Spastic-paraparesis: Causes & Reasons

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Possible Causes for spastic paraparesis

X-Linked Parkinsonism with Spasticity

He reported a family in which two brothers were affected by spastic paraplegia. [jnnp.bmj.com]

paraplegia Progressive spastic paraparesis Episodic ataxia Progressive spastic paraplegia Brisk reflexes Clonus Diplopia Dehydration Migraine Paresthesia Paraplegia Generalized [mendelian.co]

Paraplegia 11, Autosomal Recessive Spastic Paraplegia, Autosomal Recessive, Complicated, With Thin Corpus Callosum Spastic Paraplegia, Autosomal Recessive, With Mental Impairment [ukgtn.nhs.uk]

Myelopathy

The diagnosis of spinal cord disease may be delayed or missed if the presentation does not conform to the expected pattern of a symmetrical spastic paraparesis with sphincter [ncbi.nlm.nih.gov]

We present a case where progressive severe spastic paraparesis due to HM was substantially reversed with partial splenic artery emobilization (PSAE). [ncbi.nlm.nih.gov]

This virus is the cause of HTLV-1-associated myelopathy or tropical spastic paraparesis (HAM/TSP), a myelopathy characterised by chronic progressive paraparesis, spasticity [ncbi.nlm.nih.gov]

Cervical Spondylosis

Epidemiology Frequency Cervical spondylotic myelopathy is the most common cause of nontraumatic spastic paraparesis and quadriparesis. [emedicine.medscape.com]

A prospective survey of the causes of non-traumatic spastic paraparesis and tetraparesis in 585 patients. Spinal Cord. 1997 Jun. 35(6):361-7. [Medline]. [emedicine.medscape.com]

Pelizaeus-Merzbacher Disease

paraparesis syndrome. [medlink.com]

paraparesis. [ncbi.nlm.nih.gov]

One mother, obligate carrier, presented complicated SPG2 (spastic paraparesis). There was no phenotype-genotype correlation in our material. [ncbi.nlm.nih.gov]

Paraparesis

Hereditary spastic paraparesis : Spastic paraparesis, brisk reflexes, upgoing plantars. Absence of sensory signs. [ptpaces.wordpress.com]

[…] with hereditary spastic paraparesis. [journals.plos.org]

Anterior spinal artery occlusion : Spastic paraplegia, brisk reflexes, upgoing plantars. Loss of pain and temperature with a sensory level; dorsal columns spared. [ptpaces.wordpress.com]

Lathyrism

In 1873, the Italian scientist Contani coined the term “lathyrismo” (lathyrism) in patients with progressive spastic paraparesis. [medlink.com]

It is uniformly manifested by a predominantly motor spastic paraparesis with varying degrees of disability. [ncbi.nlm.nih.gov]

Abstract Neurophysiological assessments of central motor pathways were conducted of 11 Spanish subjects with varying degrees of spastic paraparesis (lathyrism). [ncbi.nlm.nih.gov]

Infantile-Onset Ascending Hereditary Spastic Paralysis

Articles Hereditary Spastic Paraplegia Information Page Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited [goldbamboo.com]

Like previously described cases, the patient presented with severe spastic paraparesis and showed rapid progression of paresis to the upper limbs. [ncbi.nlm.nih.gov]

Results: Like previously described cases, the patient presented with severe spastic paraparesis and showed rapid progression of paresis to the upper limbs. [eprints.uniss.it]

Primary Lateral Sclerosis

Hereditary spastic paraparesis was genetically confirmed in 14 patients (7 with SPG4 and 7 with SPG7 mutations). [ncbi.nlm.nih.gov]

The most common are Hereditary Spastic Paraplegia (or Paraparesis), Familial Spastic Paraparesis (or Paraplegia), and Strümpell-Lorrain Disease. [bravelets.com]

paraplegia Tropical spastic paraparesis (TSP) Cerebral palsy (CP) Blood tests to help rule out other diagnoses Electromyography (EMG) will show neuropathic changes MRI may [accessphysiotherapy.mhmedical.com]

Hereditary Spastic Paraplegia

Jane Grose, Jenny Freeman, Jon Marsden Summary Familial spastic paraparesis (aka Hereditary Spastic Paraplegia) is an inherited central nervous system disorder characterized [www6.plymouth.ac.uk]

He reported a family in which two brothers were affected by spastic paraplegia. [jnnp.bmj.com]

Service delivery for people with Hereditary Spastic Paraparesis living in the South West of England, Riviera Research Day, Torbay November 2009. [www6.plymouth.ac.uk]

Laurence Moon Syndrome

A few years later the same family was re-examined and some noted to have spastic paraparesis. [whonamedit.com]

From Wikidata Jump to navigation Jump to search rare autosomal recessive genetic disorder associated with retinitis pigmentosa, spastic paraplegia, and mental disabilities [wikidata.org]

The patient, however, had no spastic paraparesis and patients with Laurence Moon syndrome do not show polydactyly and obesity 7, 8, 12. [dentalnews.com]

Upper Motor Neuron Disease

Hereditary Spastic Paraplegia HSP (or familial spastic paraparesis) is a genetically and clinically heterogeneous group of disorders rather than a single entity. [clinicalgate.com]

Abstract An epidemic of spastic paraparesis was studied in a drought-affected rural area of Tarime district in northern Tanzania. [ncbi.nlm.nih.gov]

paraparesis (see “Station 3 Spastic Paraparesis”) such as cord compression and demyelination (would have sensory disturbance) Other causes of anterior horn cell disease such [medicaleducationleeds.com]

Myelitis

Hereditary Spastic Paraparesis about 10 years ago. [medhelp.org]

Abstract A 21-year-old woman presented with acute-onset spastic paraparesis. The MRI spinal scan revealed a contrast-enhanced T2 hyperintensity between C5-T2. [ncbi.nlm.nih.gov]

R/o compressive or vascular explanation, tropical spastic paraparesis (HTLV-I) or vacuolar myelopathy (HIV). DIAGNOSIS Dx: MRI with contrast. [hopkinsguides.com]

Pernicious Anemia

When the deficiency is severe, symptoms can worsen, leading to severe weakness, spasticity, paraplegia, and fecal and urinary incontinence. [emedicinehealth.com]

A severe deficiency can result in more serious neurological symptoms, including severe weakness, spasticity, paraplegia, and fecal and urinary incontinence. [medicinenet.com]

Infective Dermatitis Associated with HTLV-1

Abstract Fifteen families with clustering of infective dermatitis associated with HTLV-1 (IDH) and/or HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) were [ncbi.nlm.nih.gov]

Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis [ncbi.nlm.nih.gov]

Studies suggest that IDH in children may be a marker for the development of T-cell leukemia/lymphoma (ATL) or myelopathy associated with HTLV-1/tropical spastic paraparesis [ncbi.nlm.nih.gov]

Spastic Quadriplegic Cerebral Palsy Type 2

paraparesis or HTLV-I—associated myelopathy. 12, 13 Familial spastic paraparesis, or hereditary spastic paraplegia, 14 is an inherited neurologic disorder characterized primarily [nejm.org]

Physical therapy and exercise A drug to reduce spasticity Treatment of all forms of hereditary spastic paraparesis focuses on relieving symptoms. [merckmanuals.com]

Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis. American Journal of Human Genetics, 91, 1065–1072. [link.springer.com]

Syringomyelia

paraparesis of the lower limbs may occur. [amboss.com]

paraparesis: Legs Arms Skeletal Scoliosis Cranial nerve involvement: With syringobulbia Most often unilateral XII: Tongue weakness & hemiatrophy IX - X: Dysphagia; Dysarthria [neuromuscular.wustl.edu]

[…] distribution (neck, shoulders, arms) of: Dissociated sensory loss Dysthetic pain Muscle atrophy, fasciculations, and areflexia (patients may present with a claw hand deformity ) Spastic [amboss.com]

Spastic Paraplegia

Hereditary spastic paraparesis : Spastic paraparesis, brisk reflexes, upgoing plantars. Absence of sensory signs. [ptpaces.wordpress.com]

He reported a family in which two brothers were affected by spastic paraplegia. [jnnp.bmj.com]

Anterior spinal artery occlusion : Spastic paraplegia, brisk reflexes, upgoing plantars. Loss of pain and temperature with a sensory level; dorsal columns spared. [ptpaces.wordpress.com]

Distal Spinal Muscular Atrophy Type 5

See also [ edit ] Motor neuron disease Hereditary motor and sensory neuropathies Spinal muscular atrophies Charcot–Marie–Tooth disease Hereditary spastic paraplegia References [en.wikipedia.org]

Note that Friedreich and other ataxias and hereditary spastic paraparesis may also show abnormal results so that finding a reduced NCV does not always confirm CMTD as the [now.aapmr.org]

Type 2 is characterized by much more spasticity and much more prominent involvement of the legs, and may be a form of familial spastic paraparesis [ Hentati et al., 1998 ] [clinicalgate.com]

Fitzsimmons-McLachlan-Gilbert Syndrome

[…] syndrome, Rubinstein-taybi syndrome, Spastic paraparesis, Spastic spinal paralysis, Spinal cord injury, Spinal shock, Spinocerebellar ataxia, Tome-brune-fardeau syndrome [wikidoc.org]

Progressive spastic paraparesis, vitiligo, premature graying, and distinct facial appearance: a new genetic syndrome in 3 sibs. [ncbi.nlm.nih.gov]

Hereditary, SPG, Hereditary Motor-Sensory Neuropathy with Pyramidal Signs, Familial spastic paraplegia, familial spastic paraplegia, Hereditary spastic paraparesis, Type [monarchinitiative.org]

Early-Onset Familial Alzheimer Disease

Neurological signs that can be associated with EOAD are spastic paraparesis, intracerebral hemorrhages, seizures, extrapyramidal syndrome and exceptionally cerebellar ataxia [orpha.net]

Variant Alzheimer’s disease with spastic paraparesis: Clinical characterization. Neurology 2000 ; 54 : 1103 –8. [jmg.bmj.com]

Three PSEN1 mutations (P264L, E280G, and F386S) were associated with an atypical presentation including spastic paraparesis. [jmg.bmj.com]

Paraplegia

paraplegia, tropical Tropical spastic paraplegia Clinical Information Complete or partial loss of movement in the lower part of the body, including both legs Complete paralysis [icd9data.com]

The most common are Hereditary Spastic Paraplegia (or Paraparesis), Familial Spastic Paraparesis (or Paraplegia), and Strümpell-Lorrain Disease. [sp-foundation.org]

paraparesis Human T-cell lymphotropic virus (HTLV) 1-associated myelopathy-tropical spastic paraparesis (disorder) Human T-cell lymphotropic virus 1-associated myelopathy-tropical [icd9data.com]

Distal Spinal Muscular Atrophy Type 4

Hereditary spastic paraparesis HSP, also known as familial spastic paraplegias or Strumpell-Lorrain disease, comprises a clinically and genetically heterogeneous group of [emedicine.medscape.com]

Pyramidal syndrome with weakness usually starts insidiously in an ascending order affecting first the legs resulting in spastic paraparesis and bladder spasticity. [neuroweb.us]

 Primary Lateral sclerosis: a diagnosis ofexclusion Hereditary spastic paraplegia: AD disorder HTLV-1 associated myelopathy: X-linkedrecessive inheritance, increased [slideshare.net]

Cerebral Palsy

This study shows an AP4M1 mutation associated with aggressive behavior in addition to mild dysmorphic features, intellectual disability, spastic paraparesis and reduced head [ncbi.nlm.nih.gov]

Related phenotypes that were formerly classified in the CPSQ series include spastic paraplegia-47 (SPG47; 614066), spastic paraplegia-50 (SPG50; 612936), spastic paraplegia [ncbi.nlm.nih.gov]

Familial spastic paraplegia is well recognised and the clinician should always ask about family members with an unusual walking gait since childhood. [web.archive.org]

Juvenile Primary Lateral Sclerosis

PLS look-alike, progressive familial paraparesis (hereditary spastic paraparesis), is a separate condition with a more limited clinical extent and a more benign course. [emedicine.medscape.com]

Waragai [17] reported high signal intensity in the intracranial CST on T1WI in 5 patients with ALS who showed pronounced UMN signs including spastic paraparesis, but not in [neurologyindia.com]

Hereditary spastic paraplegia (HSP). See Hereditary Spastic Paraplegia Overview. [cmm.ucsd.edu]

Distal Spinal Muscular Atrophy

Mutations in the BSCL2 gene have recently been identified in families with (SPG17-linked) Silver syndrome-type hereditary spastic paraparesis as well as in families with distal [ncbi.nlm.nih.gov]

paraparesis, resembling classic Silver syndrome and dHMN type V. [ncbi.nlm.nih.gov]

Silver syndrome (OMIM #270685) is a rare form of hereditary spastic paraparesis mapped to chromosome 11q12-q14 (SPG17) in which spasticity of the legs is accompanied by amyotrophy [ncbi.nlm.nih.gov]

Adult Krabbe Disease

paraplegia (familial spastic paraparesis) Hermansky-Pudlak syndrome Hirschsprung anomaly Holoprosencephaly Huntington disease Hydrocephalus (neural tube defects, hydranencephaly [kumc.edu]

In the first family, clinical presentation mimicked familial spastic paraplegia. [ncbi.nlm.nih.gov]

paraparesis, optic atrophy, demyelinating peripheral neuropathy, abnormal MRI 0.0 0.015 11 p. [ncbi.nlm.nih.gov]

Biotinidase Deficiency

Spinal cord involvement has rarely been reported and all of the reported cases are spastic paraparesis. [ncbi.nlm.nih.gov]

Spastic paraparesis has been described in children with biotinidase deficiency and onset in later childhood and early adolescence. [ncbi.nlm.nih.gov]

Supplementation with biotin resulted in resolution of paraparesis with persistent mild spasticity in the lower limbs. [ncbi.nlm.nih.gov]

Spinal Cord Injury

Posterior tibial and sural nerve somatosensory evoked potentials: a study in spastic paraparesis in spinal cord lesions. Electroencephalogr. Clin. [doi.org]

Boucher-Neuhäuser Syndrome

Nearly 60 disease loci have been identified, which include mutations in two Abstract Background Hereditary spastic paraparesis (HSP) (syn. [spatax.wordpress.com]

Three neurological phenotypes, spastic paraparesis, neurodegeneration with brain iron accumulation and peripheral neuropathies, deserve special attention. [hal.upmc.fr]

Paraparesis, Strumpell-Lorrain Syndrome Hereditary Spastic Paraplegia (HSP) autosomal recessive, Spastic paraplegia autosomal recessive, ARSPG, Spastic paraplegia, SPG, Familial [centogene.com]

Cervical Myelopathy

Hereditary spastic paraplegia (also called familial spastic paraplegia or Strumpell-Lorrain disease) is not a single disease, but rather a heterogeneous group of genetic disorders [massagetoday.com]

paraplegia, normal pressure hydrocephalus, and spinal cord infarction can be easily differentiated on specific MRI findings. [boneandspine.com]

Multiple sclerosis (asymmetric paraparesis with sensory ataxia and hyper-reflexia). Normal-pressure hydrocephalus (cerebral spinal fluid congestion). [massagetoday.com]