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911 Possible Causes for Splenomegaly, Thrombocytosis

  • Non-Hodgkin Lymphoma

    Computed tomography scan of the chest and abdomen showed paratracheal and subcarinal lymphadenopathy and splenomegaly, with the findings being compatible with lymphoma.[ncbi.nlm.nih.gov] In the first case, the laboratory tests showed anemia, thrombocytosis, elevated inflammatory biomarkers, a low level of iron, and hypoproteinemia.[ncbi.nlm.nih.gov] Splenomegaly. Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] It also results in leukocytosis and thrombocytosis. On peripheral blood smear, spherocytes are unchanged or may even increase.[medcaretips.com] […] develop and cholecystectomy may be associated with an increased risk of ca colon ) d) Visible jaundice but no stones for cosmetic reasons – difficult group Post op develop thrombocytosis[ihaematology.com]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] One patient clearly represents a case of RARS with reactive thrombocytosis.[ncbi.nlm.nih.gov] As controls we considered 61 patients with reactive thrombocytosis referred to our Department in the same period of time.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[ncbi.nlm.nih.gov] Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[ncbi.nlm.nih.gov]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] FBC: normochromic, normocytic anaemia and reactive thrombocytosis are common in active disease.[patient.info] Similarly, the platelet count is usually normal but thrombocytosis occurs in response to inflammation.[hopkinsarthritis.org]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[ncbi.nlm.nih.gov] BACKGROUND: Polycythemia vera (PV) and essential thrombocytosis (ET) are hematological disorders characterized by excessive production of mature and functional blood cells[ncbi.nlm.nih.gov]

  • Splenic Rupture

    Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to[omicsonline.org] […] presents with elevated WBC's, fevers, pleuritic pain, and left shoulder pain (referred from phrenic nerve irritation) Hematologic findings - due to decreased splenic clearance thrombocytosis[medbullets.com] (see differential diagnoses below) References: [3] Diagnostics Laboratory tests : low Hb, leukocytosis, and thrombocytosis ; crossmatch for blood transfusion if needed In[amboss.com]

  • Essential Thrombocythemia

    […] essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly[ncbi.nlm.nih.gov] […] primary Thrombocytosis familial thrombocytosis hereditary thrombocythemia hemorrhagic thrombocythemia Primary Thrombocythemia essential thrombocytemia ET essential thrombocytosis[wikidata.org] We present the case of a 41-year-old woman with thrombocytosis and mild splenomegaly. Clinical suspicion was of chronic myeloproliferative neoplasia (CMN).[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia.[ncbi.nlm.nih.gov] One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov]

  • Adult-Onset Still Disease

    […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] Both patients had marked leukocytosis with neutrophil predominance, thrombocytosis, elevated liver enzymes and elevated acute phase rectants.[ajol.info] Arthritis (OR, 8.6; 95% confidence interval [CI], 1.5-49.1; p 0.014), pharyngitis (OR, 6.9; 95% CI, 1.5-30.2; p 0.010), splenomegaly (OR, 5.4; 95% CI, 1.1-26.7; p 0.039),[ncbi.nlm.nih.gov]

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