T Cell Deficiency: Causes & Reasons

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Possible Causes for T Cell Deficiency

DiGeorge Syndrome

We report a male infant with partial DiGeorge syndrome characterized by truncus arteriosus, typical facial dysmorphism, hypocalcemia, lymphocytopenia with T-cell deficiency [ncbi.nlm.nih.gov]

A 13-month old male was identified as T cell deficient by the T cell receptor excision circle (TREC) assay on newborn screening, and was subsequently confirmed to have cDGS [ncbi.nlm.nih.gov]

Hemizygosity of the proximal region, designated DGCR2, can cause cardiac defect and T cell deficiency. [ncbi.nlm.nih.gov]

Velocardiofacial Syndrome

In most cases, B-cells and Humoral Immunity are relatively intact although in severe T-cell deficiencies even Humoral Immunity is impaired given the role of CD4+ T-cells in [pathwaymedicine.org]

These patients also manifest severe T-cell deficiency. [jamanetwork.com]

Patients who had thymic hypoplasia, T-cell deficiency, or history of recurrent infections, were diagnosed with immune deficiency. [journals.plos.org]

Primary Immune Deficiency Disorder

They can be broadly classified into six groups based on the part of the immune system that's affected: B cell (antibody) deficiencies T cell deficiencies Combination B and [fortishealthcare.com]

T cell deficiencies Defective phagocytes Complement deficiencies Unknown (idiopathic) Risk factors The only known risk factor is having a family history of a primary immune [mayoclinic.org]

T-cell defects account for 30%, phagocytic deficiencies 18% and complement deficiencies 2%. [patient.info]

Complement Factor I Deficiency

T-cell defects account for 30%, phagocytic deficiencies 18% and complement deficiencies 2%. [patient.info]

– ) in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

Cell-mediated immune deficiency, including T-cell immune deficiency Defects in immune cell structures, such as T-cells can leave the patient vulnerable many infections that [columbiadoctors.org]

Lymphopenia

T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by decreased function of individual T cells. [diki.pl]

Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of Objective: To increase [ingentaconnect.com]

Furthermore, CD4+ deficiency secondary to infection with hepatitis C has been excluded, as no hepatitis C antibodies were detected. 4 CD4+ T cell deficiency is also a feature [adc.bmj.com]

Immunodeficiency

T-cell deficiency T-cell enumeration using flow cytometry and monoclonal antibodies§ Lymphopenia, suspected SCID or complete DiGeorge syndrome Interpretation varies by molecular [merckmanuals.com]

They can be broadly classified into six groups based on the part of the immune system that's affected: B cell (antibody) deficiencies T cell deficiencies Combination B and [mayoclinic.org]

[…] patients with abscesses and pneumatoceles (hyper-IgE syndrome), partial T-cell deficiencies, allergic disorders, or parasitic infections. [merckmanuals.com]

Idiopathic CD4 Lymphocytopenia

Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total [ncbi.nlm.nih.gov]

Since protection against Histoplasma capsulatum infection requires specific, cell-mediated immunity, histoplasmosis is well documented in patients with acquired T cell deficiencies [ncbi.nlm.nih.gov]

Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of Objective: To increase [ingentaconnect.com]

Severe Combined Immunodeficiency

Currently, 23 states include SCID testing for T-cell deficiencies in their newborn screening platform. [ncbi.nlm.nih.gov]

/delta T cells. [ncbi.nlm.nih.gov]

Fungal infections are typically noted in neutropenic (congenital or acquired) and T-cell deficient individuals. [ncbi.nlm.nih.gov]

Immunodeficiency due to MASP-2 Deficiency

35876373 GRCh38: Chr5:35876271 IL7R Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive, Severe Combined Immune Deficiency [ncbi.nlm.nih.gov]

T-B+ severe combined immunodeficiency due to JAK3 deficiency T-B+ severe combined immunodeficiency due to gamma chain deficiency T-B- severe combined immunodeficiency T-cell [se-atlas.de]

T-cell disorders also cause Ig deficiencies because the B- and T-cell immune systems are interdependent. [merckmanuals.com]

Congenital AIDS

[…] workshop “T cell deficiencies“. [sciencedaily.com]

If a T-cell deficiency is suspected, then T-cell stimulation assays may be performed. [racgp.org.au]

Giardia intestinalis Cryptosporidium parvum T cell deficiency T cells Marrow and other transplantation AIDS Cancer chemotherapy Lymphoma Glucocorticoid therapy Intracellular [en.wikipedia.org]

Autosomal Agammaglobulinemia

[…] failure of T cells to develop What step is blocked in SCID (MHC-II deficiency)?Activation of CD4 T cells Immune deficiencies w/ decreased production of-- B-cells? [memorize.com]

B and T cells usually remain normal. Chronic Mucocutaneous Candidiasis Immune deficiency T-Cell Deficiency T-Cell deficiency specific to Candida. [kumc.edu]

B-cell and T-cell defects (~30) Severe combined immunodeficiency X-linked One case per 100,000 to 500,000 persons Males T-cell deficient, B-cell competent Autosomal recessive [aafp.org]

Neutrophil Immunodeficiency Syndrome

cell deficiency Post-mortem diagnosis and mutation identification in recessive or X-linked SCID using parental DNA Confirmation of a clinical diagnosis Carrier testing in [genedx.com]

The most common form of this disorder is selective IgA deficiency. T-cell deficiency disorders: 1. [telepathology.com]

However, patients with intact T-cell function or partial T-cell deficiencies (eg, Wiskott-Aldrich syndrome, combined immunodeficiency with inadequate but not absent T-cell [merckmanuals.com]

Transient Hypogammaglobulinemia of Infancy

Our results indicate that a numerical, as well as a functional, deficiency in helper T cells underlies the deficiency in IgG production in transient hypogammaglobulinemia [ncbi.nlm.nih.gov]

Selective IgA deficiency F. Adenosine deaminase deficiencies and T-cell cytokine receptor mutations G. Transient hypogammaglobulinemia of infancy H. [proprofs.com]

Experiments with cultured lymphocytes indicated that excess suppressor-cell activity was not present in these patients, but that their T cells were deficient in providing [ncbi.nlm.nih.gov]

Purine-Nucleoside Phosphorylase Deficiency

The immunodeficiency is progressive with normal immune functions at birth, but then, T-cell deficiency with variable B-cell functions usually presents by the age of two yr [ncbi.nlm.nih.gov]

He was found to have T-cell deficiency with lack of red and white cell purine nucleoside phosphorylase enzyme activity. A spastic tetraparesis was noted. [ncbi.nlm.nih.gov]

Any of the mutations can be responsible for a lack of purine NP and the development of the characteristic T-cell deficiency syndrome. [ncbi.nlm.nih.gov]

Complement Deficiency Syndrome

Other Primary Cellular Immunodeficiencies Cellular immunodeficiencies (T-cell deficiency) discussed in previous chapters included Severe Combined Immune Deficiency (SCID), [hamad.qa]

A confirmed diagnosis shows a deficiency of CD40 ligands on T cells. [hawaii.edu]

IMMUNE DEFICIENCY DISORDERS classified into 1.Phagocytic defects 2.B cell defects 3.T cell defects 4. [welovemedicine.blogspot.com]

Thymic Aplasia

Therefore, infections characteristic of T-cell deficiency are rare in these indi-viduals. [brainkart.com]

T cell deficiencies include: DiGeorge syndrome, Wiskott Aldrich syndrome, and the acquired immunodeficiency syndrome. [clinlabnavigator.com]

cell deficiency due to thymic aplasia leading to recurrent viral/fungal infections absent thymic shadow on CXR congenital heart and great vessel defects autoimmunity syndromes [medbullets.com]

Schimke Immunoosseous Dysplasia

All tested individuals have T-cell deficiency and associated risk for opportunistic infection, a common cause of death. [checkorphan.org]

[…] characterized by a deficiency of immune T cells. [dana.org]

Results: As predicted by the clinical course, T cell deficiency in peripheral lymphoid organs, defective chondrogenesis, focal segmental glomerulosclerosis, cerebral ischaemic [experts.umn.edu]

Severe Combined Immunodeficiency with Low T- and B-Cell Numbers

Finally, T-cell deficiency may be progressive with age and not readily apparent at birth or in the first months of life. [aacc.org]

Both B and T cells are affected. The phenotype is T–B–NK–. ADA deficiency is an autosomal recessive disorder in which the age at presentation varies. [emedicine.medscape.com]

INCLUDED, SCID, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-POSITIVE, AND SENSITIVITY TO IONIZING RADIATION DUE TO NHEJ1 DEFICIENCY, INCLUDED, SCID, AUTOSOMAL [mousephenotype.org]

Combined Immunodeficiency due to CD3-Gamma Deficiency

IL-7R alpha gene mutations result in a pure T-cell deficiency. [genome.jp]

– ) in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

•IL-7 receptor ἀ chain deficiency results in lack of T-cell differentiation, proving the key role of IL-7 in human T-cell differentiation. 8. [slideshare.net]

Complement Factor D Deficiency

B-cell and T-cell defects (~30) Severe combined immunodeficiency X-linked One case per 100,000 to 500,000 persons Males T-cell deficient, B-cell competent Autosomal recessive [aafp.org]

A confirmed diagnosis shows a deficiency of CD40 ligands on T cells. [hawaii.edu]

Flow cytometry shows normal B and T cell subsets Poor response to immunizations Treatment : References: [1] [2] [3] [4] [5] [6] [7] Congenital T-cell immunodeficiencies T [amboss.com]

X-Linked Severe Combined Immunodeficiency

– ) in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

Additionally, a deficiency of CD3δ, a component of the T-cell antigen receptor, results in a near absence of circulating mature CD3+ T cells and a complete lack of γ/δ T cells [doi.org]

[…] of cell surface signals in B cells and T cells. [emedicine.medscape.com]

Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

Di George syndrome is an example of T-cell deficiency associated with congenital absence of the thymus. [slideplayer.com]

Tamra Carlson - 2019-03-11 15:17 Disease Topic Inherited T-Cell Deficiency Disorders granulomatous disease (CGD) Neutrophil disorders Epidemiology Incidence – rare Age – most [arupconsult.com]

Disorders of the adaptive immune system usually manifest as B- or T-cell defects, antibody deficiencies, or SCIDs. [aneskey.com]

Adenosine Deaminase Deficiency

ADA follows PNP in purine nucleoside catabolism, but deficiency in this enzyme causes even more severe symptoms than PNP deficiency, which is a T cell deficiency. [structure.bmc.lu.se]

T-lineage cells, resulting in profound T-cell deficiency and variable degree of B-cell dysfunction. [emedicine.medscape.com]

IVIG, management of infections with antibiotics Immunodeficiency Syndromes 0 0 T Cell Deficiencies Defect in T CellsDi George’s Syndrome (DGS) A disease that results from [slideserve.com]

Immune Defect due to Absence of Thymus

Disease Ontology : 12 A T cell deficiency that is characterized by decreased functioning of the T lymphocytes, which are drivers of cell-mediated immunity, resulting in increased [malacards.org]

Show Summary Details Quick Reference An immune deficiency in which there is thymic hypoplasia and T-cell deficiency but normal immunoglobulin levels, thus distinguishing it [oxfordindex.oup.com]

[…] are unresponsive to T cells Deficiency of all classes of immunoglobulins Normal number of T cells? [quizlet.com]

Severe Combined Immunodeficiency with Reticular Dysgenesis

cell deficiency Post-mortem diagnosis and mutation identification in recessive or X-linked SCID using parental DNA Confirmation of a clinical diagnosis Carrier testing in [genedx.com]

– ) in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

Finally, T-cell deficiency may be progressive with age and not readily apparent at birth or in the first months of life. [aacc.org]

Primary CD59 Deficiency

(SCID) Patients who make neither T-Cell dependent antibody responses nor Cell-Mediated immune responses, typically the result of genetic defects that lead to T-Cell deficiencies [quizlet.com]

T-cell immunodeficiency with epidermodysplasia verruciformis, TCRab-positive T-cell deficiency – X-linked immunodeficiency with magnesium defect – Epstein-Barr virus infection [bbrauncegat.com]

deficiency ITK Lymphoproliferative syndrome JAK3 Severe combined immunodeficiency,, T cell-negative, B cell-positive, natural killer cell-negative LCK Immunodeficiency LIG4 [genda.com.ar]

Selective IgA Immunodeficiency

T-cell defects account for 30%, phagocytic deficiencies 18% and complement deficiencies 2%. [patient.info]

B-cell and T-cell defects (~30) Severe combined immunodeficiency X-linked One case per 100,000 to 500,000 persons Males T-cell deficient, B-cell competent Autosomal recessive [aafp.org]

[…] immunodeficiencies T cell defects ( cellular immunity deficiencies ) are responsible for 5–10% of primary immunodeficiencies. [amboss.com]

Autoimmune Lymphoproliferative Syndrome Type 3

A rare autoimmune disorder characterised by a loss of lymphocyte homeostasis; B-cell lymphocytosis; expansion of an unusual population of CD4/CD8-deficient T cells, which [medical-dictionary.thefreedictionary.com]

cell -> CD4/CD8 T cells) Presentation: Tetany (hypocalcemia), recurrent viral/fungal infections, T cell deficiency, congenital heart and great vessel defects Labs: low T cells [quizlet.com]

IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach. Haematologica. 2011; 96(3):472-6. PMID: 21109689 Belot, A, et al. [invitae.com]

Facial Dysmorphism-Immunodeficiency-Livedo-Short Stature Syndrome

T-B+ severe combined immunodeficiency due to JAK3 deficiency T-B+ severe combined immunodeficiency due to gamma chain deficiency T-B- severe combined immunodeficiency T-cell [se-atlas.de]

[…] immunodeficiency with epidermodysplasia verruciformis T-cell large granular lymphocyte leukemia TCR-alpha-beta-positive T-cell deficiency Thymic aplasia Transient hypogammaglobulinemia [se-atlas.de]

Effect of CD3δ deficiency on maturation of α/β and γ/δ T-cell lineages in severe combined immunodeficiency. N. Engl. J. [nature.com]

Common Variable Immunodeficiency

Good's syndrome is a rare cause of combined B or T cell deficiency. [erj.ersjournals.com]

Christian Mueller-Eckhardt, Friederike M�hring, Volker Kretschmer, Walter H�bel & Helmut L�ffler Blut (1977) T Cell Deficiency in Patients with Autoimmune Hemolytic Anemia [nature.com]

Review Topic QID: 100424 1 Deficiency in CD8+ T cells 2 Deficiency in neutrophils M1 Select Answer to see Preferred Response PREFERRED RESPONSE 3 ARTICLES (1) Topic COMMENTS [medbullets.com]