T-cell-deficiency: Causes & Reasons

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Possible Causes for t cell deficiency

Primary Immune Deficiency Disorder

They can be broadly classified into six groups based on the part of the immune system that's affected: B cell (antibody) deficiencies T cell deficiencies Combination B and [fortishealthcare.com]

T cell deficiencies Defective phagocytes Complement deficiencies Unknown (idiopathic) Risk factors The only known risk factor is having a family history of a primary immune [mayoclinic.org]

T-cell defects account for 30%, phagocytic deficiencies 18% and complement deficiencies 2%. [patient.info]

DiGeorge Syndrome

We report a male infant with partial DiGeorge syndrome characterized by truncus arteriosus, typical facial dysmorphism, hypocalcemia, lymphocytopenia with T-cell deficiency [ncbi.nlm.nih.gov]

A 13-month old male was identified as T cell deficient by the T cell receptor excision circle (TREC) assay on newborn screening, and was subsequently confirmed to have cDGS [ncbi.nlm.nih.gov]

Hemizygosity of the proximal region, designated DGCR2, can cause cardiac defect and T cell deficiency. [ncbi.nlm.nih.gov]

Velocardiofacial Syndrome

In most cases, B-cells and Humoral Immunity are relatively intact although in severe T-cell deficiencies even Humoral Immunity is impaired given the role of CD4 T-cells in [pathwaymedicine.org]

These patients also manifest severe T-cell deficiency. [jamanetwork.com]

Patients who had thymic hypoplasia, T-cell deficiency, or history of recurrent infections, were diagnosed with immune deficiency. [journals.plos.org]

Complement Factor I Deficiency

T-cell defects account for 30%, phagocytic deficiencies 18% and complement deficiencies 2%. [patient.info]

in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

[…] protein (RFXAP) Regulatory factor X 5 (RFX5) Other T-cell deficiency DOCK8 deficiency STAT5b deficiency Omenn syndrome (due to) RAG1 RAG2 Artemis RMRP ADA Gamma C (X-linked [piduk.org]

Purine-Nucleoside Phosphorylase Deficiency

The immunodeficiency is progressive with normal immune functions at birth, but then, T-cell deficiency with variable B-cell functions usually presents by the age of two yr [ncbi.nlm.nih.gov]

He was found to have T-cell deficiency with lack of red and white cell purine nucleoside phosphorylase enzyme activity. A spastic tetraparesis was noted. [ncbi.nlm.nih.gov]

Any of the mutations can be responsible for a lack of purine NP and the development of the characteristic T-cell deficiency syndrome. [ncbi.nlm.nih.gov]

Schimke Immunoosseous Dysplasia

All tested individuals have T-cell deficiency and associated risk for opportunistic infection, a common cause of death. [checkorphan.org]

[…] characterized by a deficiency of immune T cells. [dana.org]

Results: As predicted by the clinical course, T cell deficiency in peripheral lymphoid organs, defective chondrogenesis, focal segmental glomerulosclerosis, cerebral ischaemic [experts.umn.edu]

Combined Immunodeficiency due to CD3-Gamma Deficiency

•IL-7 receptor ἀ chain deficiency results in lack of T-cell differentiation, proving the key role of IL-7 in human T-cell differentiation. 8. [slideshare.net]

IL-7R alpha gene mutations result in a pure T-cell deficiency. [genome.jp]

in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

Lymphopenia

T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by decreased function of individual T cells. [diki.pl]

Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of Objective: To increase [ingentaconnect.com]

In T lymphocytopenia, there are too few T lymphocytes, but normal numbers of other lymphocytes. It causes, and manifests as, a T cell deficiency. [en.wikipedia.org]

Severe Combined Immunodeficiency

Currently, 23 states include SCID testing for T-cell deficiencies in their newborn screening platform. [ncbi.nlm.nih.gov]

Fungal infections are typically noted in neutropenic (congenital or acquired) and T-cell deficient individuals. [ncbi.nlm.nih.gov]

Although one of them was aged 12 months, he had still not been diagnosed as having severe T-cell deficiency at the time of transfusion. [ncbi.nlm.nih.gov]

Idiopathic CD4 Lymphocytopenia

Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total [ncbi.nlm.nih.gov]

Since protection against Histoplasma capsulatum infection requires specific, cell-mediated immunity, histoplasmosis is well documented in patients with acquired T cell deficiencies [ncbi.nlm.nih.gov]

Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of Objective: To increase [ingentaconnect.com]

Common Cold

Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. [ods.od.nih.gov]

Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection. PLoS Pathog. 2016 Sep. 12 (9):e1005913. [emedicine.medscape.com]

Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 1997;272:E1002-7. [ PubMed abstract ] Prasad AS. [ods.od.nih.gov]

Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

NK cells CD45 deficiency N Normal γ/δ T cells Disorders of purine metabolism ADA deficiency Absent from birth or progressive Absent from birth or progressive Progressive [aacijournal.biomedcentral.com]

Di George syndrome is an example of T-cell deficiency associated with congenital absence of the thymus. [slideplayer.com]

Tamra Carlson - 2019-03-11 15:17 Disease Topic Inherited T-Cell Deficiency Disorders granulomatous disease (CGD) Neutrophil disorders Epidemiology Incidence – rare Age – most [arupconsult.com]

Immune Defect due to Absence of Thymus

Disease Ontology : 12 A T cell deficiency that is characterized by decreased functioning of the T lymphocytes, which are drivers of cell-mediated immunity, resulting in increased [malacards.org]

Show Summary Details Quick Reference An immune deficiency in which there is thymic hypoplasia and T-cell deficiency but normal immunoglobulin levels, thus distinguishing it [oxfordindex.oup.com]

IgG deficiency IgM deficiency Hyper IgM syndrome ( 1 2 3 4 5 ) Wiskott-Aldrich syndrome Hyper-IgE syndrome Other Common variable immunodeficiency ICF syndrome T cell deficiency [self.gutenberg.org]

Neutrophil Immunodeficiency Syndrome

cell deficiency Post-mortem diagnosis and mutation identification in recessive or X-linked SCID using parental DNA Confirmation of a clinical diagnosis Carrier testing in [genedx.com]

The most common form of this disorder is selective IgA deficiency. T-cell deficiency disorders: 1. [telepathology.com]

However, patients with intact T-cell function or partial T-cell deficiencies (eg, Wiskott-Aldrich syndrome, combined immunodeficiency with inadequate but not absent T-cell [merckmanuals.com]

Transient Hypogammaglobulinemia of Infancy

Our results indicate that a numerical, as well as a functional, deficiency in helper T cells underlies the deficiency in IgG production in transient hypogammaglobulinemia [ncbi.nlm.nih.gov]

A confirmed diagnosis shows a deficiency of CD40 ligands on T cells. [hawaii.edu]

Experiments with cultured lymphocytes indicated that excess suppressor-cell activity was not present in these patients, but that their T cells were deficient in providing [ncbi.nlm.nih.gov]

Immunodeficiency

T-cell deficiency T-cell enumeration using flow cytometry and monoclonal antibodies§ Lymphopenia, suspected SCID or complete DiGeorge syndrome Interpretation varies by molecular [merckmanuals.com]

They can be broadly classified into six groups based on the part of the immune system that's affected: B cell (antibody) deficiencies T cell deficiencies Combination B and [mayoclinic.org]

[…] patients with abscesses and pneumatoceles (hyper-IgE syndrome), partial T-cell deficiencies, allergic disorders, or parasitic infections. [merckmanuals.com]

Vitamin D Deficiency

These allergic conditions are dependent on T-helper type 2 (Th2) cells secreting interleukins, overproduction of immunoglobulin E (IgE), and eosinophil activation. [ncbi.nlm.nih.gov]

It does this by influencing T-regulatory (Th3) cells, which govern the expression and differentiation of Th1 and Th2 cells. [chriskresser.com]

A study published in the journal Nature Immunology further explains how vitamin D protects us by properly activating T cells, an important part of the immune system: “When [thehealthyhomeeconomist.com]

Vaginal Candidiasis

It is believed that vaginal immunity is dependent on local and environmental factors (such as micobicidal peptides, pH etc) far more than on T&B cell immunity and is therefore [aaaai.org]

Romani L (1997) The T cell response against fungal infections. Curr Opin Immunol 9(4): 484-490. [medcraveonline.com]

[…] not seen as a sign of systemic immune deficiency. [aaaai.org]

Vitamin B12 Deficiency

Vitamin B- 12 deficiency anemia is a condition in which your body doesn' t have enough healthy red blood cells because of a lack of vitamin B- 12. [duqoboyuhac.tk]

Like vitamin B- 12 deficiency or anemia, or even celiac disease. [duqoboyuhac.tk]

Thymic Aplasia

Therefore, infections characteristic of T-cell deficiency are rare in these indi-viduals. [brainkart.com]

T cell deficiencies include: DiGeorge syndrome, Wiskott Aldrich syndrome, and the acquired immunodeficiency syndrome. [clinlabnavigator.com]

cell deficiency due to thymic aplasia leading to recurrent viral/fungal infections absent thymic shadow on CXR congenital heart and great vessel defects autoimmunity syndromes [medbullets.com]

Adenovirus Infection

Truly disseminated adenovirus disease is rare and appears to be limited to patients with severe combined T and B cell deficiency. [ncbi.nlm.nih.gov]

Assessment of the child's immune system revealed T-cell subset abnormalities consistent with DiGeorge syndrome. [ncbi.nlm.nih.gov]

A possible link between the underlying immune deficiency and the observed complication is suggested. [ncbi.nlm.nih.gov]

Hypersensitivity

Consequently the infant has either no mature T cells or very few. [britannica.com]

Nakae S, Komiyama Y, Nambu A, et al. (2002) Antigen‐specific T cell sensitization is impaired in IL‐17‐deficient mice, causing suppression of allergic cellular and humoral [els.net]

T cells that react against these antigens then attack the B cells, and a temporary deficiency in the production of new antibodies lasts until the overt viral infection has [britannica.com]

X-Linked Severe Combined Immunodeficiency

in addition to T-cell status (T –, because there is always a T-cell deficiency in SCID). [emedicine.medscape.com]

Classically, this disease is characterised by an absence of T and NK cells, and near normal numbers of functionally deficient B cells (B( ), T(-), NK(-) phenotype). [ncbi.nlm.nih.gov]

Additionally, a deficiency of CD3δ, a component of the T-cell antigen receptor, results in a near absence of circulating mature CD3 T cells and a complete lack of γ/δ T cells [doi.org]

Autosomal Agammaglobulinemia

[…] failure of T cells to develop What step is blocked in SCID (MHC-II deficiency)?Activation of CD4 T cells Immune deficiencies w/ decreased production of-- B-cells? [memorize.com]

B and T cells usually remain normal. Chronic Mucocutaneous Candidiasis Immune deficiency T-Cell Deficiency T-Cell deficiency specific to Candida. [kumc.edu]

[…] and T-cell defects ( 30) Severe combined immunodeficiency X-linked One case per 100,000 to 500,000 persons Males T-cell deficient, B-cell competent Autosomal recessive Both [aafp.org]

Iron Deficiency

Observational studies have shown that iron-deficient individuals have defective immune function, particularly T-cell immunity, but more evidence is required. [ncbi.nlm.nih.gov]

Micronutrient deficiency suppresses immune functions by affecting the innate T-cell-mediated immune response and adaptive antibody response, and leads to dysregulation of [doi.org]

However, to avoid iron overload and T-cell activation, it seems that recipients of cardiac transplantations should not be treated with intravenous iron preparations. [nature.com]

Cernunnos-XLF Deficiency

Finally, T-cell deficiency may be progressive with age and not readily apparent at birth or in the first months of life. [aacc.org]

INCLUDED, SCID, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-POSITIVE, AND SENSITIVITY TO IONIZING RADIATION DUE TO NHEJ1 DEFICIENCY, INCLUDED, SCID, AUTOSOMAL [mousephenotype.org]

Both B and T cells are affected. The phenotype is T–B–NK–. ADA deficiency is an autosomal recessive disorder in which the age at presentation varies. [emedicine.medscape.com]

Adenosine Deaminase Deficiency

ADA follows PNP in purine nucleoside catabolism, but deficiency in this enzyme causes even more severe symptoms than PNP deficiency, which is a T cell deficiency. [structure.bmc.lu.se]

[…] results in combined bone marrow-derived (B)- and thymus derived (T)-lymphocyte deficiency, PNP-deficient patients exhibit T- cell dysfunction with normal B lymphocyte function [slideshare.net]

T cell lines. [karger.com]

Immunodeficiency due to MASP-2 Deficiency

35876373 GRCh38: Chr5:35876271 IL7R Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive, Severe Combined Immune Deficiency [ncbi.nlm.nih.gov]

T-B severe combined immunodeficiency due to JAK3 deficiency T-B severe combined immunodeficiency due to gamma chain deficiency T-B- severe combined immunodeficiency T-cell [se-atlas.de]

T-cell disorders also cause Ig deficiencies because the B- and T-cell immune systems are interdependent. [merckmanuals.com]

Anemia

The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients. [medscape.com]

HIV-1 Associated Vacuolar Myelopathy Lyme Disease Multiple Sclerosis Neurosyphilis Toxic Neuropathy Tropical Myeloneuropathies Other Problems to be Considered: Human T-cell [web.archive.org]

Piriyakhuntorn P, Tantiworawit A, Rattanathammethee T, Chai-Adisaksopha C, Rattarittamrong E, Norasetthada L. [medscape.com]

Viral Disease

Human immunodeficiency virus (HIV) is a virus that affects certain types of T cells of the immune system. [onhealth.com]

Progression of the infection decreases the body's ability to fight disease and infection, leading to acquired immune deficiency syndrome ( AIDS ). [onhealth.com]