Symmetric Lesions of the Basal Ganglia: Causes & Reasons

Possible Causes for Symmetric Lesions of the Basal Ganglia

Hallmarks of the disease are symmetrical lesions in the basal ganglia or brain stem on MRI, and a clinical course with rapid deterioration of cognitive and motor functions [ncbi.nlm.nih.gov]

Biotin-Responsive Basal Ganglia Disease

Also the above mentioned 6-year-old girl developed symmetric basal ganglia lesions and showed progressive neurological deterioration. [thieme-connect.com]

MRI Brain showing multiple symmetric focal lesions in the basal ganglia with hyperintensity on T2W and hypointensity on T1W sequence. [indianpediatrics.net]

CONCLUSIONS: Biotin-responsive basal ganglia disease is a treatable underdiagnosed disease. [ajnr.org]

Postinfectious Encephalomyelitis

The diagnosis of postinfectious encephalomyelitis with symmetric lesions in the basal ganglia was confirmed by magnetic resonance imaging in 2 patients. [ncbi.nlm.nih.gov]

basal ganglia. [jnnp.bmj.com]

ADEM lesions are often larger and have a particular tendency to be found extensively and symmetrically in the cerebral and cerebellar white matter, and occasionally in the [jnnp.bmj.com]

Basal Ganglia Lesion

Abstract This paper describes a diabetic dialysis patient presenting two episodes of symmetric basal ganglia lesions occurring 18 months apart, and discusses the MR imaging [ncbi.nlm.nih.gov]

A 21-year-old woman, who experienced manual strangulation, developed delayed parkinsonism associated with a selective symmetric basal ganglia lesion. [ncbi.nlm.nih.gov]

The typical neuroimaging finding is reversible symmetrical basal ganglia lesions with cytotoxic and/or vasogenic edema. [mdsabstracts.org]

Mitochondrial DNA-Related Leigh Syndrome and NARP

lesions in the basal ganglia, and/or thalamus, and/or brainstem. [ojrd.biomedcentral.com]

Since then, the diagnosis of Leigh syndrome has been based on symmetrical lesions in one or more areas of the central nervous system, including the basal ganglia, diencephalon [ojrd.biomedcentral.com]

such as psychomotor regression, dystonia, ataxia and/or brainstem dysfunction and (ii) MRI or CT or neuropathological findings of Leigh syndrome, as follows: bilateral symmetrical [ojrd.biomedcentral.com]

Pyruvate Dehydrogenase Deficiency

Symmetric cystic lesions and gliosis in the cortex, basal ganglia, brain stem, or cerebellum; generalized hypomyelination; and hyperintensity of the subcortical frontoparietal [ncbi.nlm.nih.gov]

[…] cystic lesions; gliosis in the cortex, basal ganglia, brain stem, or cerebellum; and generalized hypomyelination. [ncbi.nlm.nih.gov]

[…] dilatation; cerebral atrophy; hydrocephaly; partial or complete absence of the corpus callosum; absence of the medullary pyramids; abnormal and ectopic inferior olives; symmetric [ncbi.nlm.nih.gov]

Pyruvate Carboxylase Deficiency Type A

Type A is associated with symmetrical cystic lesions and gliosis in the cortex, basal ganglia, brainstem, or cerebellum and/or generalized hypomyelination, as well as hyperintensity [emedicine.medscape.com]

[…] cystic lesions; gliosis in the cortex, basal ganglia, brain stem, or cerebellum; and generalized hypomyelination. [ncbi.nlm.nih.gov]

Mitochondrial Complex 1 Deficiency Nuclear Type 27

ganglia disease; raised lactate levels in blood and/or cerebrospinal fluid; and characteristic symmetric necrotic lesions in the basal ganglia and/or brainstem.12 As variability [ncbi.nlm.nih.gov]

[…] criteria including progressive neurological disease with motor and intellectual developmental retardation/stagnation, usually regression; signs and symptoms of brainstem and/or basal [ncbi.nlm.nih.gov]

Mitochondrial Complex 1 Deficiency Nuclear Type 17

Acute Hemorrhagic Leukoencephalitis

Magnetic resonance imaging revealed symmetrical hemorrhagic lesions in the basal ganglia including the thalami. [ncbi.nlm.nih.gov]

Diagnosis was provided by MRI findings showing symmetrical lesions of the basal ganglia and thalamus, histopathological analyses of affected tissue, and the rapid clinical [jneuroinflammation.biomedcentral.com]

However, since the symmetrical basal ganglia hemorrhagic lesions in this case were developed after the first month of high-dose interferon-β-1a treatment ( 1 ), the therapy [frontiersin.org]

Dystonia with Cerebellar Atrophy (DYTCA)

The disorder was classified as Leigh syndrome after cerebral MRI had shown bilaterally symmetric lesions of the basal ganglia [ 60 ]. [neupsykey.com]

Mitochondrial Complex 1 Deficiency Nuclear Type 23

MEGDEL Syndrome

Leigh disease is characterized by symmetrical hyperdense lesions in the basal ganglia or brain stem on MRI. [karger.com]

Methyl Bromide Poisoning

A case of chronic methyl bromide intoxication showing symmetrical lesions in the basal ganglia and brain stem on magnetic resonance imaging. [neurologyindia.com]

Leigh Syndrome of Adult

[…] hyperintense lesions in the basal ganglia and/or brain stem on T2-weighted magnetic resonance images); b) typical neuropathologic changes at postmortem examination; or c) [annalsofian.org]

lesions in the basal ganglia, and/or thalamus, and/or brainstem. [ojrd.biomedcentral.com]

It is characterised neuropathologically by symmetrical vasculonecrotic lesions, primarily in the brainstem and basal ganglia, though there may also be abnormalities in the [nature.com]

Pyruvate Carboxylase Deficiency

[…] cystic lesions; gliosis in the cortex, basal ganglia, brain stem, or cerebellum; and generalized hypomyelination. [ncbi.nlm.nih.gov]

Spastic Quadriplegic Cerebral Palsy Type 2

MRI commonly shows symmetrical lesions in the basal ganglia, thalami, and brain stem. [adc.bmj.com]

Athetoid Cerebral Palsy

Follow up MRI scans showed bilateral symmetrical cystic lesions in the posterior putamen. [ncbi.nlm.nih.gov]

Although haemorrhagic lesions within the basal ganglia are a common MRI finding in neonates with HIE, few of these babies develop athetoid cerebral palsy. [ncbi.nlm.nih.gov]

Uremic Encephalopathy

Rare case of reversible acute symmetrical lesions of the bilateral Basal Ganglia associated with diabetic nephropathy and chronic renal failure. [ruralneuropractice.com]

Acute movement disorder with bilateral basal ganglia lesions in diabetic uremia. Ann Indian Acad Neurol 2011;14:211-3. [ PUBMED ] [Full text] 5. [ruralneuropractice.com]

Infantile Beriberi

Magnetic resonance imaging (MRI) picture of a patient showing characteristic bilaterally symmetrical hyper intense lesions in the basal ganglia. [academic.oup.com]

Conclusion Recognition of symmetrical T2-W hyperintense lesions in the basal ganglia with restricted diffusion and prominent lactate peak may allow early diagnosis of encephalitic [link.springer.com]

Brain imaging showed characteristic symmetric hypodense lesions in the basal ganglia on CT and/or hyper-intense lesions on T2-weighted MRI in the majority with similar lesions [academic.oup.com]

Bjornstad Syndrome

Leigh syndrome is a subacute necrotizing encephalopathy characterized by elevated levels of lactate in blood or cerebral spinal fluid; bilateral symmetric necrotic lesions [preventiongenetics.com]

[…] in the basal ganglia, brain stem, thalamus, and/or spinal cord; psychomotor delay or regression; and neurologic manifestations such as hypotonia or ataxia (Rahman and Thorburn [preventiongenetics.com]

ANE Syndrome

Magnetic resonance imaging revealed symmetrical hemorrhagic lesions in the basal ganglia including the thalami. [jneuroinflammation.biomedcentral.com]

vascular proliferation, and gliosis in the brain stem, diencephalon, basal ganglia, cerebellum, and (occasionally) cerebral white matter. [ajnr.org]

Cerebral Palsy with Spastic Diplegia

MRI commonly shows symmetrical lesions in the basal ganglia, thalami, and brain stem. [adc.bmj.com]

Uremia

Reversible symmetrical lesions located in basal ganglia found on brain magnetic resonance imaging are hallmarks of this syndrome. [ncbi.nlm.nih.gov]

basal ganglia lesions occurring in the background of diabetic end stage renal disease is a recently described condition. [annalsofian.org]

The syndrome of acute bilateral basal ganglia lesions is a rarely described complication of uremia occurring typically in the setting of concurrent long-standing diabetes [ncbi.nlm.nih.gov]

Mitochondrial Disease

The neuroimaging spectrum ranges from classical Leigh syndrome with symmetrical lesions in basal ganglia and/or brain stem to structural abnormalities including cerebellar [ncbi.nlm.nih.gov]

It is the neuroimaging, mainly the Magnetic Resonance Imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the [ijponline.biomedcentral.com]

Other findings: Bilateral symmetric hypodensities in the basal ganglia on computed tomography (CT). [clinicaladvisor.com]

Mitochondrial Complex 3 Deficiency Nuclear Type 1

(a–d) Axial (a–c) and coronal (d) MR images show typical Leigh syndrome lesions in the basal ganglia and thalami, including bilateral and symmetric hyperintense lesions in [pubs.rsna.org]

Autosomal Dominant Sensory Ataxia

lesions of the basal ganglia Abnormality of the basal ganglia Hyperkinesis Hyperactive deep tendon reflexes Generalized myoclonic seizures Rapidly progressive Clonus Distal [mendelian.co]

Photophobia Reduced visual acuity Intellectual disability, mild Intellectual disability Lower limb hyperreflexia Central scotoma Difficulty walking Degeneration of the striatum Symmetric [mendelian.co]

Myopathy with Lactic Acidosis and Sideroblastic Anemia Type 2

Brain imaging findings specific for mitochondrial disorders such as bilateral symmetric lesions of the basal ganglia and midbrain were found in four children, and two patients [adc.bmj.com]

These symptoms can be referred to symmetric lesions of neurological structures that originate, cross through, or are localized in the basal ganglia, brainstem and cerebellum [mitopedia.org]

Severe Congenital Neutropenia

Cranial CT scan showed symmetrical lesions suggesting bilateral necrosis in the basal ganglia. [ncbi.nlm.nih.gov]

Disseminated Toxoplasmosis

Magnetic resonance imaging showed diffuse symmetrical lesions of bilateral basal ganglia lacking ringed enhancement. [ncbi.nlm.nih.gov]