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776 Possible Causes for transactivation

  • Nasal Polyp

    Since the human class II, major histocompatibility complex, transactivator (CIITA) is a positive regulator of class II, major histocompatibility complex gene transcription[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    The remaining anterior horn cells contained Bunina bodies and phosphorylation-dependent transactivation response DNA-binding protein of 43 kDa (pTDP-43)-positive neuronal[ncbi.nlm.nih.gov] Abstract Transactivation response DNA-binding protein 43 kDa (TDP-43) is a key protein of sporadic amyotrophic lateral sclerosis (ALS), and phosphorylated form of TDP-43 ([ncbi.nlm.nih.gov] Novel intracytoplasmic inclusions immunoreactive for phosphorylated transactivation response DNA-binding protein 43 (p-TDP43), cystatin C, and transferrin were found in anterior[ncbi.nlm.nih.gov]

  • Renal Coloboma Syndrome

    The variability of clinical symptoms may be explained by the limited disruption of the protein sequence at the transactivation domain.[ncbi.nlm.nih.gov] […] subjects carried a novel PAX2 mutation consisting in a frameshift mutation located in Exon 8 (G91 I del), which causes premature termination of translation and loss of the PAX2 transactivation[ncbi.nlm.nih.gov]

  • Tretinoin

    Repressed transactivation. 1 Mutagenesis i 96 S A: Abolishes PKB/AKT1-mediated phosphorylation.[uniprot.org] Note: Does not bind nor transactivate RARE on its own but may do so as a heterodimer with Alpha-1.[uniprot.org] No repression of transactivation. 1 Mutagenesis i 157 S A: No effect on PKB/AKT1-mediated phosphorylation.[uniprot.org]

  • Troglitazone

    Taken together, we demonstrate that autophagy promoted via troglitazone is correlated with AMPKalpha activation and independent of PPARgamma activation and EGFR transactivation[ncbi.nlm.nih.gov] The EC50 values for transactivation of human and mouse PPARγ in a cell-based assay are 0.55 and 0.78 μM, respectively.[chemicalbook.com] EGFR signal transactivation in cancer cells . Biochem Soc Trans 2003; 31 :1203–1208. 43. Hu E , Kim JB , Sarraf P , Spiegelman BM .[nature.com]

  • Coffin-Lowry Syndrome

    The natural 5' splice site, although intrinsically weak, is not transactivated under normal conditions.[ncbi.nlm.nih.gov]

  • Hepatitis B

    […] expression of TGF-a by transactivation.[emedicine.medscape.com] Evidence strongly suggests that these transactivators may be involved in carcinogenesis.[emedicine.medscape.com] X gene The role of the X gene is to encode proteins that act as transcriptional transactivators that aid viral replication.[emedicine.medscape.com]

  • Li-Fraumeni Syndrome

    Most intriguing was the discovery of a "super-transactivation" variant within Exon 10 of TP53 (c.1079G T/p.G360V).[ncbi.nlm.nih.gov] […] depends on many things including the type of damage and the cell type p53 is a transcription factor with a central sequence-specific DNA binding domain and a N-terminal transactivation[atlasgeneticsoncology.org] […] families with Li-Fraumeni syndrome, there appears to be an autosomal dominant inheritance pattern. p53 is a transcription factor that tetramerizes before binding to DNA to transactivate[wikidoc.org]

  • Giardia Lamblia

    Deletion of the C-terminal paired domain or mutation of the basic amino acids of the paired domain resulted in a decrease of the transactivation function of Pax1.[ncbi.nlm.nih.gov]

  • Estrogen Deficiency

    INF-gamma promotes expression in immunocompetent cells of class II transactivator (CIITA), that, up-regulating expression of the major system of histocompatibility of class[ncbi.nlm.nih.gov]

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