue sclerae, abnormal teeth, and cleft palate/bifid uvula) Thin, curly hair; sparse eyebrows and eyelashes Joint contractures and hypermobility [rarediseases.info.nih.gov]

Colpocephaly

[…] scalp hair (HP:0002209); thick eyebrow (HP:0000574); long eyelashes (HP:0000527); delayed gross motor skills (HP:0002194), delayed fine motor skills (HP:0010862); normal [databases.lovd.nl]

[…] scalp hair (HP:0002209); normal eyebrow (-HP:0000534); long eyelashes (HP:0000527); delayed gross motor skills (HP:0002194), delayed fine motor skills (HP:0010862); normal [databases.lovd.nl]

[…] scalp hair (HP:0002209); thick eyebrow (HP:0000574); long eyelashes (HP:0000527); delayed gross motor skills (HP:0002194); normal lacrimal duct (-HP:0011481); ptosis (HP: [databases.lovd.nl]

Curly Hair - Acral Keratoderma - Caries Syndrome

Sparse eyebrow Hypotrichosis of eyebrow Decreased density/number of eyebrow hairs. [rarediseases.oscar.ncsu.edu]

8q22.1 Microdeletion Syndrome

Features Sex Tight/thick facial skin Blepharophimosis Telecanthus Reduced facial movement Arched/ sparse eyebrows Frontal upsweep Pinna anomaly Bulbous nose Long philtrum [docksci.com]

eyebrows. [research.ed.ac.uk]

Both subjects show typical NMLFS facial features, including tight, glistening facial skin, laterally sparse eyebrows, telecanthus, blepharophimosis, bulbous nasal tip, micrognathia [docksci.com]

Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations

Fixed elbow flexion MedGen UID: 870595 •Concept ID: C4025044 • Finding Sparse and thin eyebrow MedGen UID: 924309 •Concept ID: C4282407 • Finding Decreased density/number [ncbi.nlm.nih.gov]

Odonto-Onycho Dysplasia with Alopecia

thin, brittle, slow-growing scalp hair, fair and sparse eyebrows and eyelashes, absent axillary and pubic hair, fragile and brittle fingernails, thick and brittle toenails [orpha.net]

[…] dysplasia-alopecia syndrome Disease definition Odonto-onycho dysplasia-alopecia syndrome is a rare, genetic ectodermal dysplasia syndrome characterized by almost total alopecia with only sparse [orpha.net]

Judge-Misch-Wright Syndrome

Symptoms * Abnormal fingernails * Sparse eyebrows * Absent eyebrows * Thickened skin on palms * Thickened skin on soles * Light sensitivity * Sparse scalp hair * Absent scalp [checkorphan.org]

Zlotogora-Ogur Syndrome

[…] and twisted hair (pili torti) and absent or sparse eyebrows, hypohidrosis, dry skin, palmoplantar keratoderma, abnormal teeth (delayed eruption, microdontia/hypodontia, and [dovemed.com]

[…] and thin eyebrow Thin, sparse eyebrows 0000535 Sparse eyelashes Scant eyelashes Scanty eyelashes Thin eyelashes [ more ] 0000653 Showing of 52 | Last updated: 2/1/2021 Find [rarediseases.info.nih.gov]

[…] and thin eyebrow Sparse eyelashes Very frequently present symptoms in 80-99% of the cases: Bilateral cleft lip and palate Ectodermal dysplasia Finger syndactyly Macrotia [dovemed.com]

1q41-q42 Microdeletion Syndrome

eyebrow Tented upper lip vermilion Thick vermilion border Thin upper lip vermilion Upslanted palpebral fissure Widely spaced teeth Abnormality of limbs 3-4 finger cutaneous [ncbi.nlm.nih.gov]

[…] nasal tip Cleft palate Cleft upper lip Coarse facial features Deep philtrum Depressed nasal bridge Downslanted palpebral fissures High palate Narrow forehead Short philtrum Sparse [ncbi.nlm.nih.gov]

X-Linked Keratosis Follicularis Spinulosa Decalvans

Sparse hair over the eyebrows, eyelashes, axillae, and pubic area were noted [ Figure 1 ]. [ncbi.nlm.nih.gov]

On examination, he had diffuse alopecia of the scalp with sparse hair over eyebrows, eyelashes, and beard area. [ncbi.nlm.nih.gov]

On examination, he had alopecia over the crown area of the scalp [ Figure 5 ], with sparse hair over the eyebrows and axillae, multiple follicular papules over the trunk and [ncbi.nlm.nih.gov]

Tricho-Rhino-Phalangeal Syndrome Type 3

[…] and thin eyebrow ; Sparse eyelashes ; Triangular face Associated Genes TRPS1 (Withdrawn symbols: GC79, LGCR ) Mouse Orthologs Trps1 (Withdrawn symbols: AI115454, AI447310 [mousephenotype.org]

[…] carinatum ; Protruding ear ; Scoliosis ; Short distal phalanx of finger ; Short metacarpal ; Short metatarsal ; Short stature ; Shortening of all phalanges of fingers ; Sparse [mousephenotype.org]