Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy. J Pediatr 1998 ; 132 : 527 –30. Worle H, Maass E, Kohler B, et al.
The known adverse effects of IFN therapy include fever, neutropenia, mild anemia, mild elevation of liver function test, and, most deleteriously, spastic diplegia in infancy
A meta-analysis by Michaud et al. [ 8 ] found that interferon therapy could cause spastic diplegia and dyskinesia in infants.