Spastic Paraparesis: Causes & Reasons

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Possible Causes for Spastic Paraparesis

Myelopathy

The diagnosis of spinal cord disease may be delayed or missed if the presentation does not conform to the expected pattern of a symmetrical spastic paraparesis with sphincter [ncbi.nlm.nih.gov]

We present a case where progressive severe spastic paraparesis due to HM was substantially reversed with partial splenic artery emobilization (PSAE). [ncbi.nlm.nih.gov]

This virus is the cause of HTLV-1-associated myelopathy or tropical spastic paraparesis (HAM/TSP), a myelopathy characterised by chronic progressive paraparesis, spasticity [ncbi.nlm.nih.gov]

Lathyrism

Consequently, the principal clinical manifestation of lathyrism is non-progressive spastic paraparesis of the lower limbs. [symptoma.com]

In 1873, the Italian scientist Contani coined the term “lathyrismo” (lathyrism) in patients with progressive spastic paraparesis. [medlink.com]

It is uniformly manifested by a predominantly motor spastic paraparesis with varying degrees of disability. [ncbi.nlm.nih.gov]

Hereditary Spastic Paraplegia

[…] of the lower limbs HSMN V familial spastic paraplegia Strümpell-Lorrain disease French settlement disease Strumpell-Lorrain disease hereditary spastic paraparesis FSP HSP [wikidata.org]

Hereditary spastic paraplegia is a highly heterogeneous group of neurogenetic disorders with pure and complicated clinical phenotypes. [ncbi.nlm.nih.gov]

Hereditary spastic paraplegia with thin corpus callosum (HSP-TCC) is a frequent subtype of complicated HSP clinically characterized by a slowly progressive spastic paraparesis [ncbi.nlm.nih.gov]

Pelizaeus-Merzbacher Disease

paraparesis. [ncbi.nlm.nih.gov]

paraparesis syndrome. [medlink.com]

One mother, obligate carrier, presented complicated SPG2 (spastic paraparesis). There was no phenotype-genotype correlation in our material. [ncbi.nlm.nih.gov]

Laurence Moon Syndrome

A few years later the same family was re-examined and some noted to have spastic paraparesis. [whonamedit.com]

The patient, however, had no spastic paraparesis and patients with Laurence Moon syndrome do not show polydactyly and obesity 7, 8, 12. [dentalnews.com]

Two further patients had a slowly progressive spastic paraparesis, but polydactyly was present, thereby excluding the diagnosis of Laurence-Moon syndrome. [jmg.bmj.com]

Diffuse Cerebral Sclerosis of Schilder

paraparesis Systemic atrophies primarily affecting the CNS Huntington's Spinocerebellar ataxia ( Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia [wikidoc.org]

paraparesis Systemic atrophies primarily affecting the CNS Huntington's disease - Spinocerebellar ataxia ( Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic [bionity.com]

Diagnosis is based on clinical features (most commonly progressive spastic paraparesis) and a panel of laboratory tests. Neuroimaging. [ncbi.nlm.nih.gov]

Sjögren-Larsson Syndrome

Sjögren-Larsson syndrome (SLS) is an early childhood-onset disorder with ichthyosis, mental retardation, spastic paraparesis, macular dystrophy, and leukoencephalopathy caused [ncbi.nlm.nih.gov]

She displayed the classic triad of oligophrenia, ichthyosis, and spastic paraparesis. There was a history of parental consanguinity. [ncbi.nlm.nih.gov]

Neurological examination revealed spastic paraparesis, macular degeneration and mild mental retardation. [ncbi.nlm.nih.gov]

Myelitis

The differential diagnosis in hereditary spastic paraplegia includes: multiple sclerosis cervical spondylosis with cervical myelopathy indolent spinal cord or foramen magnum [gpnotebook.co.uk]

Abstract A 21-year-old woman presented with acute-onset spastic paraparesis. The MRI spinal scan revealed a contrast-enhanced T2 hyperintensity between C5-T2. [ncbi.nlm.nih.gov]

Hereditary Spastic Paraparesis about 10 years ago. [medhelp.org]

Foix-Alajouanine Syndrome

paraparesis|Familial convulsions AND/OR ataxia|Fatty acid hydroxylase associated neurodegeneration|Fatty acid hydroxylase associated neurodegeneration (disorder)|Haw river [averbis.com]

A 52-year-old Caucasian man was referred to our MS Center for investigation of a 2-year history of progressive spastic paraparesis, associated with dysesthesia (D6 level), [nature.com]

paraplegia 35|Sporadic cerebellar degeneration|Sporadic cerebellar degeneration (disorder) All content of the ICD-10 CM Search is based on the classifications and codes of [averbis.com]

Pyramidal Tract Lesion

Hereditary spastic paraparesis HSP, also known as familial spastic paraplegias or Strumpell-Lorrain disease, comprises a clinically and genetically heterogeneous group of [emedicine.medscape.com]

Hereditary spastic paraparesis No characteristic immunohistochemical findings are noted in hereditary spastic paraparesis (HSP). [emedicine.medscape.com]

is progressive spastic paraparesis, mainly in the legs [66] Hereditary spastic paraparesis The main differential diagnosis for HSP is PLS. [emedicine.medscape.com]

Cervical Spondylosis

Epidemiology Frequency Cervical spondylotic myelopathy is the most common cause of nontraumatic spastic paraparesis and quadriparesis. [emedicine.com]

A prospective survey of the causes of non-traumatic spastic paraparesis and tetraparesis in 585 patients. Spinal Cord. 1997 Jun. 35(6):361-7. [Medline]. [emedicine.com]

Spinal Cord Transection

Original Articles 43 Downloads 10 Citations Abstract The study was performed on a group of 17 patients with spastic paraparesis: 12 with hereditary spastic paraparesis, 3 [link.springer.com]

Posted on April 12, 2016 by admin Evaluation of the effects of muscle stretch and weight load in patients with spastic paraplegia. date: 01/01/1981 author: Odeen I, Knutsson [easystand.com]

[…] in one patient with hereditary spastic paraparesis and one with spastic paraparesis due to cord compression recurrent inhibition was normally influenced by the motor command [link.springer.com]

Krabbe Disease

Patients with late-onset forms, including adult onset, may present with blindness, spastic paraparesis, and dementia. [medlink.com]

Patients with later onset forms usually present with ataxia, weakness, blindness, spastic paraparesis, behavioral problems, and dementia. [mhmedical.com]

paraparesis). [rarediseases.org]

Syringomyelia

paraparesis of the lower limbs may occur. [amboss.com]

paraparesis: Legs > Arms Skeletal Scoliosis Cranial nerve involvement: With syringobulbia Most often unilateral XII: Tongue weakness & hemiatrophy IX - X: Dysphagia; Dysarthria [neuromuscular.wustl.edu]

[…] distribution (neck, shoulders, arms) of: Dissociated sensory loss Dysthetic pain Muscle atrophy, fasciculations, and areflexia (patients may present with a claw hand deformity ) Spastic [amboss.com]

Hematomyelia

paraparesis and ataxia with signs of lateral and posterior column affection. 19. • Diagnosis is made by MRI or CT myelography and by the exclusion of other spinal cord diseases [slideshare.net]

Six months later, an acute deterioration occurred with a spastic paraparesis (strength 3/5) and bladder dysfunction. [em-consulte.com]

[…] the spinal cord due to increased venous pressure (usually due to AVF; less commonly AVMs) and often involves acute to sub-acute progression of neurological deficits from spastic [emedicine.medscape.com]

Spinal Cord Compression

Clinical features Spastic paraparesis / tetraparesis Radicular pain at the level of the compression Sensory loss below the level of the compression Causes Degenerative disc [almostadoctor.co.uk]

Examination revealed functional upper extremities with spastic paraplegia of bilateral lower extremities. [ncbi.nlm.nih.gov]

The cord symptoms were often noted to progress rapidly to a flaccid paraplegia, although a slowly progressive spastic paraplegia could occur. [medlink.com]

Cerebral Palsy

This study shows an AP4M1 mutation associated with aggressive behavior in addition to mild dysmorphic features, intellectual disability, spastic paraparesis and reduced head [ncbi.nlm.nih.gov]

Related phenotypes that were formerly classified in the CPSQ series include spastic paraplegia-47 (SPG47; 614066), spastic paraplegia-50 (SPG50; 612936), spastic paraplegia [ncbi.nlm.nih.gov]

With appropriate management, many children, especially those with spastic paraplegia or hemiplegia, can lead near-normal lives. [merckmanuals.com]

Pernicious Anemia

When the deficiency is severe, symptoms can worsen, leading to severe weakness, spasticity, paraplegia, and fecal and urinary incontinence. [emedicinehealth.com]

The advanced state is characterized by spastic paraplegia, contractures, ataxia, and impairment of other sensory modalities. [neuropathology-web.org]

Cervical Cord Compression

[…] lower spastic paraparesis) Flaccid paresis of one or two upper extremities in the plurisegmental distribution Atrophy of hand muscles Sensory involvement in various distributions [onlinelibrary.wiley.com]

TABLE 4 Conditions That Mimic Cervical Spondylotic Myelopathy on Presentation Amyotrophic lateral sclerosis Extrinsic neoplasia (metastatic tumors) Hereditary spastic paraplegia [aafp.org]

paraplegia, normal pressure hydrocephalus, and spinal cord infarction can be easily differentiated on specific MRI findings. [boneandspine.com]

Spinal Cord Injury

Posterior tibial and sural nerve somatosensory evoked potentials: a study in spastic paraparesis in spinal cord lesions. Electroencephalogr. Clin. [doi.org]

Cervical Myelopathy

Hereditary spastic paraplegia (also called familial spastic paraplegia or Strumpell-Lorrain disease) is not a single disease, but rather a heterogeneous group of genetic disorders [massagetoday.com]

paraplegia, normal pressure hydrocephalus, and spinal cord infarction can be easily differentiated on specific MRI findings. [boneandspine.com]

Multiple sclerosis (asymmetric paraparesis with sensory ataxia and hyper-reflexia). Normal-pressure hydrocephalus (cerebral spinal fluid congestion). [massagetoday.com]

Spinal Tuberculosis

Tuberculosis of the spine is a preventable and treatable cause of spastic paraplegia. [rxpgonline.com]

Infantile Neuroaxonal Dystrophy

CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5. Brain 2009 ; 132 : 1589 – 600.. [brain.oxfordjournals.org]

PARAPLEGIA Telephone: No telephone number available Email: president@eurohsp.eu EUROPEAN FEDERATION OF ASSOCIATIONS OF PATIENTS WITH HAEMOCHROMATOSIS Telephone: No telephone [eurordis.org]

paraplegia (OMIM 610357 ; see also Hereditary Spastic Paraplegia Overview ), and hereditary ataxia ; however, cerebellar atrophy usually presents later in individuals with [ncbi.nlm.nih.gov]

Spinal Epidural Hematoma

Neurological examination revealed bilateral sensory disturbance of all modalities below the level of fourth dorsal vertebrae level and spastic paraplegia. [ruralneuropractice.com]

X-Linked Parkinsonism with Spasticity

He reported a family in which two brothers were affected by spastic paraplegia. [jnnp.bmj.com]

paraplegia Progressive spastic paraparesis Episodic ataxia Progressive spastic paraplegia Brisk reflexes Clonus Diplopia Dehydration Migraine Paresthesia Paraplegia Generalized [mendelian.co]

} Spastic paraparesis (finding) {312444006, SNOMED-CT } Spastic paresis (finding) {371028005, SNOMED-CT } Spasticity as sequela of stroke (disorder) {108691000119102, SNOMED-CT [phinvads.cdc.gov]

Paraparesis

Hereditary spastic paraparesis : Spastic paraparesis, brisk reflexes, upgoing plantars. Absence of sensory signs. [ptpaces.wordpress.com]

[…] type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 ) 2018 6 Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis [malacards.org]

Paraparesis in tropical spastic paraparesis is progressive, and the patient’s condition has followed the anticipated clinical course, with spasticity that has increased over [nejm.org]

Infantile-Onset Ascending Hereditary Spastic Paralysis

Articles Hereditary Spastic Paraplegia Information Page Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited [goldbamboo.com]

Like previously described cases, the patient presented with severe spastic paraparesis and showed rapid progression of paresis to the upper limbs. [ncbi.nlm.nih.gov]

Keywords Hereditary Spastic Paraplegia Spastic Paraparesis Primary Lateral Sclerosis Spastic Gait Hereditary Spastic Paraparesis These keywords were added by machine and not [link.springer.com]

Primary Lateral Sclerosis

Hereditary spastic paraparesis was genetically confirmed in 14 patients (7 with SPG4 and 7 with SPG7 mutations). [ncbi.nlm.nih.gov]

Two patients suffering from slowly progressing spastic paraparesis are presented. [ncbi.nlm.nih.gov]

paraplegia Tropical spastic paraparesis (TSP) Cerebral palsy (CP) Blood tests to help rule out other diagnoses Electromyography (EMG) will show neuropathic changes MRI may [accessphysiotherapy.mhmedical.com]

Upper Motor Neuron Disease

Abstract An epidemic of spastic paraparesis was studied in a drought-affected rural area of Tarime district in northern Tanzania. [ncbi.nlm.nih.gov]

Hereditary Spastic Paraplegia HSP (or familial spastic paraparesis) is a genetically and clinically heterogeneous group of disorders rather than a single entity. [clinicalgate.com]

paraparesis (see “Station 3 Spastic Paraparesis”) such as cord compression and demyelination (would have sensory disturbance) Other causes of anterior horn cell disease such [medicaleducationleeds.com]

Distal Spinal Muscular Atrophy Type 4

Pyramidal syndrome with weakness usually starts insidiously in an ascending order affecting first the legs resulting in spastic paraparesis and bladder spasticity. [neuroweb.us]

 Primary Lateral sclerosis: a diagnosis ofexclusion Hereditary spastic paraplegia: AD disorder HTLV-1 associated myelopathy: X-linkedrecessive inheritance, increased [slideshare.net]