Transaminases Increased: Causes & Reasons

Possible Causes for Transaminases Increased

Analysis of 15 Norwegian patients over age 10 years with the disorder but without signs or symptoms of cholestasis showed significantly increased serum transaminase levels [checkorphan.org]

Laboratory test reports during cholestatic periods demonstrated hyperbilirubinemia, increased transaminases and alkaline phosphatase levels, hyperlipaemia, and increased VLDL [icliniq.com]

In adult cases, cholestasis with few multinucleated or giant cells has been recognized with increased connective tissue. [icliniq.com]

Zieve's Syndrome

[…] in transaminase levels (AST< 300 IU/mL), hyperbilirubinemia and a prolonged international normalized ratio (INR). [symptoma.com]

At laboratory tests was showed an increase in total bilirubin (10.20 mg/dL) mainly of direct fraction (7.60 mg/dL), amylase (152 U/L), lipase (936 U/L), transaminases (GOT [omicsonline.org]

[…] entities are distinguished, due to the fact that the former leads to hyperlipidemia in combination with hemolytic anemia, whereas the latter is characterized by a remarkable increase [symptoma.com]

Reye Syndrome

Serum glutamic oxaloacetic transaminase and lactate dehydrogenase (LDH) values increased strikingly on the third day after the onset of coma. [ncbi.nlm.nih.gov]

The diagnosis may also be made when the typical clinical findings and history are associated with the following laboratory findings: increased liver transaminases (AST, ALT [merckmanuals.com]

The diagnosis may also be made when the typical clinical findings and history are associated with the following laboratory findings: increased liver transaminases (aspartate [merckmanuals.com]

Primary Biliary Cirrhosis

A liver profile test panel showed mild increases in transaminases, increased alkaline phosphatase activity, hypoalbuminemia, significant hyperbilirubinemia, and evidence of [clinchem.org]

Hemoglobin-thrombocytes increased rapidly and transaminases improved at day 8. [ncbi.nlm.nih.gov]

Liver Cirrhosis

As the patient's skin rash resolved, his platelets gradually increased to >150 × 10/L and liver transaminase levels gradually decreased to a normal level. [ncbi.nlm.nih.gov]

It is also associated with hormonal disorders (panhypopituitarism, hypothyroidism, hypogonadism, polycystic ovary syndrome), persistently elevated transaminases, increasing [en.wikipedia.org]

During liver injury, ALT released from damaged cells can rapidly increase ALT activity in the serum. 11 Aspartate transaminase (AST) is present not only in the liver but also [dx.doi.org]

Duchenne Muscular Dystrophy

The diagnosis of DMD should thus be considered before liver biopsy in any male child with increased transaminases [ 3 ]. [patient.info]

The diagnosis of DMD should thus be considered before liver biopsy in any male child with increased transaminases [15]. [physio-pedia.com]

Increased transaminases (aspartate aminotransferase and alanine aminotransferase, which are produced by muscle as well as liver cells). [patient.info]

Glycogen Storage Disease Type 3

Serum transaminase and creatine kinase concentrations are increased; AST and ALT levels exceeding 1000 U/L are suggestive of GSD III. [clinicaladvisor.com]

[…] nuclei mosaic appearance hepatocytic steaosis hepatocyte vacuolation cirrhosis (adults) hepatic tumors hepatic adenoma hepatocellualr carcinoma (adults) muscle weakness (increases [humpath.com]

Moreover, although elevation of liver transaminases and fasting ketosis can be prominent, blood lactate and uric acid concentrations are usually normal. [journals.lww.com]

Delta Aminolevulinate Dehydrase Deficiency

Other AEs included rash, serum creatinine increase, transaminase elevations, and fatigue. [ajmc.com]

†Grouped term includes blood creatinine increased, glomerular filtration rate decreased, chronic kidney disease (decreased estimated glomerular filtration rate). [porphyriafoundation.org]

[…] in porphyrins and very small elevations of plasma transaminases. [pubs.rsc.org]

Hepatitis A

The clinical significance of slightly to moderately increased liver transaminase values in asymptomatic patients. [doi.org]

Alcoholic Hepatitis

[…] serum IgA and IgG levels Decreased serum cholesterol level Decreased serum triiodothyronine level - Serum transaminases levels are often not greatly raised in ALD and values [euroliver.org]

Transaminases are raised (but may be normal), showing a more marked increase of the AST in comparison with ALT. [pmj.bmj.com]

ALT (ALT usually < 100 IU/L) Increased serum bilirubin level; correlates with severity Prolonged prothrombin time; correlates with severity Decreased serum albumin level Increased [euroliver.org]

Alstrom Syndrome

Renal and hepatic dysfunction was implicated in some patients by increased values of blood urea nitrogen (BUN) and creatinine, and transaminases, respectively. [ncbi.nlm.nih.gov]

Liver: Hepatic dysfunction is noticed as an asymptomatic increase in the levels of serum transaminases, followed by hepatosplenomegaly, a possible presence of hepatocellular [symptoma.com]

renal insufficiency, gonadal dysfunction, and menstrual irregularities. 2, 3 The ALMS1 gene is mapped to chromosome 2p13. 4 Increased clinical interest and defined diagnostic [pediatrics.aappublications.org]

Polymyositis

Elevation of serum creatinine phosphokinase (CPK), transaminases, lactic dehydrogenase (LDH) or aldolase activity; d. [clinicaltrials.gov]

Electromyography (EMG) triad of changes i. small amplitude, short duration polyphasic motor unit potentials ii. fibrillations, positive sharp waves, increased insertional [clinicaltrials.gov]

Penicillin Poisoning

Liver transaminases may increase by the fifth day of therapy, but return to pretreatment levels within a week after treatment has ended. [cdc.gov]

Primary HIV Infection

[…] in ergot derivative level leading to acute ergot toxicity Ethinyl estradiol-containing products (oral contraceptives) Significant increase in PrOD level Alanine transaminase [hivguidelines.org]

[…] than in the general population, whereas hepatitis B (HBV) prevalence was not increased [Helsper et al. 2012]. [hivguidelines.org]

Unexplained liver disease or abnormal transaminase levels: In primary care patients with an alanine transaminase (ALT) level 50 to 100 IU/L, HCV prevalence is 10-fold higher [hivguidelines.org]

Lassa Fever

Favipiravir was stopped in both patients secondary to nausea and increasing liver transaminase levels. [upmc-cbn.org]

Congenital Disorder of Glycosylation Type 1Q

[…] serum transaminases, iris coloboma, glaucoma, corneal clouding and bilateral dilated lateral ventricles, and extra-axial post-cerebellar space. [springerprofessional.de]

Biochemical abnormalities include increased serum transaminases, hypothyroidism, and decreased blood clotting factors antithrombin and protein C. [nature.com]

[…] serum testosterone level Reduced antithrombin III activity Elevated serum transaminases during infections Optic atrophy Dystonia Postural instability Cerebral atrophy Encephalopathy [mendelian.co]

Celecoxib

Diclofenac had worse hepatic tolerability than celecoxib in terms of AEs of transaminase increase. [dx.doi.org]

[…] function tests NOS abnormal, Proteinuria present, Transaminase NOS increased, Urine analysis abnormal NOS Other Pre-Approval Studies Adverse Events From Ankylosing Spondylitis [rxlist.com]

Blood culture positive, Blood glucose increased, Blood pressure increased, Blood uric acid increased, Hematocrit decreased, Hematuria present, Hemoglobin decreased, Liver [rxlist.com]

Hepatic Steatosis

Unfortunately, such markers may fail to detect the presence of hepatic steatosis due to the fact that many individuals have completely normal transaminases even those with [saudijgastro.com]

[…] significantly advanced steatosis. [8] A retrospective study by Fracanzani et al. showed that NASH was diagnosed in 59% and 74% of the patients with normal and increased ALT [saudijgastro.com]

Alagille Syndrome

Alagille syndrome (AS), also known as arteriohepatic dysplasia, is an autosomal dominant multisystem disorder associated with abnormalities of the liver, heart, skeleton, eye, kidneys and a characteristic facial appearance. Patients suffering from Alagille Syndrome present with the following main clinical abnormalities:[…] [symptoma.com]

Organophosphate Poisoning

Acute severe organophosphate poisoning is a serious complication seen in developing and agricultural countries. Pralidoxime and high dose atropine are the standard treatments. There is no consensus about acute severe organophosphate poisonings that are unresponsive to pralidoxime, atropine, and supportive[…] [ncbi.nlm.nih.gov]

Middle East Respiratory Syndrome

As of June 19, 2015, the World Health Organization had received 1,338 notifications of laboratory-confirmed infection with Middle East respiratory syndrome coronavirus (MERS-CoV). Little is known about the course of or treatment for MERS-CoV in pregnant women. We report a fatal case of MERS-CoV in a pregnant[…] [ncbi.nlm.nih.gov]

Venezuelan Hemorrhagic Fever

Article Navigation From the Regional Research Unit, Portuguesa State Division of Health, Guanare, Venezuela; Department of Virology, National Institute of Hygiene “Rafael Rangel,” and the Division of Epidemiology, Ministry of Health and Social Assistance, Caracas, Venezuela ; Department of Pathology, Center for Tropical[…] [doi.org]

Argentinian Hemorrhagic Fever

Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as[…] [dx.doi.org]

Bolivian Hemorrhagic Fever

To the Editor: Bolivian hemorrhagic fever (BHF) was first described in 1959 during outbreaks affecting isolated human communities in eastern Bolivia. However, it was not until 1963 that the etiologic agent, Machupo virus, was isolated from the spleen of a patient who died from this disease ( 1 ). Although no cases[…] [dx.doi.org]

Chronic Q Fever

Hello, what are you looking for? Meningitis & Encephalitis Molecular Testing The stakes are high for accurate and timely laboratory testing methods Simplexa™ VZV Direct Kit Fast and Accurate VZV Molecular Testing Simplexa™ Bordetella Direct Kit Direct detection and differentiation of Bordetella pertussis and[…] [molecular.diasorin.com]

Hepatic Form of Wilson Disease

Fonti utilizzate nella revisione corrente (February 14, 2019) Gilroy, R. Wilson Disease. Medscape Drugs & Diseases. Available online at http://emedicine.medscape.com/article/183456-overview. Accessed September 2020. (Updated 2018). Wilson Disease. National Organization for Rare Disorders (NORD). Available online at[…] [labtestsonline.it]

Primary Hemochromatosis Type 1

Epidemiology/Health Services/Psychosocial Research Abstract OBJECTIVE —In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associated with an increased risk for diabetes. There are also some reports[…] [care.diabetesjournals.org]

Congenital Disorder of Glycosylation Type 1A

Case Reports Underdiagnosis of mild congenital disorders of glycosylation type Ia Irina Giurgea et al. Pediatr Neurol. 2005 Feb. Abstract Congenital disorders of glycosylation-Ia are the most frequent type of congenital disorders of glycosylation. This condition affects the nervous system as well as other organs. The[…] [pubmed.ncbi.nlm.nih.gov]

Combined Oxidative Phosphorylation Deficiency 33

Abnormality of metabolism/homeostasis Elevated circulating creatine kinase concentration Elevated hepatic transaminase Increased serum lactate Metabolic acidosis Abnormality [ncbi.nlm.nih.gov]

[from OMIM] Show allHide all Abnormality of metabolism/homeostasis Elevated hepatic transaminases Elevated serum creatine phosphokinase Increased serum lactate Metabolic acidosis [ncbi.nlm.nih.gov]

The diseases onset of this patient was in 5 years old with the increase of serum lactic acid, creatine kinase, transaminase, methionine and tyrosine. [frontiersin.org]

Dicrocoeliasis

Results: The parasite-induced pathologic changes were assessed by presence of fluke eggs in feces, increased plasma alanine transaminase and aspartate transaminase activities [pubmed.ncbi.nlm.nih.gov]