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1 Possible Causes for Thin Filament Shortening and Disorganization

  • Nemaline Myopathy

    Loss of LMOD3 in patient muscle resulted in shortening and disorganization of thin filaments.[ncbi.nlm.nih.gov] In all other patient biopsies we observed varying degrees of thin filament shortening and disorganization (patients 1a, 7, 12a, 14a; Supplemental Table 2).[doi.org] LMOD3 was expressed from early stages of muscle differentiation; localized to actin thin filaments, with enrichment near the pointed ends; and had strong actin filament-nucleating[ncbi.nlm.nih.gov]

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