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127 Possible Causes for Thalassemia, Unconjugated Bilirubin Increased

  • Thalassemia

    Such forms of thalassemia are typically classified as minor thalassemia.[symptoma.com] thalassemia .[en.wikipedia.org] Clinical description The disease can be classified into clinical subtypes of increasing severity: silent alpha thalassemia, alpha thalassemia trait (or alpha thalassemia minor[orpha.net]

  • Pyruvate Kinase Deficiency

    In Thailand, the most common cause of chronic hemolytic anemia is thalassemia hemoglobinopathy.[ncbi.nlm.nih.gov] Severe hypertriglyceridemia has been observed in infants with beta-thalassemia major, an association termed hypertriglyceridemia-thalassemia syndrome.[ncbi.nlm.nih.gov] […] the two brothers with a more severe phenotype coinherited also had G6PD deficiency, while both had microcytosis due to the homozygosity for the non-deletional form of α-thalassemia[ncbi.nlm.nih.gov]

  • Thrombotic Microangiopathy

    unconjugated bilirubin, increased LDH, decreased haptoglobin Negative Coombs test Creatinine, urea, to follow renal function ADAMSTS-13 gene, activity or inhibitor testing[en.wikipedia.org] A 7-year-old female with β-thalassemia major developed TA-TMA-related acute kidney injury, severe hypertension, and seizures at 6 months after transplant.[ncbi.nlm.nih.gov] […] are required to control HSV infection. [9] Diagnosis [ edit ] CBC and blood film: decreased platelets and schistocytes PT, aPTT, fibrinogen: normal Markers of hemolysis: increased[en.wikipedia.org]

  • Hereditary Elliptocytosis

    Symptoms of anemia: fatigue, dizziness (MOST PATIENTS HAVE NO ANEMIA) Jaundice : increased unconjugated bilirubin in the blood (due to hemolysis) will result in physical findings[stepwards.com] The clinical and hematological parameters of a patient described here, who inherited the genes of both hereditary elliptocytosis (HE) and beta-thalassemia, seem to reflect[ncbi.nlm.nih.gov] Gilbert syndrome is the most well-known alteration in bilirubin metabolism and is manifested by an increase in unconjugated bilirubin.[bloodgenetics.com]

  • Crigler-Najjar Syndrome

    The serum unconjugated bilirubin increased in the proband from 156.4 micromol/L to 243.5 micromol/L after he started a low calorie intake, and it decreased to 51.8 micromol[ncbi.nlm.nih.gov] Clinically apparent jaundice is unusual in patients with beta-thalassemia major.[ncbi.nlm.nih.gov] […] concentration None Reduction Bile Usually pale: contains small amounts of unconjugated bilirubin Increased proportion of bilirubin monoglucoronide Prognosis Kernicterus Usually[criglernajjar.altervista.org]

  • Congenital Dyserythropoietic Anemia

    GS is typified by increased production of both unconjugated and monoconjugated bilirubin, which is more lithogenic.[ncbi.nlm.nih.gov] […] to investigate if children and adolescents with beta-thalassemia have obstructive sleep apnea.[ncbi.nlm.nih.gov] A beta-thalassemia trait inherited from the mother was demonstrated.[ncbi.nlm.nih.gov]

  • Hemoglobinemia

    In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin.[med-ed.virginia.edu] What Is Thalassemia?[emedicinehealth.com] unconjugated bilirubin and LDH or AST To confirm haemolysis * Decreased haptoglobin Features suggestive of intravascular haemolysis * Haemoglobinaemia * Haemoglobinuria *[freethesaurus.com]

  • Fetal Erythroblastosis

    The newborn will have increased unconjugated bilirubin levels, that are rapidly rising and manifesting as icterus during the first days of life.[symptoma.com] PubMed Google Scholar Whitney, J.B. and Popp, R.A.: Thalassemia. Alpha-thalassemia in laboratory mice. Amer. J. Pathol. 116 :523–525, 1984.[link.springer.com] In this case, the fetus has a hemoglobinopathy: alpha thalassemia major, leading to hydrops (the most common cause for hydrops in persons of Southeast Asian ancestry).[library.med.utah.edu]

  • Hemolytic Anemia

    In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin.[med-ed.virginia.edu] After a DNA test was performed, the patient was initially diagnosed as having alpha thalassemia.[ncbi.nlm.nih.gov] CHEMISTRY TESTS The destruction of red blood cells is characterized by increased unconjugated bilirubin, increased lactate dehydrogenase, and decreased haptoglobin levels.[aafp.org]

  • Jaundice

    This can lead to an increase in both unconjugated and/or conjugated bilirubin levels.[medicinenet.com] Causes include transfusion reactions, sickle cell anemia, thalassemia, and autoimmune disease. Large amounts of unconjugated bilirubin accumulate in the blood.[medcomic.com] Hemolytic anemia: This includes conditions such as sickle cell disease and thalassemia.[medbroadcast.com]

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