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308 Possible Causes for Thickened Aortic Valve

  • Mucopolysaccharidosis

    Autopsy showed thickened and stenotic aortic valve leaflets as well as marked concentric intimal thickening of the aorta and muscular arteries.[] After 4 months of treatment, partial inhibition of CtsB activity in treated mice reduced aortic dilatation, as well as heart valve thickening, and led to improvements in cardiac[] Left-sided valve leaflet thickening occurred in 26 patients (five with valve disease).[]

  • Mucopolysaccharidosis 1H

    Cardiopulmonary: Cardiopulmonary manifestations include aortic valve dysfunction and frequent upper and lower respiratory tract infections.[] The mitral valve was most commonly affected ( n  19), followed by the tricuspid ( n  7) and aortic ( n  3) valves.[] A common complication in these patients is carpal tunnel syndrome as a result of thickening of flexor retinaculum.[]

  • Larsen's Syndrome

    Prior echocardiography had revealed thickened aortic valve cusps. On examination, she was noted to have narrow ear canals, with grade 1 microtia.[]

  • Pulmonary Valve Stenosis

    Autopsy confirmed hydrops and showed thickened, fibrotic semilunar valves with stenosis. The myocardium was focally fibrotic with areas of calcification.[] We report a case of fatal hydrops fetalis owing to adenoviral endomyocarditis with aortic and pulmonary valve stenosis.[] A 1850-g macerated male stillborn delivered 1 week after fetal ultrasonography showed hydrops, cardiomegaly, and possible aortic valve stenosis.[]

  • Subacute Bacterial Endocarditis

    Emergency aortic valve replacement was necessary, and the aortic valve pathology showed diffusely fibrosed and thickened valve leaflets with bacterial vegetations.[] A 57 year old white man with aortic insufficiency and previously undiagnosed ankylosing spondylitis, who developed subacute bacterial endocarditis (SBE), is described.[]

  • Progeria

    Atherosclerotic dilated ascending aorta, thickened sclerotic aortic, mitral, and tricuspid valves with increased echo texture, left and right atrial and right ventricular[] […] dilatation, reduced left ventricular cavity, and thickened speckled atrial and ventricular septa were observed on echocardiography.[]

  • Fenfluramine

    The aortic valve was characterized by thickening and mild reaction to the leaflets.[] The aortic valve was characterized by thickening and mild retraction of the leaflets.[] […] mitral valve leaflet mobility restriction or thickening, elevated pulmonary artery systolic pressure, or abnormal left ventricular ejection fraction.[]

  • Subvalvular Aortic Stenosis

    Transthoracic echocardiography revealed a thickened aortic valve with pressure gradients and an estimated aortic valve area suggestive of mild aortic stenosis.[] In both cases, the aortic valves of were thickened and also markedly narrowed on one of them.[] In this case, the fibrous membrane adhered to the aortic valve and extended to the anterior leaflet of the mitral valve at one side.[]

  • Mucopolysaccharidosis 1 H-S

    CALIFORNIA LOCAL February 1, 2001 THOMAS H. MAUGH II, TIMES MEDICAL WRITER How much difference can one set of parents make when their child is diagnosed with a fatal genetic illness? In the case of Ryan Dant, all the difference in the world. Ryan was an apparently healthy 4-year-old undergoing a preschool physical[…][]

  • Rheumatic Heart Disease

    (WC) RHD - showing valvular thickening - aortic valve. (WC) Microscopic Features: [5] Caterpillar cells ( AKA Anitschkow cells) Abundant eosinophilic cytoplasm.[] Echocardiography evaluation showed thickened aortic and mitral valve leaflets with mild to moderate degree of mitral regurgitation.[] The mitral valve can be thickened, calcified, have restricted movement and the mitral valve leaflets fused together. The aortic valve may also be thickened .[]

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