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101 Possible Causes for Thickened Aortic Valve, Thickening of the Mitral Valve Leaflets

  • Mucopolysaccharidosis

    Autopsy showed thickened and stenotic aortic valve leaflets as well as marked concentric intimal thickening of the aorta and muscular arteries.[ncbi.nlm.nih.gov] After 4 months of treatment, partial inhibition of CtsB activity in treated mice reduced aortic dilatation, as well as heart valve thickening, and led to improvements in cardiac[ncbi.nlm.nih.gov] Left-sided valve leaflet thickening occurred in 26 patients (five with valve disease).[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 1 H-S

    […] disease with thickening and leaking of valves most commonly the mitral and aortic valves.[rarediseases.org] Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[ncbi.nlm.nih.gov] Aortic regurgitation is when the aortic valve becomes thickened and allows blood to flow backward from the aorta (which is the main artery of the body) into the left ventricle[rarediseases.org]

  • Mitral Valve Prolapse

    Similar changes were seen in the tricuspid valve. The pulmonary and aortic valves also showed myxomatous degeneration of their cusps.[ncbi.nlm.nih.gov] Two groups of patients were compared: those with thickening of the mitral-valve leaflets and redundancy (designated the classic form; n 319) and those without leaflet thickening[oadoi.org] The aortic valves were irregularly thickened along the length of the cusps primarily due to substantial expansion of the spongiosa.[ncbi.nlm.nih.gov]

  • Mitral Valve Stenosis

    Aortic sclerosis and stenosis: One in three elderly people have a heart murmur because of the scarring, thickening, or stiffening of their aortic valve.[webmd.com] Mitral stenosis is characterized by thickening and immobility of the mitral valve leaflets.[symptoma.com] It is a useful non-invasive tool, which helps doctors diagnose aortic valve disease. An echocardiogram can show a thickened, calcified aortic valve which opens poorly.[medicinenet.com]

  • Aortic Valve Disorder

    Aortic Valve, Mild Aortic Stenosis, Concentric LV Hypertrophy.[modernhomoeopathy.com] The inflammed leaflets thicken, fuse at the edges and calcify. The resulting mitral stenosis causes pressure in the left atrium to increase.[courses.washington.edu] In people over 70, the most common cause is thickening of the valve cusps (aortic sclerosis). People may have chest tightness, feel short of breath, or faint.[msdmanuals.com]

  • Libman-Sacks Disease

    The anterior leaflet of the mitral valve was thickened.[ahajournals.org] The 2D echo showed a decrease in aortic valve thickening and a reduction in the transvalvar doppler peak gradient to 52 mm Hg.[annalspc.com] Intraoperative inspection revealed thickened and fibrotic mitral valve leaflets with focal vegetations (Fig 3D,E ).[cardiothoracicsurgery.biomedcentral.com]

  • Rheumatic Aortic Valve Obstruction

    […] surface of the valve which, subsequent to aortic valvular osteoblast differentiation, calcifies. [1] Early in the disease process, the thickened aortic valve is said to be[emedicine.medscape.com] On two-dimensional echocardiography, rheumatic aortic valve stenosis is characterized by commissural fusion and thickening along leaflet edges.[wikiecho.org] valves The symptoms of aortic stenosis include: Fainting Coughing Severe chest pain Heart palpitations Shortness of breath Aortic valve sclerosis is defined as the thickening[gleneaglesglobalhospitals.com]

  • Subvalvular Aortic Stenosis

    Transthoracic echocardiography revealed a thickened aortic valve with pressure gradients and an estimated aortic valve area suggestive of mild aortic stenosis.[ncbi.nlm.nih.gov] In this case, the fibrous membrane adhered to the aortic valve and extended to the anterior leaflet of the mitral valve at one side.[ncbi.nlm.nih.gov] In both cases, the aortic valves of were thickened and also markedly narrowed on one of them.[ncbi.nlm.nih.gov]

  • Heart Valve Disease

    This results in generalized inflammation in the heart, this manifests in the mitral valve as vegetations, and thickening or fusion of the leaflets, leading to a severely compromised[en.wikipedia.org] Parasternal long-axis echocardiogram in a patient with severe aortic stenosis. The heavily thickened aortic valve is marked with a red arrow.[bjgp.org] The aortic valve is the most frequently affected. This build-up hardens and thickens the valve and can cause aortic stenosis, or narrowing of the aortic valve.[yourheartvalve.com]

  • Hypertrophic Cardiomyopathy

    This problem also occurs with aortic valve stenosis, in which the aortic valve becomes thickened and fails to open normally.[heartdisease.about.com] […] of an anomalous papillary muscle [arrow] onto the ventricular surface of the anterior mitral leaflet).[doi.org] Other possible causes of such thickening (e.g., aortic valve stenosis, high blood pressure, among others) should be ruled out. Another option is genetic testing.[emaxhealth.com]

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