We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly
[ncbi.nlm.nih.gov]
Splenomegaly may result in left upper quadrant discomfort.
[patient.info]
Other patients have symptoms of anemia, splenomegaly, or, in later stages, general malaise, weight loss, fever, or splenic infarction.
[merck.com]