Speech Abnormalities: Causes & Reasons

Possible Causes for Speech Abnormalities

Clinical History The 54-year-old female presented with gait impairment and slurred speech. These abnormalities progressed over several years. [eurorad.org]

In atypical PKAN, patients present with speech difficulty, mild gait abnormalities, prominent psychiatric symptoms that may include depression, emotional lability, impulsivity [orpha.net]

Keywords: Brain, abnormalities How to Cite: Dilli A, Ayaz UY, Sarıkaya S, Kaplanoglu H, Hekimog˘lu B. Hallervorden-Spatz Syndrome. [jbsr.be]

Chromosome 4q32.1-q32.2 Triplication Syndrome

abnormalities Abdomen Gastrointestinal: constipation hirschsprung disease Neurologic Behavioral Psychiatric Manifestations: autistic features [malacards.org]

[…] bridge short nose Head And Neck Ears: low-set ears small ears malformed ears squared-off ears Neurologic Central Nervous System: hydrocephalus delayed psychomotor development speech [malacards.org]

Stroke

Focusing on 3 findings (acute facial paresis, arm drift, or abnormal speech) might improve diagnostic accuracy and reliability. [ncbi.nlm.nih.gov]

Ask the person to repeat a simple sentence and look for any speech abnormality. T: Time to call 911! [medicinenet.com]

Focusing on 3 findings (acute facial paresis, arm drift, or abnormal speech) might improve diagnostic accuracy and reliability. Full Text [oadoi.org]

Kleine-Levin Syndrome

This speech abnormality became less prominent with subsequent spells. Attacks were immediately preceded by a flu-like illness. [bmcneurol.biomedcentral.com]

Abnormal speech. Your speech may be affected, resulting in slurred or child-like speech. Hyper-sexuality. [nosleeplessnights.com]

You may find that you have an abnormally high and uninhibited sexual drive during an episode. Mood changes. [nosleeplessnights.com]

Alpha-Mannosidosis

Hearing has improved to normal or near normal for speech frequencies in 3 patients. No new skeletal abnormalities have developed. [ncbi.nlm.nih.gov]

Associated motor function disturbances include muscular weakness, joint abnormalities and ataxia. [ncbi.nlm.nih.gov]

scoliosis and deformation of the sternum), hearing impairment (moderate-to-severe sensorineural hearing loss), gradual impairment of mental functions and speech, and often [ncbi.nlm.nih.gov]

Aphasia

After Leborgne, Broca identifed a number of other cases with comparable speech abnormalities, and they all had damage to a similar area in the left frontal lobe—a region that [neuroscientificallychallenged.com]

In other words, analyzing the patterns in the abnormal speech of someone who has suffered from an event like a stroke, or from someone who has a medical condition like dementia [quickanddirtytips.com]

Reading ability is diminished, and although writing ability is retained, what is written may be abnormal. [medical-dictionary.thefreedictionary.com]

Huntington Disease-Like Type 3

[…] mental functioning) People with HD might develop slurred speech and trouble eating and swallowing. [medicare.com]

Speech can become difficult at this stage and the patient may go through periods of confusion and screaming. [huntingtonsdiseasenews.com]

Additional symptoms may also occur that may be associated with Huntington's such as: anxiety, stress, tension, difficultly swallowing and speech impairment. [en.wikibooks.org]

Mitochondrial Membrane Protein-Associated Neurodegeneration

The most common symptoms are speech and gait difficulties, optic atrophy, generalized dystonia, spasticity and parkinsonism. [nbiadisorders.org]

In several patients with atypical disease whose first major symptom was palilalia, psychiatric abnormalities were misinterpreted as the cause of the speech defect. [nejm.org]

This causes temporary weakness of muscles that have involuntary contractions causing pain, twisting, abnormal posture, or changes in person’s voice or speech. [nbiaalliance.org]

Aromatic L-Amino Acid Decarboxylase Deficiency

Speech delays and abnormal eye movements may also occur. [rarediseases.org]

Myotonia Congenita

speech disturbance, or eye opening difficulty in variable combinations in addition to limbs. [tandfonline.com]

[…] lip; High-arched palate Neonatal respiratory distress (50%) Patient may eventually be weaned from respirator Delayed motor milestones Parallels degree of hypotonia Delayed speech [neuromuscular.wustl.edu]

In three patients (Patient T2, T3, and T4), myotonic stiffness affected facial musculature leading to a series of abnormities, such as facial stiffness, chewing difficulty [tandfonline.com]

Congenital Velopharyngeal Incompetence

Direct inspection with a fiberoptic nasoendoscope The diagnosis is suspected in patients with the typical speech abnormalities. [msdmanuals.com]

Patients with VPD typically exhibit hypernasal speech, abnormal articulation, and decreased intelligibility. [nationwidechildrens.org]

[…] of the palate and causing hypernasal speech. [msdmanuals.com]

Giacheti Syndrome

Abnormality of head or neck High forehead Long face Abnormality of limbs Long foot Abnormality of the eye Hypotelorism Abnormality of the nervous system Neurological speech [ncbi.nlm.nih.gov]

Pre-, peri-, and post-natal data were obtained from parents/guardians to rule out factors that could affect language/learning and cause speech abnormalities. [scielo.br]

Deeply set eye Epistaxis Menorrhagia Petechiae Large forehead Short palm Small hand Unilateral renal agenesis Ptosis Hypothalamic hamartoma Strabismus Epicanthus Absent speech [mendelian.co]

Combined Oxidative Phosphorylation Deficiency 15

Clinical features include mild global developmental delay, white matter abnormalities, ataxia, incoordination, speech and reading difficulties, T2-weighted hyperintensities [uniprot.org]

[…] facial shape Decreased activity of cytochrome C oxidase in muscle tissue Decreased activity of mitochondrial complex I Inability to walk by childhood/adolescence Poor speech [snpedia.com]

G) Significance Pathogenic Disease Combined oxidative phosphorylation deficiency 15 Leigh syndrome due to mitochondrial complex I deficiency Leigh syndrome not provided Abnormal [snpedia.com]

Cleft Uvula

Bifid Uvula Treatment Usually those who get a submucous cleft palate treated, experience speech abnormalities, since there is a loss of air in the nose, not allowing one's [buzzle.com]

The most common reason that a child is evaluated for a submucous cleft palate is abnormal nasal speech. [cleftline.org]

Impaired speech because of the difficulties or abnormalities in moving the soft palate muscles. Also, there is a loss of air in the nose. Middle ear infections. [tandurust.com]

Early-Onset Alzheimer Disease

Molecular diagnosis of autosomal dominant early onset Alzheimer’s disease: an update G Raux 1, L Guyant-Maréchal 2, C Martin 2, J Bou 1, C Penet 3, A Brice 3, D Hannequin 4, T Frebourg 2, D Campion 1 1 Inserm U 614, IFRMP, Faculty of Medicine, Rouen, France 2 Department of Genetics, Rouen University Hospital, France 3[…] [jmg.bmj.com]

Phenytoin Allergy

Common side effects may include: drowsiness, confusion; slurred speech; abnormal eye movement; or problems with balance, coordination, or muscle movement. [jgoldbergmd.com]

Maxillofacial Dysostosis

[…] the eyelids (palpebral fissures), minor external ear malformations and speech abnormalities. [rarediseases.org]

abnormalities. [rarediseases.org]

[…] poor speech articulation (dysarthria). [rarediseases.org]

Tetrasomy 15q

behavioral abnormalities; and seizures. [rarediseases.info.nih.gov]

behavioral abnormalities; and seizures .[1][2] Most cases of isodicentric chromosome 15 syndrome occur sporadically in people with no family history of the condition.[3] [rarediseases.info.nih.gov]

[…] that affects growth, learning, and speech. [alicenova.it]

16p12.2 Microdeletion Syndrome

[…] system Generalized hypotonia Abnormality of the nervous system Behavioral abnormality Delayed speech and language development Global developmental delay Seizure Etiology [ncbi.nlm.nih.gov]

Abnormality of head or neck Abnormal facial shape Abnormality of the cardiovascular system Abnormality of cardiovascular system morphology Abnormality of the musculoskeletal [ncbi.nlm.nih.gov]

cognitive and perceptual abnormalities. [ncbi.nlm.nih.gov]

X-Linked Syndromic Mental Retardation Type Snyder-Robinson

abnormalities, kyphoscoliosis, and seizures. [preprints.org]

[…] ranging from unsteady gait to inability to walk (71% [14/19]) Speech abnormalities including nasal, dysarthric, coarse, or absent speech (100% [19/19]) Abnormal palate morphology [ncbi.nlm.nih.gov]

[…] the spermine synthase gene (SMS) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech [preprints.org]

Baker-Gordon Syndrome

[…] delay, poor or absent speech, behavioral abnormalities, hyperkinetic movements, and EEG abnormalities in the absence of overt seizures (summary by Baker et al., 2018). [findzebra.com]

poor or absent speech, behavioral abnormalities, hyperkinetic movements, and EEG abnormalities in the absence of overt seizures (summary by Baker et al., 2018). [ncbi.nlm.nih.gov]

Walking and speech are delayed and moderate to profound intellectual impairment is virtually always present. [disorders.eyes.arizona.edu]

5q14.3 Microdeletion Syndrome

[…] language delays that are mostly significant; absent or severely delayed speech Abnormal facial features that include: Small-sized head with broad forehead Eyes that are set [dovemed.com]

[…] and motor delays), intellectual disabilities, distinctive facial features, and brain abnormalities This chromosomal anomaly is usually known to develop from sporadic mutations [dovemed.com]

[…] missing/deleted Some individuals with this deletion may have only mild features, while others may have severe findings that can include growth and developmental delays (speech [dovemed.com]

Spinocerebellar Ataxia Type 20

The onset of these speech abnormalities was abrupt in some cases. [ncbi.nlm.nih.gov]

RESULTS: Patients showed gait abnormality (83.7%), speech disorder (48.8%), dizziness (41.8%) and dysphagia (39.5%). [n.neurology.org]

The phenotype is distinctive, with palatal tremor, and hypermetric saccades, and early dentate (but not pallidal) calcification in the absence of abnormalities of calcium [ncbi.nlm.nih.gov]

17p13.3 Microduplication Syndrome

abnormalities, behavioral problems, recurrent infections, relatively increase of body weight, discrete facial dysmorphism including downslanting palpebral fissures, broad [pubmed.ncbi.nlm.nih.gov]

[…] and language delays Abnormal facial features that include: Small-sized head with prominent forehead Widely spaced eyes Drooping eyelid (ptosis) Low-set ears Broad nose Wide [dovemed.com]

[…] comparison with the 5 other patients previously described, revealed common phenotypic features, such as hypotonia, mild to moderate developmental delay/mental retardation, speech [pubmed.ncbi.nlm.nih.gov]

Glutamyl Ribose-5-Phosphate Storage Disease

[…] and Behavioral Abnormalities GLB029 GDSBA Global Developmental Delay, Absent or Hypoplastic Corpus Callosum, and Dysmorphic Facies GLB021 GDACCF Global Developmental Delay [malacards.org]

Gliosarcoma GLS001 Global Cerebellar Malformation GLB027 Global Developmental Delay with or Without Impaired Intellectual Development GLB025 GDDI Global Developmental Delay with Speech [malacards.org]

Colpocephaly

EEG (HP:0002353); no growth abnormality (-HP:0001507); abnormal vision (HP:0000504); no hearing loss (-HP:0000365); severe speech delay (HP:0000750); moderate intellectual [databases.lovd.nl]

(-HP:0001507); abnormal vision (HP:0000504); no hearing loss (-HP:0000365); severe speech delay (HP:0000750); severe intellectual disability; panic attacks, difficult to [databases.lovd.nl]

(-HP:0011276); no seizures (-HP:0001250); no growth abnormality (-HP:0001507); no hearing loss (-HP:0000365); moderate-severe speech delayed (HP:0000750); moderate-severe [databases.lovd.nl]

16p13.3 Microduplication Syndrome

Possible symptoms include developmental delay, speech delay, joint abnormalities, characteristic facial features, attention deficit, autism spectrum disorders, and underlying [rarediseases.info.nih.gov]

It can result in abnormal facial features, developmental delays, and birth abnormalities, including speech and learning delays. [dovemed.com]

Filippi Syndrome

However, other skeletal anomalies, such as dislocation of the elbows with hypoplasia of the radial heads and speech abnormalities, were not present in our case (Table 2). [hindawi.com]

[…] hearing and speech impairment. [docksci.com]

In addition, moderate dysmorphic features and skeletal abnormalities were noted. [ncbi.nih.ncbi.unboundmedicine.com]

Hemidystonia-Hemiatrophy Syndrome

Functional and structural brain abnormalities associated with a genetic disorder of speech and language. [mijn.bsl.nl]

Watkins, K.E., Vargha-Khadem, F., Ashburner, J., e.a. (2002). mri analysis of an inherited speech and language disorder: structural brain abnormalities. [mijn.bsl.nl]

Functional and structural brain abnormalities associated with a genetic disorder of speech and language. American Journal of Human Genetics, 65, 1215-21. [mijn.bsl.nl]

Bardet-Biedl Syndrome Type 14

While ataxia, poor coordination, brachydactyly, diabetes mellitus, speech abnormalities, liver fibrosis, hearing loss, spasticity, and cardiovascular anomaly constitute the [cureus.com]

[…] such as hypodontia, microdontia, Neurologic abnormalities such as epilepsy, ataxia, speech abnormalities, Olfactory dysfunctions such as anosmia, hyposmia, Cardiovascular [dovepress.com]

Many people with Bardet-Biedl syndrome also have kidney abnormalities, which can be serious or life-threatening. [encyclopedia.pub]