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44 Possible Causes for Total and Conjugated Bilirubin Increased

  • Hemolytic Anemia

    Total bilirubin is only modestly increased (up to 5 mg/dL) and, with rare exceptions, the conjugated (direct) fraction constitutes less than 15 percent of the total.[errolozdalga.com] Urinary urobilinogen is increased regularly, but bile is not detected in the urine unless serum conjugated bilirubin is increased.[errolozdalga.com]

  • Liver Cirrhosis

    bilirubin – measures all of the bilirubin in the blood; levels are increased with many liver diseases Direct bilirubin – measures a form of bilirubin that is conjugated ([labtestsonline.org] […] other places, particularly the heart and other muscles Gamma-glutamyl transferase (GGT) – an enzyme found mainly in the liver; very sensitive to changes in liver function Total[labtestsonline.org]

  • Physiological Neonatal Jaundice

    In this case, total and unconjugated bilirubin levels are increased, but conjugated levels remain normal.[pathophys.org] […] in total bilirubin Ethnicity suggestive of G6PD deficiency Evidence of sepsis or metabolic disorder Vomiting, Lethargy Hepatosplenomegaly Excess weight loss ( 10%) Temperature[emed.ie] This unconjugated bilirubin can be reabsorbed into the circulation, increasing the total plasma bilirubin pool.[emedicine.medscape.com]

  • Neonatal Jaundice

    In this case, total and unconjugated bilirubin levels are increased, but conjugated levels remain normal.[pathophys.org] This unconjugated bilirubin can be reabsorbed into the circulation, increasing the total plasma bilirubin pool.[emedicine.com] Hemolysis, either by immune or nonimmune mechanisms, results in greater levels of bilirubin than hepatic conjugation is able to keep pace with.[pathophys.org]

  • Liver Failure

    Serum direct and indirect bilirubin levels The total bilirubin level is increasing with the reduction of the conjugated to the unconjugated bilirubin ratio (due to reduced[slideshare.net] bilirubin – measures all of the bilirubin in the blood; levels are increased with many liver diseases Direct bilirubin – measures a form of bilirubin that is conjugated ([labtestsonline.org] […] levels The total bilirubin level is increasing with the reduction of the conjugated to the unconjugated bilirubin ratio (due to reduced conjugating capacity of the liver[slideshare.net]

  • Ileal Crohn Disease

    Gallstones in patients with ileal Crohn disease (or those who have undergone ileal resection) are frequently pigment based, reflecting an increased concentration of bilirubin[forums.studentdoctor.net] conjugates, unconjugated bilirubin, and total calcium in the gallbladder bile due perhaps to altered enterohepatic cycling of bilirubin [ 76 So I guess its billirubin cycling[forums.studentdoctor.net]

  • Acquired Hemolytic Anemia

    Total bilirubin is only modestly increased (up to 5 mg/dL) and, with rare exceptions, the conjugated (direct) fraction constitutes less than 15 percent of the total.[errolozdalga.com] Urinary urobilinogen is increased regularly, but bile is not detected in the urine unless serum conjugated bilirubin is increased.[errolozdalga.com]

  • Crigler-Najjar Syndrome Type 1

    In the bile from patients with Gilbert's syndrome, a striking increase was found in the proportion of bilirubin monoconjugates (48.6 9.8% of total conjugates) relative to[jci.org] The total bilirubin started falling at 10 days after cell infusion.[ncbi.nlm.nih.gov] UDP-glucuronosyltransferase would affect the end products of bilirubin biotransformation.[jci.org]

  • Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

    His anthropometries were: Body weight was 4.75 kg ( Investigations He had normal hemogram and normal range proteins, with conjugated hyperbilirubinemia and a total bilirubin[ijpmonline.org] […] of 4.5 mg/dL and mildly increased transaminases, normal alkaline phosphatase.[ijpmonline.org]

  • Paroxysmal Cold Hemoglobinuria

    Total bilirubin is only modestly increased (up to 5 mg/dL) and, with rare exceptions, the conjugated (direct) fraction constitutes less than 15 percent of the total.[errolozdalga.com] Urinary urobilinogen is increased regularly, but bile is not detected in the urine unless serum conjugated bilirubin is increased.[errolozdalga.com]

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