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207 Possible Causes for Thickening of the Glomerular Basement Membrane

  • Diabetic Nephropathy

    Examination of the glomerulus with electron microscopy revealed changes in the architecture of the podocytes and thickening of the glomerular basement membrane.[courses.washington.edu] Early in DN there is thickening of the glomerular basement membrane and as disease progresses mesangial expansion occurs, resulting in the loss of available filtration surface[diapedia.org] Percutaneous renal biopsy showed nodular glomerulosclerosis, mesangial matrix expansion, and thickening of glomerular basement membrane (GBM).[ncbi.nlm.nih.gov]

  • Nodular Glomerulosclerosis

    In all patients diagnosed with DGS by light microscopy, the glomerular basement membrane (GBM) was diffusely and markedly thickened, measuring 850 nm in thickness ( Figure[omicsonline.org] Diabetic glomerulosclerosis is characterized by thickening of glomerular basement membrane with increased permeability.[pathologyatlas.ro] […] of tubular basement membrane, tubular atrophy and interstitial fibrosis Isolated thickened glomerular basement membrane and proteinuria may be an early predictor of diabetic[pathologyoutlines.com]

  • Membranoproliferative Glomerulonephritis

    […] of the glomerular basement membrane. (1) MPGN was traditionally classified on electron microscopy findings into MPGN type I, II, and III.[wiredspace.wits.ac.za] Light microscopy shows glomerular basement membrane thickening and glomerular hypercellularity.[lecturio.com] […] of the glomerular basement membrane, consistent with type I MPGN.[jamanetwork.com]

  • Alport Syndrome

    The diagnosis depends on characteristic electron microscopy findings of a variably thickened and thinned glomerular basement membrane with lamellation and basket weaving.[ncbi.nlm.nih.gov] Kidney biopsy revealed a diffuse mesangial proliferation, and a focal thickening of the glomerular basement membrane was seen on electron microscopy.[ncbi.nlm.nih.gov]

  • Nail-Patella Syndrome

    Ultrastructural features of NPS including thickening of the glomerular basement membrane with electron-lucent areas were not found.[ncbi.nlm.nih.gov] Electron microscopy of a renal biopsy showed irregular thickening of the glomerular basement membrane.[ncbi.nlm.nih.gov] Electron microscopy revealed irregular thickening of the glomerular basement membrane with areas of rarefaction, giving rise to a pathognomonic ‘moth‐eaten’ appearance (Figure[ndt.oxfordjournals.org]

  • Glomerulonephritis

    There is proliferation of mesangial cells, an increase in mesangial matrix and thickening of the glomerular basement membrane.[patient.info] Light Microscopy shows diffuse thickening of the glomerular basement membrane. Immunofluorescence shows diffuse deposition of IgM and C3.[fastbleep.com] Membranous nephropathy Widespread thickening of the glomerular basement membrane occurs. Immunofluorescence reveals granular deposits of immunoglobulin and complement.[patient.info]

  • Idiopathic Membranous Glomerulonephritis

    Electron microscopic study also demonstrated thickening of glomerular basement membrane and increase of mesangial matrix as well as the presence of electron-dense deposits[ncbi.nlm.nih.gov] There is proliferation of mesangial cells, an increase in mesangial matrix and thickening of the glomerular basement membrane.[patient.info] MN is a non-inflammatory disease that is characterized by thickening of the glomerular basement membrane, subepithelial immune complex deposits, and granular staining for[clinicaladvisor.com]

  • Membranous Glomerulonephritis

    On light microscopy, SMGN showed segmental thickening of the glomerular basement membrane, with spike formation, whereas GMGN showed global lesions.[ncbi.nlm.nih.gov] Light microscopy revealed thickened glomerular basement membrane and mildly proliferative mesangial cells. Acute tubulointerstitial injury occurred in three patients.[doi.org] (A) Thickened glomerular basement membrane, as well as subepithelial fuchsinophilic deposits along the epithelium. Patient no. 2 (PASM staining; magnification, 400).[doi.org]

  • Chronic Nephritis

    Nephrotic syndrome without hematuria was noticed at age 2, although renal biopsy at age 4 revealed widespread irregular thickening of the glomerular basement membrane with[karger.com] It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.[icd10data.com] […] of the glomerular and tubular basement membranes occur, with multilamination of the lamina densa in a focal or local distribution (basket-weave pattern).[merckmanuals.com]

  • Diabetic Enteropathy

    […] nodules diffuse glomerular sclerosis basement membrane thickening progressive proteinuria as a result of an increased GFR screen for microalbuminuria if protein comes up[medbullets.com] […] of the glomerular basement membrane nodular glomerular sclerosis - hyaline deposited in glomerulus -- this is pathognomonic for a diagnosis of diabetes Kimmelstiel-Wilson[medbullets.com] […] the leading cause of death in diabetic patients Peripheral vascular disease (PVD) Stroke Microvascular complication nephropathy arteriosclerosis leading to hypertension thickening[medbullets.com]

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