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10 Possible Causes for TmP/GFR Decreased

  • Familial Hypophosphatemia

    A case of young man with low back ache and heel pains who was examined in a rheumatology outpatient and diagnosed as familial hypophosphatemia (FH), probably X-linked (XL), is presented. FH is most commonly transmitted as XL. The role of PHEX gene and fibroblast growth factor 23 is also described.[ncbi.nlm.nih.gov]

  • Cystinosis

    Cystinosis is a genetic medical condition that results in excessive deposition of cystine crystals within lysosomes, leading to extensive organ dysfunction in the human body. Cystinosis can target multiple organs in the body and, thus, has a wide symptom presentation. Aside from kidney dysfunction, the disease can[…][symptoma.com]

  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    Long-term phosphate supplementation as the sole therapy resulted in reversal of all clinical and biochemical abnormalities except the decreased TmP/GFR.[ncbi.nlm.nih.gov] Individuals with HHRH in families A to D ( Figure 2 ) exhibited hypophosphatemia and decreased TmP/GFR when compared with agematched control subjects ( Table 1 ).[jasn.asnjournals.org] […] tubular maximum for Pi reabsorption per GFR (TmP/GFR), elevated serum 1,25(OH) 2 D levels, hypercalciuria, rickets, and osteomalacia ( 1 , 2 , 22 ).[jasn.asnjournals.org]

  • Calcinosis Circumscripta

    Intact PTH levels became measurable in the normal range, and urinary tubular reabsorption of phosphate (TRP) and TmP/GFR decreased.[academic.oup.com] Despite the reduction in dietary phosphorus levels (from 1750–1250 mg daily), his TmP/GFR decreased with the concomitant administration of probenecid.[academic.oup.com] We note, however, that normalization of circulating PTH levels would also be expected to correct an elevated TmP/GFR and hyperphosphatemia.[academic.oup.com]

  • X-Linked Hypophosphatemia

    […] rate (TmP/GFR) and serum inorganic phosphorus (Pi), resulting in rickets and/or osteomalacia.[ncbi.nlm.nih.gov] CONTEXT: In X-linked hypophosphatemia (XLH), elevated fibroblast growth factor 23 (FGF23) decreases the renal tubular maximum reabsorption rate of phosphate/glomerular filtration[ncbi.nlm.nih.gov]

  • Dicarboxylic Aminoaciduria

    Plasma creatinine can be increased with high-dose TMP- SMX by inhibiting tubule secretion of for GFR per se is not compromised, and plasma creatinine decreases within 5 days[webkidneydisease.review] […] of stopping TMP-SMX.[webkidneydisease.review]

  • Hypophosphatemia

    GFR tubular maximum for phosphate/glomerular filtration rate; AA amino acids A partial list of conditions associated with hypophosphatemia includes: Decreased dietary intake[endocrinologyadvisor.com] Abbreviations: Ca calcium; Pi inorganic phosphorus; PTH parathyroid hormone; 25(OH)D 25-hydroxyvitamin D; 1,25(OH)2D 1, 25-dihydroxyvitamin D; FGF-23 fibroblast growth factor 23; TmP[endocrinologyadvisor.com]

  • Aminoaciduria

    Indeed, only one patient of the four patients with decreased TmP/GFR did not have generalised aminoaciduria, having only six raised urinary amino acids but did have three[pilotfeasibilitystudies.biomedcentral.com] However, when examining the raw data looking at the need for electrolyte supplement and TmP/GFR, the trend suggests that aminoaciduria does indicate abnormalities in these[pilotfeasibilitystudies.biomedcentral.com]

  • Generalized Arterial Calcification of Infancy

    Decrease of serum P i levels was associated with a decrease of renal tubular phosphate reabsorption (TmP/GFR) in these patients.[doi.org]

  • Hypophosphatemic Rickets and Hyperparathyroidism

    GFR tubular maximum for phosphate/glomerular filtration rate; AA amino acids A partial list of conditions associated with hypophosphatemia includes: Decreased dietary intake[endocrinologyadvisor.com] Abbreviations: Ca calcium; Pi inorganic phosphorus; PTH parathyroid hormone; 25(OH)D 25-hydroxyvitamin D; 1,25(OH)2D 1, 25-dihydroxyvitamin D; FGF-23 fibroblast growth factor 23; TmP[endocrinologyadvisor.com]

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