Transferrin Saturation Increased Causes & Reasons

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Transferrin Saturation Increased Symptom Checker: Possible causes include Third Trimester Pregnancy. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Transferrin Saturation Increased,

Negated

None

Unsure

None

Possible Causes

Third Trimester Pregnancy

The concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman,[…] [ncbi.nlm.nih.gov]

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Hemochromatosis

saturation. [ncbi.nlm.nih.gov]

Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation. [ncbi.nlm.nih.gov]

Transferrin saturation may remain increased when body iron stores and SF values are subnormal; phlebotomy that reduces transferrin saturation to low normal values may result [bloodjournal.org]

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Portal Cirrhosis

[…] serum iron and transferrin saturation and possibly results of genetic testing If these causes are not confirmed, other causes are sought: Strictures and dilations of the [merckmanuals.com]

[…] hypergammaglobulinemia and the presence of other autoantibodies (eg, anti–smooth muscle or anti-liver/kidney microsomal type 1 antibodies) Hemochromatosis: Confirmed by increased [merckmanuals.com]

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Acute Intermittent Porphyria

Periodic monitoring of serum ferritin concentration and/or transferrin saturation is therefore appropriate in individuals treated repeatedly with hemin. [ncbi.nlm.nih.gov]

Because 100 mg of hemin contains 8 mg of iron, frequent administration of hemin may increase the risk for iron overload. [ncbi.nlm.nih.gov]

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Aplastic Anemia

Aplastic anemia is a form of anemia due to failure in bone marrow production of leukocytes, erythrocytes and platelets, resulting in peripheral blood pancytopenia. Fatigue is the most common presentation as it is the first symptom of low red blood cell count. Fatigue also sets in when there is a lack of hemoglobin in[…] [symptoma.com]

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Acute Hepatic Porphyria

Alnylam presented results from their phase 3 ENVISION trial, which assessed givosiran for acute hepatic porphyria (AHP), at the European Association for the Study of the Liver (EASL) International Liver Congress in Vienna, Austria. ENVISION was a randomized, double-blind, placebo-controlled, global, multicenter study[…] [trialsitenews.com]

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Immune Thrombocytopenic Purpura

WMJ. 2009 Dec;108(9):459-61. Author information 1 University of Wisconsin Hospitals and Clinics, Department of Internal Medicine, USA. Abstract Metastatic pancreatic adenocarcinoma presenting with immune thrombocytopenic purpura is a very rare association. To date, only 1 case report found in the literature delineates[…] [ncbi.nlm.nih.gov]

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Sideroblastic Anemia

In sideroblastic anemia serum iron, serum ferritin and transferrin saturation are increased. [score99.blogspot.com]

However, in contrast, there are features of iron deficiency (normal/decreased serum iron, normal/low transferrin iron saturation, increased serum transferrin receptor concentration [clinicalgate.com]

[…] and transferrin saturation. [merckmanuals.com]

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Thalassemia Minor

Abstract Patients with heterozygous beta-thalassemia minor have a decreased hematocrit (HCT). Since the HCT is a primary determinant of whole blood viscosity, the known reduction in HCT in beta-thalassemia minor should lead to a measurable reduction of whole blood viscosity. The influence of the relatively lower[…] [ncbi.nlm.nih.gov]

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Thalassemia

Hemoglobin. 2016;40(2):127-9. doi: 10.3109/03630269.2015.1136935. Epub 2016 Feb 6. Abstract A female proband homozygous for both Hb Luton [α89(FG1)His Leu (CAC CTC), HBA2: c.269A T (or HBA1)], a high oxygen affinity hemoglobin (Hb), and for α( )-thalassemia (α-thal), (-α(4.2), leftward deletion) was first described in[…] [ncbi.nlm.nih.gov]

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Glycogen Storage Disease Type 1

saturation Maturity-onset diabetes of the young Bicornuate uterus Photophobia Cognitive impairment Behavioral abnormality Atherosclerotic lesion Hyperlipoproteinemia Acute [mendelian.co]

[…] hypoplasia Renal cortical cysts Ureteropelvic junction obstruction Abnormality of iron homeostasis Abnormality of the anterior pituitary Biliary tract abnormality Elevated transferrin [mendelian.co]

[…] pancreatitis Increased LDL cholesterol concentration Abnormal glucose tolerance Corneal arcus Premature coronary artery atherosclerosis Accelerated atherosclerosis Tendon [mendelian.co]

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Beta Thalassaemia Major

Abstract Deferoxamine is the currently available agent for the iron-chelation therapy required by Cooley's anemia patients. The difficulties associated with parenteral administration have mandated a search for alternative therapies, especially orally active iron chelators, to remove excess iron that results in damage[…] [ncbi.nlm.nih.gov]

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Hypochromic Microcytic Anemia with Iron Overload Type 2

[…] and transferrin saturation. [merckmanuals.com]

Because iron is not being used transferrin saturation is elevated ( 80%) and serum LDH is increased (ineffective erythropoiesis). [med-ed.virginia.edu]

170 ug/dL Total Iron Binding Capacity (TIBC) Transferrin only Increased 240-450 ug/dL Percent saturation Iron saturation of transferrin Decreased 33% (20-50%) Ferritin Stores [nextgencombatmedic.com]

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Thrombotic Thrombocytopenic Purpura

Plasma exchange is the principal treatment for acquired thrombotic thrombocytopenic purpura (TTP) but is invasive and may have adverse effects. Reports of immunoglobulin therapy for acquired TTP without plasma exchange are rare. A 14-year-old girl was admitted because of hemolytic anemia and thrombocytopenia.[…] [ncbi.nlm.nih.gov]

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Secondary Biliary Cirrhosis

Liver cirrhosis is a diffuse chronic liver disease affecting the entire liver. The fibrosis accumulation and distribution in the liver are known to be heterogeneous. "Localized" or "focal" cirrhosis is only anecdotically reported. Acute hepatitis E virus (HEV) infection is uncommon in western countries, especially in[…] [ncbi.nlm.nih.gov]

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Anemia due to Vitamin B6 Deficiency

Laboratory findings [ edit ] Serum Iron: high increased ferritin levels decreased total iron-binding capacity high transferrin saturation Hematocrit of about 20-30% The mean [en.wikipedia.org]

Stainable marrow hemosiderin is increased. [en.wikipedia.org]

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Hemochromatosis-Related Cardiomyopathy

[…] ferritin and increased transferrin saturation. [patient.info]

Elevated transaminase levels, serum ferritin levels, and transferrin saturation in combination increase likelihood of hemochromatosis. 5 Genetic testing is the gold standard [emdocs.net]

Transferrin saturation is increased. [textbookofcardiology.org]

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African Iron Overload

The pedigree analysis provided evidence of both a genetic effect (P less than 0.005) and an effect of increased dietary iron (P less than 0.005) on transferrin saturation [ncbi.nlm.nih.gov]

Increased dietary iron raised the mean transferrin saturation from 30 to 33 percent in subjects without the allele determining increased transferrin saturation, from 30 to [doi.org]

Among family members with increased dietary iron due to the consumption of traditional beer, transferrin saturation in serum was distributed bimodally, with 56 normal values [ncbi.nlm.nih.gov]

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Anemia due to Glutathione Metabolism Disorder

Entry H00668 Disease Name Anemia due to disorders of glutathione metabolism Subgroup Glucose-6-phosphate dehydrogenase deficiency [DS: H01375 ] Glutathione peroxidase deficiency Gamma-glutamylcysteine synthetase deficiency Glutathione synthetase deficiency 5-oxoprolinase deficiency Description Anemia due to[…] [genome.jp]

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Iron Deficiency Anemia

Note: Laboratory values are decreased Hgb, Hct, RBC count; decreased MCV, MCHC; increased RDW; decreased ferritin, serum iron, and transferrin saturation; increased TIBC! [lecturio.com]

Transferrin saturation increased in both groups with maximum mean values reached at week 4, yet response rates (RR) for serum ferritin and transferrin saturation were significantly [journals.lww.com]

Abstract Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive disease characterized by congenital hypochromic microcytic anemia, low transferrin saturation [ncbi.nlm.nih.gov]

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Iron Deficiency

Characteristics include low serum iron, increased total iron-binding capacity (TIBC), less than 16% transferrin saturation, and low serum ferritin. [bestpractice.bmj.com]

Although the transferrin level is increased, the serum iron level decreases; transferrin saturation decreases. [merckmanuals.com]

saturation (a measure of the transported form of iron) Transferrin receptor (a measure of increased red blood cell production) How is iron deficiency treated? [web.archive.org]

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Anemia

saturation. [renalandurologynews.com]

We observed a significant increase in hematocrit and transferrin saturation and a decrease in the percentage of hypochromic red cells and ferritin levels at the end of the [doi.org]

Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. [icd9data.com]

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Hypogonadism

To help determine the cause of confirmed secondary hypogonadism, testing should include serum prolactin level (to screen for pituitary adenoma) and transferrin saturation [msdmanuals.com]

If levels do not increase, true hypogonadism is likely. [msdmanuals.com]

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Restless Legs Syndrome

Ferritin levels and transferrin saturation should be followed every three months to avoid hematochomatosis. [pulmonologyadvisor.com]

RLS patients should take ferrous sulfate 325 mg twice a day on an empty stomach with vitamin C 100 mg orally twice a day to increase iron absorption. [pulmonologyadvisor.com]

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Normocytic Normochromic Anemia

saturation increased  Bone marrow: hypercellular,normoblastic or micronormoblastic reaction with vacuolation in cytoplasm, sideroblast, megakaryopoisis and normal myelopoisis [slideshare.net]

saturation; increased iron-binding capacity hypochromic, microcytic, erythrocytes a decreased amount of hemoglobin in the blood a reduction in hemoglobin below normal hemoglobin [innvista.com]

Monika Nema 75.  Peripheral smear: microcytic hypochromic ,anisopoiklocytosis ,few cell show basophilic stippling,WBC and platelet normal.  Serum iron and percent transferrin [slideshare.net]

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Microcytic Anemia

saturation increased  Bone marrow: hypercellular,normoblastic or micronormoblastic reaction with vacuolation in cytoplasm, sideroblast, megakaryopoisis and normal myelopoisis [slideshare.net]

TIBC is usually increased in iron deficiency anemia, while transferrin saturation is markedly decreased in iron deficiency anemia. [statpearls.com]

[…] decreased Normal Transferrin saturation Decreased Normal to increased Normal to slightly decreased Normal to increased Table 4. [aafp.org]

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Renal Function Impairment

Target transferrin saturation (TSAT), calculated by dividing serum iron by total iron binding capacity and multiplying by 100%, should be 20%. [merckmanuals.com]

Because of increased iron utilization with stimulated erythropoiesis, iron stores must be replaced, often requiring parenteral iron. [merckmanuals.com]

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Heart Failure

10-15% Ferritin concentration 100 ng/ml 100-300 ng/ml and transferrin saturation 20% : decreased, RDW: red blood cell distribution width II - Prognostic implications Many [web.archive.org]

[…] studies have shown anaemia to increase mortality and morbidity in HF patients ( 1, 5, 8, 9 ) and to cause the following: Higher NYHA functional class Decreased exercise capacity [web.archive.org]

[…] parameter Result Haemoglobin 13 g/dl (men) 12 g/dl (women) Hematocrite 31-32 % Mean corpuscular volume Mean corpuscular hemoglobin RBW 14 % Serum iron concentration Transferrin saturation [web.archive.org]

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Congestive Heart Failure

10-15% Ferritin concentration 100 ng/ml 100-300 ng/ml and transferrin saturation 20% : decreased, RDW: red blood cell distribution width II - Prognostic implications Many [web.archive.org]

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Chronic Kidney Insufficiency

Target transferrin saturation (TSAT), calculated by dividing serum iron by total iron binding capacity and multiplying by 100%, should be 20%. [merckmanuals.com]

Because of increased iron utilization with stimulated erythropoiesis, iron stores must be replaced, often requiring parenteral iron. [merckmanuals.com]

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