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66 Possible Causes for Splenomegaly, Thickening of the Mitral Valve Leaflets

  • Mucopolysaccharidosis

    […] trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly[en.wikipedia.org] […] slowly to 20-30mg/kg/day in divided doses 40. 40 Adverse effect drowsiness, diplopia, vertigo, araxia, blurred vision, GI upset, skin reaction, lymphadenopathy, eosinophilia, splenomegaly[slideshare.net]

  • Mucopolysaccharidosis 1 H-S

    Cardiac (Valvular) Disease Recurrent Ear, Nose, and Throat Infections Obstructive Airway Disease/Sleep Apnea Corneal Clouding Spinal Cord Compression Hepatosplenomegaly/Splenomegaly[mps1disease.com] Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[ncbi.nlm.nih.gov] Additional signs and symptoms that may develop include: Enlarged head Chronic nasal discharge Retinal degeneration Splenomegaly Enlarged abdominal organs Skeletal dysplasia[medicinenet.com]

  • Infective Endocarditis

    This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation[ncbi.nlm.nih.gov] […] history of endocarditis history of illegal drug use mitral valve prolapse and valve regurgitation (leaking) and/or thickened valve leaflets The risk of infective endocarditis[healthline.com] Additional findings may include splenomegaly, gallop or arrhythmia, pericardial or pleural rubs, rales, pallor, acute septic monoarticular arthritis or delirium.[symptoma.com]

  • Endocarditis

    PATIENT CONCERNS: A young woman, with a history of aortic stenosis, was admitted to our unit for a month of intermittent fever associated with a new diastolic heart murmur and splenomegaly[ncbi.nlm.nih.gov] Patients most at risk of developing bacterial endocarditis include those who have: Acquired valve disease (for example, rheumatic heart disease) including mitral valve prolapse[my.clevelandclinic.org] Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red[en.wikipedia.org]

  • Subacute Bacterial Endocarditis

    Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission.[ncbi.nlm.nih.gov] Patients most at risk of developing bacterial endocarditis include those who have: Acquired valve disease (for example, rheumatic heart disease) including mitral valve prolapse[my.clevelandclinic.org] Findings compatible with both SBE and marantic endocarditis due to a B-cell lymphoproliferative disorder included an elevated ESR, and splenomegaly.[ncbi.nlm.nih.gov]

  • Bacterial Endocarditis

    The condition is characterized by heart murmur, prolonged fever, bacteremia, splenomegaly, and embolic phenomena.[medical-dictionary.thefreedictionary.com] Patients most at risk of developing bacterial endocarditis include those who have: Acquired valve disease (for example, rheumatic heart disease) including mitral valve prolapse[my.clevelandclinic.org] RESULTS--Group A--9 patients aged 8-58 years, 3 men, all them with cardiac murmurs, fever and anemia, 5 with splenomegaly.[bases.bireme.br]

  • Lupus Erythematosus

    […] keratoconjunctivitis sicca as well as more uncommon manifestations Haematologic manifestations, including cytopenias, thrombophilia, thromboembolic disease, lymphadenopathy and splenomegaly[els.net] (b) Two-dimensional echocardiogram demonstrates a thickened mitral valve leaflet (arrow). (Case courtesy of Catherine M.[pubs.rsna.org] Enlargement of the spleen (splenomegaly) occurs in about 10% of people.[msdmanuals.com]

  • Essential Thrombocythemia

    […] essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly[ncbi.nlm.nih.gov] Echocardiography may reveal aortic and mitral valvular lesions, including leaflet thickening and vegetations, similar to those described in nonbacterial thrombotic endocarditis[medtextfree.wordpress.com] We present the case of a 41-year-old woman with thrombocytosis and mild splenomegaly. Clinical suspicion was of chronic myeloproliferative neoplasia (CMN).[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 2

    Individuals with this disorder may experience the following signs: abnormal retina, heart murmur and leaky heart valves, enlarged liver (hepatomegaly) enlarged spleen (splenomegaly[secure.ssa.gov] Fig. 1 Subcostal echocardiographic view showing anterior (arrowhead) and posterior mitral valve thickening with subvalvular involvement (asterisk).[karger.com] […] degenerative joints causing joint stiffness Spinal cord defects Sleep disorder such as sleep apnea Decrease in mental cognition Enlarged liver (hepatomegaly) and enlarged spleen (splenomegaly[dovemed.com]

  • Thrombocytosis

    No splenomegaly was found.[ncbi.nlm.nih.gov] Echocardiography may reveal aortic and mitral valvular lesions, including leaflet thickening and vegetations, similar to those described in nonbacterial thrombotic endocarditis[medtextfree.wordpress.com] Ultrasound of the abdomen revealed moderate splenomegaly.[ncbi.nlm.nih.gov]

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