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14 Possible Causes for Splenomegaly, Toxic Effect of Benzene

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] ., vitamin B12, folate, copper), toxic exposures (i.e., benzene, zinc, heavy metals, ethanol), pharmaceutical side effect (i.e., recent chemotherapy, growth factor stimulation[clinicaladvisor.com] We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and[ncbi.nlm.nih.gov]

  • Hypochromic Microcytic Anemia with Iron Overload Type 2

    Lymphadenopathy, splenomegaly. Once case of fatal adrenal hemmorhage. [89] Joints bones muscles cartilage: Hypotonia (generalized or tructal) with increasing severity.[autoinflammatory-search.org] toxicity Carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, cytostatic drugs, propylthiouracil Ionizing radiation Viruses: parvovirus B19, hepatitis viruses, EBV[amboss.com] This is a rare finding in CDA. 2 Case A full-term male Saudi infant presented after delivery with pallor, splenomegaly (6 cm below left costal margin) and a systolic murmur[annsaudimed.net]

  • Nitrobenzene Poisoning

    Here author highlights the rare occurrence of such cases, methaemoglobin induced severe oxidative stress, unexplained splenomegaly and leucocytosis and the ineffectivity of[ncbi.nlm.nih.gov] As with other benzene derivatives, there is a direct toxic effect FULL TEXT[annals.org]

  • IgE Myeloma

    9% of patients, respectively, in another study.[6] Shimamoto et al reported a 26% incidence of hepatomegaly, 12% splenomegaly, and 10% lymphadenopathy in IgD MM.[12] Blad[cancernetwork.com] effects in many vertebrates.[aafp.org] Although anemia, osteolytic lesions, hepatomegaly and/or splenomegaly, and PCL were frequently reported in IgE MM, none of those manifestations seem to constitute a characteristic[onlinelibrary.wiley.com]

  • Congenital Aplastic Anemia

    […] anemia is a physiologic and anatomic failure of the bone marrow, with marked decrease or absence of blood-forming elements in the marrow, peripheral pancytopenia and no splenomegaly[nejm.org] Aplastic anemia can be a temporary side effect of these treatments. Exposure to toxic chemicals.[mayoclinic.org] But the patient's splenomegaly was very mild (14 cm) and insufficient to cause symptoms of hypersplenism.[jscisociety.com]

  • Acquired Sideroblastic Anemia

    […] the cardiovascular and respiratory manifestations common to all anemias, sideroblastic anemia causes mild-to-moderate enlargement of the liver (heptomegaly) and spleen (splenomegaly[innvista.com] toxicity Carbamazepine , methimazole , NSAIDs , benzene , chloramphenicol , cytostatic drugs , propylthiouracil Ionizing radiation Viruses: parvovirus B19 , hepatitis viruses[amboss.com] , [[Splenomegaly]]) Mechanical RBC Destruction Macroangiopathic Hemolytic Anemia Cardiac Hemolysis: asscoiated with prosthetic heart valves, prosthetic patch, calcific AS,[mdnxs.com]

  • Refractory Anemia with Excess Blasts

    Exaggerated bleeding from thrombocytopenia with platelet dysfunction Infection secondary to decreased neutrophils and neutrophil dysfunction Occasional mild hepatomegaly or splenomegaly[basicmedicalkey.com] ., vitamin B12, folate, copper), toxic exposures (i.e., benzene, zinc, heavy metals, ethanol), pharmaceutical side effect (i.e., recent chemotherapy, growth factor stimulation[clinicaladvisor.com] Symptoms and signs include increased risk of infection and sore throat Hepatomegaly or splenomegaly.[syndromespedia.com]

  • Toluene Poisoning

    Abdominal sonography revealed that the abdomen was full of gas; he had splenomegaly and gall stones.[theijoem.com] The effects of t... 305.90 Other, mixed, or unspecified drug abuse, unspecified use 982.0 Toxic effect of benzene and homologues F18.10 Inhalant abuse, uncomplicated F18.120[5minuteconsult.com]

  • Congenital Hypoplastic Anemia

    See: Banti syndrome ; congestive splenomegaly transfusion-dependent anemia Anemia for which the only effective therapy is repeated blood transfusions. CAUTION![medical-dictionary.thefreedictionary.com] Aplastic anemia can be a temporary side effect of these treatments. Exposure to toxic chemicals.[mayoclinic.org] Secondary thrombocytopenia results from aplastic anemia, acute leukemia, and conditions causing splenomegaly, as cirrhosis or lymphomas, that lead to sequestration of blood[innvista.com]

  • Methoxychlor Poisoning

    Clinical presentation included epigastric pain, abdominal swelling, bloody diarrhoea, hepatomegaly, splenomegaly, and ascites.[flipper.diff.org] Repeated studies have demonstrated the genetic-damaging effects of benzene toxicity.[metabolichealing.com] In lab rats, benzene-induced toxicity causes multiple types of tumors, as well as damage and altercation to chromosome function.[metabolichealing.com]

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