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2 Possible Causes for Systemic Iron Overload due to Ineffective Erythropoiesis

  • Hereditary Sideroblastic Anemia

    Int J Hematol. 2010 Oct;92(3):425-31. doi: 10.1007/s12185-010-0688-4. Epub 2010 Sep 17. Abstract Sideroblastic anemia is characterized by anemia with the emergence of ring sideroblasts in the bone marrow. Ring sideroblasts are erythroblasts characterized by iron accumulation in perinuclear mitochondria due to impaired[…][ncbi.nlm.nih.gov]

  • Porphyria Cutanea Tarda

    erythropoiesis, resulting in hepatic iron overload.[e-ijd.org] It affects porphyrin metabolism by reducing the ability of the cytochrome P450–dependent mixed-function oxidase system, which is needed to detoxify chemicals and causes ineffective[e-ijd.org] Moreover, HIV-infected individuals may have increased estrogen production due to altered steroid metabolism, thereby disrupting heme synthesis and eventually leading to PCT[e-ijd.org]

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