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10 Possible Causes for Splenomegaly, Susceptibility to Hematologic Malignancies Increased

  • Gaucher Disease

    CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] In addition to the classic manifestations, patients suffer from increased susceptibility to hematologic and nonhematologic malignancies.[ncbi.nlm.nih.gov] [ncbi.nlm.nih.gov] Massive Splenomegaly CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[symptoma.com]

  • Splenic Subcapsular Hematoma

    Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to[omicsonline.org] However, splenectomy should be avoided if possible, particularly in children, the elderly, and patients with hematologic malignancy, to avoid the resulting permanent susceptibility[merckmanuals.com] Abdominal examination revealed tender palpable splenomegaly, without guarding.[em-consulte.com]

  • Common Variable Immunodeficiency

    Eighteen cases (69%) cases had coexistent splenomegaly with lower IgA levels (P .04) compared with the controls. Patients with low IgA levels ( 5%) (P .007).[ncbi.nlm.nih.gov] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] In addition, we demonstrated that splenomegaly, one of the most common complications in this disease, is associated with 874T/A IFNG polymorphism.[ncbi.nlm.nih.gov]

  • Infective Dermatitis Associated with HTLV-1

    No lymph node enlargement or hepato/splenomegaly were found. Another biopsy was performed, consistent with lichenification.[medicaljournals.se] increase the susceptibility to bacterial infections.[htlv.net] […] aggressive forms (acute and lymphomatous), half of the patients show weakness; skin, bone, and multiple visceral lesions; pulmonary infiltrates; hypercalcemia; hepatomegaly; splenomegaly[scielosp.org]

  • Noonan Syndrome

    Twenty-three patients (53%) had splenomegaly, 6 of these with associated hepatomegaly. One patient had a choledochal cyst and a midgut malrotation.[doi.org] […] cancer, and notably juvenile hematological malignancies [ 3, 45 ].[doi.org] At 7 months of age, non-immune neutropenia and splenomegaly have been observed.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Thrombocytopenia 5

    […] thalassemia (XLTT) GATA-1 (Xp11) X-L Anemia (mild to nil), unbalanced globin chain synthesis resembling ß-thalassemia, peripheral red cell hemolysis, dysmegakaryocytopoiesis, splenomegaly[ufrgs.br] THC5 is an autosomal dominant disorder, associated with an increased susceptibility to the development of hematologic and solid malignancies.[uniprot.org] The major clinical features of this thrombocytopenia subtype include variable thrombocytopenia, hemolytic anemia, splenomegaly, and abnormalities in hemoglobin chain synthesis[centogene.com]

  • Common Variable Immunodeficiency Type 4

    […] alopecia areata) can occur, as can malabsorption, nodular lymphoid hyperplasia of the GI tract, systemic granulomatous inflammation, lymphocytic interstitial pneumonia, splenomegaly[merckmanuals.com] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] , occasional lymphadenopathy splenomegaly, occasional lymphadenopathy cervical adenopathy in children not seen rare hepatosplenomegaly, adenopathy vasculitis Henoch-Schonlein[ufrgs.br]

  • Common Variable Immunodeficiency 11

    Coincidence of granulomatous disease and autoimmmune cytopenia with splenomegaly in CVID 32. 33. Mary Lucas et al. JACI 2010 34. 35. 36.[slideshare.net] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Abnormal accumulation of immune cells causes enlarged lymph nodes (lymphadenopathy) or an enlarged spleen (splenomegaly) in some people with CVID.[ncbi.nlm.nih.gov]

  • Monocytopenia with Susceptibility to Infections

    LYMPHOPROLIFERATIVE SYNDROME 2; LPFS2 Is also known as cd27 deficiency Related symptoms: Autosomal recessive inheritance Anemia Neoplasm Hepatomegaly Splenomegaly SOURCES:[mendelian.co] Most of the patients present with hematological abnormalities (cytopenias, early-onset myeloid malignancies) and an increased susceptibility to opportunistic infections [[bmcpulmmed.biomedcentral.com] Contrary to previous findings from our institution (3), most patients with C. glabrata fungemia in the series re ported here had solid tumors rather than hematologic malignancies[thefreelibrary.com]

  • Familial Candidiasis Type 2

    In the other cases splenomegaly, palpable mass, spontaneous rupture of the spleen, anemia, thrombocytopenia and digestive symptoms may allow for identification [ 1 , 23 ].[link.springer.com] . • The patients who are on immunosuppressive drug regimens or who have HIV infection, cancer, or hematologic malignancies have an increased susceptibility to oral candidiasis[slideshare.net]

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