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106 Possible Causes for Thrombocytopenia, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    Patients should be monitored for leukopenia and thrombocytopenia. Complications from long-term usage are not yet known. Efficacy in children has not been proven.[] The commonest side effects included neutropenia and thrombocytopenia.[] Hydroxyurea is a leukemogen and causes neutropenia and thrombocytopenia. It is also a teratogen and should not be given to females of child-bearing age.[]

  • Erythema Infectiosum

    A report is presented of a patient with neonatal erythema infectiosum who developed petechiae, transient thrombocytopenia and transient cardiac failure due to transplacental[] Virus-associated hemophagocytic syndrome.[] However, B19 parvovirus is associated with a wide clinical spectrum ranging from thrombocytopenia and neurological manifestations in immunocompromised patients and intrauterine[]

  • Malignant Histiocytosis

    The terminal event was characterized by fever, hepatosplenomegaly, thrombocytopenia, and a leukemic blood picture.[] The differential diagnosis among hemophagocytic syndromes and particularly between the virus-associated hemophagocytic syndrome (VAHS) and the malignant histiocytosis (HM)[] In case 2 the diagnosis was initially idiopathic thrombocytopenia purpura but he deteriorated on steroids, and was subsequently unsuccessfully treated with chemotherapy and[]

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[] Corticosteroids may have a role in hastening resolution of some complications, especially upper airway obstruction and possibly immune-mediated anemia and thrombocytopenia[]

  • Chediak Higashi Syndrome

    About 50% to 85% of patients eventually enter an accelerated phase, manifested by fever, lymphadenopathy, anemia, jaundice, neutropenia, thrombocytopenia, and widespread lymphohistiocytic[] In our case, a four-month-old boy, virus-associated hemophagocytic syndrome (VAHS) was suspected from generation of fever, hepatosplenomegaly, and existence of atypical lymphocytes[] Peripheral blood neutropenia becomes more profound as anaemia and thrombocytopenia develop. Most patients succumb before the age of 10 years.[]

  • Pancytopenia

    […] mm(3), and severe thrombocytopenia as thrombocyte counts below 20,000/mm(3).[] Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a noncompromised host; a case report of unusual entity.[] Craig F, Clare N, Sklar J, Banks P (1991) T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol 97: 189–194. View Article Google Scholar 16.[]

  • Castleman Disease

    There was no anemia or thrombocytopenia. Kidney biopsy was consistent with glomerular thrombotic microangiopathy (TMA).[] […] lymphoma; HLH-MAS, hemophagocytic lymphohistiocytosis- macrophage activation syndrome; IgG4, IgG4-related disease; JIA, juvenile idiopathic arthritis; M-HLH, malignancy-associated[] […] presenting with dry cough and dyspnea on exertion for 6 months and detailed exams revealed multiple pulmonary nodules, positive antinuclear antibodies, hypocomplementemia, and thrombocytopenia[]

  • Lymphoproliferative Syndrome 1

    Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.[] […] characterized by autosomal recessive inheritance, early childhood onset of Epstein-Barr virus-associated immune dysregulation typically manifesting as lymphoma, lymphomatoid[] Gastrointestinal Hepatomegaly Splenomegaly General Reduced life expectancy, death by 10 years of age in 70% of patients Hematologic Anemia Atypical lymphocytosis Pancytopenia Thrombocytopenia[]

  • Precursor-Cell Lymphoblastic Leukemia

    Although rarely observed in children affected by acute lymphoblastic leukemia, TTP is a potentially fatal illness that should be considered in the differential diagnosis of thrombocytopenia[] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[] This bleeding is commonly attributed to thrombocytopenia due to bone marrow suppressive chemotherapeutic agents.[]

  • Severe Aplastic Anemia

    Anemia most frequently causes fatigue, headaches and dizziness; thrombocytopenia provokes a tendency to bleed.[] In virus-associated hemophagocytic syndrome with an acute parvovirus B19 infection, raised levels of cytokines such as interferon γ would impair regulation of the phagocytic[] She recovered completely, but her thrombocytopenia persisted. Six weeks later she became pancytopenic. A bone marrow aspirate and biopsy showed severe aplastic anemia.[]

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