Splenomegaly: Causes & Reasons

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Possible Causes for Splenomegaly

Infectious Mononucleosis

Clinical estimates of splenomegaly are fallible. [ncbi.nlm.nih.gov]

In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical [ncbi.nlm.nih.gov]

Conclusions and Relevance In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly [doi.org]

Hemolytic Anemia

It results in hemolytic anemia and splenomegaly. [icd9data.com]

[…] suffer from a mild hemolytic anemia (Hb levels ranging from 10 to 12.7g/mL) associated with macrocytosis, reticulocytosis, hyperbilirubinemia, hyperferritinemia and slight splenomegaly [ncbi.nlm.nih.gov]

[…] hemolytic anemia, which is most often revealed by an unusual weakness and fatigue with tachycardia and exertional dyspnea, and also in some cases by jaundice, dark urine and/or splenomegaly [orpha.net]

Portal Cirrhosis

Liver cirrhosis: Liver cirrhosis with an inhomogeneous liver with irregular contour and ascites and splenomegaly Liver cirrhosis: Liver cirrhosis with an irregular liver contour [ultrasoundcases.info]

Splenomegaly is often used radiologically as an indicator of cirrhosis. [clinicaltrials.gov]

Albumin is low in ac. variceal hge USG: large collateral veins, portal cavernoma, splenomegaly. Doppler for direction, velocity and waveform characteristics of PV flow. [slideshare.net]

Hereditary Spherocytosis

Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia. [ncbi.nlm.nih.gov]

MATERIALS AND METHODS: A retrospective review was conducted to evaluate all SILS for splenomegaly performed by a single surgeon. [ncbi.nlm.nih.gov]

PSMA-targeted F-DCFPyL PET/CT was performed, which demonstrated recurrent disease in the prostatectomy bed as well as splenomegaly and mild-diffuse bone marrow activation, [ncbi.nlm.nih.gov]

Liver Cirrhosis

We performed LS in 83 patients with massive splenomegaly (≥30 cm) secondary to portal hypertension and liver cirrhosis. [ncbi.nlm.nih.gov]

Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. [ncbi.nlm.nih.gov]

Leukoerythroblastic Anemia

Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases. [merckmanuals.com]

Splenomegaly may develop. [msdmanuals.com]

Splenomegaly may develop. Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors. [merckmanuals.com]

Myeloproliferative Disease

CML: demonstrates increased production of neutrophils and marked splenomegaly. [ncbi.nlm.nih.gov]

Slow onset with presentation related to splenomegaly or anemia. [quizlet.com]

Both patients were suffering from thrombocytopenia and splenomegaly and underwent splenectomy. The weight of the spleen specimens was more than 2000 g. [ncbi.nlm.nih.gov]

Primary Myelofibrosis

We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly [ncbi.nlm.nih.gov]

Splenomegaly may result in left upper quadrant discomfort. [patient.info]

Other patients have symptoms of anemia, splenomegaly, or, in later stages, general malaise, weight loss, fever, or splenic infarction. [merck.com]

Congenital Hepatic Fibrosis

We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease. [ncbi.nlm.nih.gov]

RESULTS: Sixteen patients had morphologic abnormalities in the liver, 15 had splenomegaly (three underwent splenectomy for portal hypertension), and 14 had varices or spontaneous [ncbi.nlm.nih.gov]

A 25-year-old woman was admitted to our hospital with splenomegaly and hepatic cirrhosis of a 3-month duration and fever accompanied by abdominal pain for 3 days. [ncbi.nlm.nih.gov]

Splenic Vein Thrombosis

PubMed Search : Congestive splenomegaly spleen Page views in 2018: 5,928 Page views in 2019 to date: 3,115 Cite this page: Mansouri J. Congestive splenomegaly. [pathologyoutlines.com]

Seven of 9 patients (78 %) with massive splenomegaly (>20 cm) developed PSVT compared with 4 of 13 patients (31 %) with moderate splenomegaly (15-20 cm) and 6 of 45 patients [ncbi.nlm.nih.gov]

SVT should be considered in patients who present with splenomegaly, but no signs of hepatic, hematologic or portal pathology. [symptoma.com]

Splenic Rupture

Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to [omicsonline.org]

CONCLUSION: This is the second case of spontaneous splenic rupture without preceding splenomegaly in a patient with APL during induction chemotherapy described so far. [ncbi.nlm.nih.gov]

When splenic rupture is indicated by abdominal pain, tachycardia, or hypotension in a patient with splenomegaly, abdominal examination should be performed immediately, and [ncbi.nlm.nih.gov]

Thalassemia

Approach to the adult patient with splenomegaly and other splenic disorders. http://www.uptodate.com/home. Accessed June 14, 2016. Splenomegaly. [web.archive.org]

Many conditions — including infections, liver disease and some cancers — can cause an enlarged spleen, also known as splenomegaly (spleh-no-MEG-uh-lee). [mayoclinic.org]

Splenomegaly CT scan in a patient with chronic lymphocytic leukemia, showing splenomegaly. Yellow arrows point at the spleen. [en.wikipedia.org]

Splenic Subcapsular Hematoma

Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to [omicsonline.org]

Diseases Causing Splenomegaly Separated Into 3 Categories Mild Splenomegaly (Organ Weight Moderate Splenomegaly (Organ Weight 500–800 g) Severe Splenomegaly (Organ Weight [onlinelibrary.wiley.com]

What is the most common cause of congestive Splenomegaly in adults? [quizlet.com]

Gaucher Disease

CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands. [ncbi.nlm.nih.gov]

[ncbi.nlm.nih.gov] Massive Splenomegaly CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands. [symptoma.com]

In symptomatic patients, splenomegaly is progressive and can become massive. [emedicine.medscape.com]

Splenic Metastasis

Although most patients with splenic metastases are clinically asymptomatic for splenic lesions, there have been reports of painful splenomegaly, splenic vein thrombosis, and [ncbi.nlm.nih.gov]

Because of marked splenomegaly and findings of hypersplenism, the spleen was also resected. [ncbi.nlm.nih.gov]

Splenectomy is an appropriate treatment to avoid splenic rupture, splenic vein thrombosis and painful splenomegaly, to circumvent the splenic metastasis being a source of [ncbi.nlm.nih.gov]

Hepatosplenic Lymphoma

Splenectomy was performed due to progressive splenomegaly. [adc.bmj.com]

It occurs mainly in young adults presenting with splenomegaly and most often with hepatomegaly but without lymphadenopathy. [bloodjournal.org]

Most patients had massive splenomegaly, and bone marrow showed sinusoidal involvement by lymphoma. [mdanderson.elsevierpure.com]

Splenic Hematoma

Especially in cases with splenomegaly, the laparoscopic approach results in a shorter hospital stay and faster recovery of the patients. [ncbi.nlm.nih.gov]

Although filgrastim-induced splenomegaly, splenic hematomas, and splenic rupture are rare, clinicians working in the bone marrow transplant setting should be cognizant of [ncbi.nlm.nih.gov]

The boy’s medical history included splenomegaly due to thalassemia. [e-ultrasonography.org]

Systemic Juvenile Idiopathic Arthritis

Lymphadenopathy, splenomegaly, hepatomegaly, and sore throat are also common. [slideshare.net]

(Y) 5 (83) 5 (71) 7 (39) Hepatomegaly OR splenomegaly (I) 5 (83) 6 (86) 10 (56) Only splenomegaly (N) 2 (33) 3 (43) 1 (6) Splenomegaly AND Hepatomegaly (N) 3 (50) 2 (29) [ped-rheum.biomedcentral.com]

Minor criteria may include sore throat, lymphadenopathy, negative rheumatoid factor, abnormal liver function tests, hepatomegaly or splenomegaly. [press.mu-varna.bg]

Adult-Onset Still Disease

[…] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly [ncbi.nlm.nih.gov]

The proposed criteria consisted of fever, arthralgia, typical rash, and leukocytosis as major, and sore throat, lymphadenopathy and/or splenomegaly, liver dysfunction, and [ncbi.nlm.nih.gov]

[…] rash distributed along trunks and extremities worsened during fevers leukocytosis with at least 80% granulocytes Minor criteria: sore throat lymphadenopathy hepatomegaly or splenomegaly [utswim.wordpress.com]

Spleen Disease

splenomegaly. [ncbi.nlm.nih.gov]

If you have splenomegaly, your health care provider may advise you to avoid contact sports. [printer-friendly.adam.com]

Splenomegaly, enlargement of the spleen, the abdominal organ that serves as a temporary storage site for blood and filters out degenerated and old blood cells. [britannica.com]

Autoimmune Hemolytic Anemia

Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale. [ncbi.nlm.nih.gov]

She was found to have splenomegaly, generalized lymphadenopathy, pancytopenia, and acute hepatic failure. [ncbi.nlm.nih.gov]

The diagnosis of HLH after SOT is especially difficult, as several of the diagnostic criteria, including fever, splenomegaly, and cytopenias, are nonspecific and can be seen [ncbi.nlm.nih.gov]

Persistent Polyclonal B-cell Lymphocytosis

[…] negative lymphocytosis, the presence of binucleated lymphocytes in peripheral blood, and a polyclonal increase in serum immunoglobulin-M that may occasionally be accompanied by splenomegaly [ncbi.nlm.nih.gov]

Abstract Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. [ncbi.nlm.nih.gov]

Significant symptomatic splenomegaly requiring splenectomy is very unusual for this disorder; therefore there is a lack of descriptions of the morphologic features of the [ncbi.nlm.nih.gov]

Splenitis

The term 'splenomegaly’ refers to an enlargement of the spleen. [wagwalking.com]

Also: Splenomegaly Topics Related to Splenitis Enlarged Spleen ...the condition “... [diagnose-me.com]

Sonographic Differential Diagnosis (Henderson DVM): Splenomegaly Diffuse a) Inflammation (Splenitis) 1. Suppurative 2. Necrotizing 3. Eosinophilic 4. [sonopath.com]

Splenic Infarction

Physical examination on admission revealed a palpable splenomegaly. [ncbi.nlm.nih.gov]

Splenomegaly occurs with splenic enlargement. [emdocs.net]

On admission, he had a low-grade fever and was grossly anaemic; examination revealed splenomegaly. [ncbi.nlm.nih.gov]

Castleman Disease

Facing a patient with fever, peripheral lymphadenopathy, splenomegaly, and the biochemical and immunological picture depicted above, the physician may find it difficult to [symptoma.com]

The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy. [ncbi.nlm.nih.gov]

Splenic Abscess

Per-abdominal examination revealed a tender splenomegaly without any other lump or ascites. [atmph.org]

He was initially diagnosed as having splenomegaly due to Plasmodium vivax (P. vivax), but was later found to have a splenic abscess due to Escherichia coli (E. coli). [ncbi.nlm.nih.gov]

Figure 1: (a) Abdominal CT scan demonstrates splenomegaly with multiple hypodense areas (white arrows). [ijmm.org]

Chronic Lymphocytic Leukemia

Patients may sometimes present with hepatomegaly, splenomegaly or both and/or hemolytic anemia. [radiopaedia.org]

Patients may sometimes present with hepatomegaly, splenomegaly or both and/or a hemolytic anemia. [radiopaedia.org]

In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted. [symptoma.com]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant. [ncbi.nlm.nih.gov]

[…] diagnosed in the chronic phase and may be either asymptomatic (diagnosed through a routine white blood cell count) or present with fatigue, anaemia, weight loss, night sweats or splenomegaly [orpha.net]

Splenomegaly which may be massive ± spleen pain. Hepatomegaly. [askhematologist.com]

Polycythemia Vera

[…] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea. [ncbi.nlm.nih.gov]

[…] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly [ncbi.nlm.nih.gov]

Splenomegaly Massive splenomegaly is the most difficult complication of polycythemia vera to manage, since it is usually refractory to chemotherapy and not durably alleviated [cancertherapyadvisor.com]

Chronic Myeloid Leukemia

Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly. [ncbi.nlm.nih.gov]

One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly. [ncbi.nlm.nih.gov]

Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. [icd9data.com]