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13 Possible Causes for Symptoms Progress with Worsening Myopathy

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1F

    0003715 Polyneuropathy Peripheral nerve disease 0001271 Progressive distal muscle weakness 0009063 Slow progression Signs and symptoms worsen slowly with time 0003677 Showing[rarediseases.info.nih.gov] Hyporeflexia of lower limbs 0002600 Muscle fiber cytoplasmatic inclusion bodies 0100303 Muscle stiffness 0003552 Myalgia Muscle ache Muscle pain [ more ] 0003326 Myofibrillar myopathy[rarediseases.info.nih.gov]

  • Dermatomyositis

    Persistently elevated CPK ( 1,000U/L) and other muscle enzymes, progressively worsening clinical symptoms after five days of optimal hydration status and diuresis, and onset[revistanefrologia.com] […] of dysphagia and dysphonia directed an investigation for inflammatory myopathies.[revistanefrologia.com]

  • Nemaline Myopathy

    According to the age at symptom onset, severity of myopathy and possible progression, six types of NM are clinically distinguished: Severe congenital NM is the most severe[symptoma.com] Functional impairment of respiratory muscles and heart is not uncommon and does significantly worsen prognosis.[symptoma.com]

  • Kearns-Sayre Syndrome

    The disease progresses slowly, with new symptoms appearing and previous symptoms slowly worsening.[enerca.org] The disease progresses slowly, over decades, with new symptoms appearing and previous symptoms slowly worsening.[orpha.net] […] heart involvement (cardiomyopathy, cardiac conduction defect), cerebral involvement (ataxia, high cerebrospinal fluid protein content, intellectual deficit), skeletal muscle myopathy[enerca.org]

  • Maternally-Inherited Diabetes and Deafness

    Case report A 64 year old diabetic patient known as bearing the mt DNA mutation at the 3243 position was referred for progressive malaise, weight loss and digestive symptoms[em-consulte.com] The diagnosis of mitochondriopathy had been made at the age of 40 years on worsening of previous myopathy with proximal weakness and bilateral neurosensory hearing impairment[em-consulte.com]

  • Disorder of Carbohydrate Metabolism

    Progressive muscle weakness worsens in two-thirds of affected individuals, however in some the muscle weakness is stable. Onset forms: infant, child, adult.[en.wikipedia.org] : Exercise intolerance, symptoms tend to improve with rest.[en.wikipedia.org] Release of G-1-P – Glycogen phosphorylase PYGM : Muscle GSD type V (GSD 5, McArdle's disease, muscle phosphorylase deficiency, myophosphorylase deficiency, PYGM deficiency) Myopathy[en.wikipedia.org]

  • Autosomal Recessive Inclusion Body Myopathy Type 2

    It is an ultra-rare autosomal recessive distal myopathy due to mutations in the GNE gene. The first symptom of GNE myopathy is often foot drop.[newcastle-muscle.org] Progressive worsening leads to difficulties climbing stairs or getting up from sitting, and weakness of the hands and shoulder muscles.[newcastle-muscle.org] GNE myopathy is also known as Hereditary Inclusion Body Myopathy (HIBM), Quadriceps-Sparing Myopathy (QSM), Distal Myopathy with Rimmed Vacuoles (DMRV), Nonaka Myopathy or[newcastle-muscle.org]

  • Bethlem Myopathy

    Worsening of clinical symptoms, particularly dyspnea, necessitated delivery at 36 2/7 weeks of gestation.[ncbi.nlm.nih.gov] CASE: We report a case of progressive deterioration of left ventricular function during pregnancy in a patient with Bethlem myopathy.[ncbi.nlm.nih.gov] CONCLUSION: Bethlem myopathy may be associated with progressive left ventricular dysfunction during pregnancy and may require early delivery.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1A

    0003715 Polyneuropathy Peripheral nerve disease 0001271 Progressive distal muscle weakness 0009063 Slow progression Signs and symptoms worsen slowly with time 0003677 Showing[rarediseases.info.nih.gov] Hyporeflexia of lower limbs 0002600 Muscle fiber cytoplasmatic inclusion bodies 0100303 Muscle stiffness 0003552 Myalgia Muscle ache Muscle pain [ more ] 0003326 Myofibrillar myopathy[rarediseases.info.nih.gov]

  • Congenital Slow-Channel Myasthenic Syndrome Type 4A

    Slow channel congenital myasthenic syndrome typically worsens over years as the endplate myopathy progresses.[neupsykey.com] Although CEIs typically worsen symptoms, quinidine and fluoxetine, which reduce the duration of ACh receptor channel openings, are both effective treatments for slow channel[neupsykey.com]

Further symptoms