Transferrin Saturation Increased: Causes & Reasons

Possible Causes for Transferrin Saturation Increased

Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation. [ncbi.nlm.nih.gov]

with increased transferrin saturation (>45%) the earliest biochemical sign (Brissot et al, 2018). [magonlinelibrary.com]

Hemochromatosis-Related Cardiomyopathy

[…] ferritin and increased transferrin saturation. [patient.info]

Elevated transaminase levels, serum ferritin levels, and transferrin saturation in combination increase likelihood of hemochromatosis. 5 Genetic testing is the gold standard [emdocs.net]

Transferrin saturation is increased. [textbookofcardiology.org]

Hypochromic Microcytic Anemia with Iron Overload Type 2

[…] and transferrin saturation. [merckmanuals.com]

Because iron is not being used transferrin saturation is elevated (>80%) and serum LDH is increased (ineffective erythropoiesis). [med-ed.virginia.edu]

170 ug/dL Total Iron Binding Capacity (TIBC) Transferrin only Increased 240-450 ug/dL Percent saturation Iron saturation of transferrin Decreased 33% (20-50%) Ferritin Stores [nextgencombatmedic.com]

Sideroblastic Anemia

In sideroblastic anemia serum iron, serum ferritin and transferrin saturation are increased. [score99.blogspot.com]

However, in contrast, there are features of iron deficiency (normal/decreased serum iron, normal/low transferrin iron saturation, increased serum transferrin receptor concentration [clinicalgate.com]

[…] and transferrin saturation. [merckmanuals.com]

Portal Cirrhosis

[…] serum iron and transferrin saturation and possibly results of genetic testing If these causes are not confirmed, other causes are sought: Strictures and dilations of the [merckmanuals.com]

[…] hypergammaglobulinemia and the presence of other autoantibodies (eg, anti–smooth muscle or anti-liver/kidney microsomal type 1 antibodies) Hemochromatosis: Confirmed by increased [merckmanuals.com]

Acute Intermittent Porphyria

Periodic monitoring of serum ferritin concentration and/or transferrin saturation is therefore appropriate in individuals treated repeatedly with hemin. [ncbi.nlm.nih.gov]

Because 100 mg of hemin contains 8 mg of iron, frequent administration of hemin may increase the risk for iron overload. [ncbi.nlm.nih.gov]

Beta Thalassaemia Major

Iron-deficiency anemia is ruled out by conducting iron studies (e.g., serum iron, total iron-binding capacity (TIBC)), serum ferritin, and transferrin saturation. [ncbi.nlm.nih.gov]

Sideroblastic anemia is easily differentiated by ring sideroblasts due to iron deposition and increased erythrocyte protoporphyrin level. [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 1

saturation Maturity-onset diabetes of the young Bicornuate uterus Photophobia Cognitive impairment Behavioral abnormality Atherosclerotic lesion Hyperlipoproteinemia Acute [mendelian.co]

[…] hypoplasia Renal cortical cysts Ureteropelvic junction obstruction Abnormality of iron homeostasis Abnormality of the anterior pituitary Biliary tract abnormality Elevated transferrin [mendelian.co]

[…] pancreatitis Increased LDL cholesterol concentration Abnormal glucose tolerance Corneal arcus Premature coronary artery atherosclerosis Accelerated atherosclerosis Tendon [mendelian.co]

Anemia due to Vitamin B6 Deficiency

Laboratory findings [ edit ] Serum Iron: high increased ferritin levels decreased total iron-binding capacity high transferrin saturation Hematocrit of about 20-30% The mean [en.wikipedia.org]

Stainable marrow hemosiderin is increased. [en.wikipedia.org]

Third Trimester Pregnancy

OBJECTIVES: A proper implantation of trophoblastic cells and an appropriate metalloproteinases activity is required to cause disintegration of basal membranes of cells. The activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - TIMP-s. Survivin is a member of inhibitor of apoptosis[…] [ncbi.nlm.nih.gov]

Aplastic Anemia

Overview Aplastic anemia is a condition that occurs when your body stops producing enough new blood cells. The condition leaves you fatigued and more prone to infections and uncontrolled bleeding. A rare and serious condition, aplastic anemia can develop at any age. It can occur suddenly, or it can come on slowly[…] [mayoclinic.org]

Acute Hepatic Porphyria

No-charge genetic testing for acute hepatic porphyria Alnylam has partnered with Invitae to offer genetic testing at no charge for individuals who may carry a gene mutation known to be associated with acute hepatic porphyria (AHP). On average, it takes up to 15 years from symptom onset for a patient to receive[…] [invitae.com]

Immune Thrombocytopenic Purpura

Immune thrombocytopenic purpura (ITP), also called primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, is an autoimmune disease affecting thrombocytes. The most common presentations observed are bleeding and prolonged bleeding time leading to thrombocytopenia and anemia. Common signs are[…] [symptoma.com]

Thalassemia Minor

Abstract Patients with heterozygous beta-thalassemia minor have a decreased hematocrit (HCT). Since the HCT is a primary determinant of whole blood viscosity, the known reduction in HCT in beta-thalassemia minor should lead to a measurable reduction of whole blood viscosity. The influence of the relatively lower[…] [ncbi.nlm.nih.gov]

Thalassemia

Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells. When there isn’t enough hemoglobin, the body’s red blood cells don’t function properly and they last[…] [cdc.gov]

Delta Aminolevulinate Dehydrase Deficiency

Gut. 1994 Aug;35(8):1112-5. Author information 1 University Department of Medicine and Therapeutics, Western Infirmary, Glasgow. Abstract Patients with acute hepatic porphyria are denied essential operations because of concern that general anaesthesia and surgery will precipitate a life threatening porphyric crisis.[…] [ncbi.nlm.nih.gov]

Disorder of Iron Metabolism

The pedigree analysis provided evidence of both a genetic effect (P less than 0.005) and an effect of increased dietary iron (P less than 0.005) on transferrin saturation [ncbi.nlm.nih.gov]

Increased dietary iron raised the mean transferrin saturation from 30 to 33 percent in subjects without the allele determining increased transferrin saturation, from 30 to [doi.org]

Among family members with increased dietary iron due to the consumption of traditional beer, transferrin saturation in serum was distributed bimodally, with 56 normal values [ncbi.nlm.nih.gov]

Thrombotic Thrombocytopenic Purpura

Käytettävä termi tromboottinen trombosytopeeninen purppura Ohjaustermit microangiopathia thrombotica Moschcowitz Moschcowitzin oireyhtymä Moschcowitzin sairaus Moschcowitzin syndrooma Moschcowitzin tauti purpura thrombocytopenica thrombotica tromboottinen mikroangiopatia trombosytopeeninen tromboottinen[…] [finto.fi]

Secondary Biliary Cirrhosis

We report a case of systemic phaeohyphomycosis in a 13-year old girl. The clinical presentation was with fever, weight loss, cholestatic jaundice with hepatosplenomegaly and generalized lymphadenopathy. The patient was diagnosed initially as tuberculous adenitis and was on antituberculous therapy, but with worsening[…] [ncbi.nlm.nih.gov]

Anemia due to Glutathione Metabolism Disorder

ICD-10-CM Codes › D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism › D55-D59 Hemolytic anemias › D55- Anemia due to enzyme disorders › Anemia due to other disorders of glutathione metabolism 2016 2017 2018 2019 Billable/Specific Code D55.1 is a[…] [icd10data.com]

Hereditary Sideroblastic Anemia

saturation, Serum ferritin (FOR IDA) Serum Iron- Decreased TIBC- Increased % transferrin saturation- Decreased Serum ferritin- Decreased ZPP(FEP), Stainable bone marrow iron [quizlet.com]

[…] and transferrin saturation. [merckmanuals.com]

Neonatal Hemochromatosis

Neonatal Hemochromatosis NORD gratefully acknowledges Peter F. Whitington, MD, the Sally Burnett Searle Professor of Pediatrics and Transplantation, Northwestern University Feinberg Medical School, and Director of the Siragusa Transplantation Center, Chicago, for assistance in the preparation of this report.[…] [rarediseases.org]

Aerobic Exercise

An aerobics exercise instructor in the United States Army motivates her class to keep up the pace. Cardio and muscle endurance exercise session Aerobic exercise (also known as cardio) is physical exercise of low to high intensity that depends primarily on the aerobic energy-generating process.[1] "Aerobic" means[…] [en.wikipedia.org]

GRACILE Syndrome

transferrin iron saturation, and free plasma iron), profound lactic acidosis, and early death. [read.qxmd.com]

saturation Elevated hepatic iron concentration Hearing impairments Hepatic steatosis Increased serum ferritin Intrauterine growth retardation Lactic acidosis Renal Fanconi [en.wikipedia.org]

The main findings are fetal growth retardation, Fanconi type aminoaciduria, cholestasis, iron overload (liver hemosiderosis, hyperferritinemia, hypotransferrinemia, increased [read.qxmd.com]

Anemia of Chronic Disease

Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, decreased transferrin saturation, increased serum ferritin, increased reticuloendothelial [ncbi.nlm.nih.gov]

Diagnosis of ACD can be assessed by examination of chances in serum iron parameters with low to normal serum iron, transferrin saturation and transferrin concentrations on [ncbi.nlm.nih.gov]

** INCREASE ** cause its preventing the release what does that do to saturation of TIBC [transferrin] ?? [usmleforum.com]

Primary Hemochromatosis Type 1

[…] ferritin and increased transferrin saturation. [patient.info]

[…] ferritin levels and increased transferrin saturation DD: primary or secondary hemochromatosis (e.g., patients with chronic viral hepatitis or toxic liver disease) Persons [mgz-muenchen.de]

"Serum transferrin saturation increase is associated with decrease of antibacterial activity of serum in patients with HFE-related genetic hemochromatosis". Am. J. [en.wikipedia.org]

Hereditary Hemochromatosis

It was shown that HFE binds to TfR1 4 and that this association is inversely correlated to transferrin-iron saturation. [bloodjournal.org]

Type 4 disease manifests in the first decade of life as increased serum ferritin levels with low or normal transferrin saturation; progressive saturation of transferrin occurs [msdmanuals.com]

If serum transferrin-iron levels increase, HFE is displaced from TfR1 to permit HFE interaction with TfR2. 5 This ultimately triggers activation of hepcidin transcription. [bloodjournal.org]

Acquired Sideroblastic Anemia

[…] and transferrin saturation. [merckmanuals.com]

Because iron is not being used transferrin saturation is elevated (>80%) and serum LDH is increased (ineffective erythropoiesis). [med-ed.virginia.edu]

Normocytic Normochromic Anemia

saturation increased  Bone marrow: hypercellular,normoblastic or micronormoblastic reaction with vacuolation in cytoplasm, sideroblast, megakaryopoisis and normal myelopoisis [slideshare.net]

saturation; increased iron-binding capacity hypochromic, microcytic, erythrocytes a decreased amount of hemoglobin in the blood a reduction in hemoglobin below normal hemoglobin [innvista.com]

Monika Nema 75.  Peripheral smear: microcytic hypochromic ,anisopoiklocytosis ,few cell show basophilic stippling,WBC and platelet normal.  Serum iron and percent transferrin [slideshare.net]

Autosomal Dominant Sideroblastic Anemia

[…] and transferrin saturation. [merckmanuals.com]

[…] ferritin and increased transferrin saturation. [patient.info]