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12 Possible Causes for Spike-and-Slow-Wave or Polyspike-and-Slow-Wave Discharges, Variable Psychomotor Retardation

  • Myoclonic-Astatic Epilepsy

    retardation mainly affecting speech.[ipfs.io] Myoclonic-atonic seizures with falls are the defining symptoms. • EEG shows frequent generalized discharges of spike/polyspike-slow wave at varying frequencies of 2.5 to 3[medlink.com] Boys (74%) are more often affected than girls (Doose and Baier 1987a). [2] Prognosis Epilepsy with myoclonic-astatic seizures has a variable course and outcome.[ipfs.io]

  • West Syndrome

    […] clinical manifestations such as hypotonia, psychomotor retardation, and feeding difficulties.[ncbi.nlm.nih.gov] Leigh syndrome (LS) (sub-acute necrotizing encephalomyelopathy) is characterized by symmetric brain lesions occurring mainly in the basal ganglia and associated with variable[ncbi.nlm.nih.gov]

  • Early Infantile Epileptic Encephalopathy Type 2

    […] degree of psychomotor delay and cognitive impairment, ranging from mild to severe mental retardation [23].[journals.plos.org] .  Inter-Ictal EEG  Initial -20% show normal BG with photoparoxysmal discharges of spikes/ polyspikes-slow waves.  Within 1 year, EEG - abnormal slow BG with frequent asymmetrical[slideshare.net] ) discharges or generalized spike wave and polyspike wave activity.[dx.doi.org]

  • HSD10 Mitochondrial Disease

    Features include progressive neurodegeneration, psychomotor retardation, loss of mental and motor skills, seizures, cardiomyopathy, and visual and hearing impairment.[genecards.org] EEG repeated at 10 years of age showed predominantly generalized frequent very high amplitude spike-slow waves and polyspike-slow wave discharges during sedated sleep ( Fig[journals.plos.org] Disease description An X-linked multisystemic disorder with highly variable severity. Age at onset ranges from the neonatal period to early childhood.[uniprot.org]

  • Early Infantile Epileptic Encephalopathy Type 28

    SCAR12 is additionally characterized by onset of generalized seizures in infancy, and delayed psychomotor development with mental retardation.[selfdecode.com] .  Inter-Ictal EEG  Initial -20% show normal BG with photoparoxysmal discharges of spikes/ polyspikes-slow waves.  Within 1 year, EEG - abnormal slow BG with frequent asymmetrical[slideshare.net] Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement[selfdecode.com]

  • Progressive Epilepsy-Intellectual Disability Syndrome, Type Finnish

    […] and ranging from seizures and moderate psychomotor retardation to mild autistic features with speech and language delay Treatment: Supportive care Congenital disorders of[merckmanuals.com] Interictal EEG may demonstrate the following characteristics: A slow background that can be constant or transient Awake – Diffuse slow spike wave Non-REM sleep – Discharges[emedicine.medscape.com] Type III (intermediate form; 609241) Onset: Childhood Urine metabolites: Oligosaccharides and O-linked sialopeptides Clinical features: Intermediate between types I and II; variable[merckmanuals.com]

  • Early Infantile Epileptic Encephalopathy Type 14

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] .  Inter-Ictal EEG  Initial -20% show normal BG with photoparoxysmal discharges of spikes/ polyspikes-slow waves.  Within 1 year, EEG - abnormal slow BG with frequent asymmetrical[slideshare.net] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9, 12 ].[bmcmedgenet.biomedcentral.com]

  • Early Infantile Epileptic Encephalopathy with Suppression-Burst

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] .  Inter-Ictal EEG  Initial -20% show normal BG with photoparoxysmal discharges of spikes/ polyspikes-slow waves.  Within 1 year, EEG - abnormal slow BG with frequent asymmetrical[slideshare.net] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9, 12 ].[bmcmedgenet.biomedcentral.com]

  • Early Infantile Epileptic Encephalopathy Type 13

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] .  Inter-Ictal EEG  Initial -20% show normal BG with photoparoxysmal discharges of spikes/ polyspikes-slow waves.  Within 1 year, EEG - abnormal slow BG with frequent asymmetrical[slideshare.net] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9, 12 ].[bmcmedgenet.biomedcentral.com]

  • Early Infantile Epileptic Encephalopathy Type 26

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] .  Inter-Ictal EEG  Initial -20% show normal BG with photoparoxysmal discharges of spikes/ polyspikes-slow waves.  Within 1 year, EEG - abnormal slow BG with frequent asymmetrical[slideshare.net] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9 , 12 ].[bmcmedgenet.biomedcentral.com]

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