Splenomegaly Causes & Reasons

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Splenomegaly Symptom Checker: Possible causes include Infectious Mononucleosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Splenomegaly,

Negated

None

Unsure

None

Possible Causes

Infectious Mononucleosis

Clinical estimates of splenomegaly are fallible. [ncbi.nlm.nih.gov]

In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical [ncbi.nlm.nih.gov]

Conclusions and Relevance In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly [doi.org]

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Hemolytic Anemia

It results in hemolytic anemia and splenomegaly. [icd9data.com]

[…] suffer from a mild hemolytic anemia (Hb levels ranging from 10 to 12.7g/mL) associated with macrocytosis, reticulocytosis, hyperbilirubinemia, hyperferritinemia and slight splenomegaly [ncbi.nlm.nih.gov]

Fetal Splenomegaly: A Review. Ultrasound Q. 2017 Nov 29. [Medline]. George JN. [emedicine.com]

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Liver Cirrhosis

We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis. [ncbi.nlm.nih.gov]

Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. [ncbi.nlm.nih.gov]

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Heart Failure

Some of the extracardiac signs of heart failure are ascites, bronchial wheezing, hydrothorax, edema, liver enlargement, moist rales, and splenomegaly. [medical-dictionary.thefreedictionary.com]

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Hemochromatosis

Regression on SF revealed significant associations: TS; male sex; age; GGT; transfusion units (positive); and splenomegaly (negative) (p 0.0001, 0.0016, 0.0281, 0.0025, 0.0001 [ncbi.nlm.nih.gov]

Here we report the case of a 16-year-old Chinese boy, who was admitted with hepatalgia, jaundice, hyperpigmentation, and splenomegaly to our hospital. [ncbi.nlm.nih.gov]

An abnormally enlarged spleen (splenomegaly) may also occur. Additional symptoms occur depending on the specific organs involved. [rarediseases.org]

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Non-Hodgkin Lymphoma

Computed tomography scan of the chest and abdomen showed paratracheal and subcarinal lymphadenopathy and splenomegaly, with the findings being compatible with lymphoma. [ncbi.nlm.nih.gov]

Splenomegaly. Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy. [patient.info]

Splenomegaly is observed in approximately 40% of patients; the spleen is rarely the only involved site at presentation. [emedicine.medscape.com]

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Portal Cirrhosis

Liver cirrhosis: Liver cirrhosis with an inhomogeneous liver with irregular contour and ascites and splenomegaly Liver cirrhosis: Liver cirrhosis with an irregular liver contour [ultrasoundcases.info]

Splenomegaly is often used radiologically as an indicator of cirrhosis. [clinicaltrials.gov]

Albumin is low in ac. variceal hge USG: large collateral veins, portal cavernoma, splenomegaly. Doppler for direction, velocity and waveform characteristics of PV flow. [slideshare.net]

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Hereditary Spherocytosis

Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia. [ncbi.nlm.nih.gov]

MATERIALS AND METHODS: A retrospective review was conducted to evaluate all SILS for splenomegaly performed by a single surgeon. [ncbi.nlm.nih.gov]

PSMA-targeted F-DCFPyL PET/CT was performed, which demonstrated recurrent disease in the prostatectomy bed as well as splenomegaly and mild-diffuse bone marrow activation, [ncbi.nlm.nih.gov]

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Alcoholic Liver Disease

Splenomegaly : Portal hypertension causes the spleen to enlarge (a condition called splenomegaly). [msdmanuals.com]

[…] steatosis (fatty liver) From the collection of Dr McClain; used with permission History & Exam Key Factors abdominal pain hepatomegaly hematemesis and melena venous collaterals splenomegaly [online.epocrates.com]

Splenomegaly is the swelling of the spleen. Ascites (accumulation of fluid in the abdomen) can lead to further infection in the abdomen. [aamg.co]

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Hepatitis

Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly and Splenomegaly [symptoma.com]

Mild splenomegaly occurs in 15 to 20% of patients. Jaundice usually peaks within 1 to 2 weeks. Recovery phase: During this 2- to 4-week period, jaundice fades. [merckmanuals.com]

Physical examination may be without pathological findings, but may also reveal hepatomegaly, splenomegaly, jaundice, and signs and symptoms of chronic liver disease[ 1 9 ] [doi.org]

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Thrombocytopenia

We herein describe a case of nephrotic syndrome with thrombocytopenia, lymphadenopathy, systemic inflammation, splenomegaly, kidney enlargement, and progressive renal insufficiency [ncbi.nlm.nih.gov]

[…] intravascular coagulation Mechanical damage of the thrombocytes Artificial heart valves Use of heart-lung machine Dialysis with extracorporeal circulation Diffusion disorders Splenomegaly [flexikon.doccheck.com]

[…] to refer Isolated thrombocytopenia if platelet count 100, no other cytopenias and no accompanying clinical findings of concern such as the presence of lymphadenopathy or splenomegaly [apps.nhslothian.scot]

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Leukoerythroblastic Anemia

Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases. [merckmanuals.com]

The French authors, Emil-Weil and Clerc, 1 in 1902, and Vaquez and Aubertin, 2 in 1904, first discussed a syndrome characterized by splenomegaly due to myeloid change and [jamanetwork.com]

Splenomegaly may develop. Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors. [merckmanuals.com]

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Rheumatoid Arthritis

It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly. [ncbi.nlm.nih.gov]

Other: thyroid disorders, osteoporosis, depression, splenomegaly. [patient.info]

We review the existing literature of such cases and emphasise the importance of serological testing for RA in patients presenting with neutropaenia and splenomegaly, even [ncbi.nlm.nih.gov]

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Infective Endocarditis

This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation [ncbi.nlm.nih.gov]

Additional findings may include splenomegaly, gallop or arrhythmia, pericardial or pleural rubs, rales, pallor, acute septic monoarticular arthritis or delirium. [symptoma.com]

Signs and symptoms of IE include petechiae, anorexia, high fever, heart failure, cardiac murmur, Osler's nodes, Janeway lesions, Roth Spots, and splenomegaly. [youtube.com]

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Leukemia

Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%). [ncbi.nlm.nih.gov]

Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. [icd9data.com]

[…] leukemia (T-PLL) is the most common type of mature T-cell leukemia and is characterized by a rapidly rising peripheral blood lymphocyte count, bone marrow involvement, and splenomegaly [web.archive.org]

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Myeloproliferative Disease

CML: demonstrates increased production of neutrophils and marked splenomegaly. [ncbi.nlm.nih.gov]

Both patients were suffering from thrombocytopenia and splenomegaly and underwent splenectomy. The weight of the spleen specimens was more than 2000 g. [ncbi.nlm.nih.gov]

Slow onset with presentation related to splenomegaly or anemia. [quizlet.com]

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Primary Myelofibrosis

Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly [ncbi.nlm.nih.gov]

We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly [ncbi.nlm.nih.gov]

Splenomegaly may result in left upper quadrant discomfort. [patient.info]

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Myelodysplasia

Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which [ncbi.nlm.nih.gov]

We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and [ncbi.nlm.nih.gov]

Rare splenomegaly Prominent splenomegaly Does not meet criteria for MDS or PV Commonly multilineage dysplasia and increased blasts History of polycythemia vera Myelofibrosis [surgpathcriteria.stanford.edu]

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Splenic Metastasis

Although most patients with splenic metastases are clinically asymptomatic for splenic lesions, there have been reports of painful splenomegaly, splenic vein thrombosis, and [ncbi.nlm.nih.gov]

A computed tomography scan of the abdomen revealed a solitary lesion in the spleen, 10.5 x 10.4 x 10.1-cm, causing splenomegaly. [ncbi.nlm.nih.gov]

Because of marked splenomegaly and findings of hypersplenism, the spleen was also resected. [ncbi.nlm.nih.gov]

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Primary Immune Deficiency Disorder

Splenomegaly and generalized lymphadenopathy are present in many patients with common variable immunodeficiency (CVID). [emedicine.medscape.com]

Hepatomegaly and splenomegaly may be detected in the abdomen. In infants, crusting around the anus may be a sign of chronic diarrhoea. [patient.info]

Splenomegaly is not seen, and lymphoid tissue (i.e., adenoids) is typically extremely small [3]. [ajronline.org]

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Chronic Lymphocytic Leukemia

One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly. [ncbi.nlm.nih.gov]

In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted. [symptoma.com]

Patients may sometimes present with hepatomegaly, splenomegaly or both and/or hemolytic anemia. [radiopaedia.org]

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Subacute Bacterial Endocarditis

Findings compatible with both SBE and marantic endocarditis due to a B-cell lymphoproliferative disorder included an elevated ESR, and splenomegaly. [ncbi.nlm.nih.gov]

Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission. [ncbi.nlm.nih.gov]

Splenomegaly and clubbing of fingers and toes may occur because of prolonged infection. [symptoma.com]

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Acute Lymphoblastic Leukemia Type L1

The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop. [ncbi.nlm.nih.gov]

Other manifestations include bone pain and arthritis, hepatomegaly, splenomegaly, lymphadenopathy, extramedullary masses located in the abdomen (compression of neighboring [symptoma.com]

Hepatomegaly and/or splenomegaly due to leukemic infiltration are present in many patients at diagnosis but are often overlooked. [clinicaladvisor.com]

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Congenital Hepatic Fibrosis

We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease. [ncbi.nlm.nih.gov]

RESULTS: Sixteen patients had morphologic abnormalities in the liver, 15 had splenomegaly (three underwent splenectomy for portal hypertension), and 14 had varices or spontaneous [ncbi.nlm.nih.gov]

A 25-year-old woman was admitted to our hospital with splenomegaly and hepatic cirrhosis of a 3-month duration and fever accompanied by abdominal pain for 3 days. [ncbi.nlm.nih.gov]

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Endocarditis

PATIENT CONCERNS: A young woman, with a history of aortic stenosis, was admitted to our unit for a month of intermittent fever associated with a new diastolic heart murmur and splenomegaly [ncbi.nlm.nih.gov]

Signs and symptoms of IE include petechiae, anorexia, high fever, heart failure, cardiac murmur, Osler's nodes, Janeway lesions, Roth Spots, and splenomegaly. [youtube.com]

Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red [en.wikipedia.org]

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Splenic Vein Thrombosis

PubMed Search : Congestive splenomegaly spleen Page views in 2018: 5,928 Page views in 2019 to date: 3,115 Cite this page: Mansouri J. Congestive splenomegaly. [pathologyoutlines.com]

Seven of 9 patients (78 %) with massive splenomegaly ( 20 cm) developed PSVT compared with 4 of 13 patients (31 %) with moderate splenomegaly (15-20 cm) and 6 of 45 patients [ncbi.nlm.nih.gov]

SVT should be considered in patients who present with splenomegaly, but no signs of hepatic, hematologic or portal pathology. [symptoma.com]

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Splenic Rupture

Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to [omicsonline.org]

CONCLUSION: This is the second case of spontaneous splenic rupture without preceding splenomegaly in a patient with APL during induction chemotherapy described so far. [ncbi.nlm.nih.gov]

When splenic rupture is indicated by abdominal pain, tachycardia, or hypotension in a patient with splenomegaly, abdominal examination should be performed immediately, and [ncbi.nlm.nih.gov]

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Pernicious Anemia

Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly). [rarediseases.org]

Occasionally, splenomegaly and hepatomegaly occur. Various gastrointestinal symptoms, including weight loss and poorly localized abdominal pain, may occur. [msdmanuals.com]

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Lymphoma

At diagnosis, patients usually present with adenopathy and, in 50% of cases, splenomegaly. [orpha.net]

However, the presence of extensive retroperitoneal lymphadenopathy and splenomegaly favours lymphoma, whereas adjacent fat infiltration supports adenocarcinoma. [radiopaedia.org]

Splenomegaly. Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy. [patient.info]

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Thalassemia

Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. . [mayoclinic.org]

Splenomegaly CT scan in a patient with chronic lymphocytic leukemia, showing splenomegaly. Yellow arrows point at the spleen. [en.wikipedia.org]

Many conditions — including infections, liver disease and some cancers — can cause an enlarged spleen, also known as splenomegaly (spleh-no-MEG-uh-lee). [mayoclinic.org]

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