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127 Possible Causes for Thalassemia, Unconjugated Bilirubin Increased

  • Thalassemia

    Such forms of thalassemia are typically classified as minor thalassemia.[] thalassemia .[] Clinical description The disease can be classified into clinical subtypes of increasing severity: silent alpha thalassemia, alpha thalassemia trait (or alpha thalassemia minor[]

  • Pyruvate Kinase Deficiency

    In Thailand, the most common cause of chronic hemolytic anemia is thalassemia hemoglobinopathy.[] Severe hypertriglyceridemia has been observed in infants with beta-thalassemia major, an association termed hypertriglyceridemia-thalassemia syndrome.[] […] the two brothers with a more severe phenotype coinherited also had G6PD deficiency, while both had microcytosis due to the homozygosity for the non-deletional form of α-thalassemia[]

  • Thrombotic Microangiopathy

    unconjugated bilirubin, increased LDH, decreased haptoglobin Negative Coombs test Creatinine, urea, to follow renal function ADAMSTS-13 gene, activity or inhibitor testing[] A 7-year-old female with β-thalassemia major developed TA-TMA-related acute kidney injury, severe hypertension, and seizures at 6 months after transplant.[] […] are required to control HSV infection. [9] Diagnosis [ edit ] CBC and blood film: decreased platelets and schistocytes PT, aPTT, fibrinogen: normal Markers of hemolysis: increased[]

  • Hereditary Elliptocytosis

    Symptoms of anemia: fatigue, dizziness (MOST PATIENTS HAVE NO ANEMIA) Jaundice : increased unconjugated bilirubin in the blood (due to hemolysis) will result in physical findings[] The clinical and hematological parameters of a patient described here, who inherited the genes of both hereditary elliptocytosis (HE) and beta-thalassemia, seem to reflect[] Gilbert syndrome is the most well-known alteration in bilirubin metabolism and is manifested by an increase in unconjugated bilirubin.[]

  • Crigler-Najjar Syndrome

    The serum unconjugated bilirubin increased in the proband from 156.4 micromol/L to 243.5 micromol/L after he started a low calorie intake, and it decreased to 51.8 micromol[] Clinically apparent jaundice is unusual in patients with beta-thalassemia major.[] […] concentration None Reduction Bile Usually pale: contains small amounts of unconjugated bilirubin Increased proportion of bilirubin monoglucoronide Prognosis Kernicterus Usually[]

  • Congenital Dyserythropoietic Anemia

    GS is typified by increased production of both unconjugated and monoconjugated bilirubin, which is more lithogenic.[] […] to investigate if children and adolescents with beta-thalassemia have obstructive sleep apnea.[] A beta-thalassemia trait inherited from the mother was demonstrated.[]

  • Hemoglobinemia

    In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin.[] What Is Thalassemia?[] unconjugated bilirubin and LDH or AST To confirm haemolysis * Decreased haptoglobin Features suggestive of intravascular haemolysis * Haemoglobinaemia * Haemoglobinuria *[]

  • Fetal Erythroblastosis

    The newborn will have increased unconjugated bilirubin levels, that are rapidly rising and manifesting as icterus during the first days of life.[] PubMed Google Scholar Whitney, J.B. and Popp, R.A.: Thalassemia. Alpha-thalassemia in laboratory mice. Amer. J. Pathol. 116 :523–525, 1984.[] In this case, the fetus has a hemoglobinopathy: alpha thalassemia major, leading to hydrops (the most common cause for hydrops in persons of Southeast Asian ancestry).[]

  • Hemolytic Anemia

    In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin.[] After a DNA test was performed, the patient was initially diagnosed as having alpha thalassemia.[] CHEMISTRY TESTS The destruction of red blood cells is characterized by increased unconjugated bilirubin, increased lactate dehydrogenase, and decreased haptoglobin levels.[]

  • Jaundice

    This can lead to an increase in both unconjugated and/or conjugated bilirubin levels.[] Causes include transfusion reactions, sickle cell anemia, thalassemia, and autoimmune disease. Large amounts of unconjugated bilirubin accumulate in the blood.[] Hemolytic anemia: This includes conditions such as sickle cell disease and thalassemia.[]

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