Splenomegaly: Causes & Reasons

Possible Causes for Splenomegaly

Clinical estimates of splenomegaly are fallible. [ncbi.nlm.nih.gov]

In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical [ncbi.nlm.nih.gov]

Conclusions and Relevance In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly [doi.org]

Hemolytic Anemia

It results in hemolytic anemia and splenomegaly. [icd9data.com]

[…] suffer from a mild hemolytic anemia (Hb levels ranging from 10 to 12.7g/mL) associated with macrocytosis, reticulocytosis, hyperbilirubinemia, hyperferritinemia and slight splenomegaly [ncbi.nlm.nih.gov]

Examination New onset of pallor and anemia Jaundice Gallstones Splenomegaly +/- hepatomegaly INVESTIGATIONS Confirm haemolysis Increased absolute reticulocyte count LDH (elevation [lifeinthefastlane.com]

Portal Cirrhosis

Liver cirrhosis: Liver cirrhosis with an inhomogeneous liver with irregular contour and ascites and splenomegaly Liver cirrhosis: Liver cirrhosis with an irregular liver contour [ultrasoundcases.info]

Splenomegaly is often used radiologically as an indicator of cirrhosis. [clinicaltrials.gov]

Albumin is low in ac. variceal hge USG: large collateral veins, portal cavernoma, splenomegaly. Doppler for direction, velocity and waveform characteristics of PV flow. [slideshare.net]

Liver Cirrhosis

We performed LS in 83 patients with massive splenomegaly (≥30 cm) secondary to portal hypertension and liver cirrhosis. [ncbi.nlm.nih.gov]

Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. [ncbi.nlm.nih.gov]

Hereditary Spherocytosis

Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia. [ncbi.nlm.nih.gov]

MATERIALS AND METHODS: A retrospective review was conducted to evaluate all SILS for splenomegaly performed by a single surgeon. [ncbi.nlm.nih.gov]

Splenomegaly is almost invariable but only rarely causes abdominal discomfort. Hepatomegaly may be present. [merckmanuals.com]

Leukoerythroblastic Anemia

Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases. [merckmanuals.com]

Splenomegaly may develop. [msdmanuals.com]

Splenomegaly may develop. Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors. [merckmanuals.com]

Myeloproliferative Disease

CML: demonstrates increased production of neutrophils and marked splenomegaly. [ncbi.nlm.nih.gov]

Slow onset with presentation related to splenomegaly or anemia. [quizlet.com]

Patients with massive splenomegaly benefit from splenectomy. [lecturio.com]

Primary Myelofibrosis

We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly [ncbi.nlm.nih.gov]

Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly [ncbi.nlm.nih.gov]

Abstract Although splenomegaly is major characteristic of primary myelofibrosis (PMF), splenomegaly has been devalued due to a less reliable method based on physical examination [ncbi.nlm.nih.gov]

Congenital Hepatic Fibrosis

We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease. [ncbi.nlm.nih.gov]

RESULTS: Sixteen patients had morphologic abnormalities in the liver, 15 had splenomegaly (three underwent splenectomy for portal hypertension), and 14 had varices or spontaneous [ncbi.nlm.nih.gov]

A 25-year-old woman was admitted to our hospital with splenomegaly and hepatic cirrhosis of a 3-month duration and fever accompanied by abdominal pain for 3 days. [ncbi.nlm.nih.gov]

Splenic Metastasis

[…] and diffuse inhomogeneous spleen Chronic lymphatic leukemia: Chronic lymphatic leukemia with splenomegaly and enlarged mesenteric lymph nodes Chronic lymphatic leukemia: [ultrasoundcases.info]

A computed tomography scan of the abdomen revealed a solitary lesion in the spleen, 10.5 x 10.4 x 10.1-cm, causing splenomegaly. [ncbi.nlm.nih.gov]

Although most patients with splenic metastases are clinically asymptomatic for splenic lesions, there have been reports of painful splenomegaly, splenic vein thrombosis, and [ncbi.nlm.nih.gov]

Splenic Vein Thrombosis

PubMed Search : Congestive splenomegaly spleen Page views in 2018: 5,928 Page views in 2019 to date: 3,115 Cite this page: Mansouri J. Congestive splenomegaly. [pathologyoutlines.com]

Seven of 9 patients (78 %) with massive splenomegaly (>20 cm) developed PSVT compared with 4 of 13 patients (31 %) with moderate splenomegaly (15-20 cm) and 6 of 45 patients [ncbi.nlm.nih.gov]

SVT should be considered in patients who present with splenomegaly, but no signs of hepatic, hematologic or portal pathology. [symptoma.com]

Splenic Rupture

Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to [omicsonline.org]

CONCLUSION: This is the second case of spontaneous splenic rupture without preceding splenomegaly in a patient with APL during induction chemotherapy described so far. [ncbi.nlm.nih.gov]

When splenic rupture is indicated by abdominal pain, tachycardia, or hypotension in a patient with splenomegaly, abdominal examination should be performed immediately, and [ncbi.nlm.nih.gov]

Splenic Subcapsular Hematoma

Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to [omicsonline.org]

Diseases Causing Splenomegaly Separated Into 3 Categories Mild Splenomegaly (Organ Weight Moderate Splenomegaly (Organ Weight 500–800 g) Severe Splenomegaly (Organ Weight [onlinelibrary.wiley.com]

Abdominal examination revealed tender palpable splenomegaly, without guarding. [em-consulte.com]

Splenic Hematoma

Especially in cases with splenomegaly, the laparoscopic approach results in a shorter hospital stay and faster recovery of the patients. [ncbi.nlm.nih.gov]

Splenomegaly Spleen enlargement, or splenomegaly, is another reason for splenic pain. [news-medical.net]

Although filgrastim-induced splenomegaly, splenic hematomas, and splenic rupture are rare, clinicians working in the bone marrow transplant setting should be cognizant of [ncbi.nlm.nih.gov]

Thalassemia

Approach to the adult patient with splenomegaly and other splenic disorders. http://www.uptodate.com/home. Accessed June 14, 2016. Splenomegaly. [mayoclinic.org]

Splenomegaly CT scan in a patient with chronic lymphocytic leukemia, showing splenomegaly. Yellow arrows point at the spleen. [en.wikipedia.org]

Splenomegaly. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/003276.htm. Accessed June 14, 2016. [mayoclinic.org]

Congenital Bile Acid Synthesis Defect Type 2

Clinical features include failure to thrive, jaundice, steatorrhea, hepatomegaly, cirrhosis, rickets and splenomegaly. [preventiongenetics.com]

Other signs and symptoms may include splenomegaly and inability to absorb certain fat - soluble vitamins, vitamin D, in particular, which can lead to rickets in some individuals [ivami.com]

The spleen may also become enlarged (splenomegaly). [malacards.org]

Gaucher Disease

Radiographically, hepatomegaly and splenomegaly respond more rapidly than skeletal changes. [radiopaedia.org]

CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands. [ncbi.nlm.nih.gov]

[ncbi.nlm.nih.gov] Massive Splenomegaly CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands. [symptoma.com]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Splenomegaly which may be massive ± spleen pain. Hepatomegaly. [askhematologist.com]

[…] diagnosed in the chronic phase and may be either asymptomatic (diagnosed through a routine white blood cell count) or present with fatigue, anaemia, weight loss, night sweats or splenomegaly [orpha.net]

Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant. [ncbi.nlm.nih.gov]

Hepatosplenic Lymphoma

Most patients had massive splenomegaly, and bone marrow showed sinusoidal involvement by lymphoma. [mdanderson.elsevierpure.com]

Splenectomy was performed due to progressive splenomegaly. [adc.bmj.com]

It occurs mainly in young adults presenting with splenomegaly and most often with hepatomegaly but without lymphadenopathy. [bloodjournal.org]

Chronic Lymphocytic Leukemia

In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted. [symptoma.com]

Over half of patients are diagnosed at an early, asymptomatic stage, without lymphadenopathy, splenomegaly, cytopenias, or autoimmune phenomena. [library.med.utah.edu]

Stage II: Lymphocytosis along with either splenomegaly or hepatomegaly is present. Lymphadenopathy may or may not be present. [symptoma.com]

Autoimmune Hemolytic Anemia

Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale. [ncbi.nlm.nih.gov]

anemia caused by the excessive destruction of red blood cells by autoantibodies Splenomegaly is present in more than half the cases of autoimmune hemolytic anemia, and this [merriam-webster.com]

Systemic Juvenile Idiopathic Arthritis

Lymphadenopathy, splenomegaly, hepatomegaly, and sore throat are also common. [slideshare.net]

(Y) 5 (83) 5 (71) 7 (39) Hepatomegaly OR splenomegaly (I) 5 (83) 6 (86) 10 (56) Only splenomegaly (N) 2 (33) 3 (43) 1 (6) Splenomegaly AND Hepatomegaly (N) 3 (50) 2 (29) [ped-rheum.biomedcentral.com]

Minor criteria may include sore throat, lymphadenopathy, negative rheumatoid factor, abnormal liver function tests, hepatomegaly or splenomegaly. [press.mu-varna.bg]

Adult-Onset Still Disease

[…] rash distributed along trunks and extremities worsened during fevers leukocytosis with at least 80% granulocytes Minor criteria: sore throat lymphadenopathy hepatomegaly or splenomegaly [utswim.wordpress.com]

[…] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly [ncbi.nlm.nih.gov]

Arthritis (OR, 8.6; 95% confidence interval [CI], 1.5-49.1; p = 0.014), pharyngitis (OR, 6.9; 95% CI, 1.5-30.2; p = 0.010), splenomegaly (OR, 5.4; 95% CI, 1.1-26.7; p = 0.039 [ncbi.nlm.nih.gov]

Spleen Disease

splenomegaly. [ncbi.nlm.nih.gov]

If you have splenomegaly, your health care provider may advise you to avoid contact sports. [printer-friendly.adam.com]

Approach to the adult patient with splenomegaly and other splenic disorders. http://www.uptodate.com/home. Accessed June 14, 2016. Splenomegaly. [mayoclinic.org]

Beta Thalassaemia Major

Anemia in children with splenomegaly and peculiar changes in the bones. Am J Dis Child. 1927, 34: 347-363. Cooley TB. [litfl.com]

[…] resulting from the homozygous state of one of the thalassemia genes or one of the hemoglobin Lepore genes with onset, in infancy or childhood, of pallor, icterus, weakness, splenomegaly [medical-dictionary.thefreedictionary.com]

Hepato-splenomegaly has been contained to a modest level; hyperspienism has not developed. [nature.com]

Chronic Myeloid Leukemia

Patients with splenomegaly and abnormally high leukocyte counts were first recognized in France, Germany, and Scotland in the 1840s. [ncbi.nlm.nih.gov]

Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly. [ncbi.nlm.nih.gov]

One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly. [ncbi.nlm.nih.gov]

Persistent Polyclonal B-cell Lymphocytosis

Abstract Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. [ncbi.nlm.nih.gov]

[…] negative lymphocytosis, the presence of binucleated lymphocytes in peripheral blood, and a polyclonal increase in serum immunoglobulin-M that may occasionally be accompanied by splenomegaly [ncbi.nlm.nih.gov]

Significant symptomatic splenomegaly requiring splenectomy is very unusual for this disorder; therefore there is a lack of descriptions of the morphologic features of the [ncbi.nlm.nih.gov]

Chronic Phase of Chronic Myeloid Leukemia

Important diagnostic features are severe leukocytosis (up to > 500,000/μl ), basophilia, and extreme splenomegaly. [amboss.com]

With disease progression, splenomegaly may increase, and pallor and bleeding occur. [merckmanuals.com]

A 55-year-old man presented with splenomegaly (10 cm below left costal margin) and leucocytosis (145 × 10(9)/L). [ncbi.nlm.nih.gov]

Castleman Disease

The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy. [ncbi.nlm.nih.gov]

[…] presents as a solitary mass Plasma cell unicentric Castleman disease presents with a solitary mass and systemic symptoms, including fever, night sweats, fatigue, weight loss, splenomegaly [pathologyoutlines.com]

Splenitis

The term 'splenomegaly’ refers to an enlargement of the spleen. [wagwalking.com]

Also: Splenomegaly Topics Related to Splenitis Enlarged Spleen ...the condition “... [diagnose-me.com]

In a recent study of 130 autopsied cases of pyogenic hepatic abscess it was noted that both splenomegaly and a mild to moderate degree of anemia were present in many of the [jamanetwork.com]