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38 Possible Causes for T2-Signal Abnormalities in the Deep White Matter

  • Migrainous Stroke

    These are distinguished predominantly on history, although recent 3 T work 1 suggest that there is increased T2 signal in the cortex overlying white matter abnormalities as[] MRI may demonstrate T2 hyperintensities in the white matter of the centrum semiovale, not dissimilar to small vessel deep white matter ischemic change.[] […] well as in the brainstem 1 : migraine with aura: 8.1% migraine without aura: 2.2% controls: 0.7% For MRI appearances consider: stroke chronic small vessel deep white matter[]

  • Pilomyxoid Astrocytoma

    On MR, highly homogenous T2 signal intensity, extension of T2 signal abnormality into deep white matter as well as grey matter along with cerebrospinal fluid (CSF) dissemination[] It also may have cystic degeneration, necrosis or hemorrhage inside the lesion and signal of abnormality in T2 in adjacent deep white and gray matter (5-7).[] In magnetic resonance imaging studies, the pilomyxoid astrocytoma is often presented as a predominant solid mass with cystic interposed areas, hyperintense signal on T2, T1[]

  • Alexander Disease

    matter of the frontal lobes. b T2-weighted image shows areas of high signal intensity and cystic formation in the white matter of the frontal lobes, and significant deep[] Figure 3 Magnetic resonance imaging at 5 years, 4 months. a T2-weighted image shows increase in abnormal signals in the frontal lobe and volume loss in bilateral white matter[] […] and deep gray matter. b T2-weighted image demonstrates an increase in abnormal signals in the medulla oblongata. c Fluid attenuated inversion recovery image shows swelling[]

  • Morphea

    white matter, predominantly on the right side.[] B, Coronal T2 image reveals high signal in the corona radiata and deep white matter (black arrows), as well as the defect in the scalp tissues corresponding to her morphea[] FIGURE 1 A, Axial T2 fluid attenuation inversion recovery (FLAIR) image reveals abnormal high signal in the anterior internal capsule, right corona radiata, and periventricular[]

  • Hypomyelination - Congenital Cataract

    Radiological manifestations Cortical grey matter Deep grey matter White matter • Sulcal enlargement. • Cortical thinning. • Cortical abnormal T2 bright signal. • Basal ganglia[] MR imaging studies consistently revealed diffusely elevated T2 signal intensity of the supratentorial white matter, associated with preservation of both cortical and deep[] Cortical grey matter • Dementia (early stage). • Chorea. Deep grey • Athetosis. matter • Dystonia. White matter • Spasticity. • Hyper-reflexia. • Ataxia. 4.[]

  • Macrocephaly

    There is also a focal area of signal abnormality within the deep white matter of the right frontal lobe measuring 6x8 mm in size. Visible on T2 weighted imaging.[] This has corresponding T1 signal hypointensity which would suggest a focus of encephalomalacia. This is also non-specific. There is no evidence of migrational anomaly.[]

  • Niemann-Pick Disease Type C

    MRI Reported abnormalities include: cerebral (particularly frontal lobe) and cerebellar atrophy 2-3 . white matter high T2 signal, particularly parieto-occipital periventricular[] […] regions 3 deep grey matter and hippocampal atrophy (reported in adult-onset patient) 4 reduced midbrain to pons ratio (not as marked as in progressive supranuclear palsy[]

  • Marchiafava Bignami Disease

    Acute pontine myelinolysis presents with abnormal T2 signal intensity in the base of the pons, and when extrapontine lesions are present, they generally involve the deep gray[] matter structures that are surrounded by white matter such as the basal ganglia ( 12, 16 ).[]

  • Herpes Simplex Encephalitis

    The basal ganglia and deep white matter were spared. Figure 2.[] Confluent insular haemorrhage was visible on susceptibility-weighted sequences with parenchymal enhancement in areas of signal abnormality ( Figures 3 and 4 ).[] Axial T2 sequence (left) at the time of acute admission identifies T2 hyperintense parenchymal oedema with mild associated mass effect in the left insular region.[]

  • Degenerative Disorder

    MRI shows T2-hyperintense signal changes in the frontal and parietal periventricular and deep white matter that are initially patchy and became confluent with time (Fig. 8[] […] in the periventricular and deep cerebral white matter. b, c T2-weighted axial image of the same patient show vascular lesions in the basal nuclei and thalami ( b, arrow )[] […] and signal abnormalities in the basis of the pons ( c, arrow ).[]

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