Thiamine Decreased: Causes & Reasons

Possible Causes for Thiamine Decreased

Thiamine treatment decreased the serum concentrations of lactate and pyruvate in patient 2, but not patient 1. [ncbi.nlm.nih.gov]

Alcohol especially decreases the amount of thiamine diphosphate. [oapublishinglondon.com]

[…] intestinal thiamine absorption by 70%, decreasing serum levels of thiamine to between 30% and 98% below the lower level established for normal subjects. [web.archive.org]

Wernicke Encephalopathy

As the mechanism of Wernicke encephalopathy, we thought that decreased ability to store thiamine due to liver cirrhosis led to depletion of thiamine faster than had been expected [ncbi.nlm.nih.gov]

Other manifestations of thiamine deficiency involve the cardiovascular system (wet beriberi) and peripheral nervous system (nutritional polyneuropathy). [emedicine.medscape.com]

Thiamine deficiency → decreased cerebral glucose metabolism and mitochondrial dysfunction → depleted ATP and increased free radicals → injury of neuronal elements (e.g., myelin [amboss.com]

Beriberi

Daily needs for thiamine decrease when fat forms a large part of the diet and increase when the diet is high in carbohydrates. [health24.com]

(Etiology) Beriberi may be caused by the following factors: Decreased thiamine intake and decreased thiamine absorption by the body Chronic alcoholism Vertical transmission [dovemed.com]

[…] intestinal thiamine absorption by 70%, decreasing serum levels of thiamine to between 30% and 98% below the lower level established for normal subjects. [web.archive.org]

Cardiac Beriberi

Alcohol especially decreases the amount of thiamine diphosphate. [oapublishinglondon.com]

Cooking or processing any of the foods listed above decreases their thiamine content. [healthline.com]

The finding of decreased brain levels of thiamin pyrophophosphate (TPP) in the presence of normal levels of free thiamin and thiamin monophosphate (TMP) suggests that the [moyak.com]

Chronic Alcoholism

This means the number of thiamine transporters to bring thiamine into the enterocyte was decreased. [ebmconsult.com]

[…] of the liver, decreased intestinal absorption, impaired conversion of thiamine to its active form (thiamine pyrophosphate), and increased demand to metabolise the carbohydrates [bestpractice.bmj.com]

[…] transporter-1 (THTR-1) but not thiamine transporter-2 (THTR-2). [ebmconsult.com]

Leigh's Disease

Abstract A series of children with Leigh's disease had normal hepatic pyruvate carboxylase activity, increased cerebral thiamine diphosphate, and decreased cerebral thiamine [ncbi.nlm.nih.gov]

The use of coenzyme Q10, thiamine, and carnitine may cause a decrease in severity of symptoms in a few cases [6]. [hindawi.com]

[…] and, subsequently, decreased thiamine uptake by components of the respiratory complex of the mitochondria. [dovepress.com]

Secondary Malnutrition

Thiamin deficiency occurs because of decreased absorption as a result of the diuretic effect of alcohol and the utilization of thiamin in detoxifying alcohol.8 Opioids (Narcotics [todaysdietitian.com]

may be prevented with thiamine supplementation during intervention. [todaysdietitian.com]

Those who take in more than 30% of their total calories in alcohol generally have a significant decrease in their intake of all macronutrients and deficiencies in vitamin [todaysdietitian.com]

Water-Soluble Vitamin Deficiency

[…] by cigarette smoking, stressful injuries and oral contraceptives excessive doses can cause kidney stones and break down red blood cells VITAMIN B COMPLEX B1 - Thiamine energy [uen.org]

It is caused by poor food intake and by decreased absorption and increased excretion caused by alcohol consumption. [faqs.org]

[…] amounts of the other B vitamins (thiamine, riboflavin, niacin, vitamin B6). [nature.com]

Alcohol Abuse

RATIONALE: Low-income Coloured Western Cape communities in South Africa display high rates of problematic drinking, especially binge-drinking over weekends. Alcohol abuse in these communities is linked to the prevalence of intimate partner violence (IPV), fetal alcohol syndrome and sexual violence against women. Few[…] [ncbi.nlm.nih.gov]

Graves Disease

Graves disease is an autoimmune thyroid disorder characterized by hyperthyroidism, ophthalmopathy and goitre. The autoimmune process in Graves disease is influenced by a combination of environmental and genetic factors. The signs and symptoms of Graves' disease include insomnia, tremor, hyperactivity, hyperhidrosis,[…] [symptoma.com]

Fetal Malnutrition

Health Econ. 2017 Oct;26(10):1264-1277. doi: 10.1002/hec.3397. Epub 2016 Aug 19. Author information 1 School of Economics, Singapore Management University, Singapore. 2 Department of Economics, Ohio State University, Columbus, OH, USA. Abstract We report evidence of long-term adverse health impacts of fetal malnutrition[…] [ncbi.nlm.nih.gov]

Diphyllobothrium Latum Infection

Korean J Parasitol. 2012 Jun;50(2):143-6. doi: 10.3347/kjp.2012.50.2.143. Epub 2012 May 24. Author information 1 Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 158-710, Korea. Abstract Diphyllobothrium latum infections in 4 young Korean men detected from 2008 to 2012 are presented.[…] [ncbi.nlm.nih.gov]

Infantile Beriberi

Alcohol especially decreases the amount of thiamine diphosphate. [oapublishinglondon.com]

(Etiology) Beriberi may be caused by the following factors: Decreased thiamine intake and decreased thiamine absorption by the body Chronic alcoholism Vertical transmission [dovemed.com]

Alcohol and thiamine Alcohol consumption leads to thiamine deficiency by decreasing the transport of thiamine across the intestinal mucosa, impairing capacity of the liver [oapublishinglondon.com]

Dry Beriberi

The blood thiamine level on the 4th day of hospitalization decreased to 2.9 micrograms/dl. [pubmed.ncbi.nlm.nih.gov]

Wernicke-Korsakoff Syndrome

It is suggested that decreased alpha KGDH, rather than decreased PDHC constitutes 'the biochemical lesion' in thiamine deficiency encephalopathy first enunciated by Peters [ncbi.nlm.nih.gov]

Alcohol is known to decrease thiamine absorption by 40 percent and to result in decreased hepatic storage of the vitamin. [clinicaladvisor.com]

Thiamine deficiency → decreased cerebral glucose metabolism and mitochondrial dysfunction → depleted ATP and increased free radicals → injury of neuronal elements (e.g., myelin [amboss.com]

CoQ-Responsive OXPHOS Deficiency

In contrast, free-thiamine was slightly decreased in 15.2% of patients with other neurological conditions, and above the reference range in one SLC19A3 patient on thiamine [pesquisa.bvsalud.org]

Free-thiamine was remarkably reduced in the cerebrospinal fluid of five SLC19A3 patients before treatment. [pesquisa.bvsalud.org]

Korsakoff Syndrome

[…] from the gut, impairment of storage by the liver, thiamine transport problems, other nutritional deficiencies, decreased phosphorylation to thiamine pyrophosphate and excessive [cochranelibrary.com]

[…] deficiency through several potential mechanisms－genetic predisposition, replacement of vitamin‐containing foods by the high calorific value of alcohol, impaired absorption of thiamine [cochranelibrary.com]

Alcoholic Neuropathy

Thiamine deficiency is commonly found in alcoholic patients, due to decreased absorption and hepatic depletion. [emedicine.medscape.com]

[…] alcohol metabolism and decreased sensory nerve action potentials in the affected group. [17] A study by Michalak et al found that although erythrocyte transketolase activity [emedicine.medscape.com]

In addition, alcohol interferes with intestinal absorption of thiamine, thereby further decreasing thiamine levels in the body. [en.wikipedia.org]

ADan Amyloidosis

All fresh Bario rice are high in thiamine (>0.42 mg/100 g) but aging significantly decreased the thiamine content. [myjurnal.my]

Significant increase in phosphorus and decrease in potassium in Bario Merah Sederhana and Bario Celum depend on the concentration of minerals in the bran of the coloured Bario [myjurnal.my]

Mitochondrial Complex 1 Deficiency Nuclear Type 27

[…] and, subsequently, decreased thiamine uptake by components of the respiratory complex of the mitochondria. [ncbi.nlm.nih.gov]

In their study, Gerards et al found a homozygous nonsense mutation in the thiamine transporter gene SLC19A3 (c.20 C>A).20 This mutation resulted in a premature stop codon [ncbi.nlm.nih.gov]

Mitochondrial Complex 1 Deficiency Nuclear Type 17

[…] and, subsequently, decreased thiamine uptake by components of the respiratory complex of the mitochondria. [ncbi.nlm.nih.gov]

In their study, Gerards et al found a homozygous nonsense mutation in the thiamine transporter gene SLC19A3 (c.20 C>A).20 This mutation resulted in a premature stop codon [ncbi.nlm.nih.gov]

Myocardial Tumor

Malnutrition & Vitamin Deficiency Thiamine deficiency (Beriberi) Diagnostic criteria: Presence of thiamine deficiency Decreased blood thiamine concentration Decreased ESR [slideshare.net]

Malnutrition & Vitamin Deficiency Thiamine deficiency (Beriberi) Diagnostic criteria: Clinical features Dependent edema Low peripheral vascular resistance, decreased minimum [slideshare.net]

Improvement after adequate thiamine therapy 47. [slideshare.net]

Mitochondrial DNA Depletion Syndrome Type 8

Because of removal of the husk through milling, polished white rice lacks thiamine.13 The incidence of beriberi in Asian countries has decreased since the initiation of thiamine [dovepress.com]

Ethanol also decreases phosphorylation of thiamine to its active form.15 Protracted vomiting of any cause increases the risk of WE. [dovepress.com]

Ethanol is toxic to the intestinal mucosa, decreasing thiamine absorption by up to 90%.55 Ethanol causes increased metabolic demand because it is converted to acetyl-CoA, [dovepress.com]

Mitochondrial Complex 1 Deficiency Nuclear Type 23

[…] and, subsequently, decreased thiamine uptake by components of the respiratory complex of the mitochondria. [ncbi.nlm.nih.gov]

In their study, Gerards et al found a homozygous nonsense mutation in the thiamine transporter gene SLC19A3 (c.20 C>A).20 This mutation resulted in a premature stop codon [ncbi.nlm.nih.gov]

Maple Syrup Urine Disease Mild Variant

These patients have decreased concentrations of BCKAs and/or BCAAs with thiamine therapy in varying dosages ranging from 10 to 1000 mg/day. [motherbabyuniversity.com]

[…] responsive Similar to intermediate or intermittent MSUD Decreased BCKA or BCAA with thiamine therapy 2–40 E3 deficiency Usually no neonatal symptoms, failure to thrive, hypotonia [jn.nutrition.org]

[…] of BCAA, plus dietary overload—20-fold excess of thiamine Prognosis Mortality was 100%, often due to intercurrent infection; with BCAA-free infant formulas, the survival [medical-dictionary.thefreedictionary.com]

Uremic Neuropathy

[…] deficiency, decreased transketolase activity, - thiamine deficiency, decreased transketolase activity, decreased biotin and zinc, hyperparathyroidism decreased biotin and [slideplayer.com]

[…] segmental demyelination - axonal degeneration -> segmental demyelination - most severe distally - most severe distally  Metabolic and chemical basis - elusive - elusive - thiamine [slideplayer.com]

Alcohol Dementia

Decreased absorption of thiamine from the gastrointestinal tract. Impaired thiamine utilisation in the cells. [patient.info]

Thiamine deficiency leads to decreased level of thiamine pyrophosphate in the brain. [gponline.com]

Both are caused by damaged parts of the brain due to a lack of vitamin B1 (thiamine). [dementia.org]

Intermittent Maple Syrup Urine Disease

Thiamin -responsive maple-syrup-urine disease : decreased affinity of the mutant branched-chain alpha-keto acid dehydrogenase for alpha-ketoisovalerate and thiamin pyrophosphate [wikigenes.org]

These patients have decreased concentrations of BCKAs and/or BCAAs with thiamine therapy in varying dosages ranging from 10 to 1000 mg/day. [motherbabyuniversity.com]

There is some evidence that supplemental thiamine might increase dietary BCAA tolerance or decrease plasma BCAA on a constant dietary intake in individuals with some branchedchain [raredisorders.imedpub.com]

Classic Maple Syrup Urine Disease

Thiamine-Responsive Type Thiamine-responsive MSUD is distinct in that people with this form of the disease are expected to show a decrease in symptoms when treated with large [counsyl.com]

[…] episodic ataxiaor lethargy, semicoma, or ketoacidosis precipitated by infection or stress; episodes can be fatal; usually normal intellect Normal BCAA when asymptomatic 5–20 Thiamine [jn.nutrition.org]

Alcoholic Cerebellar Degeneration

Thiamine levels are usually low in alcoholics due to their decreased nutritional intake. [en.wikipedia.org]

Nutritional deficiency with coexisting decrease in thiamine intake, vomiting or diarrhea are common in chronic alcoholism. 34 In malnourished individuals the ability of the [laeknabladid.is]

Erythrocyte transketolase activity (TPP effect) was markedly decreased in all five acute WE patients in whom the assay could be done prior to thiamine treatment. [academic.oup.com]