Subependymal Nodules: Causes & Reasons

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Possible Causes for Subependymal Nodules

Tuberous Sclerosis

[…] bilateral, predominantly subcortical distribution of subependymal nodules in prior studies of pediatric samples. [ncbi.nlm.nih.gov]

Abstract Tuberous sclerosis complex is associated with radiologically visible abnormalities of brain structure, principally tubers and subependymal nodules. [doi.org]

nodules, and subependymal giant cell astrocytomas. [emedicine.com]

Tuberous Sclerosis Type 2

Subependymal nodules can become subependymal giant cell astrocytomas. [columbianeurosurgery.org]

nodules, SEGA. [orpha.net]

nodule - Subependymal giant cell astrocytoma - Cardiac rhabdomyoma, single or multiple - Renal angiomyolipoma or pulmonary lymphangiomyomatosisb Minor features - Multiple [health.cdc.go.kr]

Tuberous Sclerosis Type 1

nodules, SEGA. [orpha.net]

nodule - Subependymal giant cell astrocytoma - Cardiac rhabdomyoma, single or multiple - Renal angiomyolipoma or pulmonary lymphangiomyomatosisb Minor features - Multiple [health.cdc.go.kr]

There are few data regarding the efficacy of such agents in the treatment of subependymal nodules and astrocytomas, but they are certainly applied to this end. [symptoma.com]

Subependymal Giant Cell Astrocytoma

The surgical indications for this lesion and the role of CT in following up subependymal nodules of tuberous sclerosis are discussed. [ncbi.nlm.nih.gov]

INTRODUCTION: Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). [ncbi.nlm.nih.gov]

At an early stage, subependymal nodules had different characteristics in patients who developed subependymal giant cell astrocytomas from those who did not. [ncbi.nlm.nih.gov]

Hamartoma of the Central Nervous System

nodules, subependymal giant cell astrocytomas -Mass effect symptoms, such as hydrocephalus and papilledema -Seizures or infantile spasms. [pedclerk.bsd.uchicago.edu]

Subependymal nodule Tuberous sclerosis. Subependymal nodule. Similar histology to SEGA with frequent calcification. Image provided by Dr Maie Herrick. [neuropathology-web.org]

Our patient complied four major clinical features cortical dysplasia, subependymal nodules, cardiac rhabdomyoma, and multiple retinal hamartomas as well as two minor clinical [egms.de]

Rhabdomyoma of the Myocardium

[…] ectopic beats Psychomotor delay Subependymal nodule RV overload signs Subependymal giant cell astrocytoma Multiple rhabdomyomas 21 WPW Syndrome Partial seizures Cortical [bmccardiovascdisord.biomedcentral.com]

To further evaluate, noncontrast CT cranium was also done that showed the presence of multiple calcified periventricular subependymal nodules with basal ganglia calcification [mjdrdypu.org]

Imaging may reveal the presence of cortical or subependymal tubers. Renal angiomyolipomas usually manifest later in life. [emedicine.medscape.com]

Fibrillary Astrocytoma

Subependymal and parenchymal nodules occur in the cerebrum. [ncbi.nlm.nih.gov]

Although giant cell astrocytoma may develop from these subependymal nodules, tumor formation is very rare in the cortical nodules. [ncbi.nlm.nih.gov]

Infantile Choroidocerebral Calcification Syndrome

The ensuing anomalies of neuronal proliferation and differentiation result in varied expression of hamartomas in the brain—referred to as subependymal nodules and cortical [appliedradiology.com]

Usually enhance (cf occasionally mild in subependymal nodule). ?Arise from subependymal nodules. Don’t usually have malignant transformation. [radnotes.co.nz]

nodules (Case 286) Bilateral arachnoid cysts, left-sided polymicrogyria (Case 103) Brain metastases in ovarian cancer (Case 142) Breast cancer metastasis to the brain (Case [urmc.rochester.edu]

Enamel Hypoplasia - Cataracts - Aqueductal Stenosis

Neuroimaging shows characteristic presence of subependymal nodules on lateral ventricles. [sites.google.com]

The histological features of retinal hamartomas, subependymal nodules, and subependymal giant-cell astrocytomas are similar. [clinicalgate.com]

nodule Subependymal giant cell astrocytoma Cardiac rhabdomyoma (single or multiple) Renal angiomyolipoma or pulmonary lymphangiomyomatosis Minor features Multiple randomly [healio.com]

Periventricular Nodular Heterotopia Type 1

This allows these nodules to be distinguished from the subependymal nodules of tuberous sclerosis that do not follow gray matter signal and enhance after contrast administration [jmedscindmc.com]

Classical bilateral PNH is an X-chromosome-related neurodevelopmental disorder, which is characterized by bilateral symmetrical subependymal nodules on brain MRI. [pediatricneurosciences.com]

In all 4 patients, similarly to our case, periventricular heterotopia was characterized by few subependymal nodules, ranging from 1 to 7. [scielo.br]

Renal Fibroma

Subependymal nodule (SEN). Subependymal giant cell astrocytoma (SEGA). Cardiac rhabdomyoma, single or multiple. Lymphangiomyomatosis and/or renal angiomyolipoma. [patient.info]

nodule Retinal achromatic patch SGCT(subependymal giant cell tumour) Confetti skin lesions Cardiac rhabdomyomas, single or multiple Multiple renal cysts Lymphangiomyomatosis [academic.oup.com]

Presence of subependymal nodules and giant cell astrocytoma are sine qua non of TS. Small RCCs can be hyperechoic and indistinguishable from an AML on sonography. [es.slideshare.net]

Complex Cortical Dysplasia with other Brain Malformations Type 2

Heterotopia Heterotopia: subependymal nodules (arrows). [radiologyassistant.nl]

nodule Subependymal giant cell astrocytoma Cardiac rhabdomyoma Lymphangiomyomatosis Renal angiomyolipoma. [jdrntruhs.org]

There is a subependymal heterotopic nodule in the lateral wall of right frontal horn (white arrow, a,b). [mrineonatalbrain.com]

Complex Cortical Dysplasia with other Brain Malformations Type 3

Heterotopia Heterotopia: subependymal nodules (arrows). [radiologyassistant.nl]

nodule Subependymal giant cell astrocytoma Cardiac rhabdomyoma Lymphangiomyomatosis Renal angiomyolipoma. [jdrntruhs.org]

There is a subependymal heterotopic nodule in the lateral wall of right frontal horn (white arrow, a,b). [mrineonatalbrain.com]

Complex Cortical Dysplasia with other Brain Malformations Type 4

Heterotopia Heterotopia: subependymal nodules (arrows). [radiologyassistant.nl]

Our patient complied four major clinical features cortical dysplasia, subependymal nodules, cardiac rhabdomyoma, and multiple retinal hamartomas as well as two minor clinical [egms.de]

Bilateral nodules of subependymal heterotopia are contiguous and rather symmetric, extensively lining the ventricular walls. [karger.com]

Benign Tumors of the Eye, Heart, and Lungs

"Standardized whole brain mapping of tubers and subependymal nodules in tuberous sclerosis complex". [en.wikipedia.org]

The most common are cortical tubers, subependymal giant cell astrocytomas (SEGAs) and subependymal nodules. [childrenshospital.org]

nodules (SEN), which form in the walls of the ventricles--the fluid-filled cavities of the brain; and subependymal giant-call astrocytomas (SEGA), which develop from SEN [ninds.nih.gov]

Hereditary Neurocutaneous Angioma

Subependymal nodules or subependymal giant astrocstrocytoma ( SEGA). Noncalcified subependymal nodules (CT+ve). Enamel pits. [thamburaj.com]

The histological features of retinal hamartomas, subependymal nodules, and subependymal giant-cell astrocytomas are similar. [neupsykey.com]

Multiple calcified subependymal nodules protruding into ventricles (CT+ve). Shagreen patches. Hamartomatous rectal polyps (HPE+ve). Multiple retinal hamartomas. [thamburaj.com]

Platelet-Type Bleeding Disorder 19

nodules of gray matter. [nature.com]

Introduction X-linked dominant bilateral periventricular nodular heterotopia (BPNH; MIM #300049) is a neuronal migration disorder characterized by subependymal nodules of [nature.com]

[…] p.V528M was initially detected in a female autopsy case of X-linked bilateral periventricular nodular heterotopia (BPNH), a neuronal migration disorder characterized by subependymal [nature.com]

Complex Cortical Dysplasia with Other Brain Malformations Type 5

Heterotopia Heterotopia: subependymal nodules (arrows). [radiologyassistant.nl]

nodule Subependymal giant cell astrocytoma Cardiac rhabdomyoma Lymphangiomyomatosis Renal angiomyolipoma. [jdrntruhs.org]

There is a subependymal heterotopic nodule in the lateral wall of right frontal horn (white arrow, a,b). [mrineonatalbrain.com]

Dyschromatosis Universalis Hereditaria Type 1

Subependymal nodule 8. Subependymal giant cell astrocytoma 9. Cardiac rhabdomyoma, single or multiple 10. Lymphangiomyomatosis 11. Renal angiomyolipoma Minor features 1. [ijdvl.com]

Ethylmalonic Aciduria

Adult-onset glutaric aciduria type I presenting with white matter abnormalities and subependymal nodules. Neurogenetics. 2015;16:325–8. [ncbi.nlm.nih.gov]

Angiomyolipoma

Multiple calcified subependymal nodules (white arrows) in plain CT brain. B. Multiple hyperintense cortical tubers (white arrows) onT2WI MRI. C. [oatext.com]

Precursor: Subependymal nodules (SENs) without enhancement. [librepathology.org]

There were no changes in the size of the subependymal nodules. [ojrd.biomedcentral.com]

Subcortical Nodular Grey Matter Heterotopia

nodules, and subependymal giant cell astrocytomas (SEGAs). [docksci.com]

We follow five TSC patients with SGCT (four males and one girl), aged below 8 years at the beginning of medical treatment because growing of subependymal nodules and secondary [docksci.com]

[…] patients have neuropathological abnormalities such as www.centauro.it The Neuroradiology Journal 27: 565-572, 2014 cortical tubers, white matter radial migration lines, subependymal [docksci.com]

Cerebellar Vermis Aplasia with Associated Features Suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome

"Standardized whole brain mapping of tubers and subependymal nodules in tuberous sclerosis complex". [en.wikipedia.org]

nodules, giant cell astrocytoma, cardiac rhabdomyoma, lymphangiomyomatosis, lymph node angiomyolipoma. [hawaii.edu]

Brain CT shows several subependymal, periventricular, calcified nodules characteristic of TSC. [slideshare.net]

Northern Epilepsy

Subependymal giant cell tumors (also referred to as subependymal giant cell astrocytomas or SEGAs) are thought to develop from subependymal nodules and occur in approximately [clinicaladvisor.com]

Subependymal nodules are a major clinical feature that can be quite useful in the diagnosis of TSC. [clinicaladvisor.com]

Characteristic findings in individuals with TSC include: – Subependymal nodules, cortical tubers, and/or subependymal giant cell tumor, with or without hydrocephalus in the [clinicaladvisor.com]

Bilateral Temporo-Occipital Polymicrogyria

Heterotopia Heterotopia: subependymal nodules (arrows). [radiologyassistant.nl]

Coronal slicing of the brain revealed ventriculo-megaly and multiple subependymal nodules in theposterior halves of both ventricles. [documents.tips]

There is a subependymal heterotopic nodule in the lateral wall of right frontal horn (white arrow, a,b). [mrineonatalbrain.com]

Disseminated Cytomegalovirus Infection

nodules Subependymal giant cell astrocytoma The following are minor features: Confetti skin lesions (multiple 1 to 2 mm hypomelanotic macules) Gingival fibromas Multiple [ispub.com]

Brain subependymal nodule, multiple cortical and white matter tubers (Fig.2) and marked architectural disorganization with ballooned astrocytes of “Palmini type IIB” cortical [ispub.com]

nodule in TSC showing dysplastic disorganized neuroglial architecture (H&E, Left panel: 400x ; Right panel: 40x). [ispub.com]

Coats Plus Syndrome

[…] giant cell astrocytoma Subependymal nodules. [centogene.com]

nodules Variable-sized periventricular calcifications Cortical tubers also calcify Helpful Clues for Less Common Diagnoses Neurocysticercosis Best clue: Dot inside cyst Usually [neupsykey.com]

nodules, seizures, kidney cysts, rhabdomyomas and others Individuals without a positive family history, but with symptoms resembling tuberous sclerosis Individuals with a [centogene.com]

Parietal Lobe Tumor

Heterotopia Heterotopia: subependymal nodules (arrows). [radiologyassistant.nl]

Subependymal giant cell astrocytoma (SEGA) This is a tumor that develops from a subependymal nodule near the foramen of Monro. [radiologyassistant.nl]

There are multiple cortcal and subependymal nodules. The CT shows that most of the lesions are calcified. [radiologyassistant.nl]

Mandibulofacial Dysostosis Syndrome Bauru Type

FIG 16-26 Axial view (T2-weighted) in a fetus of 26 weeks’ gestation showing a typical subependymal nodule ( arrow ). (Courtesy of Heron Werner, 2005. [radiologykey.com]

Some recent unpublished reports have demonstrated that the periventricular subependymal nodules may also be detected prenatally. 2D Doppler echocardiography is a useful, noninvasive [radiologykey.com]

nodules and giant cell astrocytomas, seizures, intellectual disability), kidneys (cysts, renal cell carcinomas, angiomyolipomas), heart (rhabdomyomas, arrhythmias), and lungs [radiologykey.com]

Basal Ganglia Mass Lesion

In tuberous sclerosis, Calcified subependymal nodules along the lateral ventricle and caudo thalamic groove. [neuroradiologycases.com]

Subependymal giant-cell astrocytomas are another major manifestation of tuberous sclerosis that can present as a calcified nodule. [neuroradiologycases.com]

These lesions are larger than the subependymal nodules, show interval growth, enhance on postcontrast images and are located at ornear the foramen of Monro. 2. [neuroradiologycases.com]