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308 Possible Causes for Tendon Xanthomas

  • Heterozygous Familial Hypercholesterolemia

    Sixty-two patients had positive physical examination findings for Achilles tendon xanthomas.[ajronline.org] Tendon xanthomas are cholesterol deposits on tendons that can be felt as bumps on the surface of the backs of the heels and fingers.[ahajournals.org] […] or arthralgias Unusual skin lesions, such as cutaneous xanthomas at birth or by early childhood (eg, planar xanthomas, tuberous xanthomas; later, tendon xanthomas) Corneal[emedicine.medscape.com]

  • Familial Hypercholesterolemia

    The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX.[ncbi.nlm.nih.gov] BACKGROUND AND AIMS: The effect of LDLc lowering with PCSK9 antibodies on tendon xanthomas (TX) is unknown.[ncbi.nlm.nih.gov] Achilles tendon xanthomas are rarely seen masses that are highly associated with hyperlipidemia.[ncbi.nlm.nih.gov]

  • Hypercholesterolemia

    Xanthomas are noted commonly on the Achilles tendons and metacarpal phalangeal extensor tendons of the hands.[emedicine.medscape.com] Achilles tendon thickening is the early characteristic of Achilles tendon xanthomas.[ncbi.nlm.nih.gov] Image of tendon xanthoma, a pathognomonic physical examination finding in patients with familial hypercholesterolemia. Figure.[jaoa.org]

  • Homozygous Familial Hypercholesterolemia

    The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis[ncbi.nlm.nih.gov] Xanthomas The high cholesterol level may result in the build-up of cholesterol deposits in the skin and tendons as well – xanthomas.[aoporphan.com] RESULTS: The index cases were 24-year-old identical twin sisters with long-standing tendon xanthomas and high low-density lipoprotein cholesterol (LDL-C 10 mmol/L) but no[ncbi.nlm.nih.gov]

  • Cerebrotendinous Xanthomatosis

    A physical examination revealed prominent Achilles tendon thickness and plantar xanthomas.[ncbi.nlm.nih.gov] It should be noted that up to 30% of patients with XCT do not present with tendon xanthomas, as in the case reported.[mdsabstracts.org] tendon xanthoma in family 3.[ncbi.nlm.nih.gov]

  • Sterol 27-Hydroxylase Deficiency

    […] levels may also be reduced or normal), neurological symptoms and tendon xanthomas.[symptoma.com] Tendon xanthomas may cause discomfort and interfere with tendon flexibility.[ghr.nlm.nih.gov] Verrips A, van Engelen BG, Wevers RA, van Geel BM, Cruysberg JR, van den Heuvel LP, Keyser A, Gabreels FJ (2000) Presence of diarrhea and absence of tendon xanthomas in patients[doi.org]

  • Familial Hyperlipidemia

    His physical exam is normal and there is no tendon xanthomas or corneal arcus. Familial hypercholesterolemia (FH) is suspected.[knowledge.statpearls.com] Image of tendon xanthoma, a pathognomonic physical examination finding in patients with familial hypercholesterolemia. Figure.[jaoa.org] Hypercholesterolemic individuals with FCH never have tendon xanthomas unless they have dysbetalipoproteinemia, whereas xanthomas are commonly observed in FH individuals.[clinicaladvisor.com]

  • Hyperlipoproteinemia Type 4

    Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[medicowesome.com] Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[acc.org] Familial hypercholesterolemia has the following characteristics: Severe elevation of LDL cholesterol above 260 mg% Tendon xanthomas Premature coronary heart disease Familial[news-medical.net]

  • Hyperlipoproteinemia

    Achilles tendon xanthomas are often associated with type II hyperlipoproteinemia, in which low-density lipoprotein derived from the circulation accumulates in the tendons.[ncbi.nlm.nih.gov] Abstract We describe an adult patient with type IIa hyperlipoproteinemia, presenting with Achilles tendon xanthomas, cataracts, dementia, ataxia, pyramidal tract signs, and[ncbi.nlm.nih.gov] Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[medicowesome.com]

  • Disorder of Lipid Metabolism

    Familial hypercholesterolaemia (FH), which may present with xanthelasma ( Fig 67.1 ), tendon xanthomas, severe hypercholesterolaemia and premature coronary heart disease,[clinicalgate.com] Corneal arcus is common, and tendon xanthomas involving the dorsum of the hands, elbows, knees, and especially the Achilles tendons are present in 75% of patients.[thoracickey.com] The buildup of fats leads to atherosclerosis, early coronary artery disease, abnormal red blood cells, and xanthomas on tendons.[merckmanuals.com]

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