Thin Cerebral Cortex: Causes & Reasons

Possible Causes for Thin Cerebral Cortex

Autosomal Recessive Non-Syndromic Hydrocephalus

This accumulation causes macrocephaly, seizures, decreased IQ, and brain malformations such as thinning of the cerebral cortex and a simplified gyration pattern. [cags.org.ae]

In very severe cases, where the cerebral cortex is thinned, transillumination of the cranial cavity may be possible. [clinicalgate.com]

Lissencephaly 4 with Microcephaly

(a) Axial US image of a 39-week fetus shows marked dilatation of the ventricles (V) and marked thinning of the cerebral cortex. [pubs.rsna.org]

Bilateral Polymicrogyria

BGP tends to show excessively folded and fused gyri of an abnormally thin cerebral cortex, and an absence of the normal six-layered structure. [en.wikipedia.org]

cortex, which in normal patients is six cell layers thick, is also thinned. [en.wikipedia.org]

As mentioned prior, the MRI of an affected patient shows what appears to be a thickening of the cerebral cortex because of the tiny folds that aggregate causing a more dense [en.wikipedia.org]

Cerebral Cortical Atrophy

[…] of the cerebral cortex in areas of the brain involved in early Alzheimer's disease at the beginning of the study, compared with those who didn’t develop Alzheimer’s. [webmd.com]

We also measured the fractal dimension (complexity) of the human cerebral cortex in 3D (as in ref. 6 ), and compared surface complexity for AIDS patients vs. controls, by [pnas.org]

Cortical atrophy Several studies have shown that in MS patients there is both diffuse cortical atrophy and focal thinning of the cerebral cortex. [smw.ch]

Galloway-Mowat Syndrome Type 8

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [frontiersin.org]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [frontiersin.org]

Temporal Lobe Disorder

Thinning of the cerebral cortex in aging. Cereb. Cortex 14, 721–730 (2004). 5. Sowell, E. R. et al. Mapping cortical change across the human life span. Nat. [nature.com]

High consistency of regional cortical thinning in aging across multiple samples. Cereb. Cortex 19, 2001–2012 (2009). 4. Salat, D. H. et al. [nature.com]

which showed widespread thinning across the entire cortex. 3 In response, we would like to highlight a number of factors that could have contributed to the seemingly more [nature.com]

Delleman Syndrome

Delleman syndrome is diagnosed through magnetic resonance imaging (MRI) which may show hydrocephaly with a thin cerebral cortex and misshapen ventricles. [cags.org.ae]

Complex Cortical Dysplasia with other Brain Malformations Type 7

BGP tends to show excessively folded and fused gyri of an abnormally thin cerebral cortex, and an absence of the normal six-layered structure. [ipfs.io]

cortex, which in normal patients is six cell layers thick, is also thinned. [en.wikipedia.org]

[…] dysgenetic anterior limbs of the capsula interna and a distortion of the striatum (R > L) and mild dysgyria of the cerebral cortex (Fig. 1E and F). [ejpn-journal.com]

Deficiency of Sulfite Oxidase

Brain MRI (FLAIR): diffuse hyperintensity in basal ganglia and cystic formations in white matter, thinned cerebral cortex. and poor suck, search and moro absent, normotensive [docksci.com]

cerebral cortex (Fig. 1); brain MRI Diffusion: restricted diffusion in basal ganglia and corticomedullary junctions (Fig. 2). [docksci.com]

[…] test (40 mgr/l); EEG: it was observed burst-suppression pattern; the brain MRI FLAIR showed diffuse hyperintensity in basal ganglia and cystic formations in white matter, thinned [docksci.com]

Bilateral Temporo-Occipital Polymicrogyria

Pathologic examination in one case revealed a diffusely thin and excessively folded cerebral cortex lacking normal six-layered architecture. [n.neurology.org]

BGP tends to show excessively folded and fused gyri of an abnormally thin cerebral cortex, and an absence of the normal six-layered structure. [en.wikipedia.org]

cortex is in fact abnormally thin and has abnormal lamination; typically the cortex is unlayered or has four layers, in contrast to the normal six layers. [ipfs.io]

Polymicrogyria

Microscopic examination reveals an unusually thin cerebral cortex with abnormal lamination. [symptoma.com]

BGP tends to show excessively folded and fused gyri of an abnormally thin cerebral cortex, and an absence of the normal six-layered structure. [en.wikipedia.org]

Pathology findings in one case showed an abnormally thin cerebral cortex with excessively folded and fused gyri and an absence of the usual six layered architecture. 32 BGP [doi.org]

Fowler Syndrome

Imaging of the brain showed calcifications, profound ventriculomegaly with only a thin edging of the cerebral cortex and hypoplastic cerebellum. [ncbi.nlm.nih.gov]

Glomeruloid vascular proliferation (cerebral cortex, cerebellum, brain stem). 46XX 4 21 wks Intrauterine death Cortical thinning, hydranencephaly. [ncbi.nlm.nih.gov]

Glomeruloid vascular proliferation (cerebral cortex, cerebellum, brain stem). Joint contractures upper and lower limbs. Not undertaken. [ncbi.nlm.nih.gov]

Alobar Holoprosencephaly

Figure 1: Transfontanelle sonogram (coronal view) showing a monoventricle (down arrow) and fused thalami (upward arrow), and thin mantle of the cerebral cortex (left arrow [mdcan-uath.org]

Moreover, alobar HPE must be distinguished from hydranencephaly, the presence of the fused thalami of a dorsal sac, and the evidence of a very thin cerebral cortex may establish [journals.lww.com]

Click here to view Cranial computerized tomography (CT) showed a large hypodense monoventricle, fused thalami, severe thinning of the cerebral cortex, as well as absent [mdcan-uath.org]

Galloway-Mowat Syndrome Type 5

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [frontiersin.org]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [frontiersin.org]

Galloway-Mowat Syndrome Type 3

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [ncbi.nlm.nih.gov]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [ncbi.nlm.nih.gov]

Galloway-Mowat Syndrome Type 1

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [frontiersin.org]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [frontiersin.org]

Galloway-Mowat Syndrome Type 7

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [frontiersin.org]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [frontiersin.org]

Hereditary Cerebellar Degeneration

Conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex (the thin layer of cells [rarediseases.info.nih.gov]

Acquired Porencephaly

When a pair of symmetric cavities are very large, they may leave only a thin arch of cerebral cortex running front to back over the top of the brain like a basket handle, [encyclopedia.com]

cerebral cortex and are better demonstrated by MRI than with other studies. [emedicine.medscape.com]

Homolateral absence of the sylvian vasculature, small medullary pyramids, a low position of the fornix, and thinning of the corpus callosum are findings related to absent [emedicine.medscape.com]

Galloway-Mowat Syndrome Type 6

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [frontiersin.org]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [frontiersin.org]

Primary Lateral Sclerosis

It occurs when nerve cells in the motor regions of the cerebral cortex (the thin layer of cells covering the brain which is responsible for most higher level mental functions [malacards.org]

Thinning of the cerebral cortex in aging. Cereb Cortex 2004 ; 14 : 721 –30 ↵ Fischl B, Dale AM. [ajnr.org]

Focal thinning of the cerebral cortex in multiple sclerosis. Brain 2003 ; 126 : 1734 –44 ↵ Rosas HD, Hevelone ND, Zaleta AK, et al. [ajnr.org]

Galloway-Mowat Syndrome Type 4

cerebral cortex, gyral abnormalities, a dilation of both lateral ventricles and an enlarged extracranial space. [frontiersin.org]

At 14 days of age, cranial magnetic resonance imaging (MRI) revealed periventricular leukomalacia, hypomyelination, abnormal intensity signal in the cerebral lobes, a thin [frontiersin.org]

Complex Cortical Dysplasia with other Brain Malformations Type 2

When the deep layers of the cerebral cortex form numerous small gyri instead of organized cortical layers, the imaging result appears to be thickening or thinning of the cerebral [appliedradiology.com]

“Double cortex” appearance. 9. Heterotopias  Group of neurons is an inappropriate location – either below or above the cerebral cortex. 10. [slideshare.net]

Between the band heterotopia and the cortex is a thin layer of myelinated white matter (arrows, a,b). There is poor, irregular sulcation of the cerebral cortex. [mrineonatalbrain.com]

Complex Cortical Dysplasia with other Brain Malformations Type 3

“Double cortex” appearance. 9. Heterotopias  Group of neurons is an inappropriate location – either below or above the cerebral cortex. 10. [slideshare.net]

Between the band heterotopia and the cortex is a thin layer of myelinated white matter (arrows, a,b). There is poor, irregular sulcation of the cerebral cortex. [mrineonatalbrain.com]

Congenital Cystic Eyeball

Thin cerebral cortex with enlarged ventricles and hydrocephalus. The cerebral cortex is the thin layer of cells that covers the brain. [marchofdimes.org]

Aqueduct of Sylvius Anomaly

cerebral cortex, which usually has high T2 signal on MR (Figure 20). 9 Heterotopia Heterotopia (singular: heterotopion ) are abnormal anatomic locations of cortical grey [appliedradiology.com]

cortex are organized. [appliedradiology.com]

Microcephaly with Spastic Quadriplegia

cerebral cortex, simplified gyral pattern, global brain atrophy, delayed myelination, hypoplastic cerebellum and pons Microcephaly, smooth thin cerebral cortex, simplified [bmcneurol.biomedcentral.com]

Suppression burst Abnormal background activity bilaterally, low amplitude and frequent interictal multifocal spike Multiple independent spike foci MRI Brain Microcephaly, smooth thin [bmcneurol.biomedcentral.com]

Juvenile Primary Lateral Sclerosis

It occurs when nerve cells in the motor regions of the cerebral cortex (the thin layer of cells covering the brain responsible for higher level mental functions) gradually [brainshospital.com]

Gorlin-Bushkell-Jensen Syndrome

A thin gray layer called the cerebral cortex covers the entire cerebrum and is composed of millions of cell bodies, which give it its gray color. [isrcg.org]

Oligohydramnios

A 35 weeks extremely growth retarded male baby showed enlarged ventricles, thinned out cerebral cortex, diffuse intra-cerebral as well as peri-ventricular calcification, cerebral [ncbi.nlm.nih.gov]