Surfactant Deficiency: Causes & Reasons

Possible Causes for Surfactant Deficiency

Interstitial Lung Disease due to ABCA3 Deficiency

Interstitial lung surfactant deficiency, disease ... [ivami.com]

A clinical case is presented of surfactant protein B deficiency. [scinapse.io]

Surfactant Deficiency caused by mutations in Surfactant Protein C Surfactant Deficiency caused by mutations in Thyroid-transcription factor (NKX2-1) Surfactant Deficiency [blog.cincinnatichildrens.org]

Neonatal Respiratory Distress Syndrome

deficiency (SSD). [ncbi.nlm.nih.gov]

Thus, any infant born before term is vulnerable to surfactant deficiency. [amboss.com]

Here, the authors report a preterm infant of 33 wk gestational age with secondary surfactant deficiency due to maternal blood aspiration because of abruptio placentae. [ncbi.nlm.nih.gov]

Transitory Tachypnea of the Newborn

Levels of phosphatidylglycerol (an indicator of lung maturity) were found to be negative in certain newborns Mild surfactant deficiency has also been suggested as a causative [en.wikipedia.org]

Surfactant deficiency in transient tachypnea of the newborn. J Pediatr. 2011 Nov. 159(5):750-4. [Medline]. Kasap B, Duman N, Ozer E, Tatli M, Kumral A, Ozkan H. [emedicine.medscape.com]

In the past, respiratory distress was thought to be a problem of relative surfactant deficiency but is now characterized by an airspace-fluid burden secondary to the inability [emedicine.medscape.com]

Compression Atelectasis

Resorption atelectasis is caused by resorption of alveolar air distal to obstructing lesions of the airways; adhesive atelectasis stems from surfactant deficiency; passive [ncbi.nlm.nih.gov]

deficiency 2 depending on etiology, this deficiency may either be diffuse throughout the lungs or localized gravity dependent atelectasis (dependent atelectasis) in the most [radiopaedia.org]

deficiency leads to alveolar instability and collapse results in Adhesive atelectasis 4) Cicatrisation atelectasis: Severe parenchymal scarring which is usually caused by [respiratoryupdates.wordpress.com]

Atelectasis

Acute atelectasis may occur as a post-operative complication or as a result of surfactant deficiency. [dbpedia.org]

Surfactant deficiency Alveoli contain a substance called surfactant that helps them stay open. When there is too little of it, the alveoli collapse. [healthline.com]

Obstructive Atelectasis

deficiency 2 gravity dependent atelectasis ( dependent atelectasis ) Atelectasis can also be sub-categorized by morphology as follows: linear (plate, band, discoid, subsegmental [radiopaedia.org]

deficiency or dysfunction → increases surface tension of alveoli → instability and collapse (e.g., acute respiratory distress syndrome ( ARDS ) in adults, respiratory distress [amboss.com]

Neonatal Acute Respiratory Distress due to SP-B Deficiency

While most surfactant deficiencies are secondary to prematurity or lung injury and infection, hereditary surfactant protein B deficiency, caused by mutations in the surfactant [ommbid.mhmedical.com]

With surfactant deficiency, a greater pressure is needed to open the alveoli. [msdmanuals.com]

NEONATAL AND PEDIATRIC INTENSIVE CARE Abstract Hereditary surfactant protein B (SP-B) deficiency is an autosomal recessive disease in which affected infants are unable to [link.springer.com]

Perinatal Atelectasis

Fibrinolysin deficiency and surfactant deficiency were the two new and favorite theories of the day and, with the passage of time, the former has slipped into well deserved [neonatology.org]

Introduction and Etiology Respiratory Distress Syndrome (RDS) is a life threatening pulmonary disease primarily of the premature infant caused by surfactant deficiency Pulmonary [pedclerk.bsd.uchicago.edu]

Respiratory distress syndrome can occur in premature infants as a result of surfactant deficiency and underdeveloped lung anatomy. [aafp.org]

Interstitial Pulmonary Fibrosis of the Newborn

Surfactant Protein B (SPB) Deficiency ( SFTPB gene): SP-B deficiency presents as severe respiratory distress in the neonatal period. [hopkinsmedicine.org]

Newborn Medicine | Research | Newborn Respiratory Distress Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic [pediatrics.wustl.edu]

General imaging differential considerations include: partially treated hyaline membrane disease ( surfactant deficiency ) partial clearing of collapsed alveoli may be seen [radiopaedia.org]

Extreme Fetal Immaturity

For the L/S ratio, if the result is less than 2:1, the fetal lungs may be surfactant deficient. The presence of PG usually indicates fetal lung maturity. [en.wikipedia.org]

Surfactant deficiency. ... b. Increased chest wall compliance. ... c. Incomplete alveolar development. ... d. All of the above 5. [hawaii.edu]

These results suggest that infants with neonatal RDS have, in addition to a relative deficiency of surfactant, defective Na + transport, which plays a mechanistic role in [anestesiarianimazione.com]

Autoimmune Pulmonary Alveolar Proteinosis

Surfactant Protein B (SPB) Deficiency ( SFTPB gene): SP-B deficiency presents as severe respiratory distress in the neonatal period. [hopkinsmedicine.org]

[…] neonatal surfactant deficiency CSF2RB mutations ( GM-CSF receptor ß subunit) (MIM.138981) TTF1 (TITF-1) gene mutation (MIM.600635) ( 15517377 ) CSF2RB mutations (GM-CSF/IL [humpath.com]

雑誌 Paediatr Respir Rev 7 Suppl 1:S240-2 (2006) DOI: 10.1016/j.prrv.2006.04.191 文献 PMID: 15218289 著者 Nogee LM タイトル Genetic mechanisms of surfactant deficiency. [kegg.jp]

Meconium Aspiration Syndrome

Group B Streptococcus can have an appearance similar to Respiratory Distress Syndrome (Surfactant Deficiency), although the granulation is typically more coarse. [adhb.govt.nz]

Subsequent to studies reporting that surfactant deficiency or inactivation may contribute to neonatal respiratory failure, exogenous surfactant therapy has been implemented [ncbi.nlm.nih.gov]

deficiency or surfactant inactivation). [clinicaladvisor.com]

Pulmonary Alveolar Proteinosis

Surfactant Protein B (SPB) Deficiency ( SFTPB gene): SP-B deficiency presents as severe respiratory distress in the neonatal period. [hopkinsmedicine.org]

surfactant production May be associated with interstitial fibrosis Most idiopathic cases appear to be due to deficient surfactant degradation by macrophages Autoantibodies [surgpathcriteria.stanford.edu]

雑誌 Paediatr Respir Rev 7 Suppl 1:S240-2 (2006) DOI: 10.1016/j.prrv.2006.04.191 文献 PMID: 15218289 著者 Nogee LM タイトル Genetic mechanisms of surfactant deficiency. [kegg.jp]

Protein C Deficiency

We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success. [ncbi.nlm.nih.gov]

C deficiency. [ncbi.nlm.nih.gov]

Brody Surfactant protein deficiency in familial interstitial lung disease [7] R. Tehrani, R.A. Ostrowski, R. Hariman, W.M. [archbronconeumol.org]

Radiation Exposure-Related Interstitial Lung Disease

[…] metabolism deficiency Combined pulmonary fibrosis-emphysema syndrome Congenital alveolar capillary dysplasia Congenital chylothorax Congenital pulmonary lymphangiectasia [se-atlas.de]

Testing is available for [ edit ] Surfactant-Protein-B Deficiency (Mutations in SFTPB ) Surfactant-Protein-C Deficiency (Mutations in SFTPC ) ABCA3-Deficiency (Mutations in [en.wikipedia.org]

[…] metabolism deficiency Combined pulmonary fibrosis-emphysema syndrome Congenital alveolar capillary dysplasia Congenital chylothorax Congenital diaphragmatic hernia Congenital [se-atlas.de]

Choreoathetosis - Hypothyroidism - Neonatal Respiratory Distress

The lung form presents most commonly as IRDS at term, suggestive for congenital surfactant protein deficiency. [orpha.net]

[…] protein deficiency, and other causes of chorea. [orpha.net]

Differential diagnosis Differential diagnoses include other forms of congenital hypothyroidism, other causes of infant respiratory distress syndrome, genetic forms of surfactant [orpha.net]

Respiratory Distress Syndrome of Prematurity

The pathophysiology of respiratory failure in preterm infants is characterized by a combination of primary surfactant deficiency and surfactant inactivation as a result of [ncbi.nlm.nih.gov]

Respiratory distress syndrome (RDS) is when the neonate has difficulty breathing due to surfactant deficiency at birth. [www2.health.vic.gov.au]

With surfactant deficiency, a greater pressure is needed to open the alveoli. [msdmanuals.com]

Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia

She had no surfactant protein (SP) B deficiency. Alveolar macrophages (AM) obtained from her BAL fluid were small and showed decreased phagocytotic activity. [onlinelibrary.wiley.com]

Pulmonary Agenesis, Hypoplasia and Dysplasia

00:01 Switching gears, let’s talk a little bit about pulmonary hypoplasia, which is a slightly different problem than surfactant deficiency. 00:09 In this case, the baby has [lecturio.com]

[…] of clinical, radiologic, or biochemical evidence of surfactant deficiency in CDH and administer only 50% of the dose because of pulmonary hypoplasia. [neoreviews.aappublications.org]

[…] production (e.g., surfactant protein B deficiency, transporter abnormalities) or function (including hyaline membrane disease), pulmonary hypoplasia, congenital diaphragmatic [acdassociation.org]

Alveolar Capillary Dysplasia

deficiencies, hyaline membrane disease, pulmonary hypoplasia, acinar dysplasia, congenital alveolar dysplasia[1] Prevention None[1] Treatment Lung transplant[1] Medication [en.wikipedia.org]

Causes FOXF1 mutation (at least 40% of cases)[1] Diagnostic method Lung biopsy or FOXF1 genetic testing[1][2] Differential diagnosis Idiopathic PPHN, sepsis, pneumonia, surfactant [en.wikipedia.org]

Muscular Dystrophy-Dystroglycanopathy Type A11

deficiency (Surfactant metabolism dysfunction, pulmonary, 3) CPT deficiency, hepatic, type II Cutis laxa, Autosomal Recessive, type IIA Cystic fibrosis Cystinosis,CTNS-related [zerlaboratories.com]

[…] type IId Congenital disorder of glycosylation, type Im Congenital disorder of glycosylation, type It Congenital myopathy Congenital recessive ichthyoses (CRI) Congenital surfactant [zerlaboratories.com]

Prata-Libéral-Gonçalves Syndrome

[…] protein B, deficiency of Pulmonary valves agenesis Pulmonary veno-occlusive disease Pulmonary venous return anomaly Pulmonaryatresia intact ventricular septum Punctate acrokeratoderma [mindmappedia.com]

[…] granuloma Pulmonary Hypertension, Secondary Pulmonary hypertension Pulmonary hypoplasia familial primary Pulmonary sequestration Pulmonary supravalvular stenosis Pulmonary surfactant [bioreference.net]

Pulmonary surfactant protein B, deficiency of[?] Pulmonary valve stenosis[?] Pulmonary valves agenesis[?] Pulmonary veins stenosis[?] Pulmonary veno-occlusive disease[?] [encyclopedia.kids.net.au]

Ozone Poisoning

Critically, a lack of adequate surfactant, a deficiency often found naturally in babies born prematurely, can produce similar respiratory health complaints to those mentioned [news-medical.net]

Pulmonary Interstitial Emphysema

Indications for HFOV were severe respiratory failure due to PIE (n = 10) and severe surfactant deficiency (RDS, n = 8). [ncbi.nlm.nih.gov]

General imaging differential considerations include: partially treated hyaline membrane disease ( surfactant deficiency ) partial clearing of collapsed alveoli may be seen [radiopaedia.org]

deficiency, 2 few cases of IE have been described in the literature. [archbronconeumol.org]

Ballard Syndrome

In premature infants, surfactant deficiency leads to… Tables from this paper References SHOWING 1-10 OF 11 REFERENCES pertama haid terakhir ibu pada bayi cukup bulan yang [semanticscholar.org]

In premature infants, surfactant deficiency leads to hypoxia which eventually leads to neuromuscular disorders. [journal.fk.unpad.ac.id]

ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med. 2004 Mar 25. 350(13):1296-303. [Medline]. Gerten KA, Coonrod DV, Bay RC, et al. [emedicine.medscape.com]

Persistent Fetal Circulation

Secondary surfactant deficiency may occur in infants as a result of: [ 3 ] Intrapartum asphyxia. [patient.info]

Radiography Chest radiography maybe useful in determining whether underlying parenchymal lung disease (eg, meconium aspiration syndrome, pneumonia, surfactant deficiency) [emedicine.com]

surfactant deficiency and gentler techniques of ventilation to minimise damage to the immature lungs. [patient.info]

Maternal Diabetes Syndrome

deficiency 2 transient tachypnea of the newborn (TTN) 2 central nervous system neural tube defects 7 encephalocoeles holoprosencephaly 1 caudal regression syndrome 3 sirenomelia [radiopaedia.org]

Other potential causes of respiratory distress in infants born to mothers with GDM include increased risk of premature birth 29 (also a risk factor for surfactant deficiency [dovepress.com]

Surfactant often is deficient in immature lungs, and most commonly occurs in those IDMs born at less than 37 weeks. [pediatricweb.com]

Congenital Pulmonary Lymphangiectasia

After surfactant protein B deficiency was ruled out, an open-lung biopsy was performed, on the 18th day of life. [nejm.org]

Low volumes, granular opacities is surfactant deficiency or beta-haemolytic strep. [radnotes.co.nz]

Surfactant Deficiency Diseae (SDD) (Respiratory distress syndrome RDS, hyaline membrane disease HMD). [radnotes.co.nz]

Atrophic Rhinitis

This suggests a possible role for surfactant deficiency in the aetiopathogenesis of cases of primary atrophic rhinitis. [ncbi.nlm.nih.gov]

deficiency and the development of desmosomes. [ncbi.nlm.nih.gov]

Thus significant biochemical changes in the surfactant system of the nose is an evident and early finding in cases of primary atrophic rhinitis. [ncbi.nlm.nih.gov]

Congenital Diaphragmatic Hernia

surfactant deficiency. [journals.plos.org]

Prognosis Pulmonary hypoplasia, persistent pulmonary hypertension and surfactant deficiency are largely responsible for the outcome. [patient.info]

[…] hernia on ECMO: evidence of persistent surfactant deficiency. [link.springer.com]