Thoracolumbar Gibbus Deformity: Causes & Reasons

Possible Causes for Thoracolumbar Gibbus Deformity

During the most recent 3-month follow-up visit, the patient was found to have complete resolution of his gibbus deformity and no changes with his neurologic exam. [surgicalneurologyint.com]

Thoracolumbar kyphosis (or gibbus deformity) is a highly suggestive finding of MPS. [pubs.rsna.org]

Coarsening of facial features with increased body hair, thoracolumbar gibbus, and enlargement of the liver and spleen occur over the first few months leading to diagnosis [medicalhomeportal.org]

Mucopolysaccharidosis Type 6

[…] kyphosis or even gibbus deformity and odontoid dysplasia. [emedicine.medscape.com]

Thoracolumbar kyphosis (or gibbus deformity) is a highly suggestive finding of MPS. [pubs.rsna.org]

[…] abnormalities such as dysostosis multiplex, flattening and elongation (platyspondyly) of the vertebral bodies, and wedge-shaped vertebral bodies with anterior beaking, resulting thoracolumbar [emedicine.medscape.com]

Mucopolysaccharidosis Type 7

During the most recent 3-month follow-up visit, the patient was found to have complete resolution of his gibbus deformity and no changes with his neurologic exam. [surgicalneurologyint.com]

Both demonstrate severe gibbus deformity centered at L1 causing moderate to severe bony spinal canal stenosis On physical examination, the patient was noted to be alert and [surgicalneurologyint.com]

(a) MRI thoracolumbar spine, sagittal view. (b) CT thoracolumbar spine, sagittal view. [surgicalneurologyint.com]

Mucopolysaccharidosis Type 4A

Thoracolumbar kyphosis (or gibbus deformity) is a highly suggestive finding of MPS. [pubs.rsna.org]

Sagittal CT image shows thoracolumbar kyphosis (posterior gibbus) as the result of vertebral malformations. [pubs.rsna.org]

These abnormalities can lead to various deformities and deviations of the spinal axis, such as scoliosis and thoracolumbar kyphosis, which can reduce the caliber of the spinal [pubs.rsna.org]

Mucopolysaccharidosis Type 1 H

During the most recent 3-month follow-up visit, the patient was found to have complete resolution of his gibbus deformity and no changes with his neurologic exam. [surgicalneurologyint.com]

(a) MRI thoracolumbar spine, sagittal view. (b) CT thoracolumbar spine, sagittal view. [surgicalneurologyint.com]

Mucopolysaccharidosis Type 1

Coarsening of facial features with increased body hair, thoracolumbar gibbus, and enlargement of the liver and spleen occur over the first few months leading to diagnosis [medicalhomeportal.org]

[…] of the thoracolumbar spine 6 months -12 years Distinctive facial gestalt, with coarsening over time Hepatosplenomegaly Skeletal deformities Joint stiffness - especially distal [medicalhomeportal.org]

Within the first year, skeletal deformities, joint stiffness, and developmental delay may become apparent. [medicalhomeportal.org]

Mucopolysaccharidosis Type 2

Abstract The lysosomal storage disorder mucopolysaccharidosis type II (MPS II) is caused by a deficiency in the activity of the lysosomal exohydrolase iduronate-2-sulphatase (IDS). MPS II patients present within a spectrum of clinical phenotypes, which reflects the dynamic balance between the level of mutant protein,[…] [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 3

1NCT05134571 (ClinicalTrials.gov)October 28, 202121/10/2021A Phase 4, Single-arm, Open-label Safety and Efficacy Study of Aldurazyme® (Laronidase) as Enzyme Replacement Therapy in Participants With Mucopolysaccharidosis I (MPS I) in ChinaA Phase 4, Single-arm, Open-label Safety and Efficacy Study of Aldurazyme®[…] [ddrare.nibiohn.go.jp]

Mucopolysaccharidosis Type 4

Mucopolysaccharidosis IV NORD gratefully acknowledges Roland Rebuyon, NORD Editorial Intern from the University of Notre Dame, and Debra S. Regier, MD PhD, Director, Genetic and Genomic Education, Division of Genetics and Metabolism, Children's National Health System, for assistance in the preparation of this report.[…] [rarediseases.org]

Spondyloepimetaphyseal Dysplasia - Abnormal Dentition

The hook-shaped vertebrae and gibbus deformity at the thoracolumbar junction (lower part of the picture) mimic the findings in Hurler syndrome Fig. 3.5. [rrnursingschool.biz]

Vertebral abnormalities similar to, but milder than, those described above, including thoracolumbar gibbus deformity with ovoid, beaked vertebrae at the apex of the gibbus [rrnursingschool.biz]

Note the typical hooks (lower arrows) projecting from the anteroinferior aspect of ovoid (upper arrows) vertebrae, and the gibbus deformity at the thoracolumbar junction. [rrnursingschool.biz]

Acquired Osteosclerosis