Splenectomy: Causes & Reasons

Possible Causes for Splenectomy

Only 1 patient required conversion to open surgery because of multiple adhesions from a previous partial splenectomy. [ncbi.nlm.nih.gov]

With splenectomy her platelet counts normalised and neurological status also improved. [ncbi.nlm.nih.gov]

There are no clinical trials testing therapies in PH due to GD or splenectomy. [ncbi.nlm.nih.gov]

Babesiosis

We describe three hospitalized patients with fever attributable to babesiosis after a splenectomy. [ncbi.nlm.nih.gov]

A 52-year-old woman living on Martha's Vineyard developed postoperative fever after splenectomy for trauma. [ncbi.nlm.nih.gov]

To our knowledge, this is the first reported case treated without splenectomy. [ncbi.nlm.nih.gov]

Gaucher Disease Type 1

In the analysis we considered severity of disease, time of splenectomy, and start of enzyme replacement therapy. [ncbi.nlm.nih.gov]

splenectomy prior to starting treatment. [ncbi.nlm.nih.gov]

Starting ERT soon after clinical onset and avoiding splenectomy might reduce the risk of CL in GD1. [ncbi.nlm.nih.gov]

Thrombocytopenia

A splenectomy is the surgical procedure that partially or completely removes the spleen. [en.wikipedia.org]

[…] time to splenectomy, age and platelet count at splenectomy. [haematologica.org]

Splenectomy has tended to be avoided because of its complications, but the response rate of splenectomy is 60-80% and it has still been considered for steroid-refractory ITP [ncbi.nlm.nih.gov]

Hemolytic Anemia

The optimal duration of prophylactic antibiotic therapy post splenectomy is unknown. Recomendations range from at least 5 years post splenectomy to lifetime. [clinicaladvisor.com]

Rituximab may be used before splenectomy or may be used in individuals who relapse after splenectomy. [rarediseases.org]

Splenectomy also has no role in cold AIHA. [xpertdox.com]

Hereditary Spherocytosis

Abstract Splenectomy is considered the treatment of choice for patients with "symptomatic" hereditary spherocytosis (HS). [ncbi.nlm.nih.gov]

Sixty-two children underwent partial splenectomy for hereditary spherocytosis between 1990 and 2008. [ncbi.nlm.nih.gov]

Our study showed that partial splenectomy was not inferior to total splenectomy. [ncbi.nlm.nih.gov]

Congenital Dyserythropoietic Anemia

[…] year-old white female with a 10-year history of juvenile rheumatoid arthritis and splenomegaly developed numerous circulating nucleated red blood cells (NRBC) following splenectomy [ncbi.nlm.nih.gov]

Splenectomy was eventually performed which achieved complete resolution of ascites, increase of hemoglobin concentration and abrogation of transfusion requirements. [ncbi.nlm.nih.gov]

Splenectomy produced an increased hemoglobin (P <.001) and a reduced bilirubin level (P =.007) in comparison with values before splenectomy. [ncbi.nlm.nih.gov]

Chronic Immune Thrombocytopenic Purpura

There was one death following splenectomy, and the postoperative morbidity was 14.1%. [jamanetwork.com]

splenectomy. [ghrnet.org]

[…] to splenectomy still remains less well defined. [ncbi.nlm.nih.gov]

Splenic Metastasis

After Minazawa et al [ 16 ] firstly performed splenectomy in the splenic metastasis of ovarian cancer patient, splenectomy, as a therapeutic modality of splenic metastasis [bmccancer.biomedcentral.com]

Her elevated cancer antigen 125 immediately decreased to within the normal range after the splenectomy. [ncbi.nlm.nih.gov]

Thermal ablation for assisting hemostasis in partial splenectomy minimizes blood loss during operation. [ncbi.nlm.nih.gov]

Evans Syndrome

However, the cytopenia normalized after a splenectomy. Keywords: Autoimmune hemolytic anemia ; Idiopathic thrombocytopenic purpura ; Liver transplantation ; Splenectomy [dx.doi.org]

However, the cytopenia normalized after a splenectomy. [ekjm.org]

[…] to post-splenectomy thromboembolism [17]. [thrombosisjournal.biomedcentral.com]

Acquired Hemolytic Anemia

Continued activity of the disease following splenectomy was productive of the most extreme increases in spherocytosis. [bloodjournal.org]

[…] these injurious antibodies, by x-ray, nitrogen mustard and urethane, or to inhibit the reticuloendothelial system by Congo red saturation, have been of limited value. 5 Splenectomy [annals.org]

[…] see clumped RBC, temp effect, transfuse, avoid cold exposure, warm blood prior to transfusion steroids/splenectomy NOT EFFECTIVE intravascular do plasma phoresis rituxan-binds [quizlet.com]

Immune Thrombocytopenic Purpura

We report two cases of splenectomy during pregnancy for refractory ITP. [ncbi.nlm.nih.gov]

We propose a protocol for ITP follow-up after splenectomy. KEYWORDS: Platelet count; Splenectomy; Thrombocytopenic purpura; Trend [ncbi.nlm.nih.gov]

Unresolved issues in laparoscopic splenectomy. [americanjournalofsurgery.com]

Autoimmune Thrombocytopenia

splenectomy. [ncbi.nlm.nih.gov]

AIM: To estimate the contribution of autoimmune thrombocytopenia to hepatitis C virus-related liver cirrhosis (type C cirrhosis), we evaluated the influence of splenectomy [ncbi.nlm.nih.gov]

Similar results were noted following splenectomy in healthy donors (HD). [ncbi.nlm.nih.gov]

Primary Myelofibrosis

After splenectomy, the patient started treatment with ruxolitinib. [ncbi.nlm.nih.gov]

We provide evidence that a better quality of life and long survival in pediatric PMF may be provided by splenectomy. [ncbi.nlm.nih.gov]

Splenectomy is considered for drug-refractory splenomegaly. [ncbi.nlm.nih.gov]

Splenic Vein Thrombosis

However, it has been underappreciated in cases of splenectomy for gastric cancer. [ncbi.nlm.nih.gov]

MATERIALS AND METHODS: A group of 183 consecutive patients who underwent splenectomy were evaluated. [ncbi.nlm.nih.gov]

Eight patients have had selective variceal decompression after a splenectomy or splenic vein thrombosis with successful control of bleeding. [ncbi.nlm.nih.gov]

Splenic Subcapsular Hematoma

Emergent and urgent splenectomy remains a life-saving measure for many patients. Tags General and digestive Spleen Splenic pathology [websurg.com]

Emergent and urgent splenectomy remains a life-saving measure for many patients. Related specialties [websurg.com]

but splenectomy is still sometimes necessary. [merckmanuals.com]

Splenic Injury

Initial treatment was observation in 227, embolization in 15, and splenectomy in 17. [ncbi.nlm.nih.gov]

Compared with controls, cirrhosis was an independent risk factor for splenectomy (OR 5.4, 95% CI 2.5 to 11.5), and only splenic injury grade was associated with splenectomy [ncbi.nlm.nih.gov]

Those cases were developed after splenic injury or a splenectomy. [ncbi.nlm.nih.gov]

Splenic Hematoma

During recent years, laparoscopic splenectomy has shown to be a safe and effective surgical approach in patients with hematologic disorders requiring spleen removal. [ncbi.nlm.nih.gov]

The decision was made to perform laparoscopic splenectomy, with high suspicion of splenic hydatid cyst. [ncbi.nlm.nih.gov]

Radical treatment comprised exercsis of the cystic structure, splenectomy and caudal pancreatectomy. [ncbi.nlm.nih.gov]

Splenic Rupture

Finally, he underwent orthotropic heart transplantation without post-splenectomy sepsis or thrombotic complications 472 days after splenectomy. [ncbi.nlm.nih.gov]

The three subgroups in the OM group (total splenectomies group (26 cases), partial splenectomy (12 patients), RFA-assisted spleen-preserving surgery (10 patients) exhibited [ncbi.nlm.nih.gov]

Exploratory laparotomy revealed gross haemoperitoneum and splenic rupture requiring splenectomy. [ncbi.nlm.nih.gov]

Thrombocytopenia Due to Sequestration

Twenty-three patients (92%) had complete or good partial remissions after splenectomy. [annals.org]

Reasons for decision not to proceed to splenectomy. [onlinelibrary.wiley.com]

Some of those patients may benefit from splenectomy. [nature.com]

HIV-Associated Thrombocytopenia

Splenectomy has been used to treat HIV-positive patients with refractory thrombocytopenia. [ncbi.nlm.nih.gov]

It is contraindicated in patients who have had a splenectomy. [clinicaladvisor.com]

The last-resort measure is the indication for splenectomy. [lecturio.com]

Severe Idiopathic Pneumococcemia

Laparoscopic splenectomy versus open splenectomy for immune thrombocytopenic purpura. Surgery 1997;121:18-22. 25. [ajts.org]

In such cases, splenectomy may improve the response to transfusion. [medtextfree.wordpress.com]

Splenectomy for hemocytopenia in systemic lupus erythematosus. A controlled appraisal. Arch Intern Med 1979, 139, 773–776. PubMed Google Scholar 22. [link.springer.com]

Autoimmune Hemolytic Anemia

Splenectomy is recommended in refractory cases. [symptoma.com]

Splenectomy and rituximab are second-line therapies with proven short-term efficacy. [cancertherapyadvisor.com]

Splenectomy  First done in patients with either ITP or congenital spherocytic anemias  Welch et al (NEJM, 1950)  Splenectomy performed in 220 patients with “blood dyscrasias [slideshare.net]

Marginal Zone Lymphoma

To assess the efficacy of rituximab monotherapy in a large series of patients with SMZL and compare these results with splenectomy results. [ncbi.nlm.nih.gov]

To assess the efficacy of rituximab monotherapy in a large series of patients with SMZL and compare these results with splenectomy results. Methods. [doi.org]

KEYWORDS: Hepatitis C virus; NHL; Rituximab; Splenectomy; Splenic marginal zone lymphoma; Watch and wait [ncbi.nlm.nih.gov]

Beta Thalassaemia Major

Surgical management of beta thalassemia major involves splenectomy. Splenectomy is not routinely indicated in beta thalassemia minor. [symptoma.com]

It was emphasized, however, that the incidence was small in comparison with the large number of splenectomies in children. [nejm.org]

Surgical treatment of Cooley's anemia involves splenectomy and cholecystectomy. [symptoma.com]

Hepatosplenic Lymphoma

We reported a case of the successful intensive treatment with splenectomy, chemotherapy a first line autologous stem cell transplant. [ncbi.nlm.nih.gov]

Splenectomy was performed due to progressive splenomegaly. [adc.bmj.com]

[…] known reason) Skin rash or itchy skin Splenomegaly Thrombocytopenia Weight loss (for no known reason) Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Splenectomy [seer.cancer.gov]

Secondary Myelofibrosis

As during progression of the disease splenectomy revealed typical histological features of a high-grade hepatosplenic Tgammadelta lymphoma, the low-grade bone infiltrate was [ncbi.nlm.nih.gov]

Splenectomy Another option may be to have an operation to remove your spleen (a splenectomy). [bloodwise.org.uk]

However, for unexplained reasons, splenectomy increases the risk of blastic transformation. [theoncologyinstitute.com]

Beta Thalassemia

Only in some indications such as Gaucher's disease has partial splenectomy replaced total splenectomy. [ncbi.nlm.nih.gov]

Keywords: Anesthesia, beta thalassemia, splenectomy How to cite this article: Jyothi B, Sushma K S, Syeda S, Raza SO. [aeronline.org]

Results Patients underwent open splenectomy (47%) and laparoscopic splenectomy (53%). [mmj.eg.net]

Myelofibrosis

Palliative treatment in myelofibrosis (MF) includes transfusion support, JAK2 inhibitors, involved field radiotherapy and splenectomy. [ncbi.nlm.nih.gov]

[…] involves a wait-and-see approach for asymptomatic patients, oral chemotherapy for the hyperproliferative forms of the disease, androgens or erythropoietin for the anaemia, and splenectomy [ncbi.nlm.nih.gov]

Splenectomy Another option may be to have an operation to remove your spleen (a splenectomy). [bloodwise.org.uk]

Thalassemia

Treatment for severe forms may include transfusion, splenectomy, chelation, and stem cell transplantation. [msdmanuals.com]

[…] and meningococcal vaccines before splenectomy and antimicrobial prophylaxis with penicillin after splenectomy. [bloodjournal.org]

In addition, with recent reports of venous thromboembolic events (VTEs) after splenectomy, one should carefully consider the benefits and the risks before splenectomy is advocated [emedicine.medscape.com]