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63 Possible Causes for Thickened Corpus Callosum

  • Macrocephaly

    Other findings included a high frequency of cavum septum pellucidum or vergae, thickened corpus callosum, prominent optic nerve sheaths and a single case of venous sinus thrombosis[ncbi.nlm.nih.gov] […] of the ipsilateral genu of the corpus callosum.[ncbi.nlm.nih.gov] […] et al [ 8 ] reported 3 neurologically normal adolescents who showed enlargement of the right frontal lobe with increased volume of subcortical and deep white matter and thickening[ncbi.nlm.nih.gov]

  • Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 3

    The MRI showed generalized, severe enlargement of the corpus callosum and thickening of the cortex.[doi.org] The presence of polydactyly and megalencephaly in our patient excluded the isolated symmetric perisylvian syndromes. 9 Regarding MPMCC, a thickened corpus callosum is an essential[ajnr.org] […] of the ipsilateral genu of the corpus callosum.[journals.lww.com]

  • Syndactyly - Polydactyly - Ear Lobe Syndrome

    The presence of polydactyly and megalencephaly in our patient excluded the isolated symmetric perisylvian syndromes. 9 Regarding MPMCC, a thickened corpus callosum is an essential[ajnr.org] callosum (MPMCC) syndrome, and macrocephaly-cutis-marmorata telangiectatica congenita syndrome (MCMTC).[ajnr.org] […] seizures should also be investigated on MR imaging because the differential would include the symmetric perisylvian polymicrogyria syndromes, megalencephaly-polymicrogyria-mega-corpus[ajnr.org]

  • Facial Hemiatrophy

    CT and MR findings included unilateral focal infarctions in the corpus callosum, diffuse deep and subcortical white matter signal changes, mild cortical thickening, and leptomeningeal[ncbi.nlm.nih.gov] Cerebral hemiatrophy, monoventricular enlargement, meningocortical dysmorphia, cortical thickening and dysgenesis, unilateral focal infarctions in the corpus callosum, diffuse[doi.org] […] deep and subcortical white matter signal changes, leptomeningeal thickening and enhancement, dense mineral depositions, aneurysms, and vascular malformations have been associated[doi.org]

  • Meckel Syndrome Type 7

    corpus callosum but no findings more typical of OFD1, such as intracerebral cysts, hydrocephalus, malformations of cortical development, agenesis of the corpus callosum,[hindawi.com] He had a brain MRI which showed mild T2/fluid attenuation inversion recovery (FLAIR) hyperintensities in the medial temporal lobes bilaterally as well as a mildly thickened[hindawi.com]

  • Lissencephaly

    MRI showed diffuse pachygyria, moderate thickening of the cortex, enlarged ventricles, agenesis of the corpus callosum and septum pellucidum.[ncbi.nlm.nih.gov] Key MRI findings consist of lissencephaly with a moderately thickened cerebral cortex and agenesis of the corpus callosum.[scielo.br] In the variants of classical lissencephaly, extra-cortical anomalies are also present (total or subtotal agenesis of the corpus callosum and/or cerebellar hypoplasia).[orpha.net]

  • Complex Cortical Dysplasia with other Brain Malformations 2

    Mutations in DYNC1H1 have been associated with peripheral neuropathy 20 and more recently with brain malformations, predominantly diffuse polymicrogyria with a thickened corpus[nejm.org] callosum. 21 However, a person with the same mutation as Participant PMG-17401 (R3344Q) also had posterior-predominant pachygyria. 21 These four new cases further support[nejm.org]

  • X-Linked Partial Corpus callosum Dysgenesis

    corpus callosum is hypoplastic but not absent.[pediatricneurologybriefs.com] Four patients had an unusual thickened appearance of the corpus callosum with dysplastic splenia and no colpocephaly.[ajnr.org] It is seen to involve the genu of the corpus callosum (single arrow in A-C).[ijri.org]

  • Cortical Dysplasia Complex with other Brain Malformations 3

    Mutations in DYNC1H1 have been associated with peripheral neuropathy 20 and more recently with brain malformations, predominantly diffuse polymicrogyria with a thickened corpus[nejm.org] callosum. 21 However, a person with the same mutation as Participant PMG-17401 (R3344Q) also had posterior-predominant pachygyria. 21 These four new cases further support[nejm.org]

  • Cortical Dysplasia Complex with other Brain Malformations 4

    Mutations in DYNC1H1 have been associated with peripheral neuropathy 20 and more recently with brain malformations, predominantly diffuse polymicrogyria with a thickened corpus[nejm.org] callosum. 21 However, a person with the same mutation as Participant PMG-17401 (R3344Q) also had posterior-predominant pachygyria. 21 These four new cases further support[nejm.org]

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