Transaminases Increased: Causes & Reasons

Possible Causes for Transaminases Increased

Analysis of 15 Norwegian patients over age 10 years with the disorder but without signs or symptoms of cholestasis showed significantly increased serum transaminase levels [checkorphan.org]

Laboratory test reports during cholestatic periods demonstrated hyperbilirubinemia, increased transaminases and alkaline phosphatase levels, hyperlipaemia, and increased VLDL [icliniq.com]

In adult cases, cholestasis with few multinucleated or giant cells has been recognized with increased connective tissue. [icliniq.com]

Zieve's Syndrome

[…] in transaminase levels (AST< 300 IU/mL), hyperbilirubinemia and a prolonged international normalized ratio (INR). [symptoma.com]

At laboratory tests was showed an increase in total bilirubin (10.20 mg/dL) mainly of direct fraction (7.60 mg/dL), amylase (152 U/L), lipase (936 U/L), transaminases (GOT [omicsonline.org]

[…] entities are distinguished, due to the fact that the former leads to hyperlipidemia in combination with hemolytic anemia, whereas the latter is characterized by a remarkable increase [symptoma.com]

Reye Syndrome

Serum glutamic oxaloacetic transaminase and lactate dehydrogenase (LDH) values increased strikingly on the third day after the onset of coma. [ncbi.nlm.nih.gov]

The diagnosis may also be made when the typical clinical findings and history are associated with the following laboratory findings: increased liver transaminases (aspartate [msdmanuals.com]

[…] aminotransferase, alanine aminotransferase > 3 times normal), normal bilirubin, increased blood ammonia level, and prolonged prothrombin time. [msdmanuals.com]

Primary Biliary Cirrhosis

A liver profile test panel showed mild increases in transaminases, increased alkaline phosphatase activity, hypoalbuminemia, significant hyperbilirubinemia, and evidence of [clinchem.org]

Hemoglobin-thrombocytes increased rapidly and transaminases improved at day 8. [ncbi.nlm.nih.gov]

Liver Cirrhosis

As the patient's skin rash resolved, his platelets gradually increased to >150 × 10/L and liver transaminase levels gradually decreased to a normal level. [ncbi.nlm.nih.gov]

It is also associated with hormonal disorders (panhypopituitarism, hypothyroidism, hypogonadism, polycystic ovary syndrome), persistently elevated transaminases, increasing [en.wikipedia.org]

During liver injury, ALT released from damaged cells can rapidly increase ALT activity in the serum. 11 Aspartate transaminase (AST) is present not only in the liver but also [dx.doi.org]

Duchenne Muscular Dystrophy

The diagnosis of DMD should thus be considered before liver biopsy in any male child with increased transaminases [ 3 ]. [patient.info]

The diagnosis of DMD should thus be considered before liver biopsy in any male child with increased transaminases [15]. [physio-pedia.com]

Increased transaminases (aspartate aminotransferase and alanine aminotransferase, which are produced by muscle as well as liver cells). [patient.info]

Glycogen Storage Disease Type 3

Serum transaminase and creatine kinase concentrations are increased; AST and ALT levels exceeding 1000 U/L are suggestive of GSD III. [clinicaladvisor.com]

[…] nuclei mosaic appearance hepatocytic steaosis hepatocyte vacuolation cirrhosis (adults) hepatic tumors hepatic adenoma hepatocellualr carcinoma (adults) muscle weakness (increases [humpath.com]

Moreover, although elevation of liver transaminases and fasting ketosis can be prominent, blood lactate and uric acid concentrations are usually normal. [journals.lww.com]

Delta Aminolevulinate Dehydrase Deficiency

Other AEs included rash, serum creatinine increase, transaminase elevations, and fatigue. [ajmc.com]

†Grouped term includes blood creatinine increased, glomerular filtration rate decreased, chronic kidney disease (decreased estimated glomerular filtration rate). [porphyriafoundation.org]

[…] by exam Nausea, unable to take anything by mouth Generalized seizure (present in 10–20%) No fever or leukocytosis Investigation: hyponatremia and mildly elevated transaminases [xiahepublishing.com]

Hepatitis A

The clinical significance of slightly to moderately increased liver transaminase values in asymptomatic patients. [doi.org]

Alcoholic Hepatitis

[…] serum IgA and IgG levels Decreased serum cholesterol level Decreased serum triiodothyronine level - Serum transaminases levels are often not greatly raised in ALD and values [euroliver.org]

Transaminases are raised (but may be normal), showing a more marked increase of the AST in comparison with ALT. [pmj.bmj.com]

ALT (ALT usually < 100 IU/L) Increased serum bilirubin level; correlates with severity Prolonged prothrombin time; correlates with severity Decreased serum albumin level Increased [euroliver.org]

Alstrom Syndrome

Renal and hepatic dysfunction was implicated in some patients by increased values of blood urea nitrogen (BUN) and creatinine, and transaminases, respectively. [ncbi.nlm.nih.gov]

Liver: Hepatic dysfunction is noticed as an asymptomatic increase in the levels of serum transaminases, followed by hepatosplenomegaly, a possible presence of hepatocellular [symptoma.com]

renal insufficiency, gonadal dysfunction, and menstrual irregularities. 2, 3 The ALMS1 gene is mapped to chromosome 2p13. 4 Increased clinical interest and defined diagnostic [pediatrics.aappublications.org]

Polymyositis

Elevation of serum creatinine phosphokinase (CPK), transaminases, lactic dehydrogenase (LDH) or aldolase activity; d. [clinicaltrials.gov]

Laboratory results were notable for a CK-MM of 24845 U/L, a urine myoglobin of 2302 U/L and mildly elevated transaminases. [atmph.org]

Electromyography (EMG) triad of changes i. small amplitude, short duration polyphasic motor unit potentials ii. fibrillations, positive sharp waves, increased insertional [clinicaltrials.gov]

Penicillin Poisoning

Liver transaminases may increase by the fifth day of therapy, but return to pretreatment levels within a week after treatment has ended. [cdc.gov]

Primary HIV Infection

[…] in ergot derivative level leading to acute ergot toxicity Ethinyl estradiol-containing products (oral contraceptives) Significant increase in PrOD level Alanine transaminase [hivguidelines.org]

[…] than in the general population, whereas hepatitis B (HBV) prevalence was not increased [Helsper et al. 2012]. [hivguidelines.org]

Unexplained liver disease or abnormal transaminase levels: In primary care patients with an alanine transaminase (ALT) level 50 to 100 IU/L, HCV prevalence is 10-fold higher [hivguidelines.org]

Lassa Fever

Favipiravir was stopped in both patients secondary to nausea and increasing liver transaminase levels. [upmc-cbn.org]

Congenital Disorder of Glycosylation Type 1Q

[…] serum transaminases, iris coloboma, glaucoma, corneal clouding and bilateral dilated lateral ventricles, and extra-axial post-cerebellar space. [springerprofessional.de]

Biochemical abnormalities include increased serum transaminases, hypothyroidism, and decreased blood clotting factors antithrombin and protein C. [nature.com]

[…] serum testosterone level Reduced antithrombin III activity Elevated serum transaminases during infections Optic atrophy Dystonia Postural instability Cerebral atrophy Encephalopathy [mendelian.co]

Celecoxib

Diclofenac had worse hepatic tolerability than celecoxib in terms of AEs of transaminase increase. [dx.doi.org]

[…] function tests NOS abnormal, Proteinuria present, Transaminase NOS increased, Urine analysis abnormal NOS Other Pre-Approval Studies Adverse Events From Ankylosing Spondylitis [rxlist.com]

Blood culture positive, Blood glucose increased, Blood pressure increased, Blood uric acid increased, Hematocrit decreased, Hematuria present, Hemoglobin decreased, Liver [rxlist.com]

Hepatic Steatosis

Unfortunately, such markers may fail to detect the presence of hepatic steatosis due to the fact that many individuals have completely normal transaminases even those with [saudijgastro.com]

[…] significantly advanced steatosis. [8] A retrospective study by Fracanzani et al. showed that NASH was diagnosed in 59% and 74% of the patients with normal and increased ALT [saudijgastro.com]

Alagille Syndrome

Alagille syndrome causes intractable pruritus and disfiguring xanthomas because of retained bile acids and cholesterol. Drug therapy in addition to surgical intervention may be effective in many patients in reducing serum bile acids, cholesterol levels, pruritus, and skin xanthomas. In this report, we describe a child[…] [ncbi.nlm.nih.gov]

Organophosphate Poisoning

PDF Version MECHANISM OF ACUTE TOXICITY The mechanism of acute organophosphate pesticide toxicity can be discerned from the clinical diagnostic tools and antidotes used to treat organophosphate poisonings. Namely, the determination of red blood cell and plasma pseudocholinesterase activity and treatment with 2-PAM[…] [depts.washington.edu]

Middle East Respiratory Syndrome

As of June 19, 2015, the World Health Organization had received 1,338 notifications of laboratory-confirmed infection with Middle East respiratory syndrome coronavirus (MERS-CoV). Little is known about the course of or treatment for MERS-CoV in pregnant women. We report a fatal case of MERS-CoV in a pregnant[…] [ncbi.nlm.nih.gov]

Venezuelan Hemorrhagic Fever

Article Navigation From the Regional Research Unit, Portuguesa State Division of Health, Guanare, Venezuela; Department of Virology, National Institute of Hygiene “Rafael Rangel,” and the Division of Epidemiology, Ministry of Health and Social Assistance, Caracas, Venezuela ; Department of Pathology, Center for Tropical[…] [doi.org]

Argentinian Hemorrhagic Fever

Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as[…] [dx.doi.org]

Bolivian Hemorrhagic Fever

To the Editor: Bolivian hemorrhagic fever (BHF) was first described in 1959 during outbreaks affecting isolated human communities in eastern Bolivia. However, it was not until 1963 that the etiologic agent, Machupo virus, was isolated from the spleen of a patient who died from this disease ( 1 ). Although no cases[…] [dx.doi.org]

Chronic Q Fever

Hello, what are you looking for? Meningitis & Encephalitis Molecular Testing The stakes are high for accurate and timely laboratory testing methods Simplexa™ VZV Direct Kit Fast and Accurate VZV Molecular Testing Simplexa™ Bordetella Direct Kit Direct detection and differentiation of Bordetella pertussis and[…] [molecular.diasorin.com]

Hepatic Form of Wilson Disease

Fonti utilizzate nella revisione corrente (February 14, 2019) Gilroy, R. Wilson Disease. Medscape Drugs & Diseases. Available online at http://emedicine.medscape.com/article/183456-overview. Accessed September 2020. (Updated 2018). Wilson Disease. National Organization for Rare Disorders (NORD). Available online at[…] [labtestsonline.it]

MEGDEL Syndrome

Data provider: DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals. DOAJ is independent. All funding is via donations, 22% of which comes from sponsors and 78% from members and publisher members. Active (Data provider submitted[…] [agris.fao.org]

Primary Hemochromatosis Type 1

Although data from multiple studies suggest that HFE genetic mutations are common, the frequency of phenotypic expression and therefore the clinical consequences of the mutation remain unclear. Olynyk et al studied 3011 unrelated individuals in Australia and showed that 16 were homozygous for the C282Y mutation.[…] [emedicine.medscape.com]

Cowchock Syndrome

DISEASE: Cowchock syndrome Entry H02344 Disease Name Cowchock syndrome; X-linked Charcot-Marie-Tooth disease type 4 Supergrp Charcot-Marie-Tooth disease [DS:H00264] Description Cowchock syndrome (CMTX4) is a slowly progressive X-linked recessive disorder with axonal neuropathy, deafness, and cognitive[…] [genome.jp]

Congenital Disorder of Glycosylation Type 1A

Case Reports Underdiagnosis of mild congenital disorders of glycosylation type Ia Irina Giurgea et al. Pediatr Neurol. 2005 Feb. Abstract Congenital disorders of glycosylation-Ia are the most frequent type of congenital disorders of glycosylation. This condition affects the nervous system as well as other organs. The[…] [pubmed.ncbi.nlm.nih.gov]