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89 Possible Causes for Splenomegaly, T-Lymphocyte Count Increased

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov] Abdominal ultrasound may be required to assess for splenomegaly.[patient.info]

  • Hepatitis

    Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly and Splenomegaly[symptoma.com] Mild splenomegaly occurs in 15 to 20% of patients. Jaundice usually peaks within 1 to 2 wk. Recovery phase: During this 2- to 4-wk period, jaundice fades.[merckmanuals.com] Physical examination may be without pathological findings, but may also reveal hepatomegaly, splenomegaly, jaundice, and signs and symptoms of chronic liver disease[ 1 9 ][doi.org]

  • Primary Immune Deficiency Disorder

    Skin infections become more common as the number of CD4 T- lymphocytes reduces. Mild reduction in CD4 T- lymphocyte count ( 200) is part of normal ageing.[dermnetnz.org] Splenomegaly and generalized lymphadenopathy are present in many patients with common variable immunodeficiency (CVID).[emedicine.medscape.com] Hepatomegaly and splenomegaly may be detected in the abdomen. In infants, crusting around the anus may be a sign of chronic diarrhoea.[patient.info]

  • Precursor-Cell Lymphoblastic Leukemia

    The increase in the ALC was primarily from activated CTL019 T lymphocytes. Patient 1 was a 7-year-old girl with a second recurrence of ALL.[doi.org] Splenomegaly and thrombocytopenia were frequently observed more in CD200 patients. Increased frequency of CD34 was associated with CD200 and CD56 patients.[ncbi.nlm.nih.gov] Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[doi.org]

  • Alcoholic Liver Disease

    B and T lymphocytes are noted in the portal and periportal areas, and natural killer lymphocytes are noted around hyalin-containing hepatocytes.[emedicine.medscape.com] Splenomegaly : Portal hypertension causes the spleen to enlarge (a condition called splenomegaly).[msdmanuals.com] […] steatosis (fatty liver) From the collection of Dr McClain; used with permission History & Exam Key Factors abdominal pain hepatomegaly hematemesis and melena venous collaterals splenomegaly[online.epocrates.com]

  • Leukoerythroblastic Anemia

    count etiology of lymphopenia HIV; DiGeorge (T-cell); SCID; Immune destruction; corticosteroids (apoptosis); radiation pathogenesis of lymphopenia increased destruction;[memorize.com] Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases.[merckmanuals.com] The French authors, Emil-Weil and Clerc, 1 in 1902, and Vaquez and Aubertin, 2 in 1904, first discussed a syndrome characterized by splenomegaly due to myeloid change and[jamanetwork.com]

  • Chronic Lymphocytic Leukemia

    The increase in the ALC was primarily from activated CTL019 T lymphocytes. Patient 1 was a 7-year-old girl with a second recurrence of ALL.[nejm.org] One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[symptoma.com]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] […] apoptosis of medullary B cells has also been described. 56 T-cell impairment Most patients with MDS have lymphocytopenia, mainly due to a decrease in T-helper lymphocyte[haematologica.org] We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and[ncbi.nlm.nih.gov]

  • Nephroblastoma

    The occurrence of decreased immunoglobulin levels, leukocytes, lymphocytes, and granulocytes count, proportion of T lymphocytes and their CD4 subpopulation are not frequent[ncbi.nlm.nih.gov] It is also important to investigate “B” symptoms associated with any lymphadenopathy or splenomegaly. Laboratory tests can often be helpful in ambiguous cases.[aafp.org] The most frequent abnormal findings were increased proportion of NK cells (38.5 %), B lymphocytes (38,52 %), decreased number of erythrocytes (25.2 %), hemoglobin levels ([ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia 

    Surgical consults could also be included in the plan of care for patients with severe splenomegaly and/or bulky/painful lymphadenopathy.[cancertherapyadvisor.com] […] had some significance with certain treatment regimens, are the percentage of circulating blast cells; the degree of bone marrow involvement; the presence of hepatomegaly, splenomegaly[cancernetwork.com] Abdominal distention due to hepatomegaly and splenomegaly. Lymphadenopathy. Testicular enlargement. Gum hypertrophy. Leukaemia cutis [ 9 ].[patient.info]

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