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4,797 Possible Causes for substrates

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  • Influenza

    The neuraminidase inhibitors mimic neuraminidase's natural substrate and bind to the active site, preventing the enzyme from cleaving host-cell receptors, thereby preventing[] The reaction velocity (OD min -1 μM -1 protein) is shown based on substrate conversion. PNPA substrate was used at a final concentration of 0–4mM.[] ZSTATFLU test based on detection of viral neuraminidase using a substrate of colour-changing enzyme.[]

  • Viral Lower Respiratory Infection

    A substrate for this enzyme is coupled to a chromogen which, when cleaved by viral neuraminidase, produces a blue colour. A throat swab is the recommended specimen.[] When a throat swab containing influenza virus is added to the device, the viral enzyme hydrolyses a synthetic substrate, leading to release of chemiluminescent reporter groups[]

  • Urinary Tract Infection

    An endopeptidase involved in the cleavage of a variety of substrates, including collagen and extracellular matrix components.[]

  • Sunburn

    Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr . 1987 ; 45(4): 755 –763.[] When the bulb is intact, the enzyme that produces allicin and related pungent compounds is trapped within special compartments inside the plant cells and cannot act on its substrate[] Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency.[]

  • Dementia

    The pathologic substrates for PDD included DLB (38%), AD (32%), and nigral LB alone (24%).[] Tanizaki Yutaka Kiyohara Mitsuo Iida Toru Iwaki Regular Paper First Online: 02 August 2003 Abstract In dementia with Lewy bodies (DLB), the Lewy bodies (LBs) are an essential substrate[]

  • Otitis Media

    […] conferred by the secretion of multiple isoenzymes of lactamase, which may be plasmid or chromosomal in origin and which may be inducible (ie, present only in low levels until a substrate[]

  • Osteoporosis

    Kishnani PS, Rockman-Greenberg C, Whyte MP et al (2012) Hypophosphatasia: enzyme replacement therapy (Asfotase alfa) decreases TNSALP substrate accumulation and improves functional[] The enzyme acts as a (lipid) membrane-bound ectophosphatase with PPi, PLP, and PEA as natural substrates. Abnormal gene product .[] The phosphate motifs in bisphosphonates have a similar conformation to inorganic pyrophosphate (PPi), the natural substrate of TNSALP; thus, treatment with bisphosphonates[]

  • Infectious Mononucleosis

    […] bromo-4-chloro-3-indolyl phosphate/nitro blue tetrazolium (Sigma-Aldrich) was added, and after 15 minutes of incubation, 3-amino-9-ethyl carbazole peroxidase chromogenic substrate[] Finally, 3 genes have not yet been classified: MARCKS, a myristoylated alanine-rich protein kinase C substrate; ENSA, an alpha endosulfine; and, TITF1, thyroid transcription[] The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus[]

  • Adrenal Insufficiency

    […] also contribute to hypotension by decreasing vascular responsiveness to angiotensin II, norepinephrine and other vasoconstrictive hormones, reducing the synthesis of renin substrate[] A decrease in total cholesterol, HDL cholesterol, and LDL cholesterol concentrations, frequent in cirrhosis [ 26 ], may lead to lack of substrates for steroidogenesis [ 19[] Cholesterol biosynthesis disorders include Smith-Lemli-Opitz syndrome and abetalipoproteinemia, which interrupts the delivery of cholesterol as a substrate for steroidogenesis[]

  • Meningitis

    The yeasts are spherical to oval cells, 5–10 µm in diameter, with a polysaccharide capsule which is a major virulence factor and the substrate detected by cryptococcal antigen[]

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