Symmetric Demyelination: Causes & Reasons

Possible Causes for Symmetric Demyelination

Central pontine myelinolysis is a rare neurologic disorder defined by symmetric demyelination in the central base of the pons. [ncbi.nlm.nih.gov]

Symmetric demyelination of the basis pontis. CPM is a degeneration of a symmetrical midline patch of the basis pontis. [neuropathology-web.org]

Focal symmetric demyelination in the central nervous system may be precipitated by aggressive correction of a hyper- or hypo-osmolar state and until recently has been associated [ncbi.nlm.nih.gov]

Marchiafava-Bignami Disease

Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism whose main pathology is symmetrical demyelination and necrosis of the corpus callous. [ncbi.nlm.nih.gov]

Marchiafava- Bignami disease is the symmetrical demyelination of the middle portion of the corpus callosum observed in people with chronic alcoholism. [ncbi.nlm.nih.gov]

Magnetic resonance imaging showed symmetrical demyelination with partial necrosis in the genu, body, and anterior splenium of the corpus callosum. [ncbi.nlm.nih.gov]

Adult-Onset Autosomal Dominant Leukodystrophy

2012, Número 4 Rev Mex Neuroci 2012; 13 (4) Santiesteban VNJ, Merayo LRY, Montoto A, Camejo LZ Idioma: Español Referencias bibliográficas: 13 Paginas: 220-222 Archivo PDF: 135.49 Kb. RESUMEN La leucodistrofia metacromática (LDM) es una patología neurodegenerativa rara, de herencia autosómica recesiva. Se[…] [medigraphic.com]

Pseudometachromatic Leukodystrophy

demyelination in the periventricular white matter and cerebellum that may converge with disease progression, with frontal predominance in the late stages (juvenile forms [elsevier.es]

demyelination in the periventricular white matter and cerebellum that may converge with dis ease progression, with frontal predominance in the late stages (juvenile forms [redalyc.org]

[…] central nervous system, and can lead to symptoms similar to those of schizophrenia.2Imaging findings MRI findings include hyperintense areas of diffuse, bilateral, and often symmetrical [elsevier.es]

Chronic Polyneuropathy

Distal acquired demyelinating symmetric neuropathy. Neurology 2000; 54: 615-620 11 Viala K, Renie L, Maisonobe T et al. [thieme-connect.com]

Symptoms typically include symmetrical, proximal and/or distal paresis and sensory loss. [thieme-connect.com]

Chronic inflammatory demyelinating polyradiculoneuropathy: diagnostic and therapeutic challenges for a treatable condition. [thieme-connect.com]

Glomeruloid Hemangioma

Electromyography confirmed a diffuse, symmetrical demyelinating lesion of the sensorimotor fibers affecting all four limbs, with an associated axonal lesion in the lower limbs [scielo.br]

Neuropathy is characterized by being of the thick-fiber, sensorimotor type with a demyelinating pattern that initially manifests itself as a distal symmetric sensory alteration [scielo.br]

[…] both of a demyelinating disease and of axonal degeneration. [scielo.br]

Demyelinating Polyneuropathy

distal acquired demyelinating symmetric neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and sensory chronic inflammatory demyelinating polyradiculoneuropathy [medlink.com]

Demyelination should be present as defined by the the EFNS/PNS criteria. 1 ‘Distal acquired demyelinating symmetric neuropathy’ (DADS) shows typically distal symmetrical, [jnnp.bmj.com]

symmetric; 2%-17% of patients), an asymmetric distribution (multifocal acquired demyelinating sensory and motor neuropathy or Lewis-Sumner syndrome; 6%-15%), pure sensory [ajmc.com]

Chronic Inflammatory Demyelinating Polyneuropathy

Distal acquired demyelinating symmetric polyneuropathy (DADS) is proposed as a distinct entity from classic chronic inflammatory demyelinating polyneuropathy (CIDP). [ncbi.nlm.nih.gov]

RESULTS: Patients were classified as having typical CIDP (60%), MADSAM (34%), demyelinating acquired distal symmetric neuropathy (8%) or pure sensory CIDP (1%). [ncbi.nlm.nih.gov]

CANOMAD Syndrome

symmetric neuropathy (DADS), and multifocal acquired demyelinating sensory and motor neuropathy (MADSAM). [ahcmedia.com]

demyelinating sensory and motor neuropathy (also known as Lewis-Sumner syndrome), sensory-predominant CIDP, distal acquired demyelinating symmetric neuropathy (DADS), chronic [medilib.ir]

symmetric (DADS) - Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) - Focal (lumbosacral plexus, brachial plexus, or ≥1 peripheral nerve involvement [eyewiki.aao.org]

Peripheral Motor Neuropathy

Polyneuropathy Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Sjogren’s Syndrome Types when there is a suspected cause: Diabetic Neuropathy or Glucose Intolerance [neuropathysupportnetwork.org]

Chronic inflammatory demyelinating polyneuropathy Chronic inflammatory demyelinating polyneuropathy is the commonest acquired cause of chronic demyelinating neuropathy and [gmjournal.co.uk]

and a symmetric versus asymmetric or multifocal pattern of involvement. [aafp.org]

GALOP Syndrome

Indications Adult onset neuropathy: Clinical neuropathy features Distal Symmetric Sensory > Motor ↑ Likelihood of positive test Age > 50 Gait disorder Tremor Disability 2° [neuromuscular.wustl.edu]

Syndromes, Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info Clinical Indications for Measurement: Diagnostic work-up of Gait disorder, accompanied by Symmetric [neuromuscular.wustl.edu]

[…] sensory or motor loss Demyelination Serum IgM M-protein: 50% Lab standards 80% to 85% clinical specificity Interpretation of + result Diagnosis Dx of immune neuropathy Distinguish [neuromuscular.wustl.edu]

Dysmyelination with Jaundice

(a)T2-weighted MR image shows symmetric demyelination in the frontal lobe white matter. [es.slideshare.net]

[…] peripheral neuropathy later on decerebrate posturing can be seen as well as blindness CSF: increased protein, sulfatide in urine MRI: symmetric demyelination SPARING SUBCORTICAL [quizlet.com]

(a) T2-weighted MR image shows symmetric confluent demyelination in the peritrigonal white matter and the corpus callosum. [es.slideshare.net]

Adult Metachromatic Leukodystrophy

Symmetrical demyelination was found in the cerebral hemispheres, but was moderate in the cerebellum, brain stem and spinal cord. [link.springer.com]

The Magnetic Resonance Imaging (MRI) of these patients showed a diffuse, bilateral and symmetrical demyelination. [diagnosticpathology.biomedcentral.com]

MRI showed a diffuse demyelination, bilateral and often symmetrical, which could be temporarily limited to the periventricular areas. [ncbi.nlm.nih.gov]

Diphtheritic Neuropathy

• Most commonly a symmetric, mixed sensori-motor polyneuropathy • May respond to steroids or plasmapheresis • Pathology marked by demyelination pattern of injury with some [alpfmedical.info]

MAG (DADs-M: distal acquired demyelinating symmetric neuropathy variant of CIDP with monoclonal M-protein) b. [hickoryneurology.net]

*ii11 4 ii12 * Box 3: Variants of chronic inflammatory demyelinating polyradiculoneuropathy c Symmetrical sensory and motor CIDP c Sensory CIDP c Motor CIDP c Multifocal acquired [healthdocbox.com]

Juvenile Metachromatic Leukodystrophy

An MRI image of her brain showed bilateral symmetrical demyelination. [synapse.koreamed.org]

However, intellectual deterioration during follow up, evidence of extensive, symmetrical and periventricular demyelination on MRI of brain and metachromatic on sural nerve [annalsofian.org]

Initially, the involvement of the white matter in MLD is patchy, but after some time all the white matter is affected, often in a symmetrical fashion, so that the demyelinated [78stepshealth.us]

Polyneuropathy

Polyneuropathies associated with paraproteinemias include distal acquired demyelinating symmetric (DADS-M) neuropathy (also known as an ataxic, sensory-predominant CIDP variant [neurology.org]

CIDP can be classified as classical and variant types, the latter of which is rare, including pure motor, pure sensory, distal acquired demyelinating symmetric (DADS) neuropathy [nnjournal.net]

symmetric (DADS) neuropathy or frequently anti-MAG neuropathy; MMN = multifocal motor neuropathy; M protein = monoclonal protein; N-NSS = negative neuropathic sensory symptoms [neurology.org]

Fatal Neonatal Radiculoneuropathy

Chronic symmetric sensorimotor loss and areflexia coupled with nerve conduction findings of demyelination essentially defines the illness. [neurology.mhmedical.com]

symmetrical neuropathy; DADS). [neurology.mhmedical.com]

[…] with large fiber attributable sensory loss and spared sensory nerve action potentials (see Sinnreich et al), and a slowly progressive distal neuropathy (distal acquired demyelinating [neurology.mhmedical.com]

Extensive Burns

These consisted of perivascular areas of demyelination distributed symmetrically in the brain and affecting the white matter predominantly. [ncbi.nlm.nih.gov]

POEMS Syndrome

Needle electromyography confirmed diffuse, symmetrical, demyelinating, and axonal lesions in the sensorimotor fibers that affected all four limbs. [oaepublish.com]

A nerve conduction study (NCS) showed length-dependent, symmetric and non-focal demyelinating features with increased terminal latency indices (TLIs) in the lower limbs. [ncbi.nlm.nih.gov]

Neuropathy, the dominant clinical feature of POEMS syndrome, is typically distal, symmetric, and slowly progressive with demyelinating changes. [ncbi.nlm.nih.gov]

Toxic Polyneuropathy

and a symmetric versus asymmetric or multifocal pattern of involvement. [aafp.org]

The prevalence of peripheral neuropathy was 44%: subclinical neuropathy accounted for 56%, acute inflammatory demyelinating polyneuropathy (AIDP) for 15% and distal symmetrical [atmph.org]

Charcot-Marie-Tooth Disease Type 1C

CMT1C was described mostly as a mild or moderate form of slowly progressive symmetric length-dependent sensory-motor demyelinating polyneuropathy often associated with pes [bmcneurol.biomedcentral.com]

[…] slowly progressive sensory-motor demyelinating polyneuropathy, and lower limbs are affected more often. [bmcneurol.biomedcentral.com]

The position of the substitution is on the very left end of the HR domain Full size image Discussion CMT1C has been described as a symmetrical length-dependent mild form of [bmcneurol.biomedcentral.com]

Monoclonal Gammopathy of Undetermined Significance

[…] inflammatory demyelinating polyneuropathy and 6 pts (17%) a distal acquired demyelinating symmetric polyneuropathy. [ncbi.nlm.nih.gov]

This is the classic description of distal acquired demyelinating symmetric (DADS) sensory and motor neuropathy. [nebraska.pure.elsevier.com]

RESULTS: In36/223 pts. (16%) a neuropathy was diagnosed (MGUS associated neuropathy, MGUS-N). 20 pts. (55%) had a distal symmetric axonal neuropathy, 10 pts. (28%) had a chronic [ncbi.nlm.nih.gov]

Postinfectious Encephalomyelitis

[…] postinfectious demyelinating process. [ncbi.nlm.nih.gov]

perivenular demyelination. [neurologyindia.com]

The nature and monophasic course of illness in these 2 patients, as well as the symmetric involvement of specific regions of the basal ganglia, may result from an immune-mediated [ncbi.nlm.nih.gov]

Paraneoplastic Polyneuropathy

Paraproteinemias Demyelinating: MGUS i.e. [epomedicine.com]

and a symmetric versus asymmetric or multifocal pattern of involvement. [aafp.org]

Typically, distal symmetric sensory symptoms are followed by motor weakness with progressive proximal involvement. [nejm.org]

Cortical Blindness

Central pontine myelinolysis and extrapontine myelinolysis are characterized by symmetric demyelination subsequent to rapid shifts in serum osmolality. [ncbi.nlm.nih.gov]

Spinal Demyelination

Marchiafava-Bignami disease(MBD) is a rare complication of chronic alcoholism characterized by symmetrical demyelination of the corpus callosum. [journal.biolpsychiatry.or.kr]

[…] myelinolysis Due to rapid shift in serum osmolality Rapid correction of hyponatremia Symmetric T2 hyperintensity, iso- hypointense on T1, no contrast enhancement, may have [posterng.netkey.at]

Osmotic demyelination syndrome following correction of hyponatremia. N Engl J Med 1986;314:1535-1542. Martin RJ. [journal.biolpsychiatry.or.kr]

Lethal Ataxia with Deafness and Optic Atrophy

[…] foci of necrosis in basal ganglia, thalamus, midbrain and pons • mainly affects grey matter • associated with vascular proliferation, gliosis, neuronal loss, demyelination [emilytam.com]

[…] most common form of MLD 1-2 years of age, falling/gait problems, hypotonia then they regress, and can develop quadriparxsis develop mixed UMN/LMN signs, leukodystrophy and demyelinating [quizlet.com]

Multifocal Motor Neuropathy

This article discusses CADP with emphasis on multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, distal acquired demyelinating symmetric [ncbi.nlm.nih.gov]

Muscle Nerve, 31(6): 663-80 [ CR ] [ PM ] [ EČ ][ GS ] O`Ferrall, E.K., White, C.M., Zochodne, D.W. (2010) Demyelinating symmetric motor polyneuropathy with high titers of [scindeks.ceon.rs]

Zochodne, Demyelinating symmetric motor polyneuropathy with high titers of anti‐GM1 antibodies, Muscle & Nerve, 42, 4, (604-608), (2010) ., European Federation of Neurological [doi.org]

Limited Cutaneous Systemic Scleroderma

We report a female patient with a known history of CREST syndrome, which developed a slowly progressive, distal symmetric demyelinating sensorimotor polyneuropathy (PN), with [ncbi.nlm.nih.gov]

Acute Pandysautonomia

Finally, in rare cases, an acute polyradiculoneuropathy mimicking GBS may be the presenting manifestation of acute myeloid leukaemia.[ 19,20 ] Chronic Demyelinating symmetric [mjhid.org]

Patients with AMAN have pure motor symptoms and appear clinically very similar to patients with the demyelinating form of GBS with ascending symmetric paralysis. [gbs-cidp-nsw.org.au]

and a symmetric versus asymmetric or multifocal pattern of involvement. [aafp.org]