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56 Possible Causes for Systemic Autoinflammation

  • Vasculitis

    To date, several cases of systemic lupus erythematosus, Aicardi-Goutieres syndrome, familial chilblain lupus, retinal vasculopathy-cerebral leukodystrophy have been reported[ncbi.nlm.nih.gov] These include the primary systemic vasculitides, monogenic autoinflammatory diseases and neuroinflammatory diseases.[ucl.ac.uk] Abstract Three prime repair exonuclease 1 degrades single and double stranded DNA with 3'-5' nuclease activity and its mutations are related to type 1 IFN mediated autoinflammation[ncbi.nlm.nih.gov]

  • Uveitis

    Autoinflammation may simply be defined as self-directed tissue inflammation, where local factors at disease-prone sites determine activation of the innate immune system.[doi.org] […] signals emanate [ 34 ]; this hypothesis is closely allied with the proposed generic definition of autoinflammation.[doi.org] From the standpoint of the danger theory, the ultimate susceptibility to disease lies not with the adaptive immune system but with the target tissue itself, from which danger[doi.org]

  • Erythema Nodosum

    Ahmet Gül, Behçet Disease, Textbook of Autoinflammation, 10.1007/978-3-319-98605-0_35, (647-665), (2019).[doi.org] Peterson, Oral Manifestations of Systemic Diseases and Their Treatments, Contemporary Oral Medicine, 10.1007/978-3-319-72303-7_18, (1523-1639), (2019).[doi.org]

  • Juvenile Rheumatoid Arthritis

    Schneider, Systemic Juvenile Idiopathic Arthritis, Pediatrics in Systemic Autoimmune Diseases, 10.1016/B978-0-444-63596-9.00003-7, (53-84), (2016). Christian M.[doi.org] Hedrich, Shaping the spectrum — From autoinflammation to autoimmunity, Clinical Immunology, 10.1016/j.clim.2016.03.002, 165, (21-28), (2016).[doi.org]

  • Systemic Scleroderma

    Lupus erythematosus, vasculopathy, instead of autoinflammation, appears to be clinically important in systemic scleroderma.[ncbi.nlm.nih.gov] The fact that autoinflammation does not represent the major role in the maintenance of the disease is also evident by the lack of therapeutic effects of classical systemic[ncbi.nlm.nih.gov] A complex pathomechanism accounts systemic sclerosis as a form of collagenosis.[ncbi.nlm.nih.gov]

  • Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.medscape.com]

  • Acute Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com]

  • Cryopyrin-Associated Periodic Syndrome

    Hoffman, Autoinflammation: translating mechanism to therapy, Journal of Leukocyte Biology, 90, 1, (37-47), (2011). Keith A. Sikora and Alexei A.[doi.org] Binstadt, Advances in the pathogenesis and treatment of systemic juvenile idiopathic arthritis, Pediatric Research, 10.1038/pr.2013.187, 75, 1-2, (176-183), (2013). T.[doi.org] Grom, Update on the pathogenesis and treatment of systemic idiopathic arthritis, Current Opinion in Pediatrics, 10.1097/MOP.0b013e32834cba24, 23, 6, (640-646), (2011).[doi.org]

  • Pyoderma

    The dominant hypothesis is that altered innate immunity leads to systemic autoinflammation ( 5 ).[frontiersin.org]

  • Cardiac Tamponade

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com]

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