Hypertriglyceridemia: Causes & Reasons

Possible Causes for Hypertriglyceridemia

Acute Pancreatitis

T2DM and hypertriglyceridemia often coexist. [ncbi.nlm.nih.gov]

Hypertriglyceridemia is the third most common cause of acute pancreatitis. [ncbi.nlm.nih.gov]

Severe hypertriglyceridemia is the 3rd-leading cause of acute pancreatitis. [ncbi.nlm.nih.gov]

Familial Hypercholesterolemia Type 1

Managing hypertriglyceridemia in special situations. Table 6. Managing hypertriglyceridemia in special situations. [mdpi.com]

Yuan G et al. (2007) Hypertriglyceridemia: its etiology, effects and treatment. CMAJ 176 : 1113–1120 5. [nature.com]

Overproduction or decreased removal of VLDL TG in serum Rx: niacin and/or fenofibrate type 5 mixed hypertriglyceridemia Increased production or decreased clearance of VLDL [quizlet.com]

Zieve's Syndrome

We report a case of ZS with severe hypertriglyceridemia. [insights.ovid.com]

Because the hypertriglyceridemia was not severe in those cases, no aggressive measures were taken in addressing the hypertriglyceridemia such as plasmapheresis or intravascular [journals.lww.com]

Leslie Zieve described patients with a combination of alcoholic liver disease, hemolytic anemia and hypertriglyceridemia. [en.wikipedia.org]

Hyperlipidemia

A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy. [emedicine.medscape.com]

In those with an underlying primary hypertriglyceridemia and associated obesity, estrogenic medications can depress triglyceride removal mechanisms, leading to the chylomicronemia [ncbi.nlm.nih.gov]

Contents: • Lipids and lipoprotein particles • Epidemiology and pathophysiology • Familial hypercholesterolemia • Polygenic hypercholesterolemia and combined hyperlipidemia • Hypertriglyceridemia [karger.com]

Familial Partial Lipodystrophy

We herein report a case of premature atherosclerosis in a patient with familial partial lipodystrophy (FPL), diabetes mellitus, hypertension and hypertriglyceridemia. [ncbi.nlm.nih.gov]

抄録 We herein report a case of premature atherosclerosis in a patient with familial partial lipodystrophy (FPL), diabetes mellitus, hypertension and hypertriglyceridemia. [jstage.jst.go.jp]

Acanthosis and severe hypertriglyceridemia developed later in life, followed by diabetes. [ncbi.nlm.nih.gov]

Lipodystrophy

Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis. J Clin Gastroenterol 2002 ;34: 472 - 475 40. [doi.org]

However, the role of apoCIII in hypertriglyceridemia in lipodystrophy and the effects of leptin replacement on apoCIII levels are unknown. [ncbi.nlm.nih.gov]

The metabolic abnormalities associated with lipodystrophy include insulin resistance, hypertriglyceridemia, and hepatic steatosis. [ncbi.nlm.nih.gov]

Congenital Generalized Lipodystrophy Type 4

In those patients suffering from hypertriglyceridemia, eruptive xanthomas can frequently been observed. [symptoma.com]

Four of them had hypertriglyceridemia. Three of them had atlantoaxial instability. [ncbi.nlm.nih.gov]

Furthermore, about three out of four patients affected by CGL4 develop hypertriglyceridemia during late childhood or adolescence. [symptoma.com]

Congenital Generalized Lipodystrophy

Thiazolidinediones also may be helpful in improving insulin resistance, hyperinsulinemia, and hypertriglyceridemia. [symptoma.com]

One of its features is a disturbance in lipid metabolism characterized by hypercholesterolemia and hypertriglyceridemia. [ncbi.nlm.nih.gov]

Hypertriglyceridemia, liver cirrhosis, diabetes mellitus, as well as cardiovascular complications are frequently observed. [symptoma.com]

Congenital Generalized Lipodystrophy Type 2

In those patients suffering from hypertriglyceridemia, eruptive xanthomas can frequently been observed. [symptoma.com]

Other characteristics include hepatomegaly affecting liver functions, gum hypertrophy, hypertriglyceridemia, arterial hypertension, acanthosis nigricans, hirsutism, cardiac [checkorphan.org]

[…] lipodystrophy (CGL), also known as Berardinelli-Seip syndrome, is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia [flybase.org]

Congenital Generalized Lipodystrophy Type 1

In those patients suffering from hypertriglyceridemia, eruptive xanthomas can frequently been observed. [symptoma.com]

Because the hypertriglyceridemia and diabetes were refractory to treatment, the authors present this case in order to re? [dialnet.unirioja.es]

Other metabolic complications included hypertriglyceridemia, fatty liver disease and polycystic ovary syndrome (PCOS). [mayoclinic.org]

Familial Hypercholesterolemia Type 2

Managing hypertriglyceridemia in special situations. Table 6. Managing hypertriglyceridemia in special situations. [mdpi.com]

A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy. [emedicine.medscape.com]

Yuan G et al. (2007) Hypertriglyceridemia: its etiology, effects and treatment. CMAJ 176 : 1113–1120 5. [nature.com]

Familial Hyperlipidemia

D., 1980, Very low density lipoprotein overproduction in genetic forms of hypertriglyceridemia, Eur. J. Clin. Invest. 10:17–22. [link.springer.com]

One common inherited condition is called familial hypertriglyceridemia. [webmd.com]

IDLs) by the liver Increased chylomicrons remnants and IDLs Elevated TGs and cholesterol levels Reduced LDLs Increased risk of atherosclerosis and coronary disease Familial Hypertriglyceridemia [quizlet.com]

Hyperlipoproteinemia Type 5

Hypertriglyceridemia (Hypertriglyceridemia) - Genes APOA5, APOC2, LIPI LMF1, GPIHBP1, LPL. [ivami.com]

Managing hypertriglyceridemia in special situations. Table 6. Managing hypertriglyceridemia in special situations. [mdpi.com]

Yuan G et al. (2007) Hypertriglyceridemia: its etiology, effects and treatment. CMAJ 176 : 1113–1120 5. [nature.com]

Alstrom Syndrome

Associated endocrinologic features include hyperinsulinemia, early-onset type 2 diabetes, and hypertriglyceridemia. [ncbi.nlm.nih.gov]

The patient had underlying cone-rod dystrophy of the retinas, nystagmus, obesity, progressive sensorineural hearing impairment, diabetes mellitus, and hypertriglyceridemia [ncbi.nlm.nih.gov]

Pancreatitis secondary to severe hypertriglyceridemia has been reported. [symptoma.com]

Hyperlipoproteinemia Type 3

Managing hypertriglyceridemia in special situations. Table 6. Managing hypertriglyceridemia in special situations. [mdpi.com]

A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy. [emedicine.medscape.com]

(FHTG), the familial forms of hypertriglyceridemia. [clinicaltrials.gov]

Hyperlipoproteinemia Type 4

[…] triglycerides, Hyperglyceridaemia, Hyperglyceridemia, Triglycerides high, Hypertriglyceridaemia, Hypertriglyceridemia (disorder), hyperglyceridemia, Hypertriglyceridemia, [fpnotebook.com]

Genetic determinants of hypertriglyceridemia. [frontiersin.org]

A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy. [emedicine.medscape.com]

Hyperlipoproteinemia Type 1

A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy. [emedicine.medscape.com]

Pathophysiology of hypertriglyceridemia. Biochim Biophys Acta. 2012 May. 1821(5):826-32. [Medline]. [emedicine.medscape.com]

April 10, 2007 176 (8) 1113-1120; DOI: https://doi.org/10.1503/cmaj.060963 © 2007 Canadian Medical Association or its licensors Fig. 1: Clinical manifestations of primary hypertriglyceridemia [cmaj.ca]

Chylomicronemia Syndrome

The marked hypertriglyceridemia is usually due to the interaction of a common familial form of hypertriglyceridemia and a common acquired form of hypertriglyceridemia secondary [ncbi.nlm.nih.gov]

150-886 1.7-9.9 Severe hypertriglyceridemia >886 >10 The Endocrine Society 2012 (ref) Normal Mild hypertriglyceridemia 150-199 1.7-2.3 Moderate hypertriglyceridemia 200-999 [cmecorner.com]

A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy. [emedicine.medscape.com]

Lecithin Acyltransferase Deficiency

In 2 patients hypertriglyceridemia and hypercholesterolemia were present, the latter because of an increase in unesterified cholesterol. [ncbi.nlm.nih.gov]

One cause of low HDL in hypertriglyceridemia may be the high triglyceride level itself. [ahajournals.org]

Patients may present with HDL deficiency, corneal opacification, hemolytic anemia, hypertension, hypertriglyceridemia, and proteinuria. [emedicine.medscape.com]

Glycogen Storage Disease Type 1

Hyperlipidemia and plasma effects [ edit ] A secondary effect of low insulin levels is hypertriglyceridemia. [en.wikipedia.org]

[…] include hypercholesterolemia (decreased high-density lipoprotein [HDL] cholesterol and increased low-density lipoprotein [LDL] cholesterol), together with the characteristic hypertriglyceridemia [emedicine.medscape.com]

The cardinal features of this disorder are post absorptive hypoglycemia, lactic acidosis, hypertriglyceridemia, and hyperuricemia. [cags.org.ae]

Glycogen Storage Disease

[…] by renin-angiotensin-aldosterone system (RAS) and uric acid, and the increase in both small dense LDL and modified LDL which is characteristic of GSD Iota(a) as well as hypertriglyceridemia [ncbi.nlm.nih.gov]

Hyperlacticacidemia, which develops as a byproduct of enhanced glycolysis Hyperuricemia, which arises due to shunting of glucose-6-phosphate into the pentose phosphate pathway Hypertriglyceridemia [online.epocrates.com]

At age 18 years of age, she had marked hypertriglyceridemia (3860 mg/dL) and eruptive xanthomas and was treated with fenofibrate, atorvastatin, and fish oil. [ncbi.nlm.nih.gov]

Citrullinemia Type 2

Administration of arginine: effective in decreasing blood ammonia concentration, reducing calorie/carbohydrate intake, increasing protein intake improves hypertriglyceridemia [flipper.diff.org]

High liver enzymes 0002910 Fluctuations in consciousness 0007159 Hallucinations Hallucination Sensory hallucination [ more ] 0000738 Hepatomegaly Enlarged liver 0002240 Hypertriglyceridemia [rarediseases.info.nih.gov]

Chronic Pancreatitis

• Systemic disease such as hypertriglyceridemia, possibly hyperparathyroidism • Autoimmune pancreatitis associated with rheumatological diseases such as systemic lupus erythematosus [cnn.com]

Hypercalcemia Chronic kidney disease Congenital conditions, such as pancreas divisum Ischemia — insufficient blood supply to the pancreas Hyperlipidemia — elevated blood fat levels Hypertriglyceridemia [uvahealth.com]

[…] surgical removal of the gall bladder Alcohol/tobacco induced Pancreatitis – strict abstinence from alcohol and/or tobacco Drug Induced Pancreatitis – avoid offending medication Hypertriglyceridemia [patients.gi.org]

Wiedemann-Rautenstrauch Syndrome

Classification: A1 Subject: Biology and Life Sciences lipodystrophy neonatal progeroid syndrome hypertriglyceridemia HUTCHINSON-GILFORD PATIENT BENZODIAZEPINES COLLAGEN SKIN [lib.ugent.be]

Excessive hairiness 0001007 Hydrocephalus Too much cerebrospinal fluid in the brain 0000238 Hydronephrosis 0000126 Hypermetropia Farsightedness Long-sightedness [ more ] 0000540 Hypertriglyceridemia [rarediseases.info.nih.gov]

F451339C-F0ED-11E1-A9DE-61C894A0A6B4 700 a Fricx, C 700 a André, J 700 a Vamos, E 650 a Biology and Life Sciences 653 a lipodystrophy 653 a neonatal progeroid syndrome 653 a hypertriglyceridemia [lib.ugent.be]

Chronic Kidney Insufficiency

Clinical Topics: Diabetes and Cardiometabolic Disease, Dyslipidemia, Prevention, Hypertriglyceridemia, Lipid Metabolism, Nonstatins, Novel Agents, Statins, Hypertension, Smoking [acc.org]

Dietary modification may be helpful for hypertriglyceridemia. Statins are effective for hypercholesterolemia. [merckmanuals.com]

[…] statin treatment in CKD patients under the age of 50 years, but also to provide information on secondary causes of dyslipidemia such as nephrotic syndrome and to identify hypertriglyceridemia [acc.org]

Gout

However, some cases of back pain with radiculopathy secondary to this etiology have been reported. 56-year old male patient, with history of arterial hypertension, hypertriglyceridemia [ncbi.nlm.nih.gov]

Hypertension, renal insufficiency, hypertriglyceridemia, hypercholesterolemia, hyperuricemia, diabetes, obesity, and early menopause were each associated with a higher risk [ncbi.nlm.nih.gov]

[…] females with gout tend to be postmenopausal; pathophysiology predisposing conditions: common chronic diseases assoc w/ gout include alcoholism, obesity, hypertension, CAD, and hypertriglyceridemia [wheelessonline.com]

Arteriosclerosis

On the other hand, age-specific average CAVI scores of the hypercholesterolemia and hypertriglyceridemia group, the hyperglycemia group, the ischemic changes group, and the [bmccardiovascdisord.biomedcentral.com]

LDL.Factors associated with a less pronounced risk include:o Lack of exercise.o Stressful life style.o Weight gain: largely because obesity induceshypertension, diabetes, hypertriglyceridemia [slideshare.net]

In patients with marked hypertriglyceridemia, LDL cholesterol levels may increase, which likely reflects the ability of the LDL receptor to clear the increased LDL generated [emedicine.com]

Alagille Syndrome

This report describes a 3 year-old girl with Alagille syndrome, hepatic cholestasis, systemic hypertension, hypercholesterolemia, hypertriglyceridemia, and tetralogy of Fallot [ncbi.nlm.nih.gov]

Cholestasis manifests by conjugated hyperbilirubinemia, hepatosplenomegaly, hypercholesterolemia, hypertriglyceridemia, and coagulopathy. [orpha.net]

Chronic Alcoholism

[…] pancreatitis Cardiovascular system: Holiday heart syndromes Dilatative cardiomyopathy caused by alcoholism Arterial hypertension Apoplexy Coronary heart disease Metabolism : Hypertriglyceridemia [flexikon.doccheck.com]

Coronary Atherosclerosis

Diabetes and Cardiometabolic Disease, Dyslipidemia, Invasive Cardiovascular Angiography and Intervention, Noninvasive Imaging, Prevention, Atherosclerotic Disease (CAD/PAD), Hypertriglyceridemia [acc.org]

Health-care providers should identify for patients the importance of physical activity as primary or adjunctive therapy for such medical conditions as hypertension, hypertriglyceridemia [web.archive.org]

The role of hypertriglyceridemia in atherogenesis is complex, although it may have a small independent effect (2). [merckmanuals.com]