Spastic Paraplegia: Causes & Reasons

Possible Causes for Spastic Paraplegia

The disease spectrum for Pelizaeus-Merzbacher disease and spastic paraplegia type 2 is extraordinarily broad, ranging from a spastic gait in the pure form of spastic paraplegia [ncbi.nlm.nih.gov]

[…] disease,spastic paraplegia 2, uncomplicated) (PLP1), mRNA Gene names i Name: PLP1 ORF Names: hCG_17970 Organism i Homo sapiens (Human) Taxonomic identifier i 9606 [ NCBI [uniprot.org]

Abstract Pelizaeus-Merzbacher disease (PMD) and its allelic disorder, spastic paraplegia type 2 (SPG2), are among the best-characterized dysmyelinating leukodystrophies of [ncbi.nlm.nih.gov]

Laurence Moon Syndrome

From Wikidata Jump to navigation Jump to search rare autosomal recessive genetic disorder associated with retinitis pigmentosa, spastic paraplegia, and mental disabilities [wikidata.org]

Other signs include mental retardation ataxia, muscle rigidity, and spastic paraplegia. [accesspediatrics.mhmedical.com]

Lau·rence-Moon syn·drome ( law'rĕnts mūn ), [MIM*245800] disorder characterized by mental retardation, pigmentary retinopathy, hypogenitalism, and spastic paraplegia; autosomal [medical-dictionary.thefreedictionary.com]

Hereditary Spastic Paraplegia

[…] dominant hereditary spastic paraplegias, and X-linked hereditary spastic paraplegias. [medlink.com]

Key words: hereditary spastic paraplegia; spastic paraplegia; muscle spasticity; genetics; mutation RESUMO Paraplegias espásticas hereditárias (PEH) constituem um grupo de [scielo.br]

[…] presents a webinar-based case review on Hereditary Ataxia and Hereditary Spastic Paraplegia. [education.questdiagnostics.com]

Sjögren-Larsson Syndrome

paraplegia. [medical-dictionary.thefreedictionary.com]

Examination revealed mental retardation and spastic paraplegia with ankle clonus. [ijdvl.com]

The Sjogren-Larsson syndrome is a neurocutaneous, autosomal recessive and disabling condition, characterized by congenital ichthyosis, spastic paraplegia and mental retardation [ncbi.nlm.nih.gov]

Lathyrism

Clinical manifestations are marked by spastic paraplegia, and degenerative pathological changes are noted in the spinal cord to account for this effect. [doi.org]

Progressive spastic paraplegia.. Pain.. Hyperesthesia.. Paresthesia.. Angiolathyrism - causes sudden death.. Aneurisms.. [specialityclinic.com]

Main involvement is spastic paraplegia with exaggerated tendon jerks and extensor response plantar. [healthdrip.com]

Diffuse Cerebral Sclerosis of Schilder

paraplegia, followed by mental and physical deterioration. [icd9data.com]

[…] paraparesis Systemic atrophies primarily affecting the CNS Huntington's Spinocerebellar ataxia ( Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia [wikidoc.org]

paraplegia ) Spinal muscular atrophy : Werdnig-Hoffman disease - Kugelberg-Welander disease - Fazio Londe syndrome - MND ( Amyotrophic lateral sclerosis (ALS), Progressive [bionity.com]

Pernicious Anemia

When the deficiency is severe, symptoms can worsen, leading to severe weakness, spasticity, paraplegia, and fecal and urinary incontinence. [emedicinehealth.com]

A severe deficiency can result in more serious neurological symptoms, including severe weakness, spasticity, paraplegia, and fecal and urinary incontinence. [medicinenet.com]

Foix-Alajouanine Syndrome

paraplegia of the lower extremities that progresses to flaccid paralysis, often ascending, loss of sphincter control, and progressive sensory loss. [medicine.academic.ru]

[…] amaurotic axonal idiocy|Spastic paraplegia 35|Sporadic cerebellar degeneration|Sporadic cerebellar degeneration (disorder) All content of the ICD-10 CM Search is based on [averbis.com]

The clinical characteristics given by these authors were of progressive paraplegia, at first spastic, then flaccid with atrophy, the process advancing slowly upward in the [jamanetwork.com]

Myelopathy

TABLE 4 Conditions That Mimic Cervical Spondylotic Myelopathy on Presentation Amyotrophic lateral sclerosis Extrinsic neoplasia (metastatic tumors) Hereditary spastic paraplegia [aafp.org]

Hereditary spastic paraplegia (also called familial spastic paraplegia or Strumpell-Lorrain disease) is not a single disease, but rather a heterogeneous group of genetic disorders [massagetoday.com]

paraplegia, normal pressure hydrocephalus and spinal cord infarction ( Table 4 ). 10 Most of these conditions can easily be distinguished from CSM based on characteristic [aafp.org]

Cerebral Palsy

Related phenotypes that were formerly classified in the CPSQ series include spastic paraplegia-47 (SPG47; 614066), spastic paraplegia-50 (SPG50; 612936), spastic paraplegia [ncbi.nlm.nih.gov]

Many children with spastic hemiplegia or paraplegia have normal intelligence; children with spastic quadriplegia or a mixed syndrome may have severe intellectual disability [merckmanuals.com]

51 (SPG51; 613744), and spastic paraplegia-52 (614067). [ncbi.nlm.nih.gov]

Spinal Cord Transection

: Strumpell's familial spastic paraplegia: genetics and neuropathology. J. Neurol. Neurosurg. Psychiatry 37:8–20, 1974. [link.springer.com]

Posted on April 12, 2016 by admin Evaluation of the effects of muscle stretch and weight load in patients with spastic paraplegia. date: 01/01/1981 author: Odeen I, Knutsson [easystand.com]

CrossRef PubMed Google Scholar [10] Harding A.E. : Hereditary “pure” spastic paraplegia: a clinical and genetic study of 22 families. J. Neurol. Neurosurg. [link.springer.com]

Krabbe Disease

paraplegia from the middle of the second decade, and all patients had diminished GALC activity in their leukocytes. [ncbi.nlm.nih.gov]

paraplegia, followed by mental and physical deterioration. [icd9data.com]

[…] polymorphism (PCR-SSCP) analysis, subsequent sequence determination, and restriction enzyme digestion of PCR products, initial symptoms were the onset of slowly progressive spastic [ncbi.nlm.nih.gov]

Spinal Cord Compression

Examination revealed functional upper extremities with spastic paraplegia of bilateral lower extremities. [ncbi.nlm.nih.gov]

The cord symptoms were often noted to progress rapidly to a flaccid paraplegia, although a slowly progressive spastic paraplegia could occur. [medlink.com]

paraplegia with a sensory level at the trunk Weakness of the legs, sacral loss of sensation and extensor (upward) plantar reflexes Specific syndromes associated with cord [dundeemedstudentnotes.wordpress.com]

Classic Pelizaeus-Merzbacher Disease

PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Neurogenetics 2005;6:1-16. Wolf NI et al. [rarediseases.org]

PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Neurogenetics. 2005 Feb;6(1):1-16. Epub 2004 Dec 31. Review. [medlineplus.gov]

Elucidation of the pathogenic mechanism and potential treatment strategy for a female patient with spastic paraplegia derived from a single-nucleotide deletion in PLP1. [rarediseases.org]

X-Linked Spastic Paraplegia Type 1

Paraplegia AR na na CACNA1E Epileptic Encephalopathy AD 99.94 25 of 25 CASK Nonspherocytic Hemolytic Anemia, Mental Retardation And Microcephaly With Pontine And Cerebellar [igenomix.es]

Paraplegia AR 93.35 25 of 27 INS Permanent Neonatal Diabetes Mellitus, Hyperproinsulinemia AD,AR 100 78 of 84 ITGA6 Epidermolysis Bullosa Junctionalis With Pyloric Atresia [igenomix.es]

HYMAI Paternal Uniparental Disomy Of Chromosome 6, Transient Neonatal Diabetes Mellitus AD na na IBA57 Multiple Mitochondrial Dysfunctions Syndrome, Autosomal Recessive Spastic [igenomix.es]

Pelizaeus-Merzbacher Disease Type Löwenberg-Hill

Clinical features of hereditary spastic paraplegia due to spastin mutation. [cambridge.org]

Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. [cambridge.org]

paraplegia. [cambridge.org]

Connatal Pelizaeus-Merzbacher Disease

PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2. [medlineplus.gov]

Infantile Neuroaxonal Dystrophy

CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5. Brain 2009 ; 132 : 1589 – 600.. [brain.oxfordjournals.org]

paraplegia (OMIM 610357 ; see also Hereditary Spastic Paraplegia Overview ), and hereditary ataxia ; however, cerebellar atrophy usually presents later in individuals with [ncbi.nlm.nih.gov]

PARAPLEGIA Telephone: No telephone number available Email: president@eurohsp.eu EUROPEAN FEDERATION OF ASSOCIATIONS OF PATIENTS WITH HAEMOCHROMATOSIS Telephone: No telephone [eurordis.org]

Pyramidal Tract Lesion

Hereditary spastic paraparesis HSP, also known as familial spastic paraplegias or Strumpell-Lorrain disease, comprises a clinically and genetically heterogeneous group of [emedicine.medscape.com]

But I just read in this website spastic cerbral palsy is pyramidal and non spastic is extrapyramidal. How can that be? [physicsforums.com]

Of the 45 known gene loci, 20 have been identified as causative. [57] About 40% of autosomal dominant HSP cases are linked to the spastic paraplegia 4 (SPG4) locus on chromosome [emedicine.medscape.com]

Cervical Myelopathy

paraplegia, normal pressure hydrocephalus, and spinal cord infarction can be easily differentiated on specific MRI findings. [boneandspine.com]

the main feature of which is progressive spasticity in the lower limbs due to pyramidal tract dysfunction. [massagetoday.com]

Myelitis

The differential diagnosis in hereditary spastic paraplegia includes: multiple sclerosis cervical spondylosis with cervical myelopathy indolent spinal cord or foramen magnum [gpnotebook.co.uk]

= Hello, Juliet, Hereditary spastic paraplegia (HSP) is one of the degenerative diseases of the nervous system. [medhelp.org]

Cervical Spondylosis

TABLE 4 Conditions That Mimic Cervical Spondylotic Myelopathy on Presentation Amyotrophic lateral sclerosis Extrinsic neoplasia (metastatic tumors) Hereditary spastic paraplegia [aafp.org]

Severe cases of cervical spinal canal stenosis can also cause paraplegia, and significant loss of function also rarely, if ever, occurs. [termedia.pl]

paraplegia, normal pressure hydrocephalus and spinal cord infarction ( Table 4 ). 10 Most of these conditions can easily be distinguished from CSM based on characteristic [aafp.org]

Cervical Cord Compression

TABLE 4 Conditions That Mimic Cervical Spondylotic Myelopathy on Presentation Amyotrophic lateral sclerosis Extrinsic neoplasia (metastatic tumors) Hereditary spastic paraplegia [aafp.org]

paraplegia, normal pressure hydrocephalus, and spinal cord infarction can be easily differentiated on specific MRI findings. [boneandspine.com]

paraplegia, normal pressure hydrocephalus and spinal cord infarction ( Table 4 ). 10 Most of these conditions can easily be distinguished from CSM based on characteristic [aafp.org]

Spinal Tuberculosis

Tuberculosis of the spine is a preventable and treatable cause of spastic paraplegia. [rxpgonline.com]

uncontrolled spasticity, painful paraplegia, spinal tumor syndrome, and instability confirmed by image. [scielo.br]

Surgery for those patients with neurological deficit at the acute phase of the disease is limited to cases of conservative treatment failure, fast onset, recurrent paraplegia [scielo.br]

Spinal Epidural Hematoma

Neurological examination revealed bilateral sensory disturbance of all modalities below the level of fourth dorsal vertebrae level and spastic paraplegia. [ruralneuropractice.com]

If intervention is delayed, permanent sequelae of SEH can include sensory deficits, paraplegia, spasticity, neuropathic pain, and urinary or anal sphincter dysfunction. [nysora.com]

Neurological complications of spinal haematoma include paraplegia, spasticity, neuropathic pain, and urinary and anal sphincter dysfunction. [intechopen.com]

Cervical Herniated Disc

For patients with more severe symptoms, such as spastic paresis and paraplegia, or those who fail conservative therapy, surgical treatment may be necessary. [symptoma.com]

Hematomyelia

[…] the spinal cord due to increased venous pressure (usually due to AVF; less commonly AVMs) and often involves acute to sub-acute progression of neurological deficits from spastic [emedicine.medscape.com]

paraplegia to flaccid paralysis, loss of sphincter tone, and ascending sensory loss. [9] Spinal subarachnoid hemorrhage (SAH) may cause symptoms due to blood in the subarachnoid [emedicine.medscape.com]

Syringomyelia

This can further lead to spasticity which may progress to paraplegia/quadriplegia, decubitus ulcers, recurrent pneumonia, and bowel and bladder dysfunction.[35] Neurological [statpearls.com]

Spinal Cord Injury

Functional electrical stimulation and suppression of spasticity following spinal cord injury. Bull. N. Y. Acad. Med. 68(2): 351 – 364 ; 1992. [doi.org]

Recovery of sensory and supraspinal control of leg movement in people with chronic paraplegia: A case series. Arch. Phys. Med. Rehabil. 95(4): 610 – 614 ; 2014. [doi.org]

X-Linked Parkinsonism with Spasticity

PMID 15043967. ^ "Hereditary spastic paraplegia". nhs.uk. 2017-10-18. Retrieved 2018-01-28. ^ Fink JK (2003). "The Hereditary Spastic Paraplegias". [en.wikipedia.org]

spastic paraplegia loci. [journals.lww.com]

[…] hereditary spastic paraplegia 34 (DOID:0110785) Alliance: disease page Synonyms: SPG34; X-linked spastic paraplegia 34; X-linked spastic paraplegia type 34 Alt IDs: OMIM:300750 [informatics.jax.org]