Speech Abnormalities: Causes & Reasons

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Possible Causes for Speech Abnormalities

Hallervorden-Spatz Syndrome

Speech was also grossly abnormal. She was completely bed ridden for the past six months. No significant family history was obtained. [jpgmonline.com]

Referral for adaptive aids as needed (e.g., a walker or wheelchair for gait abnormalities) Speech therapy and/or assistive communication devices for PKAN-related dysarthria [ncbi.nlm.nih.gov]

These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred. [jpgmonline.com]

Chromosome 4q32.1-q32.2 Triplication Syndrome

abnormalities Abdomen Gastrointestinal: constipation hirschsprung disease Neurologic Behavioral Psychiatric Manifestations: autistic features [malacards.org]

[…] bridge short nose Head And Neck Ears: low-set ears small ears malformed ears squared-off ears Neurologic Central Nervous System: hydrocephalus delayed psychomotor development speech [malacards.org]

Stroke

Focusing on 3 findings (acute facial paresis, arm drift, or abnormal speech) might improve diagnostic accuracy and reliability. [ncbi.nlm.nih.gov]

Ask the person to repeat a simple sentence and look for any speech abnormality. T: Time to call 911! [medicinenet.com]

Focusing on 3 findings (acute facial paresis, arm drift, or abnormal speech) might improve diagnostic accuracy and reliability. Full Text [dx.doi.org]

Alpha-Mannosidosis

Hearing has improved to normal or near normal for speech frequencies in 3 patients. No new skeletal abnormalities have developed. [ncbi.nlm.nih.gov]

Associated motor function disturbances include muscular weakness, joint abnormalities and ataxia. [ncbi.nlm.nih.gov]

scoliosis and deformation of the sternum), hearing impairment (moderate-to-severe sensorineural hearing loss), gradual impairment of mental functions and speech, and often [ncbi.nlm.nih.gov]

Kleine-Levin Syndrome

This speech abnormality became less prominent with subsequent spells. Attacks were immediately preceded by a flu-like illness. [bmcneurol.biomedcentral.com]

Abnormal speech. Your speech may be affected, resulting in slurred or child-like speech. Hyper-sexuality. [nosleeplessnights.com]

You may find that you have an abnormally high and uninhibited sexual drive during an episode. Mood changes. [nosleeplessnights.com]

Giacheti Syndrome

Abnormality of head or neck High forehead Long face Abnormality of limbs Long foot Abnormality of the eye Hypotelorism Abnormality of the nervous system Neurological speech [ncbi.nlm.nih.gov]

Pre-, peri-, and post-natal data were obtained from parents/guardians to rule out factors that could affect language/learning and cause speech abnormalities. [scielo.br]

Neurological speech impairment MedGen UID: 11531 •Concept ID: C0037822 • Disease or Syndrome A term referring to disorders characterized by the disruption of normal speech [ncbi.nlm.nih.gov]

Aphasia

After Leborgne, Broca identifed a number of other cases with comparable speech abnormalities, and they all had damage to a similar area in the left frontal lobe—a region that [neuroscientificallychallenged.com]

In other words, analyzing the patterns in the abnormal speech of someone who has suffered from an event like a stroke, or from someone who has a medical condition like dementia [quickanddirtytips.com]

Reading ability is diminished, and although writing ability is retained, what is written may be abnormal. [medical-dictionary.thefreedictionary.com]

Huntington Disease-Like Type 3

[…] eye movements Impaired gait, posture and balance Difficulty with the physical production of speech or swallowing Impairments in voluntary movements — rather than the involuntary [mayoclinic.org]

Speech can become difficult at this stage and the patient may go through periods of confusion and screaming. [huntingtonsdiseasenews.com]

Additional symptoms may also occur that may be associated with Huntington's such as: anxiety, stress, tension, difficultly swallowing and speech impairment. [en.wikibooks.org]

Mitochondrial Membrane Protein-Associated Neurodegeneration

The most common symptoms are speech and gait difficulties, optic atrophy, generalized dystonia, spasticity and parkinsonism. [nbiadisorders.org]

In several patients with atypical disease whose first major symptom was palilalia, psychiatric abnormalities were misinterpreted as the cause of the speech defect. [nejm.org]

This causes temporary weakness of muscles that have involuntary contractions causing pain, twisting, abnormal posture, or changes in person’s voice or speech. [nbiaalliance.org]

Aromatic L-Amino Acid Decarboxylase Deficiency

Speech delays and abnormal eye movements may also occur. [rarediseases.org]

Combined Oxidative Phosphorylation Deficiency 15

Clinical features include mild global developmental delay, white matter abnormalities, ataxia, incoordination, speech and reading difficulties, T2-weighted hyperintensities [uniprot.org]

[…] facial shape Decreased activity of cytochrome C oxidase in muscle tissue Decreased activity of mitochondrial complex I Inability to walk by childhood/adolescence Poor speech [snpedia.com]

G) Significance Pathogenic Disease Combined oxidative phosphorylation deficiency 15 Leigh syndrome due to mitochondrial complex I deficiency Leigh syndrome not provided Abnormal [snpedia.com]

Congenital Velopharyngeal Incompetence

Patients with VPD typically exhibit hypernasal speech, abnormal articulation, and decreased intelligibility. [nationwidechildrens.org]

Direct inspection with a fiberoptic nasoendoscope The diagnosis is suspected in patients with the typical speech abnormalities. [merckmanuals.com]

Abnormal articulation Leakage of food or liquid through the nose while eating Services We Offer Genetic Evaluation and Testing Speech Evaluation Instrumental Speech Assessment [nationwidechildrens.org]

Cleft Uvula

Bifid Uvula Treatment Usually those who get a submucous cleft palate treated, experience speech abnormalities, since there is a loss of air in the nose, not allowing one's [buzzle.com]

The most common reason that a child is evaluated for a submucous cleft palate is abnormal nasal speech. [cleftline.org]

Impaired speech because of the difficulties 4. Abnormalities in moving the soft palate muscles 5. Loss of air in the nose 6. Middle ear infections Treatment 1. [healthmedicalinfohmi.blogspot.com]

Spinocerebellar Ataxia Type 20

The onset of these speech abnormalities was abrupt in some cases. [ncbi.nlm.nih.gov]

RESULTS: Patients showed gait abnormality (83.7%), speech disorder (48.8%), dizziness (41.8%) and dysphagia (39.5%). [n.neurology.org]

The phenotype is distinctive, with palatal tremor, and hypermetric saccades, and early dentate (but not pallidal) calcification in the absence of abnormalities of calcium [ncbi.nlm.nih.gov]

Neuronal Ceroid Lipofuscinosis Type 10

Mental deterioration in childhood [ more ] 0002376 Neurological speech impairment Speech disorder Speech impairment Speech impediment [ more ] 0002167 Optic atrophy 0000648 [rarediseases.info.nih.gov]

Metabolism abnormality [ more ] 0001939 Abnormality of movement Movement disorder Unusual movement [ more ] 0100022 Developmental regression Loss of developmental milestones [rarediseases.info.nih.gov]

5%-29% of people have these symptoms Ataxia 0001251 Behavioral abnormality Behavioral changes Behavioral disorders Behavioral disturbances Behavioral problems Behavioral/ [rarediseases.info.nih.gov]

Alexander Disease

Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, seizures, and poor coordination. [kennedykrieger.org]

Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, and poor coordination. [streetdirectory.com]

Early-Onset Alzheimer Disease

Article type: Short Communication Authors: Sinning, Mariana a ; b ; * | van Rooyen, Jan Piere c | Venegas-Francke, Pablo a | Vásquez, Carolina a ; 1 | Behrens, María Isabel a ; b | Ramírez, Alfredo c ; d ; * Affiliations: [ a ] Hospital Clínico de la Universidad de Chile, Santiago, Chile | [ b ] Clinica Alemana de[…] [content.iospress.com]

Tetrasomy 15q

behavioral abnormalities; and seizures .[1][2] Most cases of isodicentric chromosome 15 syndrome occur sporadically in people with no family history of the condition.[3] [rarediseases.info.nih.gov]

[…] vary from person to person, common signs and symptoms include poor muscle tone in newborns; developmental delay ; mild to severe intellectual disability ; delayed or absent speech [rarediseases.info.nih.gov]

Maxillofacial Dysostosis

[…] the eyelids (palpebral fissures), minor external ear malformations and speech abnormalities. [rarediseases.org]

abnormalities. [rarediseases.org]

[…] poor speech articulation (dysarthria). [rarediseases.org]

X-Linked Syndromic Mental Retardation Type Snyder-Robinson

abnormalities, kyphoscoliosis, and seizures. [preprints.org]

Bone abnormalities (e.g., osteoporosis, kyphoscoliosis, fractures, joint contractures) are also characteristic. [orpha.net]

[…] spermine synthase gene ( SMS ) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech [preprints.org]

Davis-Lafer Syndrome

behavioral abnormalities, cortical malformations in some patients, and variable dysmorphic facial features. [rgd.mcw.edu]

NEURODEVELOPMENTAL DISORDER WITH ATAXIC GAIT, ABSENT SPEECH, AND DECREASED CORTICAL WHITE MATTER Neurodevelopmental Disorder with Central and Peripheral Motor Dysfunction [rgd.mcw.edu]

MOVEMENTS, LOSS OF SPEECH, AND SEIZURES NEURODEVELOPMENTAL DISORDER WITH SEVERE MOTOR IMPAIRMENT AND ABSENT LANGUAGE NEURODEVELOPMENTAL DISORDER WITH SPASTIC QUADRIPLEGIA [rgd.mcw.edu]

Roy-Maroteaux-Kremp Syndrome

behavioral abnormalities, cortical malformations in some patients, and variable dysmorphic facial features. [rgd.mcw.edu]

NEURODEVELOPMENTAL DISORDER WITH ATAXIC GAIT, ABSENT SPEECH, AND DECREASED CORTICAL WHITE MATTER Neurodevelopmental Disorder with Central and Peripheral Motor Dysfunction [rgd.mcw.edu]

MOVEMENTS, LOSS OF SPEECH, AND SEIZURES NEURODEVELOPMENTAL DISORDER WITH SEVERE MOTOR IMPAIRMENT AND ABSENT LANGUAGE NEURODEVELOPMENTAL DISORDER WITH SPASTIC QUADRIPLEGIA [rgd.mcw.edu]

Hemidystonia-Hemiatrophy Syndrome

Functional and structural brain abnormalities associated with a genetic disorder of speech and language. [mijn.bsl.nl]

Watkins, K.E., Vargha-Khadem, F., Ashburner, J., e.a. (2002). mri analysis of an inherited speech and language disorder: structural brain abnormalities. [mijn.bsl.nl]

Functional and structural brain abnormalities associated with a genetic disorder of speech and language. American Journal of Human Genetics, 65, 1215-21. [mijn.bsl.nl]

Colpocephaly

EEG (HP:0002353); no growth abnormality (-HP:0001507); abnormal vision (HP:0000504); no hearing loss (-HP:0000365); severe speech delay (HP:0000750); moderate intellectual [databases.lovd.nl]

(-HP:0001507); abnormal vision (HP:0000504); no hearing loss (-HP:0000365); severe speech delay (HP:0000750); severe intellectual disability; panic attacks, difficult to [databases.lovd.nl]

(-HP:0011276); no seizures (-HP:0001250); no growth abnormality (-HP:0001507); no hearing loss (-HP:0000365); moderate-severe speech delayed (HP:0000750); moderate-severe [databases.lovd.nl]

ARID1b-Related Disorder

Corpus callosum abnormalities, intellectual disability, speech impairment, and autism in patients with haploinsufficiency of ARID1B. Clin Genet. 2012;82:248–55. [ncbi.nlm.nih.gov]

Filippi Syndrome

However, other skeletal anomalies, such as dislocation of the elbows with hypoplasia of the radial heads and speech abnormalities, were not present in our case (Table 2). [hindawi.com]

In addition, moderate dysmorphic features and skeletal abnormalities were noted. [ncbi.nih.ncbi.unboundmedicine.com]

Filippi syndrome is also characterized by mild to severe intellectual disability; some affected individuals may have abnormal language and speech development, potentially [rareguru.com]

Glutamyl Ribose-5-Phosphate Storage Disease

[…] and Behavioral Abnormalities GLB029 GDSBA Global Developmental Delay, Absent or Hypoplastic Corpus Callosum, and Dysmorphic Facies GLB021 GDACCF Global Developmental Delay [malacards.org]

Gliosarcoma GLS001 Global Cerebellar Malformation GLB027 Global Developmental Delay with or Without Impaired Intellectual Development GLB025 GDDI Global Developmental Delay with Speech [malacards.org]

Congenital Disorder of Glycosylation Type 2I

[…] carbohydrate deficient glycoprotein syndrome with clinical characteristics in the single reported case to date of moderate mental retardation with slow and inarticulate speech [ncbi.nlm.nih.gov]

Most affected children do not develop normal speech patterns. [rarediseases.org]

Constitutionally, patients commonly have failure to thrive due to feeding and GI abnormalities and global developmental delay. [atm.amegroups.com]

Spinocerebellar Degeneration

Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary [hon.ch]

Spinocerebellar Degeneration - Corneal Dystrophy

Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary [hon.ch]