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50 Possible Causes for Splitting of the Glomerular Basement Membrane

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  • Autosomal Dominant Alport Syndrome

    Renal biopsy in four affected patients demonstrated characteristic thickened and split glomerular basement membranes on electron-microscopy.[ncbi.nlm.nih.gov]

  • X-Linked Alport Syndrome

    In classic Alport syndrome, diagnostic evaluation shows persistent microhematuria on urinalysis and splitting of the glomerular basement membrane on kidney biopsy .[amboss.com] Genetic mutations of collagen IV cause thinning and splitting of the glomerular basement membrane.[nephcure.org] […] of the glomerular basement membrane detected by electron microscopy Progressive, high-frequency, sensorineural deafness Anterior lenticonus and perimacular flecks Characteristic[astor.ahc.umn.edu]

  • Autosomal Recessive Alport Syndrome

    Collagen IV nephropathies (COL4Ns) comprise benign familial microscopic hematuria, thin basement membrane nephropathy (TBMN), X-linked Alport syndrome (AS) and also autosomal recessive and dominant AS. Apart from the X-linked form of AS, which is caused by hemizygous mutations in the COL4A5 gene, the other[…][ncbi.nlm.nih.gov]

  • Hereditary Nephritis

    Although electron microscopy uniformly showed marked thinning or splitting of the glomerular basement membrane, parallel splitting of the glomerular basement membrane with[ncbi.nlm.nih.gov] Abstract A characteristic electron microscopic lesion-longitudinal splitting of the glomerular basement membranes with accumulation of dark particles-was found in some cases[ncbi.nlm.nih.gov] Each biopsy specimen was scored for splitting of glomerular basement membranes (GBMs).[ncbi.nlm.nih.gov]

  • Congenital Nephrotic Syndrome

    Electron microscopy of renal necropsy showed foot process loss, focal thickening and splitting of the glomerular basement membrane and mesangial expansion.[ncbi.nlm.nih.gov]

  • Immune Complex-Mediated Membranoproliferative Glomerulonephritis

    IM: C3 deposits on basement membrane Both : EM: basement membrane thickening, GBM splitting (“train-track” appearance) No single effective treatment Diabetic nephropathy Leading[amboss.com] […] and reduplication of basement membrane Large subendothelial electron dense deposit along glomerular basement membrane[pathologyoutlines.com] Diffuse, global endocapillary proliferation with extensive glomerular basement membrane (GBM) splitting in MPGN type I (Jones silver stain). Figure 3.3.[barnardhealth.us]

  • Focal Embolic Glomerulonephritis

    IM: C3 deposits on basement membrane Both : EM: basement membrane thickening, GBM splitting (“train-track” appearance) No single effective treatment Diabetic nephropathy Leading[amboss.com] […] cause of ESRD in the industrialized world LM: thickening of the glomerular basement membrane, nodules within glomeruli ( Kimmelstiel-Wilson nodules ) Treatment of underlying[amboss.com] […] of the glomerular basement membran e (" train-track " appearance) Immunofluorescent microscopy: IgG deposits on basement membrane References: [1] [15] Treatment General measures[amboss.com]

  • Frasier Syndrome

    In all cases, electron microscopy results showed widespread thinning, splitting, and lamellation of the glomerular basement membrane, which mimicked hereditary nephritis.[ncbi.nlm.nih.gov]

  • Dense Deposit Disease

    It is a rare entity which is characterized by a unique histopathological feature – splitting of the glomerular basement membrane (GBM) with interposition of mesangial cells[clinicaladvisor.com] Additionally, the glomerular basement membrane is thickened.[pathwaymedicine.org] Methenamine silver also stains the glomerular basement membrane of the thickened capillary loops to reveal splitting or tram tracking (IMAGE 11 ) similar to what is observed[path.upmc.edu]

  • X-Linked Deafness 4

    […] may have only thin glomerular basement membranes without other alterations Abnormal distribution of laminin alpha1 and laminin alpha5 in glomerular basement membrane correlates[pathologyoutlines.com] The altered glomerular basement membrane (GBM) functions adequately in early life.[patient.info] Electron microscopy shows a characteristic sequence of changes from thinning of the glomerular basement membrane (GBM), developing into areas of thinning and thickening, and[en.wikipedia.org]

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