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141 Possible Causes for Structurally Abnormal Mitochondria

  • Chronic Alcoholism

    Ethanol also causes structural abnormalities in the liver mitochondria which leads to ketosis superimposed by starvation, chronic malnutrition [ 13, 14 ].[]

  • Alzheimer Disease

    The association of apoE4 with hyperphosphorylation of tau ( 129 ) and the occurrence of neurofibrillary tangle-like structures in neurons ( 67 ) could result in an abnormal[] […] distribution of mitochondria in neurons.[] […] disruption of microtubules in cultured neurons by apoE4 may accentuate the mitochondrial dysfunction, or the mitochondrial dysfunction may in part cause the cytoskeletal abnormality[]

  • Cardiomyopathy

    Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.[]

  • Myocardial Infarction

    Structural and functional abnormalities in mitochondria isolated from ischemic dog myocardium.[]

  • Histiocytoid Cardiomyopathy

    In electron microscopy we found a severe rarefication of disrupted myofibrils and numerous swollen mitochondria with abnormal structures, vacuolization and disorganized cristae[] […] can be increased and that the structure of mitochondria may be abnormal in cardiomyocytes of patients with histiocytoid cardiomyopathy, 12 – 15 and that biochemical investigations[] […] histiocytoid cardiomyopathy may present with lactic acidosis, 11 that histiocytoid cardiomyopathy may be associated with mitochondrial myopathy, 12 that number and size of mitochondria[]

  • Lafora Disease

    Increased Size & Number Abnormal shape & structure No ragged red fibers Vessels: Degenerating endothelial cells & pericytes Normal connective tissue CNS Neuropathology Neuronal[] Majority die 6 years Respiratory failure ; Cardiomyopathy Muscle pathology: Variable severity Myopathy: Fiber degeneration & Regeneration Increased glycogen in muscle fibers Mitochondria[]

  • Leigh's Disease

    abnormal mitochondria noted under electron microscope.[] Abnormalities of the mitochondrial structure with tubular and myelinic transformation of the cristae suggested that a mitochondriopathy is responsible for the cardiomegaly[] Lipid droplets were seen in association with abnormal mitochondria. 49 In agreement with this description, our ultrastructural study confirms that SURF1 mutations may be associated[]

  • Chronic Progressive External Ophthalmoplegia

    The mitochondrial diseases are uncommon multisystem disorders characterized by the presence of functionally and/or structurally abnormal mitochondria.[] The EM morphometric fraction of structurally abnormal mitochondria was increased in group A, and there was a similarly increased fraction of normal-appearing mitochondria[] Histochemical stains, obtained from the right vastus lateralis, showed ragged-red fibers and wide-spread abnormalities in the number, size, and the structure of mitochondria[]

  • Lyme Neuroborreliosis

    abnormality leads to ATP synthesis defects.[] The authors told Alzforum they next intend to investigate the role of CHCHD10 in mitochondria.[] , Manfredi added, it remains unknown if the CHCHD10 mutation alters the ATP production machinery in a way that mangles cristae, or if the mutation alters cristae and the structural[]

  • MELAS Syndrome

    abnormal mitochondria with occasional paracrystalline inclusions and circular cristae.[] […] cells of the choroidal and retinal vessels, the dilator and sphincter muscle of the iris, cornea, lens epithelium, and ciliary epithelium all contained many, often enlarged, structurally[]

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