Tall-stature: Causes & Reasons

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Possible Causes for tall stature

Klinefelter Syndrome

These patients usually present with tall stature. We report a case of KS with short stature due to growth hormone deficiency. [ncbi.nlm.nih.gov]

Physical examination revealed tall stature, thin built, small testes size, and absence of beard and pubic hairs. [ncbi.nlm.nih.gov]

They tend to have tall stature and long legs and may have difficulties with speech and language development. [icd9data.com]

Marfan Syndrome

It is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and sublaxation of the lens A hereditary disorder [icd9data.com]

It is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens. [fpnotebook.com]

A nine-year-old girl was referred to our pediatric endocrinology clinic for tall stature. [ncbi.nlm.nih.gov]

Pneumothorax

Spontaneous pneumothorax Primary (idiopathic or simple pneumothorax) Ruptured subpleural apical blebs Risk factors Family history Male gender Asthenic body habitus (slim, tall [amboss.com]

Tall stature and low body mass index are also associated with higher rates of PSP. [web.archive.org]

stature) (e.g., in Marfan syndrome) Smoking: 90% of cases; up to 20-fold increase in risk (risk increases with cumulative number of cigarettes smoked) Homocystinuria Secondary [amboss.com]

Spontaneous Pneumothorax

Risk Factors See Primary Spontaneous Pneumothorax regarding body habitus Tall Stature Low BMI See Secondary causes above Tobacco Abuse Increases the risk of both primary and [fpnotebook.com]

Tall stature and low body mass index are also associated with higher rates of PSP. [karger.com]

(tall, thin) Familial pneumothorax Genetic disorders To elaborate, PSP is strongly related to smoking in both sexes; with the risk increasing by more than 20-fold in men [thoracicgroup.com]

Gigantism

This boy appears likely to have neurofibromatosis type 1 (NF1) which raises the question of subtle GH excess in NF1 patients with tall stature. [ncbi.nlm.nih.gov]

Most common causes of tall stature/growth acceleration Normal variant genetic tall stature Endocrine abnormalities Precocious puberty Hyperthyroidism Gigantism Exogenous obesity [doi.org]

Convert to ICD-10-CM : 253.0 converts approximately to: 2015/16 ICD-10-CM E22.0 Acromegaly and pituitary gigantism Approximate Synonyms Acromegaly Constitutional tall stature [icd9data.com]

Congenital Generalized Lipodystrophy Type 1

stature Increased body height 0000098 Triangular face Face with broad temples and narrow chin Triangular facial shape [ more ] 0000325 Umbilical hernia 0001537 Showing of [rarediseases.info.nih.gov]

0025128 Reduced intrathoracic adipose tissue 0003809 Reduced subcutaneous adipose tissue Reduced fat tissue below the skin 0003758 Splenomegaly Increased spleen size 0001744 Tall [rarediseases.info.nih.gov]

Luteinizing Hormone Deficiency

Signs and symptoms of excess GH In children (gigantism): Abnormally rapid growth Very tall stature Painful joints Excessive sweating. [innerbody.com]

Acromegaly

Convert to ICD-10-CM : 253.0 converts approximately to: 2015/16 ICD-10-CM E22.0 Acromegaly and pituitary gigantism Approximate Synonyms Acromegaly Constitutional tall stature [icd9data.com]

Carney complex Occasionally caused by ectopic secretion of GH-releasing hormone or GH secreted by lymphoma, hypothalamic tumor, bronchial carcinoid, or pancreatic tumor Tall [accessmedicine.mhmedical.com]

stature 2016 2017 2018 2019 Billable/Specific Code Applicable To Constitutional gigantism E34.4 ) constitutional tall stature ( ICD-10-CM Diagnosis Code E34.4 Constitutional [icd10data.com]

Congenital Generalized Lipodystrophy Type 2

stature and precocious development of genitals. [peertechz.com]

[…] characteristics of this syndrome are prominent superficial veins, muscle hypertrophy, hirsuitism, abundant curly scalp hair, voracious appetite, accelerated skeletal growth with tall [peertechz.com]

Klinefelter Syndrome with XY/XXY Mosaic

stature with eunuchoid features, and psychosocial morbidity. 1 3 How common is Klinefelter’s syndrome? [bmj.com]

They tend to have tall stature and long legs and may have difficulties with speech and language development. Gynecomastia may be present. [icd10data.com]

stature, and abnormal body proportions (long legs, short trunk). [genome.gov]

Marshall-Smith Syndrome

stature Increased body height 0000098 Thick eyebrow Bushy eyebrows Dense eyebrow Heavy eyebrows Prominent eyebrows Thick eyebrows [ more ] 0000574 Umbilical hernia 0001537 [rarediseases.info.nih.gov]

0009882 Short mandibular rami 0003778 Short philtrum 0000322 Short sternum 0000879 Sporadic No previous family history 0003745 Synophrys Monobrow Unibrow [ more ] 0000664 Tall [rarediseases.info.nih.gov]

Gigantism - Acromegaly

Publisher Full Text Tall stature: a difficult diagnosis? [unboundmedicine.com]

stature 2016 2017 2018 2019 Billable/Specific Code Applicable To Constitutional gigantism E34.4 ) constitutional tall stature ( ICD-10-CM Diagnosis Code E34.4 Constitutional [icd10data.com]

Convert to ICD-10-CM : 253.0 converts approximately to: 2015/16 ICD-10-CM E22.0 Acromegaly and pituitary gigantism Approximate Synonyms Acromegaly Constitutional tall stature [icd9data.com]

Sotos Syndrome

Constitutional tall stature Tall stature in childhood usually presents less initial concern than short stature because, at least in early childhood, being tall can be advantageous [childgrowthfoundation.org]

Her mother also had tall stature and a long narrow face. The baby and her mother were suspected of having familial SS. [ncbi.nlm.nih.gov]

Sotos syndrome, or cerebral gigantism, is a rare genetic condition characterized by tall stature, gigantism, dolichocephaly, advanced bone age and learning disability. [ncbi.nlm.nih.gov]

Familial Short Stature

Search terms included short stature, tall stature, and growth hormone. [aafp.org]

Evaluation of Children with Tall Stature Figure 3. Algorithm for the evaluation of children with tall stature. History. [aafp.org]

Tall stature Unusual tallness in girls--Some girls may grow unusually tall for their age if their parents are tall Precocious puberty--This growth disorder is characterized [childrensnational.org]

Straight Back Syndrome

An asymptomatic 45-year-old man was referred to our hospital for detailed evaluation of a systolic ejection murmur. The intensity of the murmur increased on deep expiration and decreased on deep inspiration, showing so-called reversed Rivero-Carvallo's sign. Using cardiac magnetic resonance imaging, we demonstrated[…] [ncbi.nlm.nih.gov]

SHOX-Related Short Stature

Describe when treatment is indicated for children with short and tall stature. [pedsinreview.aappublications.org]

The short stature arises from haploinsufficiency of the SHOX gene, whereas overdosage contributes to tall stature. [naturalheightgrowth.com]

Genet. (1997) [ Pubmed ] Short stature homeobox-containing gene duplication on the der(X) chromosome in a female with 45,X/46,X, der(X), gonadal dysgenesis, and tall stature [wikigenes.org]

Eunuchism

An exact parallel to the gelding referred to above can be found in the eunuch of the Orient. "The Biology, Physiology and Sociology of Reproduction" by Winfield S. Hall I have attendants for my harem, eunuchs enough to make an army. "The Temptation of St. Antony" by Gustave Flaubert Why, they travel abroad now[…] [finedictionary.com]

Distal Symphalangism

stature 33 HP:0000098 21 short 1st metacarpal 33 HP:0010034 22 broad foot 33 HP:0001769 23 single transverse palmar crease 33 HP:0000954 24 camptodactyly 60 Occasional (29 [malacards.org]

stature 32 HP:0000098 21 short 1st metacarpal 32 HP:0010034 22 broad foot 32 HP:0001769 23 single transverse palmar crease 32 HP:0000954 24 camptodactyly 59 Occasional (29 [malacards.org]

[…] creases 33 HP:0007598 17 abnormality of the distal phalanx of finger 60 Occasional (29-5%) 18 camptodactyly of finger 33 HP:0100490 19 short finger 60 Occasional (29-5%) 20 tall [malacards.org]

Chudley-Rozdilsky Syndrome

More on Disproportionate tall stature » Causes of Disproportionate tall stature Some of the causes of the condition may include: Causes of Disproportionate Tall Stature: 15q [familydiagnosis.com]

stature 0001519 Downslanted palpebral fissures Downward slanting of the opening between the eyelids 0000494 Facial palsy Bell's palsy 0010628 Hyperlordosis Prominent swayback [rarediseases.info.nih.gov]

More Causes of Disproportionate tall stature » Causes List for Disproportionate tall stature Possible causes of Disproportionate tall stature (or similar symptoms) may include [familydiagnosis.com]

Aromatase Deficiency

The GH deficiency (GHD) coexists paradoxically with tall stature, raising the question whether or not a true GHD is part of this rare syndrome. [ncbi.nlm.nih.gov]

The child presented with obesity, tall stature, delayed bone age, osteoporosis, hyperinsulinemia with acanthosis nigricans, and hypergonadotropic hypogonadism with cystic [ncbi.nlm.nih.gov]

Collectively, these men are reported to have undetectable estrogen; normal to high levels of testosterone and gonadotropins; tall stature with delayed skeletal maturation [ncbi.nlm.nih.gov]

Weaver Syndrome

However, tall stature is very common, reported in 90% of affected individuals. [zora.uzh.ch]

Clinical description WVS is an overgrowth disorder that covers a very wide clinical spectrum: some affected individuals have only tall stature while others have a classic [orpha.net]

Their father, apart from tall stature (206.5 cm) had normal hands and facies and no joint restrictions. [nature.com]

48,XXXY Syndrome

While often compared with 47,XXY/Klinefelter syndrome because of shared features including tall stature and hypergonadotropic hypogonadism, 48,XXYY, 48,XXXY and 49,XXXXY syndromes [durlingdigital.com]

stature;HP:0000144 Decreased fertility;HP:0000175 Cleft palate;HP:0000277 Abnormality of the mandible;HP:0000286 Epicanthus;HP:0000316 Hypertelorism;HP:0000324 Facial asymmetry [pediascape.org]

Treatment HP:0000003 Multicystic kidney dysplasia;HP:0000025 Functional abnormality of male internal genitalia;HP:0000028 Cryptorchidism;HP:0000046 Scrotal hypoplasia;HP:0000098 Tall [pediascape.org]

Congenital Malformation of the Inner Ear

stature / gigantism / growth acceleration [csbg.cnb.csic.es]

Tall stature) Acrocallosal syndrome (Tallness, Tall stature) Acromegaloid changes, cutis verticis gyrata and corneal leukoma ... ... [familydiagnosis.com]

stature - scoliosis - hearing loss Crouzon syndrome - acanthosis nigricans Hartsfield-Bixler-Demyer syndrome Hypochondroplasia Isolated brachycephaly Isolated cloverleaf [csbg.cnb.csic.es]

Trisomy X Syndrome

The common physical features of females with triple-X syndrome are having a tall stature, epicanthic folds, and poor muscle tone. [biology-online.org]

Triple X syndrome is typically associated with several features e.g small head, tall stature, delayed developmental milestones, premature ovarian failure, psychiatric disorders [mdsabstracts.org]

Tall stature as presenting symptom in a girl with triple X syndrome. J Pediatr Endocrinol Metab. 2003;16:233-235. Samango-Sprouse CA, Rogol A. [rarediseases.org]

17q11 Microdeletion Syndrome

[…] deletions frequently exhibit milder manifestations of NF1; Type-1 NF1 deletions were found to be disproportionately associated with facial dysmorphic features (90% of patients), tall [genatlas.medecine.univ-paris5.fr]

stature Associated Genes - Mouse Orthologs - Source OMIM:613675 (names, synonyms, disease associated genes), Orphanet (disease classes), HGNC, Ensembl, MGI (gene symbols, [mousephenotype.org]

tall stature (subject 7, height 2.9 SD at 4 years) and another had macrocephaly (subject 2). [nature.com]

XYY Syndrome

RESULTS: Clinical examination revealed a tall stature and severe acne, and endocrinological/metabolic assessment revealed insulin resistance. [ncbi.nlm.nih.gov]

A case of myotonic dystrophy with 47 XYY presented with tall stature and mental retardation. The patient was a 37-year-old male. [ncbi.nlm.nih.gov]

The slow development of cognitive and motor activities and tall stature is common in XYY patients. [ncbi.nlm.nih.gov]

Hypogonadism

stature, especially if the legs are disproportionately long, gynecomastia, small or soft testes, and a eunuchoid body habitus) Considerations in the physical examination [emedicine.medscape.com]

stature, reduced fertility, and development of breast tissue certain types of tumours certain types of autoimmune disorders. [yourhormones.info]

[…] of the extent of virilization Staging of puberty: Use the Tanner criteria for genitalia, pubic hair, and axillary hair Examination for signs of Klinefelter syndrome (eg, tall [emedicine.medscape.com]

46,XX Ovotesticular Disorder of Sex Development

We describe a girl in whom tall stature was a dominant feature. Case report: A girl was referred aged 15.6 years with primary amenorrhoea and slim build. [endocrine-abstracts.org]

Tall stature and gonadal dysgenesis in a non-mosaic girl 45,X. Horm Res Paediatr 2010;73:210–4. Google Scholar [degruyter.com]

hirsutism, severe acne ) Both males and females Childhood Tall stature Osteoporosis (e.g., fractures following minimal trauma) Mothers of affected children may experience [amboss.com]

48,XXYY Syndrome

It has similarities to 47, XXY Klinefelter's syndrome, with tall stature, micro-orchidism, hypergonadotropic hypogonadism and infertility in males. [ncbi.nlm.nih.gov]

The 48,XXYY syndrome is a form of hypergonadotropic hypogonadism, characterized by tall statures, aggressive behavior, mental retardation, and stasis changes reflecting vascular [ncbi.nlm.nih.gov]

Karyotyping should be considered in individuals presenting with tremor and a history of developmental delay, learning disabilities, tall stature, or microorchidism. [ncbi.nlm.nih.gov]

Disproportionate Short Stature - Ptosis - Valvular Heart Lesions

Search terms included short stature, tall stature, and growth hormone. [aafp.org]

Laryngomalacia Pulmonary arterial hypertension Hypertriglyceridemia Abnormality of the ribs Tachycardia Bilateral cryptorchidism Dyspnea Diabetes mellitus Disproportionate tall [mendelian.co]

CATSHL syndrome CATSHL syndrome stands for “camptodactyly, tall stature, and hearing loss.” [nature.com]